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;CURRICULUM VITAE

Arun .M. Dharmarajan School of Anatomy and Human Biology The University of Western Australia Nedlands, Perth Western Australia 6907 AUSTRALIA

Telephone: (08) 6488 2981 Fax: (08) 6488 1051

e-mail: dharma@anhb.uwa.edu.au PERSONAL Citizenship: Australian Citizen Marital Status : Married, with one son Home Address : 23 Woolley Street Willetton, Perth, W. AUSTRALIA 6155 Telephone: (08) 9354 3742 PROFESSIONAL EMPLOYMENT Professor, School of Anatomy and Human Biology, The University of Western Australia, Nedlands, Perth, WA, December 2001. Associate Professor, Department of Anatomy & Human Biology, The University of Western Australia, Nedlands, Perth, Western Australia, March, 1995-2001 Director- Reproductive Endocrinology Research Laboratories, Department of Gynecology and Obstetrics, Johns Hopkins University, July 1992-November 1994 Acting Director- Division of Reproductive and Developmental Biology Research, Depart-ment of Gynecology and Obstetrics, Johns Hopkins University, April, 1991-July 1992 Associate Director- Core-Radioimmuno Assay Laboratories, Department of Gynecology and Obstetrics, Johns Hopkins University, June. 1990-November 1994 Assistant Professor - Department of Gynecology and Obstetrics, School of Medicine and joint appointment with Reproductive Biology, School of Hygiene and Public Health, Johns Hopkins University, Feb. 1989-1994, Associate Professor (June 1994-January 1995) Instructor- Department of Gynecology and Obstetrics, School of Medicine and joint appointment with Reproductive Biology, School of Hygiene and Public Health, Johns Hopkins University, Feb. 1988-1989 Part-time tutor- Department of Anatomy and Human Biology, Nedlands, Western Austra-lia, 1982-1985. Lecturer- Department of Physiology, University of Sri-Lanka, Peradeniya, 1976-1981.

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EDUCATION St. Thomas College, Gurutalawa & Mt. Lavinia, Sri-Lanka, 1962-1968. General Certifi-cate of Education (Advanced Level) (Biological Sciences). University of Madras, Madras, India, 1969-1972. Bachelor of Science (Biology). University of Madras, Madras, India, 1972-1976. Master of Science (Huamn Physiology, Anatomy & Biochemistry). University of Sri-Lanka, Peradeniya, 1977-1981. Master of Medical Sciences (Physiology). University of Western Australia, Nedlands, Western Australia, 1982-1985. Doctor of Philosophy, Department of Anatomy and Human Biology, Reproductive Endocrinology. Johns Hopkins University, Baltimore, Maryland, USA, 1986-1987. Postdoctoral fellowship, Departments of Gynecology and Obstetrics and Department of Population Dynamics. PRIZES AND AWARDS 1. First class in Pre-University Examinations 1969, University of Madras, India. 2. First class in B.Sc Degree Examinations 1972, University of Madras, India. 3. First rank in the M.Sc Degree Examination 1976, University of Madras, India 4. College Prefect, St. Thomas College, Colombo, Sri-Lanka 1966. 5. University of Western Australia Research Studentship 1983. 6. Tuition scholarship, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205. 7. Mellon Foundation Postdoctoral Fellowship - 1986-1987. 8. Lalor Foundation Postdoctoral Fellowship - 1987-1988. 9. Poster presentation Prize Winner- American Fertility Society Annual Meeting, Orlando, Florida, USA 1991. 10. Poster presentation Prize Winner-American Fertility Society Annual Meeting

Montreal, Canada, 1993.

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A. TEACHING EXPERIENCE 1. At University of Sri-Lanka, Peradeniya (1976-1981) Physiology. 6 hour lecture and laboratory course for medical and dental stu-

dents. Advanced Cell Biology. Two-hour laboratory course for graduate and ad-

vanced undergraduate students. Structure and Function of Cell Nucleus. Two-hour lecture course for junior

and senior biology major and beginning graduate students. Developmental Biology Seminar. One-hour seminar for graduate students. 2. At University of Western Australia (1982-1985) Reproductive Biology. second and third year science students. Histology. Second and third year undergraduate science students and second

year medical students. Human Biology. First year Science, arts, and Human Movement students 3. At Johns Hopkins University (1988-present) Population Dynamics 2 (Reproductive Physiology). Three-unit lecture course

for candidates for M.P.H., Msc., and Ph.D. degrees. I have been participating in that course from 1988.

Population Dynamics 9. (Advanced Reproductive Biology). Three unit semi-

nar course for advanced graduate students. Population Dynamics 4. (Molecular Endocrinology). Three unit seminar

course for graduate students 4. At University of Western Australia, Department of Anatomy and Human Biology Human biology 100 Medical Histology 235 Human Biology 206 (Reproductive Biology) Human Biology 306 (Reproductive Biology; Coordinator) Endocrinology and Reproduction NS210

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B. STUDENTS AND POSTDOCTORAL FELLOWS SUPERVISED (45 in Total) Currently there are 6Ph.D students ,one Postdoctoral Fellow, one Research Assistant in Professor Dharmarajan’s laboratory. Miss Clare Berry, 2006, Ph.D student Miss. Melissa Berg, 2000, Ph.D Student Mr. Jeremy Drake, 2001, Ph.D Student Mr. Matt Dalrymple, 2001, Ph.D Student Miss Inez Czerwionka 2004, Ph.D student Mrs Ambili Unni 2004, Ph.D student Simon Mahoney, 2005, Ph.D students Llyod White, 2005, Ph.D student Michael Thomas, 2005, Hons student Elizabeth White, 2005, Hons student Karen Bosel, 2005, Hons student Miss Clare Berry, 2004, Hons Student Miss Sally McLaren, 2004, Hons Student Mr Daniel Kam, 2003/2004 Hons Student Mr. Simon Mahoney 2003/2004 Hons Student Mr. Ryan Grant, 2000, Hons Student Mr. David Lim, Hons’ Student Miss. Melissa Fogliani, 2000, M.Sc Student Ms. Jo Berry: 2000, Hons Student Mr Damien Hewitt, 2000, Hons Student Miss Jodi Mableson, Hons Student, 2000 Mr. David Lim, 2000, M.Med. Scie Student

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Ms. Jo Torrisi: 1999, Hons Student Dr. Steve Junk, 1999-2003, Ph.D Student (Graduated in 2003) Ms. Cara Bradley: 1998, Hons thesis: Cloning and characterisation of inhibitor of apoptosis protein (IAP) in the rat ovary. Ms. Priya Balaraman: 1998, Hons thesis: Role of SCF/c-kit in follicular atresia. Ms. Chin-w.Chan: 1998, Hons thesis: Anti-apoptotic action of Alzheimer Abeta. Mr. Ricky Lareu, 1998-2002, Ph.D (Ricky was awarded distinction for his Ph.D thesis) Ms. Sharon Roughton: 1997, Hons thesis: Role of fas and FasL in corpus luteum apoptosis 1998(Ph.D) Mr. Michael Abdo: 1997 Hons thesis: Role of TNF and its second messengers in corpus lutem apoptosis, 1998-2002 (Ph.D). Michael was Awarded distinction for his Ph.D thesis Ms. Nicole Holycross: 1996, Hons thesis: Role of apoptosis in ovulation Dr. Koji Kugu, 1993-1994. Thesis: Role of calcium/calmodulin protein kinase II in ovulation. Dr. S. Preutthipan, 1992-1994. Thesis: Role of nitric oxide in corpus luteum function in the rabbit. Dr. Serena Chen, 1992-1994. Thesis: Insulin-like growth factor regulation of progesterone production in the rabbit. Dr. Sandy Goodman, 1992-1994. Thesis: Apoptosis during corpus luteum regression in the rabbit. Dr. Dean Moutos, 1990-1992. Thesis: Estradiol regulation of corpus luteum blood flow in the rabbit. Dr. Dennis Murray, 1990-1992. Thesis: The effect of GnRH analogue on progesterone production in the. pseudopregnant rabbit. Dr. Yuji Takehara, 1991-1993. Thesis: Role of interleukin in ovulation. Dr. Katsuhide Endo, 1989-1991. Thesis: Role of epidermal growth factor in hCG-induced ovulation. Dr. Vanna Zanagnolo, 1989-1992. Thesis: Effects of an analog of gonadotropin releasing hormone on rabbit ovarian function.

