Corporate Presentation - ANAVEX...Baseline Week 7 RSBQ Hand Behaviors 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 Baseline Week 7 Sleep -CSHQ-Waking During the Night RSBQ Hand Behaviors 2 4 6

Nasdaq: AVXL | November 2020

Corporate Presentation

Christopher U Missling, PhD | President & CEO

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This presentation contains forward-looking statements made within the meaning of the Private Securities LitigationReform Act of 1995 by Anavex® Life Sciences Corp. and its representatives. These statements can be identified byintroductory words such as “expects,” “plans,” “intends,” “believes,” “will,” “estimates,” “forecasts,” “projects,” or words ofsimilar meaning, and by the fact that they do not relate strictly to historical or current facts. Forward-looking statementsfrequently are used in discussing potential product applications, potential collaborations, product development activities,clinical studies, regulatory submissions and approvals, and similar operating matters. Many factors may cause actualresults to differ from forward-looking statements, including inaccurate assumptions and a broad variety of risks anduncertainties, some of which are known and others of which are not. Known risks and uncertainties include thoseidentified from time to time in reports filed by Anavex Life Sciences Corp. with the Securities and ExchangeCommission, which should be considered together with any forward-looking statement. No forward-looking statement isa guarantee of future results or events, and one should avoid placing undue reliance on such statements. Anavex LifeSciences Corp. undertakes no obligation to update publicly any forward-looking statements, whether as a result of newinformation, future events or otherwise. Anavex Life Sciences Corp. cannot be sure when or if it will be permitted byregulatory agencies to undertake clinical trials or to commence any particular phase of any clinical trials. Because ofthis, statements regarding the expected timing of clinical trials cannot be regarded as actual predictions of when AnavexLife Sciences Corp. will obtain regulatory approval for any “phase” of clinical trials. We also cannot be sure of the clinicaloutcome for efficacy or safety of our compounds. Potential investors should refer to the risk factors in our reports filedon Edgar.

Forward Looking Statement

* = Orphan Drug Designation by FDA

PRECLINICAL PHASE 1 PHASE 2 PHASE 3

ANAVEX®2-73(Blarcamesine)

ALZHEIMER’S DISEASE

FRAGILE X

CANDIDATE

ANAVEX®3-71(AF710B)

*FRONTOTEMPORAL DEMENTIA (FTD)


PARKINSON’S DISEASE

ANAVEX®1-41DEPRESSION

STROKE

PARKINSON’S DISEASE


ANGELMAN’S

ANAVEX®1066ACUTE & NEUROPATHIC PAIN

*RETT SYNDROME

*INFANTILE SPASMS

PARKINSON’S DISEASE DEMENTIA

VISCERAL PAIN

Broad Pipeline Targeting Neurodegenerative andNeurodevelopmental Diseases with Significant Unmet Medical Need

Fast Track, Rare Pediatric, Orphan Drug (U.S./EU)

*RETT SYNDROME

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U.S. ANAVEX®2-73-RS-001

AVATAR ANAVEX®2-73-RS-002

ANAVEX®2-73-PDD-001

AD ANAVEX®2-73-AD-004

ANAVEX®3-71-001

*RETT SYNDROME EXCELLENCE ANAVEX®2-73-RS-003

• Differentiated clinical-stage CNS assetstargeting significant and growing markets

• Patent protection to 2030-2039, worldwide rightsfor all product candidates

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Targeting Large Market Opportunities with Significant Unmet Medical Need

1) Alzheimer’s Disease Facts and Figures. Alzheimers Dement 2018;14(3):367-429.2) Marras C et al 2018. npj Parkinson's Disease volume 4, Article number: 213) Based on prevalence number on orphanet

All U.S. Patient Numbers

• Rett Syndrome Program Received Fast Track Designation and is Eligible for Pediatric Priority Review Voucher

• Pursuing Large Markets with High Unmet Need by Applying Genetic Precision Medicine

• Novel CNS Mechanism of Action Upstream of Neurodevelopment and Neurodegeneration

• Compelling first Human Patient Data in Parkinson’s Disease Dementia, Rett Syndrome and Alzheimer’s Disease

