Updated: 6 May 2015

__________________________Signature

WILLIAM M. COPLIN, MD, FCCM, FNCS

E-mail: wmcoplin@gmail.com

EDUCATIONMedical: Baylor College of Medicine, Houston, TX, MD May 1989Baccalaureate: University of Chicago, IL, AB, Biological Sciences June 1985Other: University of Alabama, Birmingham, Physics, Summer 1983Other: Cornell University, Ithaca, NY, Biology, Summer 1980

DATES1985-19891981-198519831980

POSTGRADUATE TRAININGFellowships: University of Washington, SeattleSenior Fellow, Department of Neurological Surgery (Critical Care)Senior Fellow, Division of Pulmonary & Critical Care MedicineResidency: University of Washington, Seattle, NeurologyInternship: University of Washington, Seattle, Internal Medicine

1995-19961994-19961990-19931989-1990

FACULTY APPOINTMENTSAssociate Professor, Departments of Neurology & Neurological Surgery, Wayne State University, Detroit, MIAssistant Professor, Neurological Surgery, Wayne State University, Detroit, MIAssistant Professor, Neurology, Wayne State University, Detroit, MIActing Instructor, Neurology/Medicine, University of Washington, Seattle

2001-2012

1996-20011996-20011993-1996

HOSPITAL OR OTHER PROFESSIONAL APPOINTMENTSTrauma Performance Improvement Patient Safety Committees, Penrose Hospital, Colorado Springs, COStroke Excellence Committee, Penrose-St. Francis Health Services, Colorado Springs, COMedical Staff, Penrose Hospital, Colorado Springs, COMedical Staff, St. Mary-Corwin Hospital, Pueblo, CONeurocritical Care & Neurosciences Medical Director, Neurosciences System of Care, Centura Health, Englewood CONeurosciences Council (co-chair) Centura Health, Englewood,

2014-2015

2014-2015

2014-20152014-20152013-2015

2013-20152013-2015

COPLIN_CV_05.06.2015

COSpine Council (co-chair), Centura Health, Englewood, COTrauma Council (ad hoc), Centura Health, Englewood, COGrowth & Innovation Committee, Centura Health, Englewood, COClinical Improvement Steering Committee (invited guest, ad hoc), Centura Health, Englewood, COPhysician Champion, System Stroke Coordinators, Centura Health, Englewood, COLevel-One Trauma, Trauma Morbidity and Mortality, and Trauma Quality Improvement Operations Committees, St. Anthony Hospital, Lakewood, COPharmacy & Therapeutics Committee, St. Anthony Hospital,

Lakewood, COCritical Care Practice Council, St. Anthony Hospital,

Lakewood, COStroke/Neuroscience Peer Review Committee, St. Anthony Hospital, Lakewood, CODirector, Neurocritical Care, St. Anthony Hospital, Lakewood, COMedical Staff, St. Anthony Hospital, Lakewood, COComprehensive Stroke Research Committee, Penrose Hospital, Colorado Springs, CONeurosciences Committee, Littleton Adventist Hospital, Littleton, COTrauma Committee (ad hoc), Littleton Adventist Hospital, Littleton, CONeurosciences Committee, Parker Adventist Hospital, Parker, COSpine Committee, Parker Adventist Hospital, Parker, COTrauma Committee (ad hoc), St. Mary-Corwin Hospital,

Pueblo, COTBI Committee, St. Anthony Summit Medical Center, Frisco,

COResuscitation Committee, Detroit Medical Center hospitals, MISystem-Wide Stroke Committee, Detroit Medical Center hospitals, MISystem-Wide Critical Care Committee, Detroit Medical Center hospitals, MIPharmacy and Therapeutics Committee, Detroit Medical Center hospitals, MIChief of Neurology, Detroit Receiving Hospital, MIMedical Director, Neurotrauma & Critical Care, Detroit Receiving Hospital, MIEthics Committee, Detroit Receiving Hospital, MIPhysician Champion, Organ Donation Protocol Committee, Detroit Receiving Hospital, MIProgram Director, Neurotrauma and Neurocritical Care Fellowships, Wayne State University/Detroit Medical Center,

2013-20152013-20142013-2015

2013-2015

2013-2015

2013-20152013-20152013-2015

2013-20142013-20152013-2015

2013-20152013-20152013-20152013-20152013-20152013-20152010-2012

2009-20122009-20121999-20121999-20111998-20111998-20121998-2012

1997-2011

1996-20121996-20121996-2012

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MILevel-One Trauma and Trauma Morbidity and Mortality Committees, Detroit Receiving Hospital, MISpecial Care Committee, Detroit Receiving Hospital, MIMedical Staff, Detroit Receiving Hospital/Detroit Medical Center hospitals, MI

MAJOR PROFESSIONAL SOCIETIESNeurocritical Care Society – Founding Board Member (inception-2013; http://www.neurocriticalcare.org/about-us/history); initial Co-Chair, Long-Range Planning Committee (past); Annual Meeting Committee (past); External Ventricular Drain Guidelines Committee (current); Co-Chair, Emergency Neurological Life Support Certification Subcommittee (current)

American Neurological Association

American Stroke Association/American Heart Association – Stroke Council

American Association of Neurological Surgeons – Executive Committee, Joint Section on Neurotrauma & Critical Care (2000-present)

Congress of Neurological Surgeons – Executive Committee, Joint Section on Neurotrauma & Critical Care (2000-present)

Society of Critical Care Medicine – Past Chair, Neuroscience Section (2004-2006); Program Planning Committee (2004-2009); Course Director, Neurocritical Care (2005-2009); Sedation and Analgesia Practice Parameters Committee (1998-2010)

American Academy of Neurology – Past Chair, Critical Care and Emergency Neurology Section (2005-2007); Executive Committee, Critical Care and Emergency Neurology Section (2007-2009); Course Director, Neurotrauma Course (past)