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Dr. John Hesla, 1988-1989. Thesis: Role of oxygen free radical in corpus luteum regression. Dr. Toyo Miyazaki, 1987-1989. Thesis: Role of oxygen free radical in hCG-induced ovulation. Dr. Eugene Katz, 1987-1988. Thesis; Luteinized unruptured follicles in the rabbit. Dr. Kou Sueoka, 1986-1988. Thesis: Early pregnancy factor in the rabbit ovary. Dr. Kuo, 1986-1988. Thesis: Role of angiotensin in hCG-induced ovulation. CONFERENCES/WORKSHOPS ATTENDED 1. Workshop on "Educational Science". Sponsored by W.H.O. Peradeniya, Sri-

Lanka, 1977. 2. Workshop on "Teaching Human Reproduction, Family Planning & Population

Dynamics". Sponsored by W.H.O. Colombo, Sri-Lanka, 1978. 3. Workshop on "Methodology of Biomedical Research". W.H.O. Colombo, Sri-

Lanka, 1978. 4. National Workshop on "Teaching Human Reproduction, Family Planning &

Population Dynamics". Sponsored by W.H.O. Colombo, Sri-Lanka, 1979. 5. Sri-Lanka Association for the Advancement of Science, Colombo, Sri-Lanka, 1979. 6. Sri-Lanka Medical Association, Colombo, Sri-Lanka, 1981. 7. Workshop to evaluate family health training programs. UNFPA, Singapore, 1981. 8. Workshop on "Attitude and Their Measurement". Medical Education Unit, Perade-

niya, Sri-Lanka, 1981. 9. Australian Conference on Electron Microscopy, Brisbane, 1984. 10. Anatomical Society of Australia and New Zealand, Perth, 1984. 11. International Association of Medical Laboratory Technologists, Perth, Australia,

1984. 12. Australian Society for Reproductive Biology and Endocrine Society of Australia,

Combined Annual Meeting, Melbourne, 1984, 1995, 1997, 1998 13. Society for Gynecologic Investigation, 1986, 1987, 1988, 1989, 1990, 1991, 1992,

1994

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14. Society for the Study of Reproduction, 1986, 1987, 1988, 1989, 1990, 1991, 1992, 1993, 1994, 1996, 1997, 1998

15. American Association of Anatomists, 100th Meeting, Washington, DC, 1987. 16. Endocrine Society, 1988, 1989, 1991, 1992, 1993, 1994

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MEMBERSHIP IN SOCIETIES 1. Sri-Lanka Association for the Advancement of Science, Colombo, 1976-1981. 2. Sri-Lanka Medical Association, Colombo, Sri-Lanka, 1976-1981. 3. Australian Society for Reproductive Biology, 1982-1985; 1994-present. 4. Anatomical Society of Australia and New Zealand, 1982-1985. 5. Endocrine and Reproductive Biology Society (Western Australia), 1982-1985. 6. Australian Society for Electron Microscopy, 1982-1985. 7. Australian Society for Stereology and Image Analysis, 1982-1985. 8. International Association of Medical Laboratory Technologists, 1982-1985. 9. Society for the Study of Reproduction, 1986-present. 10. Endocrine Society (US), 1986-present. 11. American Fertility Society, 1986-present. 12. Society for Gynecologic Investigation, 1991-present 13. Endocrine Society (Australia), 1994-present 14. Australian and New Zealand Society for Cell Biology (excecutive committee member), 1995-present

Service (The University of Western Australia) Department Related: In addition to routine participation in all Academic Staff meetings, I have taken on several administrative duties in the department. I have served as a member of Departmental

• Equipment committee (Chair) • Accommodation committee • Honours Committee (Chair, 1996, 2004, 2005, 2006) • Animal Users Committee a position of considerable responsibility. This requires

liaison with the Animal Ethics Committee in the use of animals by all staff and students in this department.

• Undergraduate Teaching and Learning Committee. This is the primary advisory committee for undergraduate teaching matters (excluding Honours). The two major roles of this committee are to a) facilitate teaching activities and developments, both within and external to the Department and b) to maintain comprehensive statistics on undergraduate teaching activities, including costs.

• Executive Committee (on number of occasions)

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• Postgraduate Committee(1999-). In these roles I am involved in formulation of departmental research strategies.

All postgraduate students are interviewed annually by the Postgraduate Committee and the committee monitors their progress and provides assistance if necessary. I am the coordinator of the undergraduate courses, Co-coordinated A&HB 312 and currently coordinate 210/206 I am one of the faculty Course advisers for the 2nd and 3rd year Anatomy and Human Biology Students. University Related Faculty of Science/Medicine

• Science Faculty Representative, Centre for Cell and Molecular Biology, The University of Western Australia, January 1995-1998

• Science Faculty Representative for Curriculum Development of the new Degree “Bachelor of Molecular Biology” (1998-1999)

• MBBS Selection Committee (2000-2003). • Member, Board of Studies of Science • Program co-ordinator, European Language

University-wide Services

I have served and continue to serve on some important University Committees. I have been a member of the following University Committees: • • Publication Audit Committee • Scholarship Committee [Biological and Medical Sciences;1998, 1999 (Chair)] • Scholarship Committee, University of Western Australia (2003-2005) • ARC Small Grants Committee [Biological and Medical Sciences; 1997, 1998,

1999 (Chair), 2001, 2002, 2003;Chair] • Internal Research Grants Scheme Working party (2000) • As a Chair of the ARC small grants Committee, I was asked to address the UWA

scientific community on ‘how to write small grants’. This was organised by the Research Administration, UWA.

• Academic Board Nominee, SIMS project, UWA • Chair, Stakeholders Reference Group, SIMS project, UWA • Postgraduate School Board

OUTSIDE THE UNIVERSITY Johns Hopkins University, Baltimore, USA

• Member, Animal care committee, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine.

• Member, Committee on Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine.

• Associate, Population Centre, Johns Hopkins University • Faculty Interviewer, applicants for admission to Department of Gynecology and

Obstetrics and Gynecology, Johns Hopkins University School of Medicine.

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• Program chairman, Reproductive Endocrinology Seminar Series, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine.

External The list below details my involvement in Editorial Boards, refereeing of papers for international/national journals, service on reviewing and funding panels, membership of professional societies, and my involvement in the organization and programming of national and international conferences. Adhoc Grant Reviewer

• National Science Foundation • United States Department of Agriculture • John Sealey Memorial Endowment Fund for Biomedical Research • National Health Medical Research Council • Australian Research Council • Cancer Foundation • Medical Research Fund of Western Australia • Welcome Trust (UK) • Sir Charles Gardner Hospital, WA • National Heart Foundation • Heart Foundation of Western Australia • Cancer Foundation of Western Australia

Editorial Board

• Reproductive Toxicology (1996-2000) • Biology of Reproduction (1998-2002) • Endocrinology (1999-2002) • Molecular and Cellular Endocrinology (2001-2005) • Reproductive Biology and Endocrinology (2002-2005) • Human Reproduction (nominated, 2005) • Theriogenology (nominated, 2005) • Apoptosis (nominated, 2005) • Reproductive BioMedicine (2005-) • Bio Methods (2006)

Peer Reviewer,

• Journal of Biology of Reproduction, • Endocrinology, • Journal of Reproduction and Fertility, • Reproductive Toxicology, • American Journal of Obstetrics and Gynecology, • Human Reproduction, • Fertility and Sterility, • American Journal of Physiology,

