Copyright © 2004 by Chem-Space Associates, Inc. ALL RIGHTS RESERVED Atmospheric Pressure Focusing Edward W Sheehan, Ross C Willoughby, David F. Fries Chem-Space
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Atmospheric Pressure FocusingAtmospheric Pressure Focusing
Chem-Space Associates, Inc., Pittsburgh, PA
University of South Florida, St. Petersburg, FL
Copyright © 2004 by Chem-Space Associates, Inc. ALL RIGHTS
RESERVED
Background
The generation of ions at atmospheric pressure is accomplished by a
variety of means; including electrospray, atmospheric pressure
chemical ionization (APCI), atmospheric pressure MALDI, and
photoionization. A general characteristic of all these ion sources
is the need for a large volume in order to form ions or charged
particles/droplets. Needle/capillary sources such as electrospray
and APCI, disperse ions radially from the axis in high electric
fields and gases emanating from tubes and nebulizers. Even
desorption techniques, such as atmospheric pressure-MALDI, will
disperse ions radially in a solid angle from a surface.
This radial dispersion can be a large as 5-10 cm in
diameter!!
The motion of ions at atmospheric pressure is influenced by
electric, viscous, and thermal forces (see below). In low electric
fields, the motion is dominated by random motion (thermal) and gas
flow (viscous). In contrast to this, the motion of ions in high
electric fields is dominated by electric field and gas stream
lines. With electric fields driving the motion of the ions in the
direction of the field and viscous forces imparting an acceleration
(forward force), a deceleration (backward force), or radial
movement (orthogonal force) on the motion of the ion. The total
motion in high electric fields can then be described as the
addition of the force vectors of both electric fields and gas
stream lines.
Methods
One solution to collecting and focusing this dispersive plasma is
to place a high-transmission element (HTE), between the plasma and
the sampling aperture or capillary. Three types of HTE's are
considered:
Surface Laminated Surface Toroidal Surface
Various HTE's were sandwiched between an electrospray nebulizer and
a collection surface. A dilute of blue dye (0.01%, TPM 5EO/5PO,
Milliken, Corp.) was electrosprayed. All points, from the aerosol
chamber to the collection area were observed for the deposition of
dye. In addition, ion current was measured at all surfaces and
inside a vacuum system. Utilizing the program SIMION, ion
trajectories, depositon, and loses were predicted.
Copyright © 2004 by Chem-Space Associates, Inc. ALL RIGHTS
RESERVED
Motion of Ions Due to Viscous Forces
at Atmospheric Pressure
Motion of Ions in Electric Fields at Atmospheric Pressure
Focusing
Copyright © 2004 by Chem-Space Associates, Inc. ALL RIGHTS
RESERVED
High Transmission Surface
High Transmission Surface
High Transmission Surface
Laminated Surface
Laminated Surface
Laminated Surface
Toroidal Laminated Surface
Toroidal Laminated Surface
Toroidal Laminated Surface
Atmospheric Pressure Focusing
Conclusions
To focus and collect ions at atmospheric pressure one needs
to:
Control or sculpt all the electric fields, from the regions of ion
generation to ion focusing; and
Control the viscous forces, both concurrent and counter-current,
from ion generation to sampling through sampling apertures.
Put simply:
Ions Motion in High Electric Fields at Atmospheric Pressure is the
Sum of
Electric & Viscous Forces
The SIMION ion optics simulation program can be used to predicted
and verify the motion of ions at atmospheric pressure incorporating
the both electric and viscous force components.
By matching high electric and low electric field sources with an
optimized high-transmission surface and gas flow one can collect,
focus, and deliver gas-phase ions from dispersive atmospheric
sources onto small cross- sectional areas—2-3 mm!
Having the ability of forming these small cross-sectional beams one
must match the dimensional of the ion beam with small openings for
transfer into vacuum systems. Transferring this ion beam into the
vacuum system is addressed at our companion poster, Poster
#100.
Acknowledgements
The authors would like to thank the National Institute of Health
for financial support through the SBIR Program (grant # R43
RR143396-1) and David Fries and his staff at the College of Marine
Sciences (St. Petersburg, FL) for the use of their labs and
manufacturing facilities.
References
Single Surface High-Transmission Element: Sheehan, E.W.,
Willoughby, R.C., "Apparatus and method for focusing ions and
charged particles at atmospheric pressure", US Patent 6,744041
(June 1, 2004).
Laminated High-Transmission Element: Sheehan, E.W., Willoughby,
R.C., US Patent Application No. 10/449,167.
Toroidal High-Transmission Element: Sheehan, E.W., Willoughby,
R.C., US Patent Pending.
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