CURRICULUM VITAE

Name: Nikhil Kumar Chanani, MD Position: Pediatric Cardiologist Sibley Heart Center Cardiology 2835 Brandywine Rd., #300, Atlanta, Georgia 30341 Office: 404-256-2593 Fax: 678-547-1494

Medical Director, Cardiac Services, Quality Staff Cardiac Intensivist Pulmonary Hypertension Program Children’s Healthcare of Atlanta (CHOA) Atlanta, Georgia Assistant Professor of Pediatrics Emory University School of Medicine Atlanta, Georgia

Home Address: 1930 Durand Mill Drive NE Atlanta, Georgia 30307 Cell: 404-694-1317 Home: 678-974-7696 Email: chananin@kidsheart.com Citizenship: USA Education: 1993-1997 Stanford University AB Economics (with Distinction and with Honors)

Stanford, CA BS Biology (with Distinction) Honors Thesis: “Racial Selection on HMO Enrollment Patterns for Medicare Beneficiaries”

9/1997- 6/2002 Harvard Medical School MD with Cum Laude in a Special Field Boston, MA 6/2002-6/2003 University of California (UCSF) Intern Pediatrics, Critical Care Pathway

San Francisco, California 7/2003-6/2005 UCSF Resident Pediatrics, Critical Care Pathway

San Francisco, California 7/2005-6/2008 UCSF Fellow Division of Cardiology San Francisco, California Department of Pediatrics 7/2008-6/2010 LPCH Fellow Cardiovascular Intensive Care (CVICU) Stanford, California (Senior Clinical) Department of Pediatrics Licensure and Certification: 2005-2012 Medical Licensure, California – A87113 2005 Drug Enforcement Agency Licensure – FC1732925 2005 PALS and NALS certified (recertified in 2007, 2009) 2005 Certified, Diplomate of the American Board of Pediatrics – No. 083213 2007 Fluoroscopy X-Ray Supervisor and Operator, California - Permit No. RHC 166385 2008 Certified, American Board of Pediatrics, sub-board of Pediatric Cardiology 2010 Medical Licensure, Georgia - 64196 Principal Positions Held:

2002-2005 UCSF Resident Pediatrics San Francisco, California 2005-2008 UCSF Fellow Cardiology San Francisco, California 2008-2010 LPCH Fellow Cardiovascular Intensive Care Unit Stanford, California (Senior Clinical) Other Positions Held Concurrently: 2005-2007 St. Luke’s Hospital Staff Physician Department of Pediatrics San Francisco, California 2005-2010 The Permanente Medical Group Pool Physician Department of Pediatrics San Francisco, California Honors and Awards: 1995 Research Fellowship, Endocrine Society 1997 AB with Distinction and Honors (for honors thesis), Stanford University 1997 BS with Distinction, Stanford University 1998 Summer Research Fellow, UCSF (grant from Harvard Medical School) 2000-2001 Research Grant, Harvard Medical School 2002 MD with Cum Laude in Special Field, Harvard Medical School 2002 Gerald S. Foster Award (for service), Harvard Medical School 2006-2007 Training Grant, Research Training in Cardiovascular Development NIH/NHLBI T32 HL007544 (Principal Investigator: Harold Bernstein, UCSF) 2010 American College of Cardiology Fellow-in-Training Travel Grant 2014 Sibley Heart Center Cardiology, Physician High Performance Award Keywords/Areas of Interest: Congenital heart disease, pediatrics, cardiology, health care economics, cardiac intensive care, outcomes, neurodevelopment, pulmonary hypertension, quality improvement, machine learning, risk prediction modeling Professional Activities Professional Memberships: 1997-present American Association of Physicians of Indian Origin 1997-2002 Massachusetts Medical Society, Medical Student member 2002-present American Academy of Pediatrics 2001-present American Heart Association 2005-2010 Western Society of Pediatric Cardiology 2006-present American College of Cardiology 2008-present Pediatric Cardiac Intensive Care Society 2010-present Southeast Pediatric Cardiovascular Society 2011-present Society of Critical Care Medicine, Pediatric Section Service to Professional Organizations: 2010-present Peer Reviewer, American Heart Association, Committee on Cardiovascular Development 2011-present Executive Committee Member, Pediatric Cardiac Critical Care Consortium 2012-2014 Member, Cardiac Advisory Group, Virtual PICU Systems 2015-present Member, LumeDx Pediatric User Group Service to Professional Publications: 2009-present Invited reviewer, Pediatric Cardiology