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• Endocrine, • Molecular and Cellular Endocrinology, • Journal of Reproduction and Fertility, • Journal of Endocrinology, • Reproduction, Fertility and Development, • Apoptosis, • Cell Death and Differentiation, • Histochemical Journal, • Domestic Animal Endocrinology, • IGF and Growth Factor Research, • Theriogenology, • Journal of Society of Gynecologic Investigation. • Cancer Research • Cancer Research and Therapeutics • Reproduction

Member, By-Laws Committee, Society for Study of Reproduction (1993-1994), USA Member, Scientific Committee, Society for Gynecological Investigation (1993-1994), USA Member, Executive Committee, Australian and New Zealand Society for Cell Biology (1995-1997) Member, Program Committee, Society for the Study of Reproduction (SSR), USA (1997-1998, 2003-2005) Member, Program committee, Australian Society of Reproductive Biology (1998) Endocrine Society of Australia (1998) Newsletter Editor, Australian Society for Reproductive Biology Member, Membership Committee, Society for the Study of Reproduction (SSR, 2001, 2002, 2003), USA Member, SSR strategic Planning Committee (2003-2004) Scientific Committee, International Symposiun on “apoptosis and Cancer” (Trivandrum, India 2005; Goa, India, 2007) GRANT SUPPORT: (since 1986; corpus luteum studies and related studies) Total funded grants 14 (US$1,450373) 1. Quantitative histological and physiological studies of the rabbit corpus luteum using an in vitro perfusion system. Lalor Foundation; 9/1/87 - 8/31/89; Light and electron microscope studies of corpus luteum structure /function relationships during pseudo-pregnancy; P.I. - A. M. Dharmarajan, Ph.D. $40,000 2. Angiogenesis and the development of the rabbit corpus luteum. Institutional Research Grant-10/1/88 - 9/30/89; This project explored the role of angiogenesis in forma-tion of the rabbit ovarian corpus luteum; P.I. - A. M. Dharmarajan, Ph.D and J. R. Rone, Ph.D. $10,000

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3. Histological and physiological regulation of rabbit corpus luteum. Rockefeller Foundation; 1/1/89 - 6/30/92; The focus of this project is the regulation of corpus luteum function by precursors and gonadotropins. P.I. - A. M. Dharmarajan, Ph.D. $190,000 4. Effects of an analog of gonadotropin-releasing hormone treatment on rabbit ovarian function: quantitative histological and physiological studies. IRGPC; 9/1/89 - 8/31/90; The main objective of this research program was to evaluate the effects of treatment with a GnRH analog combined with exogenous gonadotropin on rabbit ovula-tion and corpus luteum structure and function both in vivo and in vitro. P.I. - A. M. Dharmarajan, Ph.D. $10,000 5. Effects of an analog of gonadotropin-releasing hormone treatment on ovulation and corpus luteum function: quantitative histological and physiological studies. Lalor Foundation; 9/1/89 - 5/31/93; The main objective of this research program is to evaluate the effects of treatment with a GnRH analog combined with exogenous gonadotropin on rabbit ovulation and corpus luteum structure and function both in vivo and in vitro. P.I. V.Zanagnolo, M.D. $40,000 6. Cocaine: Effects on corpus luteum structure and function in the pregnant rabbit. IRGPC; 5/1/89-4/30/90; The main objective of this study is to examine the effects of cocaine on corpus luteum function. Co investigator- A.M. Dharmarajan, Ph.D. $ 10,000 7. Corpus luteum maintenance and regression in the rabbit:quantitative structure-function relationships. IRGPC; 11/1/90-10/31/91; The main objective of this study was to examine the regulation of corpus luteum function. Co-investigator- A.M. Dharmarajan. $10,000. 8. Ovulation-Studies using in vitro perfused ovaries. 5 RO1 HD19430-07; 3/1/88-12/31/93; The main objective of this study is to identify interrelationships among factors recognized to stimulate ovulation. Co-PI- A.M. Dharmarajan, Ph.D.;20% effort. $420,227 (direct cost) 9. The Hopkins Population Center. 2P30 HD06268; 7/1/92-6/30/97. Associate Director of Core-Radioimmunoassay laboratories- Co-PI- A.M. Dharmarajan, Ph.D., 15% effort. $400,000 (direct cost) 10. Insulin-like growth factor-I regulation of corpus luteum function. Stetler Re-search Fund for Women Physicians.6/1/93-5/30/95. The main objective of this study is to investigate the effect of IGF-I on corpus luteum function:biochemical and molecular approach. P.I- A.M. Dharmarajan; $40,000 11. Insulin-like growth factor-I regulation of corpus luteum function. IRGPC; 11/1/93-10/30/94. The main objective of this study is to investigate the effect of IGF-I on corpus luteum function:biochemical and molecular approach. Co-P.I- A.M. Dharmarajan, Ph.D.; $12,000 12. Ovulation, follicle rupture, oocyte maturation and establishment of the corpus luteum. Rockefeller Foundation. GA PS 9414. 7/1/94-6/30/95. The main objective of

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this study is to investigate the effect of various factors on follicular dynamics and corpus luteum formation. Co-P.I- A.M. Dharmarajan, Ph.D.; 50% effort. $46,300. 13. Regulation of physiological cell death in the corpus luteum. IRGPC; 5/1/94-6/30/94. The main objective of this study is to establish the molecular mechanisms responsible for corpus luteum regression during pregnancy. Co-P.I- A.M. Dharmarajan, Ph.D.; $12,000 Grants funded and pending (University of Western Australia, 1995-2001)

1/1/1995-31/12/1996. Role of IGF-I in corpus luteum function. Australian Research Council; $58, 000 (funded), P.I.- A.M. Dharmarajan, Ph.D.

1/1/1996-31/12/1998. Regulation of apoptosis during corpus luteum regression. National Health and Medical Research Council; $135, 000 (funded), P.I.-A.M. Dharmarajan, Ph.D.

1/1/1996-31/12/1998. Role of apoptosis in aging of the female reproductive system. Raine Medical Research Foundation; $96,325 (funded) P.I.- A.M. Dharmarajan, Ph.D.

1/1/1998-31/12/1998. Role of nitric oxide in the control of ovulation. Australian Research Council, $17,050 (funded), P.I. A.M. Dharmarajan, Ph.D

1/1/1999-31/12/1999. Apoptosis-associated signalling pathways in follicular atresia. Australian Research Council, $17,000 (funded), P.I. A.M. Dharmarajan, Ph.D

1/1/01-31/12/01. Tumour necrosis factor-alpha signal transduction in corpus luteum apoptosis. Australian Research Council, $10,000 (funded). P.I. A.M. Dharmarajan, Ph.D

1/1/99-31/12/03. The role of GnRH on corpus luteum apoptosis. National Institute of Health (NIH, USA), US$48000 (for 4 years; Funded). A.M. Dharmarajan (consultant/Co-PI)

1998, NH&MRC Equipment Grant (with Drs Yeoh, Olynyk, Dawkins), $80,000

2000, NH&MRC Equipment Grant (with Drs Yeoh, Harvey, Beazley), $70,000 2001-2002. Examining Proliferation and Apoptosis in the Placenta During Development and Pre-Eclampsia. Women and Infants Research. $ 15,000 (Funded), Co-P.I, A.M. Dharmarajan 2002-2003. Proliferation and apoptosis in the placenta during development and pre-eclampsia. Western Australian Institute for Medical Research $26,500 (Funded). P.I, A.M. Dharmarajan 2006-2008 The role of the placental glucocorticoid barrier in preventing fetal growth retardation 3 years $416,375 Co P.I A. Dharmarajan (Funded) 2006-2007 Role of Frizzled Related protein in Keratinocyte Apoptosis. NIH (pending).