• Sufficient Cash for >24 months To Achieve Key Milestones – Including non-dilutive Cash from Australian Government for Alzheimer’s Trial, and from Rettsyndrome.org for Rett Syndrome Trial

Continued Significant Value-creating Events with Several Clinical Readouts in 2020/2021:

• Two Phase 2 Adult Rett Syndrome Trials (ClinicalTrials.gov Identifier: NCT03758924, NCT03941444)

• Phase 2/3 Pediatric Rett Syndrome Trial (ClinicalTrials.gov Identifier: NCT04304482)

• Phase 2b/3 Alzheimer’s Disease Trial (ClinicalTrials.gov Identifier: NCT03790709)

• Phase 1 of ANAVEX®3-71 with focus on Frontotemporal Dementia (ClinicalTrials.gov Identifier: NCT04442945)

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Transformative Events for Anavex

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The company has multiple near-term clinical milestonesCatalysts to Drive Value

Full enrollment Phase 2 Parkinson’s disease dementia (PDD)Rett syndrome program received FDA Fast Track Designation and is eligible for FDA Pediatric Priority Review VoucherInitiate EXCELLENCE Phase 2/3 in pediatric Rett syndrome (RTT)Initiate Phase 1 ANAVEX®3-71Full enrollment U.S. Phase 2 RTTTopline data Phase 2 PDD Topline data U.S. Phase 2 RTT – Q4 2020Topline data AVATAR Phase 2 RTT – 1H 2021Topline data Phase 1 ANAVEX®3-71 – 1H 2021

Clinical Trials – MoA and First Clinical Data:• Rett Syndrome (RTT) • Alzheimer’s Disease (AD)• Parkinson’s Disease Dementia (PDD)

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ANAVEX®2-73 MoA: S1R Activation is Upstream from other Therapeutic TargetsNeural cells suffer functional loss in neurological disorders which causescellular stress

Pathologies include:

ü Aβ, Tau and ApoE fragmentation and dysfunction

ü Proteinopathy

ü Microglia activation, migration, and dysregulation

ü Apoptosis feedback loops that lead to neuronal degradation

ü Autophagy dysfunction

ü Mitochondrial Dysfunction and Oxidative Stress that leads to further neuronal degradation

ü Neurodegeneration that spreads through a cascade of stress responses

S1R activates neuroprotective signals that help neurons return to homeostasis

S1R = Sigma-1 Receptor

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ANAVEX®2-73 Establishes Human Proof-of-Concept and SIGMAR1 Target Occupancy

0 mg /kg 1 mg/kg 10 mg/kg 30 mg/kg

2D [18F]FTC-146-PET imaging of ANAVEX®2-73: Dose-dependent ANAVEX®2-73 Target Engagement

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Source: Reyes S et al, AAIC 2018; Hampel H et al. Alzheimer’s Dement. 2020;00:1–14; *Alzheimer's Disease Cooperative Study Activities of Daily Living 23-item scale (ADCS-ADL)

p=0.015

SIG

MAR

1 R

NA

expr

essi

on (T

PM)

Decrease (Negative) Increase (Positive)

ANAVEX®2-73 positive response in functional(ADCS-ADL*) outcome in Alzheimer’s disease patients

correlate with SIGMAR1 mRNA levels

p-value of Mann–Whitney U testAll n=20 patients in study. Slope of ADCS-ADL* from baseline to week 57 with available genomic data

Sigma-1 receptor agonists have been shown to restore neuronal functions in neurodegenerative processes

ANAVEX®2-73 enhancesautophagy and alleviates Tau pathology in neurodegenerative disease models

Sigma-1 receptor agonists have a neuroprotective effect in neurodegenerative disease models

SIGMAR1 Activation has been Shown to Modulate Multiple Aspects of Neurodegenerative Processes

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Devastating neuro-developmental disease in girls with both movement impairment and cognitive impairment

Rett Syndrome (RTT)

§ Non-inherited genetic postnatal disorder caused by mutationsin the MECP2 gene

Ø Occurs almost exclusively in girlsØ Leads to severe impairments, affecting nearly every aspect of the child’s lifeØ Impairment includes ability to speak, walk, eat and even breathe easilyØ Hallmark of RTT is near constant repetitive hand movements while awakeØ Occurs worldwide in approximately one in every 10,000 to 15,000 live female

births

What is Rett Syndrome?