2011-present Invited reviewer, Future Cardiology 2013-present Invited reviewer, American Journal of Cardiology 2015-present Invited reviewer, BMC Surgery 2016-present Invited reviewer, BMJ Open 2016-present Invited reviewer, Cardiology in the Young Invited Presentations: International: 2014 Pediatric Cardiac Intensive Care Society, 10th International Conference, Miami, Florida

“Long Term Outcomes in Heterotaxy Syndrome” 2016 Pediatric Cardiac Intensive Care Society, 12th International Conference, Miami, Florida

“Norwood Management” National: 2001 Oral Abstract Presentation, American Heart Association Scientific Sessions, Anaheim, California

“Differential Effects of Amrinone and Milrinone on Cardiac Inflammation” 2007 Oral Abstract Presentation, American Heart Association Scientific Sessions, Orlando, Florida

“Cryoablation for Atrioventricular Nodal Reentrant Tachycardia (AVNRT) in 154 Young Patients: 4mm vs. 6mm Catheter Tip Sizes”

2011 Speaker, Neonatology 2011, Atlanta, Georgia “PDA: To Close or Not to Close”

2013 VPS Users Group Meeting, Los Angeles, California “Peri-operative Characteristics: How We Use VPS Data”

2014 Cardiac Neurodevelopmental Symposium, Atlanta, Georgia “Neuroprotective Care in the Hospital: Empirically Supported or Wishful Thinking?” 2016 Speaker, The Pediatric Cardiac Rehab Patient, Atlanta, Georgia “Approach to the Pediatric Patient with Heart Disease: Pushing the Limits” Regional: 2005-2008 Pediatric Resident Conference Series, UCSF and San Francisco General Hospital 2008-2010 Pediatric Resident Conference Series, LPCH 2010-Current Pediatric Cardiology Fellows Lecture Series, Emory University and CHOA 2011-Current Neonatology Fellows Lecture Series, Emory University and CHOA 2013 National Association of Pediatric Nurse Practitioners-Georgia Chapter, Atlanta, Georgia 2013 Kids at Heart, Atlanta, Georgia. 2014 Pediatric Solid Organ Transplant Workshop, Atlanta, Georgia. 2014 Pediatric Grand Rounds, Children’s Healthcare of Atlanta, Scottish Rite, Atlanta, Georgia. 2014 Pediatric Grand Rounds, Grady Memorial Hospital, Atlanta, Georgia 2014 Neonatal Transport Lecture Series, Atlanta, Georgia. 2016 Neonatology Grand Rounds, Northside Hospital. Other: Postgraduate and Continuing Education Coursework: 9/2006-10/2006 Designing Clinical Research Workshop Training in Clinical Research, Post-Graduate Program Department of Epidemiology and Biostatistics, UCSF School of Medicine 11/2006 Conference on Heart Failure in Children and Young Adults Heart Institute, Children’s Hospital of Orange County 3/2007, 3/2009 Conference on Childhood Pulmonary Vascular Disease Department of Pediatrics, UCSF School of Medicine 9/2007 ECMO Training Program Division of Neonatology, Department of Pediatrics, UCSF School of Medicine

9/2008 Intensive Course in Clinical Research: Study Design & Performance Stanford Center for Clinical and Translational Education and Research 7/2009 ECMO Certification Program, LPCH 7/2010 ECMO Certification Program, CHOA 2/2016-6/2016 Quality Academy: Practical Methods for Healthcare Improvement, Emory Healthcare Research Support: 9/2010-present Sub-Investigator: “Pediatric Intensive Care Units at Emory University’s Trial in Glycemic Control”

NIH Grant 1R01HL096871 - 01A1 Award, PI: Kevin Maher, MD 7/2010-present Sub-Investigator: “Role of Inflammatory Response in Brain Injury following neonatal Mediators in

Cardiac Surgery”. Thrasher Foundation Grant, PI: William Mahle, MD 8/2012–present Co-Principal Investigator (Site-specific): “Therapeutic Hyopthermia after Pediatric Cardiac Arrest”.