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Consultancy: NOVOGEN and UPSTATE BIOTECHNOLOGY, USA Patent Aplication (April 2006)

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FULL MANUSCRIPTS PUBLISHED IN INTERNATIONAL PEER-REVIEWED JOURNALS 1. Perera, K.M.H., Dharmarajan, A.M. and Wijewansa, H.G. (1978). The assess-

ment of study difficulty in dental students. Sri-Lanka Dental Journal 9, 35-39. 2. Dharmarajan, A.M., Perera, K.M.H., Balasuriya, P.B. and Mathiaparanam, S.

(1981). Relationship of grip strength to anthropometric measurements: A correlational and canonical variate analysis. Asian Medical Journal 24 (11) 797-805.

3. Dharmarajan, A.M., Perera, K.M.H. and Thangarajah, S.A. (1982). The

relationship between rectal and axillary temperatures in children. Indian Journal of Physiology and Pharmacology 26(1), 101.

4. Perera, K.M.H., Sriskandakumar, S. and Dharmarajan, A.M. (1982). Test anxiety

correlates of study difficulty in veterinary students. Sri-Lanka Veterinary Journal 12, 42-55.

5. Dharmarajan, A.M. and Perera, K.M.H. (1983). Motor nerve conduction velocity

in relation to handedness of adult humans. IRCS Medical Science 11, 761. 6. Perera, K.M.H., Dharmarajan, A.M. and Perera, C. (1982). Career decisions and

motivational influences among medical students: a view from Sri-Lanka. Indian Journal of Medical Education 24, 48-60.

7. Dharmarajan, A.M., Meyer, G.T. and Bruce, N.W. (1983). Morphometric

analysis of the corpus luteum of 16 day pregnant rats: the effect of preparative procedures on volume of luteal cell, interstitial and vascular compartments. American Journal of Anatomy 168, 51-65.

8. Bruce, N.W., Meyer, G.T. and Dharmarajan, A.M. (1984). Rate of blood flow and

growth of the corpora lutea of pregnancy and of previous cycles throughout pregnancy in the rat. Journal of Reproduction and Fertility 71 (2), 445-452.

*9. Dharmarajan, A.M., Bruce, N.W. and Meyer, G.T. (1985). Quantitative

ultrastructural characteristics relating to transport between luteal cell cytoplasm and blood in the corpus luteum of the pregnant rat. American Journal of Anatomy 172:87-99.

10. Dharmarajan, A.M., Bruce, N.W. and McArdle, H.J. (1986). A comparison of

flow rates and composition of ovarian lymph and blood in the day 16 pregnant rat. Journal of Reproduction and Fertility 77 (1) 169-176.

11. Dharmarajan, A.M., Mastroyannis, C., Yoshimura, Y., Atlas, S.J., Wallach, E.E.

and Zirkin, B.R. (1988). Quantitative light microscopic analysis of corpus luteum growth during pseudopregnancy in the rabbit. Biology of Reproduction 38:863-870.

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12. Yoshimura, Y., Dharmarajan, A.M., Gipps, S., Adachi, T., Hosoi, Y., Atlas, S.J. and Wallach, E.E. (1988). Effects of prostacyclin on ovulation and microvasculature of the in vitro perfused rabbit ovary. American Journal of Obstetrics and Gynecology 159:977-982.

13. Yoshimura, Y., Hosoi, Y., Atlas, S.J., Dharmarajan, A.M., Adachi, T. and

Wallach, E.E. (1988). Effect of the exposure of intrafollicular oocytes to clomiphene citrate (CC) on pregnancy outcome in the rabbit. Fertility and Sterility 50:153-158..

*14. Dharmarajan, A.M., Yoshimura, Y., Sueoka, K., Atlas, S.J., Dubin, N.H., Zirkin,

B.R., Ewing, L.L. and Wallach, E.E. (1988). Progesterone secretion by the isolated perfused luteal ovary during pseudopregnancy in the rabbit. Biology of Reproduc-tion 38:1137-1143.

15. Sueoka, K., Dharmarajan, A.M., Michael, E., Atlas, S.J. and Wallach, E.E. Detec-

tion of early pregnancy factor (EPF) using the rabbit ovary and oviduct perfused in vitro (1988). Journal of Reproduction and Fertility 84:325-331.

16. Sueoka, K., Dharmarajan, A.M., Miyazaki, T., Atlas, S.J. and Wallach, E.E.

(1988). Platelet activating factor (PAF) - induced early pregnancy factor (EPF activity from the perfused rabbit ovary and oviduct. American Journal of Obstetrics and Gynecology 159:1580-1584.

17. Dharmarajan, A.M., Sueoka, K., Miyazaki, T., Atlas, S.J., Ghodgaonkar, R.B.,

Dubin, N.H., Zirkin, B.R. and Wallach, E.E. (1989). Prostaglandins and progesterone production in the in vitro perfused pseudopregnant rabbit ovary. Endocrinology 124:1198-1203.

18. Sueoka, K., Dharmarajan, A.M., Miyazaki, T., Atlas, S.J. and Wallach, E.E.

(1989). In vivo and in vitro determination of early pregnancy factor components from rabbit ovary and oviduct. Journal of Reproduction and Fertility 87:47-53.

19. Wallach, E.E., Atlas, S.J., Dharmarajan, A.M., Oski, J.A. and Santulli, R. (1989).

The periovulatory interval: Physiologic and endocrinologic implications. In: Development of Preimplantation Embryos and Their Environment, A.R. Liss, New York, p. 87.

20. Dharmarajan AM, Bruce, N.W. and Meyer, G.T. (1989). Quantitative comparison

of luteal histology in the rat and rabbit: Changes from mid to late gestation. Journal of Anatomy 1989; 166:191-201.

21. Katz, E., Dharmarajan, A.M., Sueoka, K., Ghodgaonkar, R.B., Dubin, N.H, and

Wallach, E.E. (1989). Effects of systemic administration of indomethacin on ovula-tion, luteinization and steroidogenesis in the rabbit ovary. American Journal of Obstetrics and Gynecology 161:1361-1366.

22. Waddell, B.J., Bruce, N.W. and Dharmarajan, A.M. (1989). Changes in ovarian

blood flow and secretion of progesterone and 20α-hydroxypregn-4-en-one on days

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16 and the morning and afternoon of day 22 of pregnancy in the rat. Biology of Reproduction 41:989-996.

23. Miyazaki, T., Kuo, T.C., Dharmarajan, A.M., Atlas, S.J. and Wallach, E.E.

(1989). In vivo administration of allopurinol affects ovulation and early embryonic development in rabbits. American Journal of Obstetrics and Gynecology 161:1709.

24. Wallach, E.E., Atlas, S.J., Santulli, R., Wright, K.H., Dharmarajan, A.M.,

Miyazaki, T. and Oski, J.O. (1990). Mechanism of ovulation. In: Gamete Physiology, Serono Symposia, Massachusetts, p. 163.

25. Hernandez, E.R., Hurwitz, A., Payne, D.W., Dharmarajan, A.M., Purchio, A.F.

and Adashi, E.Y. (1990). Transforming growth factor �1 inhibits ovarian androgen production: Gene expression, cellular localization, mechanism(s) and site(s) of action. Endocrinolgy 127:2804-2811.

26. Miyazaki, T., Sueoka, K., Dharmarajan, A.M., Atlas, S.J., Bulkley, G.B. and

Wallach, E.E. (1991). The effect of inhibition of oxygen free radicals on ovulation and progesterone production by the in vitro perfused rabbit ovary. Journal of Reproduction and Fertility 91:207-212.

27. Dharmarajan, A.M., Bruce, N.W. and Waddell, B.J. (1991). Quantitative changes

in steroidogenic organelles in the corpus luteum of the pregnant rat in relation to progestin secretion on day 16 in the morning and afternoon of day 22. American Journal of Anatomy 190:273-278.