1999-present

~2000-2011

~1997-present~1996-present

~1996-present

~1994-present

~1990-present

MEDICAL LICENSUREColorado DR.0053222 (11/25/2013 – 4/30/2015)Michigan 4301068197 (5/22/1996 – 1/31/2015)Washington MD00028748 (expired 2/7/97)

BOARD CERTIFICATIONFLEX (630207004, 12/1990)Neurology (expires 3/2018)Neurocritical Care (expires 12/2020)___________________________________________________________________________________________________COPLIN_CV_05.06.2015

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Advanced Cardiac Life SupportAdvanced Trauma Life Support – InstructorEmergency Neurological Life Support - Instructor

HONORS/AWARDSBest Attending Physician (Nursing), Detroit Receiving HospitalNeurology Residents’ Teaching Award, Wayne State UniversityPresidential Citations, Society of Critical Care MedicineSchool of Medicine Teaching Award, Wayne State UniversityJoseph F. Dasta Pharmacy Research Award (with Denise H Rhoney, PharmD), Society of Critical Care MedicineNursing Research Award, Society of Critical Care Medicine

2010-20112008-20091999, 20072003-20042003

2000

SERVICE

Centura HealthNeurotrauma & Neurocritical Care, Acute Stroke Team, Neurology inpatient service – on-call emergency and inpatient coverage and consultative coverage and availabilitySt. Anthony Hospital, Penrose Hospital, St. Francis Medical Center Neurocritical Care, Neurotrauma, Acute Stroke Team, Neurology, and Neurosurgery – consultative and clinical guidance availability, case reviewsCentura Health Neurosciences System of Care (15 hospitals and 9 affiliates)

Centura Health Neuroscience System of Care (SOC) Accomplishments

Neuroscience SOC Redefined and updated to include all neurology, neurological surgery and some psychiatry, otolaryngology, and physical medicine & rehabilitation diagnoses

Neuroscience disease-based database constructed Centura regained top market share for stroke and TIA Centura Health Physician Group neuro-interventionalists

joined to cross-cover multiple facilities St. Anthony Hospital achieved Joint Commission (TJC)

Comprehensive Stroke Center certification Avista Adventist and St. Catherine’s hospitals achieved

TJC Primary Stroke Center certification Avista Adventist and St. Anthony North hospitals

obtained fulltime neurology acute care coverage Avista Adventist Hospital achieved TJC Spine

Certification Neuroscience-specific outreach and provider/staff

education established (over 102 encounters) Littleton Adventist Hospital (LAH) opened Centura’s first

2013-2015

2013-2015

2013-2015

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Epilepsy Monitoring Unit (EMU) LAH performed the world’s first asleep Deep Brain

Stimulation (DBS) surgery with the Mazor® Robotic Guidance System

Centura became the US’s first healthcare system to partner (with CortiCare®) in continuous EEG cloud monitoring

Two research studies with platform presentations at the International Stroke Conference; won “best of” honors for representation at American Heart Association Annual Sessions National Meeting

One abstract accepted and presented at the Society of Critical Care Medicine

National presentation at Society of Interventional Neurology Annual Meeting (Ms. Santos, System VP Neuroscience & administrative dyad partner)

System-wide standardization for swallow screen, stroke patient and family education, and stroke order sets

System-wide standardization for Triage Back Pain Protocol

System guidelines of care and order set standardization for Therapeutic Temperature Management after Cardiac Arrest, Spinal Cord Injury, Severe Traumatic Brain Injury

Wayne State UniversityClinical

Neurotrauma & Neurocritical Care inpatient services – shared duty, continual availabilityDetroit Receiving, Harper, Sinai-Grace, Hutzel, and Children’s hospitalsAcute stroke team – shared duties for continuous coverageDetroit Receiving, Harper, Sinai-Grace, Huron Valley, and Children’s hospitals; Michigan Stroke NetworkNeurology inpatient service – ad hoc ward coverageDetroit Receiving HospitalNeurotrauma, Stroke, Neurocritical Care, Pulmonary & Critical Care, Trauma Surgery, and Burn Surgery fellows – supervision and trainingNeurology, Neurological Surgery, Emergency Medicine, Physical Medicine & Rehabilitation residents – supervision and training

Departmental/DivisionalDepartment of Neurology Internal Review CommitteeDepartment of Neurological Surgery Internal Review

CommitteeFellowship Director, Neurotrauma and Neurocritical

Care Fellowships

1996-2011

1997-2011

1996-2011

1996-2011

1996-2011

1997-2011

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School of MedicineEmergency Medicine Chair Search CommitteePediatrics Chair Search Committee

Professional (e.g., other medical or scientific organizations and societies)

April 1997 - 2003American Academy of Neurology Critical Care and Emergency Neurology SectionCredentialing Committee

February 1998 - 2011NACABI Intraventricular Thrombolysis TrialExecutive Committee

December 1998 – 2010Society of Critical Care MedicineSedation and Analgesia Practice Parameters Committee

February 2000 – January 2002Society of Critical Care MedicineNeurosciences Section, Secretary/Treasurer

May 2000 – May 2008Interventional Management of Stroke clinical trialSteering Committee

Fall 2000 - PresentAANS/CNS Joint Section on Neurotrauma and Critical CareExecutive Committee – Critical Care and Neurocritical Care liaison

Spring 2001 – Spring 2009American Academy of Neurology Section on Emergency and Critical CareExecutive Committee

January 2002 – 2004Society of Critical Care MedicineNeurosciences Section, Chair-Elect

August 2002 – September 2014Neurocritical Care SocietyBoard of Directors, founding member

January 2004 – PresentSociety of Critical Care MedicineNeurosciences Section, Chair

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January 2002 – 2004AANS/Brain Trauma FoundationGuidelines for the Management of Severe Traumatic Brain Injury Committee

November 2012 – PresentNeurocritical Care SocietyBrain Death Subcommittee of NCS Ethics Committee

January 2013 – PresentNeurocritical Care SocietyExternal Ventricular Drains Guidelines Committee and co-author

January 2015 – PresentNeurocritical Care SocietyEmergency Neurological Life Support Subcommittee on Certification, Co-Chair

Community (e.g., presentations for lay audiences, educational outreach, media presentations/interviews)

News service interviews: Traumatic brain injury, stroke, and hemicraniectomy, hypothermia: MSNBC et al.