NIHLBI 5U01HL094345-04, Lead Investigator: Frank Moler, MD 3/2013-present Co-Investigator: “A multiple ascending dose study of tadalafil to assess the pharmacokinetics and

safety in a pediatric population with pulmonary arterial hypertension”. Eli Lilly H6D-MC-LVIG. Principal Investigator: Usama Kanaan, MD

3/2013-present Co-Investigator: “A Double Blind Efficacy and Safety Study of the Phosphodiesterase Type 5 Inhibitor Tadalafil in Pediatric Patients with Pulmonary Arterial Hypertension”. Eli Lilly H6D-MC-LVHV. Principal Investigator: Usama Kanaan, MD

2/2013-present Principal Investigator: “Single-Dose Study to Evaluate the Pharmoacokinetics, Pharmacodynamics, Safety, and Tolerability of Apixaban in Pediatric Subjects at Risk for a Venous or Arterial Thrombotic Disorder.” Bristol-Myers Squibb CV 185-118

7/2013-6/2014 Principal Investigator: “A-PEWS: Analytical Pediatric Early Warning System for Cardiac Intensive Care Units (CICU)”

7/2014-6/2015 Principal Investigator: “icuCIA: Development of Intelligent ICU Clinical Intervention Assistant Devices for Pediatric Patient Care.” Center for Pediatric Innovation, Pediatric Research Center, CHOA/Emory/Georgia Tech.

2/2015-9/2016 Principal Investigator: “Development of Intelligent ICU Clinical Intervention Assistant Device for Pediatric Patient Care.” Center for Pediatric Innovation, Pediatric Research Center, CHOA/Emory/Georgia Tech

7/2016-6/2016 Principal Investigator: “cicuCAD: Developing Early Cardiac Arrest Detection in the Pediatric Cardiac Intensive Care Unit Using BedMaster Streaming Data.” Center for Pediatric Innovation, Pediatric Research Center, CHOA/Emory/Georgia Tech

Government and Other Professional Service: University/Hospital Service: 1998-2001 Admissions Committee, Harvard Medical School 2001 Member, Registrar Selection Committee, Harvard Medical School 2002-2005 Curriculum Committee, Department of Pediatrics, UCSF 2007-2008 Fellows and Residents Advisory Group – Ucare (UCSF) 2009-2010 Member, Children’s Heart Center Research Committee, LPCH 2010-present Member, Cardiac Service Line Quality and Outcomes Working Group, CHOA 2010-present Member, Cardiac ICU Patent Care Committee, CHOA 2011-present Physician Leader, Cardiac Service Line Epic Workgroup 2011-present Resident Selection Committee, Emory University Department of Pediatrics 2011-present Physician Liaison, VPS-CHOA 2012-present Member, Venous Thromboembolism Task Force, CHOA 2012-present Member, EPIC Physician Oversight Committee, CHOA 2013-2015 Member, Faculty Life Course Committee, Emory University 2014-present Grant Reviewer, Center for Pediatric Innovations, Georgia Tech 2015-present Chair, Cardiac Services Hospital Acquired Infection Prevention Program 2015-present Member, Specialty Subcommittee, Quality Committee, The Children’s Care Network 2015-present Member, Patient Safety Huddle, Children’s Healthcare of Atlanta 2016 Evaluator, Atlantic Pediatric Device Consortium

2016-present Adviser, Global Center for Medical Innovation 2016-present Panelist, Reveille Start-up Evaluation Public Service: 9/1998-11/1998 Chairperson, South Asian Health Forum, Boston, Massachusetts 2014-present Member, Emerging Leaders for Children’s, Atlanta, Georgia Summary of Service Activities: Teaching and Mentoring: 4/1996-6/1996 Teaching Assistant, Microeconomics, Department of Economics, Stanford University 11/1998-1/1999 Teaching Assistant, Harvard Medical School Physiology Block

Developed and organized a weekly supplementary course for first year HMS students, to augment their Physiology core curriculum.

9/2000-3/2001 Tutor, Patient/Doctor 2, Harvard Medical School Reviewed clinical examination skills with second year students.

10/2004-12/2004 Small Group leader – Major Organ Systems 11/2007-12/2007 UCSF School of Medicine

Facilitating small group sessions for first year medical students in the Cardiovascular Organs block 2005-2008 Teaching Fellow, Pediatric Cardiology Pediatric Residency Training Program, UCSF

Dedicated bedside and didactic teaching for medical students and pediatric residents rotating on the Cardiology Service (independent of teaching provided while on service)