28. Dharmarajan, A.M., Bruce, N.W. and Waddell, B.J. (1991). Changes in

ultrastructure of transport systems and in rates of progestin secretion in the corpus luteum during late pregnancy in the rat. American Journal of Anatomy 191:208-214.

29. Kuo, T-C., Endo, K., Dharmarajan, A.M., Miyazaki, T., Atlas, S.J. and Wallach,

E.E. (1991). Angiotensin II has a direct effect on the ovary in vitro perfused rabbit ovary. Journal of Reproduction and Fertility 92:469-474.

30. Miyazaki, T., Dharmarajan, A.M., Atlas, S.J., Katz, E. and Wallach, E.E. (1991). Do prostaglandins lead to ovulation in the rabbit by stimulating

proteolytic enzyme activity?. Fertility and Sterility 55:1183-1188. 31. Dharmarajan, A.M., Zanagnolo, V.L., Dasko, L.M., Zirkin, B.R., Ewing, L.L. and

Wallach, E.E. (1991). Estradiol regulation of the rabbit corpus luteum: In vivo and in vitro studies. Endocrinology 128:2678-2684.

32. Endo, K., Atlas, S.J., Rone, J.R., Zanagnolo, V.L., Kuo, T-C., Dharmarajan, A.M.

and Wallach, E.E. (1992). Epidermal growth factor inhibits follicular response to hCG: possible role of cell-cell communication in the response to gonadotropin. Endocrinology 130:186-192

33. Dharmarajan, A.M., Zanagnolo, V.L., Dasko, L.M., Hardy, M.P. and

Wallach, E.E. (1992). Changes in rabbit corpus luteum progesterone

18

secretion and cellular morphology following unilateral luteectomy or ovariectomy. Biology of Reproduction 46:251-255.

34. Hesla, J.H., Miyazaki, T., Dasko, L.M., Wallach, E.E. and Dharmarajan,

A.M. (1992). Superoxide dismutase activity, lipid peroxide production and corpus luteum steroidogenesis during natural luteolysis and regression induced by oestradiol deprivation of the pseudopregnant rabbit ovary. Journal of Reproduction and Fertility 95:915-924.

35. Murray, D.L., Dharmarajan, A.M. and Wallach, E.E. (1992). Luteal phase

deficiency:Physiology and clinical aspects. Postgraduate Obstetrics and Gynecology 12 (2): 1-6.

36. Hurwitz, A., Hernandez, E.R., Payne, D.W., Dharmarajan, A.M. and

Adashi, E.Y. (1992). Interleukin-1 is both morphogenic and cytotoxic to cultured rat ovarian cells: Obligatory role for heterologous contact-indepen-dent cell-cell interaction. Endocrinolgy 131:1643-1649.

37. Kaufman, G., Dharmarajan, A.M., Takehara, Y., Cropp, C.S. and Wallach,

E.E. (1992). The role of protein kinase C in gonadotropin-induced ovulation in the in vitro perfused rabbit ovary. Endocrinology 131:1804-1809.

38. Wallach, E.E. and Dharmarajan, A.M. (1992). Prostaglandins and

ovulation. In: Local Regulation of Ovarian Function. Parthenon Publishing, United Kingdom.

39. Dharmarajan, A.M., Atlas, S.J. and Wallach, E.E. (1993). Rabbit ovarian in

vitro perfusion. In: Methods in Reproductive Toxicology, Eds. R.F. Chapin and J. Heindel, Academic Press.

40. Takehara, Y., Dharmarajan, A.M., Kaufman, G., Wallach, E.E. (1994).

Effect of interleukin 1β on ovulation in the in vitro perfused rabbit ovary. Endocrinology 134: 1788-1793.

*41. Dharmarajan, A.M., Goodman, S.B., Tilly, K.I. and Tilly, J.L. (1994).

Apoptosis during functional corpus luteum regression: evidence of a role for chorionic gonadotropin in promoting luteal cell survival. Endocrine Journal, 2:295-303.

42. Yoshimura, Y., Hosoi, Y., Atlas, S.J., Ghodgaonkar, R., Dubin, N.H.,

Dharmarajan, A.M., Wallach, E.E. (1994). Inhibition of gonadotropin-induced ovulation in rabbits by perfusion with dibutyryl cAMP via reduction of ovarian prostaglandin production. Journal of Reproduction and Fertility 101:207-212.

43. Moutos, D., Schryer, B., Hurn, P. and Dharmarajan, A.M. (1995). The

effect of exogenous estrogen on corpus luteum blood flow and quantitative histology in the pseudopregnant rabbit. Journal of Reproduction and Fertility 103:357-362.

19

44. Chen, S.H., Dharmarajan, A.M., Wallach, E.E. and Mastroyannis, C.

(1995). RU486 inhibits ovulation, fertilization and early embryonic development in rabbits: in vivo and in vitro studies. Fertility and Sterility

64:627-633 45 Hurn, P.D., Kearney, M.L., Kirsch, J.R., Dharmarajan, A.M. and

Traystman, R.J. (1995). Post-ischemic cebereal blood flow recovery in the female: effect of 17�-estradiol. Journal of Ceberal Blood flow and Metabolism 15:666-672

46. Kugu, K., Dharmarajan, A.M., Preutthipan, S.P. and Wallach, E.E. (1995).

The role of calcium/calmodulin-dependent protein kinase II in gonadotropin-induced ovulation in the in vitro perfused rabbit ovary. Journal of Reproduction and Fertility 103:273-278.

47. Zanagnolo, V.L., Dharmarajan, A.M., Endo, K. and Wallach, E.E. (1996). Effects

of acetylsalicyclic acid (aspirin) and naproxen sodium on ovulation in the rabbit. Fertility and Sterility 65:1036-1043

48. Zanagnolo, V.L., Dharmarajan, A.M., Hesla, J. and Wallach, E.E. (1996). Effects

of an analog of gonadotropin releasing hormone on rabbit ovarian function. Endocrinology 137:5400-5406

49. Burton, PJ., Dharmarajan, AM., Hisheh, S. and Waddell, BJ (1996). Induction of

myometrial 11β-hydroxysteroid dehydrogenase type 1 mRNA and protein expression late in rat pregnancy. Endocrinology 137:5700-5706

50. Keenan, D.L., Dharmarajan, A.M and H. Zacur (1997). Dietary carrot results in

diminished ovarian progesterone secretion, wheras a metabolite, retnoic acid, stimulates progesterone secretion in the in vitro perfused rabbit ovary. Fertility and Sterility , 68:358-363.

52. *51. Hesla, J.S., Preutthipan, S.P., Maguire, M.P., Chang, T.S.K., Wallach,

E.E. and Dharmarajan, A.M. (1997). Nitric oxide modulates hCG-induced ovulation in the rabbit. Fertility and Sterility 67: 548-552.

53. Wolf, V., Ke, G., Dharmarajan, A.M., Bielke, W., Artuso, L., Suurer, S and

Friis, R. (1997). DDC-4, an apoptosis-associated gene, is a secreted frizzled relative. FEBS Letters, 417:385-389.

54. Chen, SH., Zanagnolo, V, Preutthipan, S, Roberts, K, Goodman, S. B and

Dharmarajan, A.M. (1997). Role of Insulin-like growth factor-I in progesterone production and cell death in the rabbit corpus luteum. Endocrine 6:73-77

55. Goodman, S.B., K. Kugu., Chen, S.H., Preutthipan, S, Tilly, K.I., Tilly, J.L.

and and Dharmarajan, A.M. (1998). Estradiol-mediated suppression of apoptosis in the rabbit corpus luteum is associated with a shift in expression

20

of bcl-2-family members favoring cellular survival. Biology of Reproduction, 59:820-827.