Michigan Stroke Initiative, Enhancing Access to Acute Stroke Care in Michigan Communities, 1999-2011

Great Lakes Transplantation Association, medical advisory board, 1999-2011

Wayne County Traffic Safety Commission, 2000-2011

Community Stroke education, Detroit, MI

Community Education and Feedback for Waiver of Informed Consent for Hemicraniectomy clinical trial, Detroit, MI

Brain Injury Association of Michigan

Brain Injury Association of Colorado, May 2014

Online Live Chat – Stroke Prevention – Centura Health, May 2013

Centura Health Neurosciences System of Care, Affiliate, Critical Access and Community Outreach, May 2013-January 2015 (* = multiple) – includes presentations,

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clinical and didactic education, case reviews, etcCheyenne Regional Medical Center, Cheyenne, WYDenver Health Medical Center, Denver, COAspen Valley Hospital, Aspen, COSt. Vincent’s Hospital, Leadville, CO*Longmont United Hospital, Longmont, CO*Platte Valley Medical Center, Brighton, CO*Good Samaritan Medical Center, Lafayette, COHeart of The Rockies Regional Medical Center, Salida, CO*San Luis Valley Regional Medical Center, Alamosa, CO*Rio Grande Hospital, Del Norte, CO*Conejos County Hospital, La Jara, COPagosa Springs Medical Center, Pagosa Springs, CO*San Juan Regional Medical Center, Farmington, NMSouthwest Memorial Hospital, Cortez, COLincoln Community Hospital, Hugo, COMiners’ Colfax Medical Center, Raton, NMKit Carson County Memorial Hospital, Burlington, COGoodland Regional Medical Center, Goodland, KS

ConsultingRemifentanil Advisory Board, Glaxo-Wellcome, February 1998

Tirilazad Mesylate in SAH advisory panel, Pharmacia & Upjohn, April 1999

Innercool Therapies, Stroke Initiative, April 2000

Medivance Hypothermia Panel/Arctic Circle, Feb. 2002 – 2011Integra Neurosciences, 2002 – Present

Ortho-McNeil, 2003 – 2008

ESP Pharma, 2003 – 2005

PDL Biopharma, 2005-2008

UCB Pharma, 2015 – Present

Bard Medical, 2015 – Present

Multiple investment banking organizations

Scholarly Service

Grant Review Committees

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National

June 1999 - 2005NIH/NINDS - MemberCell Death and Injury in Neurodegeneration Study Section (formerly Brain Disorders and Clinical Neurosciences –3)

NIH/NINDS: Clinical Trials Study Group – Ad hoc

Regional/Local

Rehabilitation Institute of Michigan internal grant

reviews – last 2011

Service for Peer-Reviewed Journals

Editorial Board Membership – Neurocritical Care

Review of Manuscripts – ad hoc reviews for Neurosurgery, Journal of the Neurological Sciences, American Journal of Kidney Diseases, Respiratory Care, Neurology, Stroke, Archives of Neurology, Cerebrovascular Diseases, New England Journal of Medicine, Journal of Stroke and Cerebrovascular Diseases, Annals of Neurology, Journal of Neuroimaging, Critical Care, and Critical Care Medicine

Moderator for numerous scientific sessions, e.g., Rocky Mountain Neurocritical Care Conference, Denver, 2013 (Course Director); Neurocritical Care Society; Society of Critical Care Medicine (Course Director, Neurocritical Care); American Academy of Neurology (Course director, Neurotrauma, 2002-2003); International Neurocritical Care Symposia – Panama; IInd National Workshop – Critical Care Neurology, Hyderabad, India (Course Director, Critical Care Neurology, 2003)

OTHER SERVICE DATES

TEACHING

Centura Health Neurosciences System of Care, Centura Health Hospital Affiliates, Colorado Critical Access Hospital Outreach

Undergraduate students

2013-2015

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Bedside roundingNursing and Respiratory Therapy

Medical studentsBedside roundingRocky Vista University College of Osteopathic Medicine

Residents/FellowsBedside rounding and didactic (see didactic below)St. Anthony Hospital Surgical residentsUniversity of Colorado Pulmonary & Critical Care

Medicine fellows

Physicians/Nurses/Pharmacists (CME/CEU/CE)Bedside/clinical rounds; didactics; case reviews for Neurology, Stroke/ICH/SAH, Neurosurgery, Trauma, Neuroradiology, Skull-Base Surgery/Otolaryngology/Head & Neck Surgery, and Emergency Medicine; also see Invited Lectures/Presentations

Wayne State University

Teaching at Wayne State UniversityUnder the categories below, list course number/title or type of teaching activity and your role. Indicate year(s) when taught.