11Source: https://www.rettsyndrome.org/about-rett-syndrome

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Phase 2 PART A: Improvement in All Key Domains

SUMMARY• Phase 2, safety, tolerability, efficacy for 7 weeks, oral, liquid formulation,

5 mg daily (relatively low dose)• Part A: Intensive PK, n=6, Completed• Part B: Randomized, double-blind, placebo-controlled, n=25, ongoing• Females > 18 years, classic RTT w/MECP2 mutation• Evaluations at baseline (Week 0), Week 4 & Week 7 (End of Treatment)• Good safety and tolerability: No serious adverse events, only three grade 1-2 adverse events

U.S. Rett Syndrome ANAVEX®2-73-RS-001 Trial (NCT03758924)

EFFICACY* • Global severity RSBQ and CGI-I

RSBQ = Rett Syndrome Behavior QuestionnaireCGI-I = Clinical Global Impressions – Improvements

• Secondary: Behavior (ADAMS), Sleep (CSHQ), VAS (top caregiver concerns), Seizure diary

• Response Biomarker*: Glutamate, GABA; Genetic biomarker: DNA & RNA profiles

*Preliminary evaluation of efficacy: two-tailed, nonparametric tests (conservative)

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RSBQ improves by

over 30%

p = 0.027

p = 0.042p = 0.042

p = 0.042

28%

55%

46%

76%

Phase II to Phase III Phase III to NDA/BLA

Biomarkers Increase Probability of Success

Without Biomarkers With Patient Selection Biomarkers

Precision Medicine

Thomas DW et al. Clinical Development Success Rates 2006-2015. BIO Industry Analysis

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1) Hamberger, A., et al., Elevated CSF glutamate in Rett syndrome. Neuropediatrics, 1992. 23(4): p. 212-3.;2) Lappalainen, R. and R.S. Riikonen, High levels of cerebrospinal fluid glutamate in Rett syndrome. Pediatr Neurol, 1996. 15(3): p. 213-6; 3) J.L. Neul at al., Metabolic signatures differentiate Rett syndrome from unaffected siblings. Frontiers in Integrative Neuroscience (2020) Vol14, Art 7, doi:10.3389/fnint.2020.00007 14

Loss of synaptic homeostasis can impair nerve cells (neurons) and their connections

In patients with RTT, MeCP2 deficiency leads to increasedlevels of Glutamate, in comparison to healthy controls1,2,3, which results in excitatory-inhibitory imbalance and further synaptic dysfunction

Glutamate as potential biomarker of microglia activation and synaptic dysfunction

Phase 2 PART A: Reported Improvements Correlate with Biomarkers

U.S. Rett Syndrome ANAVEX®2-73-RS-001 Trial (NCT03758924)

REPORT on PART A: INTENSIVE PK SUBCOHORT• Plasma levels of the biomarker Glutamate decreased significantly (Week 0 vs. Week 7; 2-tailed

Wilcoxon signed rank test, p = 0.046)• Levels of Glutamate at Week 7 directly correlated with CGI-I scores at Week 7 (2-tailed

Spearman’s rho = 0.837, p = 0.038)• Greater decreases in Glutamate associated with greater improvement in these efficacy scores• GABA changes demonstrated an inverse correlation of the magnitude of Glutamate changes (2-

tailed Spearman’s rho = -0.829, p = 0.042)

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RSBQ & CGI-I Glutamate & CGI-I Glutamate & Hand Behaviors Glutamate & Sleep

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p = 0.046

p = 0.003

p = 0.038p = 0.021 p = 0.005

Improve-ment

Glutamate decreases by

over 40%

Significant Correlations:

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ANAVEX®2-73 Phase 2 U.S. Rett Syndrome Study

Primary and Secondary Endpoints• PK, safety and tolerability of

ANAVEX®2-73• Behavioral symptoms• Sleep function• Seizure activity

Pre-specified Endpoints• Genetic variants SIGMAR1

(rs1800866), COMT (rs113895332/rs61143203) with influence on treatment effect

N=31 7RTT patient population

Randomization3:2

ANAVEX®2-73Active dose#

Placebo

• Diagnosis of confirmed RTT

• Patients age >18• Entire DNA and RNA

sequencingANAVEX®2-73-RS-001 STUDY ()*

# Oral liquid solution once daily; Dose restricted to maintain complete blinding

* Includes a 6 patient cohort undergoing a 7-week pharmacokinetic (PK) assessment with safety, tolerability, pharmacokinetic and efficacy evaluation of ANAVEX®2-73