1/2006 Lab Instructor, Introduction to the Morphology of Congenital Heart Disease UCSF School of Medicine 6/2009 Small Group instructor – Cardiology Lab, Stanford Medical School 5/2011 Guest Lecturer, Emory School of Nursing, Nurse Practitioner Program 2014-2015 Mentor, Emory University School of Medicine, Discovery Program Teaching Aids: 8/2006-Current Powerpoint presentation on a number of topics pertaining to Pediatric Cardiology 4/2012 Physician adviser, Computer-Based Tutorial for Adolescent transitions within Pediatric Cardiology Faculty Development: 11/2007 Teacher Observation Program, TIP-TOP Faculty Development

Academy of Medical Educations (UCSF)

Doctoral Thesis Committee Member: 2014 Chihwen Cheng, Georgia Tech 2016 Jinha Lee, Georgia Tech 2017 Janani Venugopalan, Georgia Tech Research and Creative Activities Research Awards and Grants: Past: 1996 Endocrine Society Research Grant 1998 Harvard Medical School Summer Research Fellowship 2000-2001 Harvard Medical School Research Grant 2006-2007 Training Grant, Research Training in Cardiovascular Development NIH/NHLBI T32 HL007544 (Principal Investigator: Harold Bernstein, UCSF)

2013 Georgia Tech-Children’s HealthCare of Atlanta Seed Grant, “A-PEWS: Analytical Pediatric Early Warning System for Cardiac Intensive Care Units (CICU)”

Peer Reviewed: 1. Taylor WE, Najmabadi H, Strathearn M, Jou NT, Liebling M, Rajavashisth T, Chanani N, Phung L, Bhasin S.

Human stem cell factor promoter deoxyribonucleic acid sequence and regulation by cyclic 3',5'-adenosine monophosphate in a Sertoli cell line. Endocrinology 1996 Dec; 137(12): 5407-14.

2. Chanani NK, Cowan DB, Takeuchi K, Poutias DN, Garcia LM, del Nido PJ, McGowan FX Jr. Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation 2002 Sep 24; 106(12 Suppl 1): I284-9.

3. Jun SL, Chanani NK, Moore P, Higgins CB. Images in cardiovascular medicine. Magnetic resonance imaging of a

posttraumatic myocardial infarction and ventricular septal defect with a closure device in place. Circulation 2007 Jan 16; 115(2):e13-5.

4. Chanani NK, Chiesa NA, Dubin AM, Avasarala K, Van Hare GF, Collins KK. Cryoablation for Atrioventricular

Nodal Reentrant Tachycardia in Young Patients: Predictors of Recurrence. Pacing Clin Electrophysiol 2008 Sep; 31(9):1152-9.

5. Das S, Chanani NK, Deshpande S, Maher KO. B-type natriuretic Peptide in the recognition of critical congenital

heart disease in the newborn infant. Pediatr Emerg Care. 2012 Aug;28(8):735-8.

6. Hebson CL, Chanani NK, Rigby MR, Wolf MJ, Deshpande SR, Montegna LM, Maher KO. Safe and Effective Use of a Glycemic Control Protocol for Neonates in a Cardiac ICU. Pediatr Crit Care Med. 2013 Mar;14(3):284-9.

7. Wolf MJ, Chanani NK, Heard ML, Kanter KR, Mahle WT. Early renal replacement therapy during pediatric cardiac

extracorporeal support increases mortality. Ann Thorac Surg. 2013 Sep;96(3):917-22.

8. Cheng CW, Chanani NK, Venugopalan J, Maher KO, Wang MD. icuARM – An ICU Clinical Decision Support System Using Association Rule Mining. IEEE J Transl Eng Health Med. 2013 Nov 21;1(1):122-31 .

9. Iannucci GJ, Oster ME, Chanani NK, Gillespie SE, McCracken CE, Kanter KR, Mahle WT. The Relationship

Between In-House Attending Coverage and Nighttime Extubation Following Congenital Heart Surgery. Pediatr Crit Care Med. 2014 Jan 3.

10. Gaies M, Cooper DS, Tabbutt S, Schwartz SM, Ghanayem N, Chanani NK, Costello JM, Thiagarajan RR, Laussen

PC, Shekerdemian LS, Donohue J, Willis GM, Gaynor JW, Jacobs JP, Ohye RG, Charpie JR, Pasquali SK, Scheurer MA. Collaborative quality improvement in the cardiac intensive care unit: development of the Paediatric Cardiac Critical Care Consortium (PC4). Cardiol Young. 2014 Aug 28:1-7.