Undergraduate studentsShadowing elective in Neurology/Neuro-Emergencies/Neurocritical Care/Neurotrauma for high school and Wayne State University college students

Graduate studentsSchool of Pharmacy Students – regular rotation through NeuroICU

Shadowing elective for Wayne State University Law School students

Neuropsychology resident and fellow didactics – traumatic brain injury

Certified Registered Nurse Anesthetist studentsLectures - airway management and ventilation of the brain-injuredClinical Preceptorship – neuroemergencies, neurotrauma, and neurocritical care

1996-2012

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Advanced Cinical Nurse Practitioner studentsClinical Preceptorship - neuroemergencies, neurotrauma, and neurocritical care

Medical studentsYear Two – lectures and small group didactic sessionsNeuropathophysiology courseObjective Structured Clinical ExamNeurology Clinical Vignettes

Year Three – attending physician for Neurocritical Care/Neurology clinical rotation – included didactic core lectures

Year Four – elective clinical attending and preceptorships in Neurocritical Care, Neurology, Stroke/Vascular Neurology, Neurological Surgery, Critical Care Medicine, Trauma Surgery, and Emergency Medicine – included didactic lectures

Residents/FellowsNeurology Residents – rounding attending physician (NeuroICU and ward services), mentoring, didactic lecturesNeurology Resident Teaching ConferenceNeurology Journal ClubNeurology Professor’s RoundsStroke Conference

Neurological Surgery Residents – rounding attending physician, (NeuroICU and ward services), mentoring, didactic lecturesNeurosurgery Resident Core LecturesNeurosurgery Journal ClubNeurotrauma Conference

Emergency Medicine Residents – rounding attending physician (1st-year NeuroICU rotation and Senior Resident electives), mentoring, didactic lectures

Pharmacy Practice Residents -- rounding attending physician (NeuroICU rotation), research mentoring, didactic lectures

General Surgery Residents – rounding consulting physician, mentoringTrauma Conference

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Internal Medicine Residents’ board review - Neurology

Physical Medicine & Rehabilitation Residents – NeuroICU elective rounding attending physician, mentoring, didactic lectures

Physical Medicine & Rehabilitation Lecture Series

Neurotrauma Fellows – Program Director, rounding attending physician, research mentoring, didactic lectures

Neurocritical Care Fellows -- Program Director, rounding attending physician, research mentoring, didactic lectures

Pulmonary & Critical Care Medicine Fellows – rounding attending physician (scheduled Neurocritical Care rotation and electives), mentoring, didactic lecturesCore LecturesFundamentals in Critical Care Support Course – Neurologic Assessment and Support

Emergency Medicine Critical Care Fellows -- rounding attending physician, mentoring, didactic lectures

Trauma Surgery Fellows -- rounding attending physician (scheduled Neurotrauma/Neurocritical Care rotation and elective), mentoring, didactic lectures

Burn Surgery Fellows – rounding attending physician (elective Neurocritical Care rotation), mentoring, didactic lectures

Physicians/Nurses/Pharmacists (CME/CEU/CE)Didactics; case reviews for Neurology, Stroke/ICH/SAH, Neurosurgery, Trauma, Neuroradiology, and Emergency Medicine; also see Invited Lectures/Presentations

Nutritionist/dietician didactics

Speech and Language Therapy didactics

Faculty (CME)

University of Washington

Graduate Professional students

1993-1996

1995

1993-19961993-19961995

1993-19961993-199619951995-19961993-19951993-19951993-19951993-19941993-1994

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Law B520 (Trial Advocacy)

Medical studentsHuman Biology 550 (Basic Neurology)Medicine 686 (Neurology Clerkship)Human Biology 541 (The Respiratory System)

Residents/FellowsNeurology Resident Teaching ConferencesNeurology Journal ClubNeurological Surgery Resident Teaching ConferenceRespiratory/Critical Care ConferenceVA Chief of Medicine RoundsVA Medicine Noon ConferencesUniversity of Washington Medicine Noon ConferencesSwedish Hospital Medicine Noon ConferencesSwedish Hospital Medicine Morning Report

Physicians/Nurses/Pharmacists (CME/CEU/CE)Neurology, Neurological Surgery, Pulmonary & Critical Care Medicine Grand Rounds and conferences and didactics - also see Invited Lectures/Presentations

MentorshipMultiple medical, pharmacy, nurse anesthetist, acute care nurse practitioner, and dietician students and residentsFaith Abbott, DO, neurotrauma fellowPrasad Policherla, MD, neurotrauma and neurocritical care fellowRodney Leacock, MD, neurotrauma and neurocritical care fellowJacqueline Kraus, MD, neurotrauma and neurocritical care fellowGregory Norris, MD, neurotrauma and neurocritical care fellowAhmed Abdulsalam, MD, neurocritical care fellowBenjamin Atkinson, MD, neurotrauma and neurocritical care fellow

Theses/Dissertations mentoring assistance – Wayne State UniversityBill D. Underwood, MD, PhD, clinical and editorial, heat shock protein and other gene expression after penetrating traumatic brain injuryJulie G. Pilitsis, MD, PhD, clinical and editorial, central nervous system free fatty acid metabolism and disposition after acute brain injuryJohn J. Steele III, MD, PhD, clinical and editorial, electrophysiological alterations and topography after acute

1993-1996

1996-2011

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brain injury

Course and curriculum development Refining Skills in Nutrition Support (Educational

Planning Committee) 1999 Critical Care Neurology (IInd National Workshop –

Critical Care Neurology, Hyderabad, India) 2003 Neurotrauma (American Academy of Neurology) 2002 &

2003 Neurocritical Care (Society of Critical Care Medicine)

2005-2009 Neurocritical Care in Catastrophic Conditions

(Neurocritical Care Society) 2011 Rocky Mountain Neurocritical Care Conference (Centura

Health) 2013

GRANTS, CONTRACTS, AND OTHER FUNDING

Active and Pending Grants and Contracts

None

Previously funded NIH Grant as PINIH/NINDS 1 RO1 NS38905-01, Early hemicraniectomy to manage traumatic brain injury. 7/16/99 – 6/30/03, $260,606