*

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ANAVEX®2-73 Phase 2 Rett Syndrome AVATAR Study

Primary and Secondary Endpoints• Safety and tolerability of




N=33 7RTT patient population

Randomization3:2


Placebo


• Patients age >18• Entire DNA and RNA

sequencingANAVEX®2-73-RS-001 STUDY (NCT0


*

* Includes a 3 patient cohort undergoing a 3-week pharmacokinetic (PK) assessment with safety, tolerability, pharmacokinetic and efficacy evaluation of ANAVEX®2-73

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ANAVEX®2-73-RS-003 Rett Syndrome EXCELLENCE Study

Primary and Secondary Endpoints• Safety and tolerability of




N>69 12RTT patient population

Randomization2:1


Placebo


• Patients age 5-18• Entire DNA and RNA

sequencingANAVEX®2-73-RS-001 STUDY (NCT037


Alzheimer’s disease is a progressive, irreversible neurological disease and the most common cause of dementia

Alzheimer’s Disease (AD)

§ Alzheimer’s disease incidence highly correlates with age

Ø AD prevalence in US:~5,700,000Ø Estimated 50 million people live with dementia worldwideØ Today, there are no commercially available therapies to

address the underlying cause of Alzheimer’sØ The current annual cost of dementia is estimated at $1 trillion,

a figure set to double by 2030

Alzheimer’s Disease (AD)

19Source: www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/parkinson-s-disease-dementia

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ANAVEX®2-73 Demonstrated Improved MMSE1 and ADCS-ADL2 Scores in Phase 2a AD Study through 148 Weeks

Source: Hampel et al. A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer’s disease therapy: Analysis of the blarcamesine (ANAVEX2-73) Phase 2a clinical study. Alzheimer’s Dement. 2020;00:1–14

1 Mini Mental State Examination (MMSE)2 Alzheimer’s Disease Cooperative Study Group - Activities of Daily Living Inventory (ADCS-ADL)

Adju

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cha

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Adju

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cha

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SE)

p-value < 0.0008 p-value < 0.0001

N=8

N=13

N=8

N=13

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ANAVEX®2-73 Phase 2b/3 Alzheimer's Disease and ATTENTION-AD OLE Study

Primary Endpoints• ADAS-Cog• ADCS-ADL• Safety and tolerability of

ANAVEX®2-73

Key Secondary Endpoints• CDR-SB• Structural and functional MRI• Biomarkers: Abeta40/Abeta42, T-tau,

P-tau, NFL, YKL-40, neurogranin, BACE1



# Oral capsule once daily; Dose restricted to maintain complete blinding

N=450 48Early AD patient population

Randomization1:1:1

ANAVEX®2-73High dose#

ANAVEX®2-73Medium dose#

Placebo

• Confirmed amyloid pathophysiology (CSF/amyloid PET)

• Patients aged 60 to 85 years

• MMSE score 20-28• Entire DNA and RNA

sequencing

… and Open Label Extension (OLE) 96 weeks

Up to 80 percent of those with Parkinson’s disease eventually experience Parkinson’s disease dementia

Parkinson’s Disease Dementia§ Parkinson’s disease is a fairly common neurological disorder in older

adults, estimated to affect nearly 2 percent of those older than age 65

Ø PD prevalence in US:~1,000,000Ø The brain changes caused by Parkinson’s disease begin in a region

that plays a key role in movementØ Highly heterogeneous multisystem disorderØ Etiology of cognitive impairment in PD has not yet been fully elucidatedØ As Parkinson’s brain changes gradually spread, they often begin to

affect mental functions, including memory and the ability to pay attention, make sound judgments and plan the steps needed to complete a task

Parkinson’s Disease Dementia (PDD)