* 56. Guo, K., Wolfe, V, Dharmarajan, A.M., Feng, Z., Bielke, W., Suurer, S and

Friis, R. (1998). Apoptosis-associated gene expression in the corpus luteum of the rat. Biology of Reproduction, 58:739-746

57. Sridaran, R., Hisheh, S and Dharmarajan, A.M. (1998). Induction of

apoptosis by gonadotropin-releasing hormone agonist during early pregnancy in the rat. Apoptosis 3:51-57.

58. Martins R.N, Chan C-W, Waddington E, Veurink G, Laws S, Croft K, and

Dharmarajan AM (1999). Beta-Amyloid and Oxidative Stress in the pathogenesis of Alzheimer’s Disease. in Antioxidants and Disease in Antioxidants in Human Health , 367-391. (Editor Basu et al. Publishers: Cabi Publishing, a Division of CAB International, Published United Kingdom).

59. Roughton, S.A., Lareu, R. Bittles, A.H and Dharmarajan, A.M. (1999). Fas and

FasL Messenger Ribonucleic Acid and Protein Expression in the Rat Corpus Luteum During Apoptosis-Mediated Luteolysis. Biology of Reproduction, 60:797-804

60. Dharmarajan, A.M., Hisheh, S., Singh, B., Parkinson, S, Tilly, K.I. and

Tilly, J. (1999). Anti-oxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: A novel role for superoxide dismutase in regulating bax expression, Endocrinology, 140:2555-2561.

61. Van Wezel I.L., Dharmarajan, A.M., Lavranos, T.C. and Rodgers, R.J.

(1999). Evidence for alternative pathways of granulosa cell death in healthy and slightly atretic bovine antral follicles. Endocrinology, 140:2602-2612.

62. Papadopoulos, V., Dharmarajan, A.M., Li, H., Culty, M., Lemay, M. and

Sridaran, R. (1999). Mitochondrial Peripheral-Type Benzodiazepine Receptor Expression. Biochemical Pharmacology , 58:1389-1393

63. Chan, C-w., Dharmarajan, A., Atwood, C.S., Huang, X., Tanzi, R.E., Bush,

I. And Martin, R.N. (1999). Anti-apoptotic action of Alzheimer Aβ. Alzheimer’s Reports, 2:113-119.

64. Marti, A., Jaggi, R., Vallan, C., Ritter, P., Baltzer A., Dharmarajan, A.M.

and Friis, R.R. (1999). Physiological apoptosis in hormone dependent tissues:involvemnet of caspases. Cell death and Differentiation, 6 (12):1190-1200

65. Rao, R.M, Dharmarajan, A.M. and Rao, A.J. (2000). Cloning,

characterization of an apoptosis-associated gene in the human placenta. Apoptosis, 5:49-56.

21

66. Waddell B.J, Hisheh S, Dharmarajan, A.M. and Burton, P.J. (2000).

Apoptosis in rat placenta is zone-dependent and is stimulated by glucocorticoids. Biology of Reproduction, 63: 1923-1927

67. Junk, S.M., Dharmarajan, A.M. and Yovich, J.L. (2001). Development to

blastocyst is improved by the injection of donor cytoplasm into in vitro matured mouse oocyte. Reprod Tech, 10:5:256-260.

68. Bruce, N.W, Hisheh, S. and Dharmarajan, A.M. (2001). Patterns of

apoptosis in the corpora lutea of the rat during the estrus cycle, pregnancy and under in vitro culture. Reproduction, Fertility and Development, 13, 105-109

69. Abdo, M.A., Richards, A., Atiya, N., Singh, B., Parkinson, S., Hisheh, S and

Dharmarajan, A.M. (2001). Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea. Reproduction, Fertility and Development, 13:395-403

70. Junk, S.M., Murch, A.R., Dharmarajan, A.M. and Yovich, J.L. (2002).

Cytogenetic analysis of embryos generated from in vitro matured mouse oocytes reveals an increase in micronuclei due to chromosome fragmentation. J. Assist Reprod Genetics, 19:67-71.

71. Berg, M.N., Dharmarajan, A.M. and Waddell, B.J. (2002). Glucocorticoids and

progesterone inhibit apoptosis in the lactating rat mammary gland. Endocrinology, 143: 222-227.

72. Junk, S.M., Dharmarajan, A.M. and Yovich, J.L. (2003). FSH priming

improves oocyte maturation, but priming with FSH or hCG has no effect on subsequent embryonic development in an in vitro maturation program. Theriogenology, 59(8):1741-9.

73. Lacher, MD., Siegenthaler, A., Jaeger, R., Yan, X., Hett, S., Xuan, L., Surer,

S., Lareu, R., Dharmarajan, A.M. and Friis, R. (2003). Role of DDC-4/sFRP, a secreted frizzled-related protein, in the onset of apoptosis in mammary involution. Cell Death and Differentiation, 10:528-538.

74. Abdo, MA., Hisheh, S. and Dharmarajan, A.M. (2003). The Role of Tumor

Necrosis Factor-alpha and the Modulating Effect of the Caspases in Rat Corpus Luteum Apoptosis, Biology of Reproduction, 68: 1241-1248.

75. Yang, H., Bhat, GK., Wadley, R., Wright, KL., Chung, BM., Whittaker, JA.,

Dharmarajan, A.M. and Sridaran, R (2003). Gonadotropin-releasing hormone inhibits synthesis of nitric oxide and steroidogenesis by luteal cells in the pregnant rat, Biology of Reproduction, 68: 2222-2231.

76. Lareu, R.R., Bradley, C.K., Lacher, M.D., Sridaran, R., Friis, RR. and

Dharmarajan, A.M. (2003). Regulated expression of inhibitor of apoptosis protein 3 in the rat corpus luteum. Biology of Reproduction, 68: 2232-2240

22

77. Drake, J.M., Friis, R.R. and Dharmarajan, A.M. (2003). The role of sFRP,

A secreted Frizzled-related protein in ovulation. Apoptosis, 8:389-397. 78. Minnie, H., Mulders, S., Friis, R., Dharmarajan, A.M. and Richards, J.A

(2003). Expression and localization of secreted frizzled-related protein-4 (sFRP-4) in the rodent ovary. Evidence for selective upregulation in luteinized granulosa cells. Endocrinology, 144:4597-4606.

79. Lim D., Flicker L., Dharmarajan A., Martins, RN (2003). Can testosterone

replacement decrease the memory problem of old age. Med Hypotheses, 60(6):893-896.

80. Preutthipan, S., Chen, S.H., Tilly, J.L., Kugu, K. and Dharmarajan, A.M.

(2004). Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum. Reproductive BiolMedicine Online, 9(3):264-270.

81. Dharmarajan, A.M., Goodman, S.B., Atiya, N., Parkinson, S.P., Lareu,

R.R., Tilly, K.I. and Tilly, J.L. (2004). Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum:evidence of a role for placental-derived factors in promoting luteal cell survival. Apoptosis, 9:807-814.

82. Verdile, G., Gnjec, A., Miklossy, J., Fonte, J., Veurink, G., Bates, K.,

Kakulas, B., Mehta, P., Milward, E.A., Tan, N., Lareu, R., Lim, D., Dharmarajan, A. and Martins, R.N. (2004). Protein markers for Alzheimer’s disease in the frontal cortex and cerebellum. Neurology, 63(8), 1385-1392.

83. Clark, L.J., Irvin-Rodgers, H.F., Dharmarajn, A.M. and Rodgers, R.R.

(2004). Theca interna: The other side of bovine follicular atresia. Biology of Reproduction, 71:1071-1078.

84. Charles, A.K., Hisheh, S., Liu, D., Rao, R.M., Waddell, B.J., Dickinson J.E.,

Rao, A.J. and Dharmarajan, A.M. (2005). The expression of apoptosis related genes in the first trimester human placenta using a short term in vitro model. Apoptosis, 10:135-40.