Previously submitted, not funded Grants and Contracts as PINIH/NINDS 1 R21 NS048744-01, IntraCranial Pressure Prevention and Control Investigation. (Coplin)

1999-2003

CLINICAL TRIALS ACTIVITIESWithin last two years:• A Non-Transfer Protocol for Patients with Stable, Mild,

Isolated Traumatic Brain Injury at Level III and IV Trauma Centers, co-PI

• Neurotelemetry: Remote cEEG Monitoring and Reading for Neurocritical Care Patient Management, co-PI and abstract presenter

• Boehringer-Ingelheim 1160.189 (ESUS study), local PI – while at Centura Health

• POINT, co-investigator – while at Centura Health• Association Between Pharmacological Thromboprophylaxis

And Hemorrhage Progression In Patients With Hemorrhagic Stroke, co-investigator, abstract presenter, and lead author for manuscript in progress

• Pharmacological Thromboprophylaxis Reduces the Odds of Venous Thromboembolism In Patients With Hemorrhagic

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Stroke, co-investigator, abstract presenter, and lead author for manuscript in progress

PUBLICATIONS• Recent and representative publications in journals (selected from > 69).

Does not include presentations, abstracts, book chapters, or articles ‘in preparation’ or ‘submitted.’

Chesnut, R, et al. A Consensus-based Guide to the Interpretation of the BEST TRIP ICP Trial. J Neurotrauma. 2015;in press

Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014;371(26):2457-66.

Frank JI, Schumm LP, Wroblewski K, Chyatte D, Rosengart AJ, Kordeck C, et al. Hemicraniectomy and durotomy upon deterioration from infarction-related swelling trial: randomized pilot clinical trial. Stroke. 2014;45(3):781-7.

Levy AS, Salottolo K, Coplin WM, Smith R, Santos P, Bar-Or D. Pharmocologic thromboprophylaxis reduces the odds of venous thromboembolism in patients with hemorrhagic stroke. Stroke. 2014 – presented at 2014 International Stroke Conference, San Diego

Levy AS, Salottolo K, Coplin WM, Orlando A, Smith R, Santos P, Bar-Or D. Association between pharmacologic thromboprophylaxis and hemorrhage progression in patients with hemorrhagic stroke. Stroke. 2014 – presented at 2014 International Stroke Conference, San Diego

Coplin WM. Traumatic spinal cord injury. In: NCS Practice Update Textbook, Neurocritical Care Society, 2014.

Liu-DeRyke X, Levy PD, Parker D Jr, Coplin W, Rhoney DH. A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. Neurocrit Care. 2013;19:41-7.

Bhattacharya P, Kansara A, Chaturvedi S, Coplin W. What drives the increasing utilisation of hemicraniectomy in acute ischaemic stroke? J Neurol Neurosurg Psychiatry. 2013; 84(7):727-31.

Nagaraja N, Bhattacharya P, Norris G, Coplin W, Narayanan S, Xavier A, et al. Arrival by ambulance is associated with acute stroke intervention in young adults. J Neurol Sci. 2012;316(1-2):168-9.

Coplin WM. Critical care management of acute ischemic stroke. Neurology. Continuum (Minneap Minn). 2012;18(3):547-59.

Naff N, Williams MA, Keyl PM, Tuhrim S, Bullock MR, Mayer SA, et al. Low-___________________________________________________________________________________________________COPLIN_CV_05.06.2015

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dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial. Stroke. 2011;42(11):3009-16.

Kullar R, Chin JN, Edwards DJ, Parker D, Coplin WM, Rybak MJ. Pharmacokinetics of single-dose daptomycin in patients with suspected or confirmed neurological infections. Antimicrob Agents Chemother. 2011;55(7):3505-9.

Rhoney DH, Coplin WM, Lin Y, Frankel M, Lyden PD, Levine SR. Time of day, outcome, and response to thrombolytic therapy: the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trial experience. J Stroke Cerebrovasc Dis. 2010;19(1):40-8.

Browning L, Parker D, Jr., Liu-DeRyke X, Shah A, Coplin WM, Rhoney DH. Possible removal of topiramate by continuous renal replacement therapy. J Neurol Sci. 2010;288(1-2):186-9.

Zwienenberg-Lee M, Hartman J, Rudisill N, Madden LK, Smith K, Eskridge J, et al. Effect of prophylactic transluminal balloon angioplasty on cerebral vasospasm and outcome in patients with Fisher grade III subarachnoid hemorrhage: results of a phase II multicenter, randomized, clinical trial. Stroke. 2008;39(6):1759-65.

Ramappa P, Thatai D, Coplin W, Gellman S, Carhuapoma JR, Quah R, et al. Cardiac troponin-I: a predictor of prognosis in subarachnoid hemorrhage. Neurocrit Care. 2008;8(3):398-403.

Liu-Deryke X, Janisse J, Coplin WM, Parker D, Jr., Norris G, Rhoney DH. A comparison of nicardipine and labetalol for acute hypertension management following stroke. Neurocrit Care. 2008;9(2):167-76.

Chang CW, Torbey MT, Diringer MN, Coplin W, Mayer SA, Hemphill EC, et al. Neurointensivists: part of the problem or part of the solution? Crit Care Med. 2008;36(10):2963-4; author reply 5.

Benson RR, Meda SA, Vasudevan S, Kou Z, Govindarajan KA, Hanks RA, et al. Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury. J Neurotrauma. 2007;24(3):446-59.

Murugappan A, Coplin WM, Al-Sadat AN, McAllen KJ, Schwamm LH, Wechsler LR, et al. Thrombolytic therapy of acute ischemic stroke during pregnancy. Neurology. 2006;66(5):768-70.