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Source: Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C. Cognitive decline in Parkinson disease. Nat RevNeurol. 2017 Apr;13(4):217-231. doi: 10.1038/nrneurol.2017.27. Epub 2017 Mar 3. PMID: 28257128; PMCID: PMC5643027; www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/parkinson-s-disease-dementia

QD = once per day

Placebo(QD)

ANAVEX®2-73 High Dose(10, 20, 30, then 50 mg QD)

2-week baselineincluding

actigraphy

• PDD Patient Population– Diagnosis of probable Parkinson’s disease

dementia– Diagnosis of idiopathic Parkinson’s disease– Patients aged ≥ 50 years– MoCA score 13-23

N=44

N=44

N=132

ANAVEX®2-73 PoC Phase 2 PDD Study Design

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• Key Primary and Secondary Endpoints– Safety and tolerability– CDR Cognitive Domain of Attention– Sleep function– MDS-UPDRS– Actigraphy (24-hour monitoring)– Entire DNA and RNA sequencing

• Pre-specified Endpoints– Genetic variants SIGMAR1

(rs1800866), – COMT(rs113895332/rs6114320

3) with influence on treatment effect

ANAVEX®2-73 Medium Dose(10, 20, then 30 mg QD)

N=44

A Phase 2 trial to Assess the Safety, Tolerability and Efficacy of ANAVEX®2-73 (blarcamesine) Oral Capsules in the Treatment of Parkinson’s Disease Dementia

2-week baseline period 3-week up-titration period 11-week target dose treatment period

Week 14Baseline Week 3Screening

Study data collected at Baseline, Week 8 and 14

ANAVEX®2-73-PDD-001 is a Proof of Concept (PoC) Phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group, 3-arm, 14-week study

1:1:1 randomization

Week 8

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Key cognitive features addressed by ANAVEX®2-73 (blarcamesine)Key Cognitive Domains

The criteria from the National Institute on Aging and Alzheimer’s Association (NIA-AA) workgroup mention the following five cognitive domains when diagnosing MCI-AD:(a) Episodic memory(b) Attention(c) Language(d) Visuospatial skills(e) Executive functions

Source: Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):270-9. doi: 10.1016/j.jalz.2011.03.008. Epub 2011 Apr 21. PMID: 21514249; PMCID: PMC3312027.

Episodic memory Choice reaction timeWord recognitionPicture recognitionNumeric working memory

Related CDR system

domains

Addressed in PoCPhase 2 PDD Study

✅

✅

✅

✅

✅

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Significant Improvements in Episodic Memory with Increased Dose

All participants; ANAVEX2-73 = Active 30 mg, Active 50 mg vs PlaceboJ-T test based on actual maintenance dose: p = 0.003

ANAVEX®2-73-PDD-001 Study: Dose-dependent, statistically significant improvement of Quality of Episodic Memory with ANAVEX®2-73 (blarcamesine)

(cou

nts)

Quality of Episodic Memory (counts)All participants

Time: 14 weeks change from baseline

• A high score reflects ability to store, hold and retrieve information of an episodic nature (e.g., an event or name)

• CDR system Quality of Episodic Memory highly correlated (70%) with ADAS-Cog (r = 0.7)1

Direction of Improvement

21.40

-1.20

-20.82

+42.22

1. Wesnes K, Edgar C, Andreasen N, Annas P, Basun H, Lannfelt L, et al. Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer’s disease. Acta Neurol Scand 2010; 122:270–7

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Broad and Significant Effects with ANAVEX®2-73 (blarcamesine) in PDD PatientsSummary of Topline Results:

• ANAVEX®2-73 (blarcamesine): a novel, oral, investigational sigma-1 receptor (Sig-1R / SIGMAR1) agonist with multimodal activity

• Data confirm SIGMAR1 as gene “signature” biomarker of response to ANAVEX®2-73 (blarcamesine) confirming SIGMAR1 activation as mechanism of action

• Broad and statistically significant improvements in CDR system Cognitive Domain of Attention assessed by Choice Reaction Time (p = 0.039) and Digital Vigilance (p = 0.008) and CDR system Episodic Memory (p = 0.047), representing complex cognitive tasks with impact on quality of life such as making a choice between similar objects and remembering daily personalexperiences, which are mostly impaired in both PD and AD1