85. Spalding, K.L., Dharmarajan, A.M. and Harvey, A.R. (2005). Caspase-

independent retinal ganglion cell death following target ablation in the neonatal rat. European Journal of Neuroscience, 21:33-45.

86. Spalding, K.L., Cui, Q., Dharmarajan, A.M. and Harvey, A.R. (2005) Injury-

induced retinal ganglion cell loss in the neonatal rat retina. In: Retinal Degenerative Diseases edited by Joe G. Hollyfield, Robert E. Anderson, and Matthew M. LaVail. Springer, New York, NY (in press, 10/1/05)

87. Worawittayawong P, Leigh, CM, Cozens, G, Peirce, EJ, Setchell, BP,

Sretarugsa, P, Dharmarajan, A. and Breed, WG. (2005). Germ cell organization in the seminiferous epithelium of a murid rodent from southern

23

asia, the greater bandicoot rat, resembles that of humans, rather than that of common laboratory rodents. International Journal of Andrology, 28:180-188.

88. Kam, D., Charles, A. and Dharmarajan A. (2005). Caspase-14 expression

in the human placenta. RBM Online, 11(2):236-243. 89. Spalding, K.L., Cui, Q., Dharmarajan, A.M. and Harvey, A.R. (2006)

Injury-induced retinal ganglion cell loss in the neonatal rat retina. In: Retinal Degenerative Diseases edited by Joe G. Hollyfield, Robert E. Anderson, and Matthew M. LaVail. Springer, New York, NY (in press, 10/1/05).

90. Feng, HQ., Shearwood, AM., Ying, ZW., Zeps, N., Joseph, D.,

Iacopetta, B. and Dharmarajan, A. (2006). Expression of Secreted Frizzled-Related Protein 4 (sFRP-4) and Beta-Catenin in Colorectal Carcinoma. Cancer Letters , 231(1):129-137.

91. Fox, S. and Dharmarajan A. (2006). Wnt Signalling in Malignant

Mesothelioma. Frontiers in Bioscience (in press;Accepted December 2005).

92. Lareu, RR., Lacher, MD., Friis, RR. and Dharmarajan A. (2006).

Cloning and characterization of a novel zinc finger protein (rZFP96) in the rat corpus luteum. Biochemica and Biophysica Acta- Gene Structure and Expression . 1732(1-3):69-75. Epub 2005 Dec 29.

93. Hampel, J.K., Brownrigg, L.M., Vignarajah, D., Croft, K.D., Dharmarajan, A.,

Bentel, J., Puddey, I.B., and Yeap, B.B. (2006). Differential modulation of cell cycle, apoptosis and PPARgamma 2 gene expression by PPAR gamma agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells. Prostaglandins, Leukotrienes & Essential Fatty Acids, 74, 283-293.

94. Vijayababu, MR., Kanagaraj, P., Arunkumar, A., Illangovan, R., Dharmarajan, A.

and Arunakaran, J. (2006). Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: A possible mediation by IGFBP-3. Oncology Research, 16(2), 67-74.

95. Hewitt, DP., Mark, P., Dharmarajan, A. and Waddell, BJ. (2006). Placental

expression of secreted frizzled related protein-4 in rat and the impact of glucocorticoid-induced fetal and placental growth restriction. Biology of Reproduction (Epub, March 15, 2006).

96. White, L., Dharmarajan A. and Charles A. (2006). Caspase-14: A new player in

cytotrophoblast differentiation. RBM online (in press) 97. Mahoney, S., Berry, C., Hisheh, S. and Dharmarajan, A. (2006). X-Linked

inhibitor of apoptosis protein expression and chemoresistance in ovarian cancer. Oncology Research (submitted)

24

98. Mahoney, S., Hisheh, S., Millward, M., Brown,D., Kelly,G. and Dharmarajan, A. (2006). Effects of phenoxodiol on cell proliferation and apoptosis in androgen dependent prostate cancer. British Journal of Cancer (submitted).

99. ABSTRACTS PUBLISHED IN PROCEEDINGS OF SOCIETIES

1. Dharmarajan, A.M. and Jiffry, M.T.M. (1979). Assessment of handedness. Proceedings of the Sri-Lanka Association for Advancement of Science 35, 15.

2. Dharmarajan, A.M. and Jiffry, M.T.M. (1980). The reliability and validity of

some handedness questionnaire items. Proceedings of the Sri-Lanka Association for Advancement of Science 36, 15.

3. Jameel, M.M.M., Dharmarajan, A.M., Jiffry, M.T.M. and Nicholas, R.A.D.

(1980). Assessment of sighting dominance in right and left handers. Proceedings of the Sri-Lanka Association for Advancement of Science 36, 15.

4. Dharmarajan, A.M. (1981). The relationship of motor nerve conduction

velocity to handedness in the adults. Proceedings of the Sri-Lanka Medical Association 18, 24.

5. Blumer, W.F.C., Bruce, N.W., Dharmarajan, A.M. and Meyer, G.T. (1983).

Stereological measurements of spaces in the corpus luteum. Australian Symposium on Stereology, Image Analysis and Mathematical Morphology. Melbourne.

6. Dharmarajan, A.M., Bruce, N.W. and Meyer, G.T. (1984). Surface area relation-

ships of luteal cells and adjacent capillary membranes in pregnant rats. Proceedings of the Eighth Australian Conference on Electron Microscopy 8, 24. Brisbane.

7. Zimmerman, M., McGeachie, J., Dharmarajan, A.M. and Dilley, R. (1984). The

effect of nicotine on aortic endothelial cell ultrastructure: A quantitative analysis. Proceedings of the Eighth Australian Conference on Electron Microscopy 8, 45. Brisbane.

8. Dharmarajan, A.M., Bruce, N.W., Meyer, G.T. and Blumer, W.F.C. (1984).

Effect of various fixation procedures on quantitative structure of the rat corpus luteum. Proceedings of the 16th Congress of the International Association of Medical Laboratory Technologists 16 (4), 30. Perth.

9. Dharmarajan, A.M., Bruce, N.W. and Meyer, G.T. (1984). Quantitative

comparison of luteal histology in the rat and rabbit: Changes over mid to late gestation. Proceedings of the Anatomical Society of Australia and New Zealand 22, 74. Perth.

25

10. Dharmarajan, A.M., Bruce, N.W. and Meyer, G.T. (1984). Interstitial space and transport in rat corpora lutea. Proceedings of the Australian Society for Reproduc-tive Biology 16, 12. Melbourne.

11. Dharmarajan, A.M., Bruce, N.W. and McArdle, H.J. (1985). Flow rate and

composition of ovarian lymph in the day 16 pregnant rat. Proceedings of the Australian Society for Reproductive Biology 17, Abstract.

12. Waddell, B.J., Bruce, N.W. and Dharmarajan, A.M. (1985). Ovarian secretion

of progestins during late pregnancy in the rat. Proceedings of the Australian Society for Reproductive Biology 17, Abstract.

13. Dharmarajan, A.M., Mastroyannis, C., Yoshimura, Y., Atlas, S.J., Wallach, E.E.,

and Zirkin, B.R. (1987). Growth of the corpus luteum during pseudopregnancy in the rabbit. Proceedings of the 100th Meeting of the American Association of Anatomists, Washington, DC, Abstract (page 34A).

14. Dharmarajan, A.M., Yoshimura, Y., Atlas, S.J., Zirkin, B.R. and Wallach, E.E.

(1987). Transformation of ruptured follicles into corpora lutea in vitro: steroidogenic and morphological characteristics. Proceedings of the 34th Annual Meeting - Society for Gynecologic Investigation, Atlanta, GA, Abstract #157.

15. Yoshimura, Y., Dharmarajan, A.M., Gipps, S., Adachi, T., Hosoi, Y., Atlas, S.J.

and Wallach, E.E. (1987). Local effects of prostacyclin on in vitro ovulation. Proceedings of the 34th Annual Meeting - Society for Gynecologic Investigation, Atlanta, GA, Abstract #29P.