Mayer SA, Coplin WM, Chang C, Suarez J, Gress D, Diringer MN, et al. Core curriculum and competencies for advanced training in neurological intensive care: United Council for Neurologic Subspecialties guidelines. Neurocrit Care. 2006;5(2):159-65.___________________________________________________________________________________________________COPLIN_CV_05.06.2015

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Mayer SA, Coplin WM, Chang C, Suarez J, Gress D, Diringer MN, et al. Program requirements for fellowship training in neurological intensive care: United Council for Neurologic Subspecialties guidelines. Neurocrit Care. 2006;5(2):166-71.

Esper DH, Coplin WM, Carhuapoma JR. Energy expenditure in patients with nontraumatic intracranial hemorrhage. JPEN J Parenter Enteral Nutr. 2006;30(2):71-5.

Borsody M, Burke A, Coplin W, Miller-Lotan R, Levy A. Haptoglobin and the development of cerebral artery vasospasm after subarachnoid hemorrhage. Neurology. 2006;66(5):634-40.

Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol. 2006;60(5):508-17.

Barrett RJ, Hussain R, Coplin WM, Berry S, Keyl PM, Hanley DF, et al. Frameless stereotactic aspiration and thrombolysis of spontaneous intracerebral hemorrhage. Neurocrit Care. 2005;3(3):237-45.

Larive LL, Rhoney DH, Parker D, Jr., Coplin WM, Carhuapoma JR. Introducing hypertonic saline for cerebral edema: an academic center experience. Neurocrit Care. 2004;1(4):435-40.

Rhoney DH, Tam VH, Parker D, Jr., McKinnon PS, Coplin WM. Disposition of cefepime in the central nervous system of patients with external ventricular drains. Pharmacotherapy. 2003;23(3):310-4.

Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, et al. Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. Neurosci Lett. 2003;349(2):136-8.

Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, et al. Measurement of free fatty acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke. Brain Res. 2003;985(2):198-201.

Carhuapoma JR, Gupta K, Coplin WM, Muddassir SM, Meratee MM. Treatment of refractory fever in the neurosciences critical care unit using a novel, water-circulating cooling device. A single-center pilot experience. J Neurosurg Anesthesiol. 2003;15(4):313-8.

Rhoney DH, Parker D, Jr., Formea CM, Yap C, Coplin WM. Tolerability of bolus versus continuous gastric feeding in brain-injured patients. Neurological Res. 2002;24(6):613-20.

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Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, et al. Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observation. J Neurosurg. 2002;97(2):272-9.

Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, et al. Clinical trials in head injury. J Neurotrauma. 2002;19(5):503-57.

Kraus JJ, Metzler MD, Coplin WM. Critical care issues in stroke and subarachnoid hemorrhage. Neurol Res. 2002;24 Suppl 1:S47-57.

Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30(1):119-41.

Coplin WM, Rhoney DH, Rebuck JA, Clements EA, Cochran MS, O'Neil BJ. Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin. Neurol Res. 2002;24(8):842-8.

Tirschwell DL, Coplin WM, Becker KJ, Vogelzang P, Eskridge J, Haynor D, et al. Intra-arterial urokinase for acute ischemic stroke: factors associated with complications. Neurology. 2001;57(6):1100-3.

Pilitsis JG, Diaz FG, Wellwood JM, O’Regan MH, Fairfax MR, Phillis JW, et al. Quantification of free fatty acids in human cerebrospinal fluid. Neurochem Res. 2001;26(12):1265-70.

Joshi N, Chaturvedi S, Coplin WM. Poor prognosis of acute stroke patients denied thrombolysis due to early CT findings. J Neuroimaging. 2001;11(1):40-3.

Coplin WM, Cullen NK, Policherla PN, Vinas FC, Wilseck JM, Zafonte RD, et al. Safety and feasibility of craniectomy with duraplasty as the initial surgical intervention for severe traumatic brain injury. J Trauma. 2001;50(6):1050-9.

Coplin WM, Cochran MS, Levine SR, Crawford SW. Stroke after bone marrow transplantation: frequency, aetiology and outcome. Brain. 2001;124(Pt 5):1043-51.

Coplin WM, Broderick J, Tomsick TT. Intraarterial recombinant tissue plasminogen activator for ischemic stroke: an accelerated dosing regimen. Neurosurgery. 2001;49(1):228-9.

Coplin WM. Intracranial pressure and surgical decompression for traumatic brain injury: biological rationale and protocol for a randomized clinical trial. Neurol Res. 2001;23(2-3):277-90.

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Vinas FC, Kazmierczak C, Coplin WM. Active intracerebral hemorrhage from the lateral posterior choroidal artery. Arch Neurol. 2000;57(6):889-90.

Tipps LB, Coplin WM, Murry KR, Rhoney DH. Safety and feasibility of continuous infusion of remifentanil in the neurosurgical intensive care unit. Neurosurgery. 2000;46(3):596-601; discussion -2.

Rhoney DH, Tipps LB, Murry KR, Basham MC, Michael DB, Coplin WM. Anticonvulsant prophylaxis and timing of seizures after aneurysmal subarachnoid hemorrhage. Neurology. 2000;55(2):258-65.

Rebuck JA, Murry KR, Rhoney DH, Michael DB, Coplin WM. Infection related to intracranial pressure monitors in adults: analysis of risk factors and antibiotic prophylaxis. J Neurol Neurosurg Psychiatry. 2000;69(3):381-4.

Devlin JW, Coplin WM, Murry KR, Rengachary SS, Wilson RF. Nimodipine-induced acute hypoxemia: case report. Neurosurgery. 2000;47(5):1243-6; discussion 6-7.

Coplin WM, Pierson DJ, Cooley KD, Newell DW, Rubenfeld GD. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000;161(5):1530-6.