• Statistically significant dose-dependent (p = 0.003) improvement of CDR system Episodic Memory, which has been shown to be highly correlated (70%) with the Alzheimer’s Disease Assessment Scale–Cognitive score (ADAS-Cog; r = 0.7)2

• ANAVEX®2-73 (blarcamesine) does not impair sleep and has a positive effect on REM sleep behavior disorder

• ANAVEX®2-73 (blarcamesine) was generally safe, well tolerated, and improved safety profile compared to dementia drugs associated with typical adverse effects

• These results support continued development in PDD / PD as well as currently ongoing Phase 2 and Phase 2/3 clinical studies with ANAVEX®2-73 (blarcamesine) in Rett syndrome3 and Alzheimer’s disease4

• Data will be submitted to the U.S. Food and Drug Administration to seek regulatory guidance 1. Mahurin, R. K., & Pirozzolo, F. J. (1993). Application of Hick’s law of response speed in Alzheimer and Parkinson diseases. Perceptual and Motor Skills, 77(1), 107–1132. Wesnes K, Edgar C, Andreasen N, Annas P, Basun H, Lannfelt L, et al. Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer’s disease. Acta Neurol Scand 2010; 122:270–73. ClinicalTrials.gov Identifiers: NCT03758924, NCT03941444, NCT043044824. ClinicalTrials.gov Identifiers: NCT03790709, NCT02756858

Anavex is pursuing Large Markets by Applying Precision Medicine to Develop Treatments for bothGlobal Aging CNS diseases (Alzheimer’s, Parkinson’s), as well as catastrophic Orphan Genetically caused diseases, Rett Syndrome with High Unmet Needs

COMPELLING INITIAL HUMAN DATAANAVEX®2-73 Phase 2 Parkinson’s disease dementia, ongoing Phase 2 in Rett syndrome and Phase 2a trial in Alzheimer’s with favorable safety and initial efficacy results through 148 weeks

PRECISION MEDICINE IMPROVES CHANCE OF CLINICAL SUCCESS

Testing for biomarkers demonstrated improved clinical response to ANAVEX®2-73 in Rett syndrome correlated with glutamate and for Alzheimer’s and Parkinson’s patients carrying wild-type (WT) SIGMAR1 gene

SUFFICIENT CASH TO ACHIEVE KEY MILESTONESSufficient cash for >24 months to achieve key milestones, including non-dilutive cash from Australian government for Alzheimer ’s trial and from Rettsyndrome.org for Rett syndrome trial

OVERARCHINGMESSAGE

A novel approach is needed to address thetotality of CNS diseases

NOVEL CNS MECHANISM OF ACTIONANAVEX®2-73, an orally available Sigma-1 receptor agonist, is upstream of neurodevelopment and neurodegeneration andhas been shown to restore homeostasis

WORLDWIDE COMMERCIAL RIGHTS AND STRONG IP FOUNDATION

We retain global commercial rights to all of our product candidates and our lead product candidate, ANAVEX®2-73, including patent protection to 2030-2039

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$ 277BEconomic burden2018 Alzheimer’sAssociation

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Anavex Life Sciences ExpertiseManagement Team

Scientific Advisory Board Members

Christopher U. Missling PhD - President & CEO

Daniel Klamer, PhD - VP of Business Development & Scientific Strategy

Walter E Kaufmann, MD - Chief Medical Officer

Stephan Toutain, MS, MBA – Chief Operating Officer

Emmanuel O Fadiran, RPh, PhD - SVP of Regulatory Affairs

Jeffrey Cummings, MD

Corinne Lasmezas, PhD

Ottavio Arancio, MD, PhD

Andrew Cole, MD

Daniel Weintraub, MD

Paul Aisen, MD

Norman Relkin, MD, PhD

Jacqueline French, MD

Dag Aarsland, MD, PhD

Tangui Maurice, PhD

Corporate OfficeAnavex®Life Sciences Corp.51 West 52nd Street, 7th floorNew York, NY 100191-844-689-3939

Shareholder & Media [email protected] NASDAQ: AVXL

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Corporate Presentation - ANAVEX...Baseline Week 7 RSBQ Hand Behaviors 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 Baseline Week 7 Sleep -CSHQ-Waking During the Night RSBQ Hand Behaviors 2 4 6