11. Chanani NK, Cheng CW, Maher KO, Wang MD. Data Driven Personalized Risk Prediction in Pediatric Intensive

Care Units. Poster, 44th Critical Care Congress, Society of Critical Care Medicine. Phoenix, Arizona. Jan 2015. 12. Alten JA, Rhodes LA, Tabbutt S, Cooper DS, Graham EM, Ghanayem N, Marino BS, Figueroa MI, Chanani NK,

Jacobs JP, Donohue JE, Yu S, Gaies M. Perioperative feeding management of neonates with CHD: analysis of the Pediatric Cardiac Critical Care Consortium (PC4) registry. Cardiol Young. 2015 Dec;25(8):1593-601.

13. Pethiyagoda T, Chanani NK, Cheng C, Wang MD. PEPCOR ??? A risk prediction model for pediatric intensive

care units utilizing ventilator days and length of stay. 2016 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), 2016, pp. 86-89.

14. Teele SA, Jacobs JP, Border WL, Chanani NK. Heterotaxy Syndrome: Proceedings From the 10th International

PCICS Meeting. World J Pediatr Congenit Heart Surg. 2015 Oct;6(4):616-29.

15. Venugopalan J, Zhang Z, Chanani NK, Maher KO, Wang MD. Time-Series Data Analysis to Predict Mortality and Readmission in the Intensive Care Unit. Submitted.

16. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B,

Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E1, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC Jr, Clark AE, Dean JM; THAPCA Trial Investigators. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med. 2017 Jan 26;376(4):318-329

Posters: 1. Iannucci G, Oster M, Chanani NK, Kanter K, Mahle W. Does 24/7 In-House Attending Physician Coverage Improve

Outcomes Following Congenital Heart Surgery? Pediatric Cardiac Intensive Care Society 9th International Conference 2012.

2. Bhatia A, Lawrence P, Simon D, Chanani N, Kanaan U, Kogon B. The Potts Shunt as a Management Strategy in a

Child with Severe Pulmonary arterial Hypertension. 6th Annual Pulmonary Hypertension Conference 2013. 3. Cheng CW, Chanani NK, Maher KO, Wang MD. icuARM-II: Improving the Reliability of Personalized Risk

Prediction in Pediatric Intensive Care Units. The 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics 2014.

4. Cheng C, Maher K, Wang M, Chanani NK. Data Driven Personalized Risk Prediction in Pediatric Intensive Care Units. Society for Critical Care Medicine Critical Care Congress, 2015.

5. Hailey C, Chanani NK, Chhabra J, Smitley L. Ultra Wideband Monitoring in the Pediatric Patient. American Academy

of Pediatrics, National Conference and Exhibition, 2015.

6. Wolf M, Glanville M, Mahle WT, Maher KO, Chanani NK, Deshpande S. Clinical Practice Guideline Lowering Threshold Hemoglobin in Cyanotic Infants Postoperatively. Society for Critical Care Medicine Critical Care Congress 2016.

Non-Peer Reviewed: 1. Riley C, Chanani NK: Chapter Editors: CICU Quick Reference. In: Pediatric Cardiac Intensive Care Handbook.

Jones M, Klugman D, Fitzgerald R, Kohr LM, Costello JC, Berger, JT, Bronicki R, 1st edition. Washington, DC; 2014.

2. Hamrick SE, Chanani NK. Editors: Perinatal Cardiovascular Disease. Clin Perinatol. March 2016. Prior Research Experience: 6/1993-9/1993 Research Fellow, Reproductive Endocrinology, Research and Education Institute, Harbor-UCLA 6/1994-9/1994 Medical Center, Torrance, CA. Performed molecular biology techniques and independently researched 6/1995-9/1995 and designed a protocol to test Stem Cell Factor promoter region. Awarded fellowship from the

Endocrine Society. Adviser: Dr. Shalender Bhasin. 8/1996-6/1997 Research Analyst, National Bureau of Economic Research, Stanford, CA.

Assisted in research on general Health Care issues. Developed and worked with a HCFA survey of Medicare recipients examining the role of socioeconomic factors in HMO selection. Also helped develop decision analysis models to determine cost-effectiveness of treating heart disease. Adviser: Dr. Mark McClellan.

9/2000-9/2001 Research Associate, Department of Anesthesia and Cardiac Surgery, Children’s Hospital, Boston, MA. Research on the role of phosphodiesterase inhibitors in cardiac inflammation, including the role of cell signaling precipitated by TNF and NFкB modulation. Advisers: Dr. Francis X. McGowan, Jr. and Dr. Douglas Cowan.

References available upon request.

Prepared January 2017