PRESENTATIONS

International/national, local/regional, and invited Seminars and Grand Rounds since May 2013

1. Online Live Chat – Stroke Prevention – Centura Health – 5/23/132. Stroke in the Emergency Department: What to do… - St. Catherine

Hospital (med staff) – 5/29-133. Zombie Neurobiology: Are We Ready For The Looming Apocalypse? –

University of Virginia Neurology Grand Rounds – 5/31/134. Optimal Glucose Control in Hemorrhagic Stroke – St. Anthony

Hospital (MD/RN) – 6/13/135. TBI Case Studies – St. Anthony Neuro/Trauma Nursing Staff – monthly

x 2, first 6/14/136. Brain Injury Management – Grand Rounds Santo Tomas Hospital,

Panama – 6/19/137. Delayed Brain Injury - 3rd International Neurocritical Care

Symposium, Panama – 6/20/138. Updates in Neuromonitoring of TBI Patients - 3rd International

Neurocritical Care Symposium, Panama – 6/20/139. Brain Tissue Oxygen Based Therapy and Outcome after Severe

Traumatic Brain Injury - 3rd International Neurocritical Care Symposium, Panama – 6/21/13

10. Update in the Management of Traumatic Spinal Cord Injury - 3rd

International Neurocritical Care Symposium, Panama – 6/21/13___________________________________________________________________________________________________COPLIN_CV_05.06.2015

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11. Traumatic Spinal Cord Injury – St. Anthony Trauma Multidisciplinary QI – 7/1/13

12. Early Goal Directed Therapy for Traumatic Brain Injury – Cheyenne Regional Medical Center (WY) – 7/9/13

13. Hospital Neurological Assessments – Penrose Hospital (Centura Stroke Coordinators’ monthly meeting) – 7/12/13

14. Traumatic Spinal Cord Injury – Panorama Orthopedics (physician/PA staff) – 7/15/13

15. Controversies in Spine Injury – Parker Adventist Hospital (Spine Committee) – 7/30/13

16. Clearing the Spine in the ED: Exam, Imaging, Gear Removal, and Transition to Further Care: The Neuro Doc's Perspective – 1st Annual Rocky Mountain Sports Medicine Symposium, Durango – 8/2/13

17. Hypoxia Unplugged: Altitude and Carbon Monoxide– 1st Annual Rocky Mountain Sports Medicine Symposium, Durango – 8/3/13

18. Neurological Assessment – St. Anthony North (nursing) – 8/7/1319. You Won’t Get Far If You Keep On Sticking Your Hand In The

Medicine Jar: Steroids Work, Don’t They? – Littleton Adventist Hospital (trauma) – 8/15/13

20. Transfusion “Requirements” in Traumatic Brain Injury – Littleton Adventist Hospital (trauma) – 8/15/13

21. Toxic Encephalopathies: Ethanol Withdrawal – Critical Care Karma, Porter Adventist Hospital – 8/21/13

22. Blood Pressure Management for Different Types of Stroke - St. Anthony Hospital – 8/26/13

23. Severe Traumatic Brain Injury: Initial Assessment and Resuscitation – St. Anthony Hospital – 8/29/13

24. Use of Clinical Examination Scales in Patients with Neurological Injury: Why All the Confusion? – St. Anthony Hospital (Neurocritical Care board review series) – 9/9/13

25. Monitoreo Multimodal en Neurointensivo - Asociación Colombiana de Medicina Interna – Pasto – 9/13/13

26. Presión Tisular de Oxígeno Cerebral - Asociación Colombiana de Medicina Interna – Pasto – 9/13/13

27. Minimizing Perioperative Spine Surgery Infections: Why All The Confusion? – Parker Adventist Hospital (Spine Committee) – 9/17/13

28. Traumatic Spinal Cord Injury – Neurocritical Care Society – Philadelphia – 10/2/13

29. General Approach to Ventilating the Comatose Trauma Patient – St. Anthony Hospital (trauma) – 10/7/13

30. Fluids, Electrolytes, Resuscitation Do’s and Don’ts – St. Anthony Hospital (Neurocritical Care board review series) – 10/10/13

31. Hypercalcemia – Heart of the Rockies Regional Medical Center, Salida – 10/10/13

32. Coagulopathies – Littleton Adventist Hospital (trauma) – 10/17/13

33. Acute Management of Neurological Emergencies – St. Mary-Corwin (nursing) – 10/19/13

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34. Neuropharmacology – Rocky Mountain Neurocritical Care Conference – 10/29/13

35. Neuroendocrinology – Rocky Mountain Neurocritical Care Conference – 10/30/13

36. Spinal Cord Injury – Rocky Mountain Neurocritical Care Conference – 10/30/13

37. Natural, Supernatural, and Man-Made Catastrophes – Rocky Mountain Neurocritical Care Conference – 10/30/13

38. Zombie Neurobiology: Are We Ready For The Looming Apocalypse? – St. Mary’s Medical Center’s 4th Annual Neuroscience Symposium – Advancements in Neuroscience, Palm Beach Gardens, FL – 11/2/13

39. Traumatic Intracranial Hemorrhage – Mercy Regional Medical Center Trauma Conference – 11/9/13

40. Traumatic Intracranial Hemorrhage – Mercy Regional Medical Center – 11/11/13

41. Toxic Encephalopathies: Ethanol Withdrawal – Mercy Regional Medical Center – 11/11/13

42. Mild TBI Transfer Algorithm – Mercy Regional Medical Center – 11/13/13

43. Zombie Neurobiology: Are We Ready For The Looming Apocalypse? – Critical Care Karma - 11/18/13

44. Severe TBI – St. Anthony Hospital (Neurocritical Care board review series) – 11/26/13

45. Workup, Management, and Disposition of Mild Traumatic Brain Injury: Why All The Confusion? – St. Vincent Hospital, Leadville – 12/2/13

46. Multimodality Monitoring in Neurocritical Care – St. Anthony Hospital (Neurocritical Care board review series) – 12/5/13

47. Spinal Cord Injury – St. Anthony Hospital (nursing) – 12/6/1348. There Will Be Blood – Aspen Valley Hospital (trauma) – 12/10/1349. Workup, Management, and Disposition of Mild Traumatic Brain

Injury: Why All The Confusion? – Mercy Regional Medical Center – 12/11/13

50. “Neuroradiology”. Lecture for RNs. St. Anthony Hospital - 2/20/14

51. “HACA: 33 vs 36C”. CCPSA Journal Club. St. Anthony Hospital - 2/24/14

52. “Traumatic Brain Injury”. Wilz Neuroscience and Trauma Symposium. Pueblo Convention Center - 3/1/14

53. “Appropriate TBI Admissions and TBI Management, Including Rehab and Follow Up”. San Luis Valley Regional Medical Center - 3/17/14

54. “Fluid and Electrolyte Management In Critically-Ill Patients After Neurological Catastrophes”. Neurotrauma Critical Care Review and Update for Practicing Neurosurgeon. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, San Francisco - 4/5/14

55. “Traumatic Brain Injury”. Miners’ Colfax Medical Center. Raton, ___________________________________________________________________________________________________COPLIN_CV_05.06.2015

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NM - 4/10/1456. “Telestroke” St. Thomas More Emergency Department. Canon

City, CO - 4/16/1457. “Alcohol Withdrawal Syndrome: A New Approach To Prevention

and Intervention of Severe Alcohol Withdrawal Symptoms”. Mercy Regional Medical Center. Durango, CO - 4/17/14

58. “Alcohol Withdrawal Syndrome: Interdepartmental/Interdisciplinary Approach Based on the Evidence Based Medicine Review”. Mercy Regional Medical Center. Durango, CO - 4/17/14

59. “Alcohol Withdrawal Syndrome: Protocol/Standardization of Treatment in Inpatients, Pre-ICU, ICU, and ED Patients”. Mercy Regional Medical Center. Durango, CO - 4/17/14

60. “Traumatic Brain Injury”. Platte Valley Medical Center - 4/24/1461. “Therapeutic Temperature Management after Neurological

Catastrophe: Why All the Confusion?”. Trauma Multidisciplinary Meeting. St. Anthony Hospital - 5/5/14

62. “Hospital Neurological Stroke Assessments”. Mega Nursing Grand Rounds. Porter Adventist Hospital - 5/6/14

63. “Disability”. Rural Trauma Team Development Course. San Luis Valley Regional Medical Center - 5/8/14

64. “Zombie Neurobiology: Are We Ready For The Looming Apocalypse?” South State EMS. Penrose Hospital. Colorado Springs, CO - 5/13/14

65. “Workup, Management, and Disposition of Mild Traumatic Brain Injury: Why All The Confusion?” Pagosa Springs Medical Center - 5/15/14

66. “Mild Brain Injury – When to Refer; When and Where to Manage”. Brain Injury Alliance of Colorado Summit County Conference. Beaver Run, CO - 5/16/14

67. “VTE Prophylaxis Timing after Brain and/or Spinal Cord Injury”. Penrose-St. Francis Trauma Education. Colorado Springs, CO – 9/5/14

68. “Traumatic Spinal Cord Injury”. Neurocritical Care Society. Seattle, WA – 9/10/14

69. “Guidelines are great for neurocritical care in general, but not for real experts like me.” Neurocritical Care Society. Seattle, WA – 9/14/14

70. “Concussion”. Copper Mountain Emergency Medicine. Edwards, CO – 10/23/14

71. “Head Injury and Hollywood: A Case Study of the Three Stooges”. Mercy Regional Medical Center Trauma Conference. Durango, CO – 10/25/14

72. “Urgent Warfarin Reversal”. Association of California Nurses. Santa Ana, CA – 10/28/14

73. “Association Between Pharmacological Thromboprophylaxis and Hemorrhage Progression in Patients with Hemorrhagic Stroke”. St. Mary’s Medical Center’s 5th Annual Neuroscience Symposium – A Lustrum of Progress. Palm Beach Gardens, FL – 11/1/14

74. “Association Between Pharmacologic Thromboprophylaxis and ___________________________________________________________________________________________________COPLIN_CV_05.06.2015

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Hemorrhage Progression in Patients With Hemorrhagic Stroke”. Best of AHA Specialty Conferences at Scientific Sessions. Chicago, IL – 11/17/14

75. “Concussion and Clearing the Spine in the ED: Exam, Imaging, Gear Removal, and Transition to Further Care”. Rio Grande Hospital Quarterly Trauma Review and CME. Del Norte, CO – 11/21/14

76. “Current Trends In Neurotrauma”. Wilz Trauma Symposium. Pueblo, CO – 3/7/15

77. “Zombie Neurobiology: Are We Ready For The Looming Apocalypse?”. 12th Annual Critical Care Symposium. Manchester, UK – 4/23/15

78. “Pharmacological Thromboprophylaxis, Venous Thromboembolism & Hemorrhage Progression In Patients With Hemorrhagic Stroke: Why All The Confusion? 12th Annual Critical Care Symposium. Manchester, UK – 4/24/15

79. “Neurocritical Care Update” 12th Annual Critical Care Symposium. Manchester, UK – 4/24/15

80. “Extubation Readiness Independent Of Level Of Consciousness”. 12th Annual Critical Care Symposium. Manchester, UK – 4/24/15

81. “Coagulopathy and VTE: Timing of Use of Chemical Prophylaxis & Management of VTE Events in the Perioperative Period”. Neurotrauma Critical Care Review and Update. 83rd American Association of Neurological Surgeons Annual Scientific Meeting. Washington, DC – 5/2/15

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