16. Mastroyannis, C., Dharmarajan, A.M., Yoshimura, Y., Atlas, S.J. and Wallach,

E.E. (1987). Microvasculature of rabbit corpora lutea during pseudopregnancy. Proceedings of the 34th Annual Meeting - Society for Gynecologic Investigation, Atlanta, GA, Abstract #32P.

17. Dharmarajan, A.M., Yoshimura, Y., Atlas, S.J., Dubin, N.H., Wallach, E.E. and

Zirkin, B.R. (1987). Progesterone secretion by the in vitro perfused rabbit ovary: relationship to corpus luteum weight and luteal cell volume and number. Proceed-ings of the 20th Annual Meeting of the Society for the Study of Reproduction, Champaign, IL, Abstract #269.

18. Sueoka, K., Dharmarajan, A.M., Michael, E.M., Atlas, S.J. and Wallach, E.E.

(1987). Detection of early pregnancy factor from the ovary and oviduct of the pregnant rabbit. Proceedings of the 43rd Annual Meeting of the American Fertility Society, Reno, Nevada, Abstract #013.

19. Katz, E., Dharmarajan, A.M., Sueoka, K., Atlas, S.J., Zirkin, B.R. and Wallach,

E.E. (1987). Effects of systemic administration of indomethacin on ovulation, luteinization, and steroidogenesis in the rabbit ovary. Proceedings of the 43rd Annual Meeting of the American Fertility Society, Reno, Nevada, Abstract #P279.

26

20. Yoshimura, Y., Hosoi, Y., Atlas, S.J., Dharmarajan, A.M., Adachi, T. and Wallach, E.E. (1987). Effect of the exposure of intrafollicular oocytes to clomiphene citrate (CC) on pregnancy outcome in the rabbit. Proceedings of the 43rd Annual Meeting of the American Fertility Society, Reno, Nevada, Abstract #049.

21. Sueoka, K., Dharmarajan, A.M. and Wallach, E.E. (1988). Platelet activating

factor (PAF)-induced early pregnancy factor (EPF) activity from the perfused rabbit ovary and oviduct. Society for Gynecologic Investigation, Baltimore, MD, Abstract #099.

22. Dharmarajan, A.M., Sueoka, K., Atlas, S.J., Ghodgaonker, R.B., Dubin, N.H.,

Zirkin, B.R. and Wallach, E.E. (1988). Progesterone and prostaglandin production by the in vitro perfused postovulatory rabbit ovary during pseudopregnancy. Proceedings of the Endocrine Society, New Orleans, LA, Abstract #695.

23. Dharmarajan, A.M., Sueoka, K., Atlas, S.J., Dubin, N.H., Zirkin, B.R. and

Wallach, E.E. (1988). Regulation of progesterone production by in vitro perfused pseudopregnant rabbit ovary. Proceedings of the 21st Annual Meeting of the Society for the Study of Reproduction. Seattle, WA, Abstract #390.

24. Katz, E., Dharmarajan, A.M. and Wallach, E.E. (1988). Perifollicular vascular

network of indomethacin-induced luteinized unruptured follicles (LUF) in the rabbit. Proceedings of the 44th Annual Meeting of the American Fertility Society, Atlanta, GA, Abstract #045.

25. Miyazaki, T., Sueoka, K., Dharmarajan, A.M., Atlas, S.J., Bulkley, G.B. and

Wallach, E.E. (1988). The role of oxygen radicals in ovulation in the in vitro perfused rabbit ovary. Proceedings of the 44th Annual Meeting of the American Fertility Society, Atlanta, GA, Abstract #007.

26. Cropp, C.S., Dharmarajan, A.M., Miyazaki, T., Sueoka, K., Atlas, S.J. and

Wallach, E.E. (1989). The effects of phorbol ester on ovulation in the in vitro perfused ovary. Society for Gynecologic Investigation, San Diego, CA, Abstract #261.

27. Dharmarajan, A.M., Miyazaki, T., Kuo, T.C., Atlas, S.J., Zirkin, B.R. and

Wallach, E.E. (1989). Direct in vitro effect of estradiol on progesterone secretion by the rabbit corpus luteum. Proceedings of the 22nd Annual Meeting of the Society for the Study of Reproduction. St. Louis, MO, Abstract #102.

28. Miyazaki, T., Dharmarajan, A.M., Kuo, T.C. and Wallach, E.E. (1989).

Superoxide desmutase (SOD) activity and lipid peroxide in the rabbit corpus luteum (CL) during pseudopregnancy. Proceedings of the 45th Annual Meeting of the American Fertility Society. San Fransicso, CA, Abstract #035.

29. Kuo, T.C., Dharmarajan, A.M., Miyazaki, T., Atlas, S.J. and Wallach, E.E.

(1989). Effect of angiotensin II and its receptor blocker on ovulation in the rabbit ovary perfused in vitro. Proceedings of the 12th Annual Meeting of the Asian and

27

Oceanic Congress of Obstetrics and Gynecology. Taipei, Taiwan, Abstract # FC4-H.1.

30. Dharmarajan, A.M., Rone, J. and Wallach, E.E. (1990). Early vascularization of

the corpus luteum in the pseudopregnant rabbit: Quantitative histologic and steroidogenic changes. Proceedings of the 37th Annual Meeting - Society for Gynecologic Investigation, St. Louis, Mo. Abstract # 182.

31. Oski, J.A., Dharmarajan, A.M. and Wallach, E.E. (1990). The effect of

leukotriene inhibition on bradykinin induced ovulation. Proceedings of the 37th Annual Meeting - Society for Gynecologic Investigation, St. Louis, MO. Abstract # 408.

32. Dharmarajan, A.M., Miyazaki, T., Dasko, L.M. and Wallach, E.E. (1990). Are

estradiol-induced changes in progesterone secretion related to superoxide dismutase activity in the rabbit corpus luteum? Proceedings of the Endocrine Society, Atlanta, GA, Abstract # 697.

33. Dharmarajan, A.M., Dasko, L.M. and Wallach, E.E. (1990). Effect of unilateral

luteectomy on ovarian progesterone secretion and plasma progesterone and estradiol levels in pseudopregnant rabbits. Proceedings of the 23rd Annual Meeting of the Society for the Study of Reproduction, Knoxville, TN, Abstract # 299.

34. Hesla, J., Kuo, T.C., Dharmarajan, A.M., Miyazaki, T. and Wallach, E.E. (1990).

Assisted fertilization in the rabbit via zona opening: A model for enhanced fertilization in oligospermia. Proceedings of the 46th Annual Meeting of the American Fertility Society, Washington, DC Abstract # p60.

35. Endo, K., Atlas, S.J., Zanagnolo, V.L., Dharmarajan, A.M. and Wallach, E.E.

(1991). Does epidermal growth factor affect granulosa cell response to HCG?. Proceedings of the 38th Annual Meeting of Society for Gynecologic Investigation, St. Antonio, TX. Abstract # 392.

36. Dharmarjan, A.M., Dasko, L.M., Hardy, M.P., Zanagnolo, V.L. and

Wallach,E.E. (1991). Changes in cellular morphology and steroidogenic enzyme content of the rabbit corpus luteum (CL) following unilateral luteectomy (ULL) and unilateral ovariectomy (ULO). Proceedings of the Endocrine Society, Washington, DC, Abstract # 349.

37. Dasko, L.M., Dharmarajan, A.M., Zanagnolo, V.L., Hardy, M.P. and

Wallach, E.E. (1991). Are estradiol-induced changes in progesterone (P) production related to cellular morphology and steroidogenic enzyme content of rabbit corpus luteum (CL)? Proccedings of the Society for the Study of Reproduction, Vancouver, BC, Canada, Abstract # 224

38. Zanagnolo, V.L., Dharmarajan, A.M., Endo, K. and Wallach, E.E. (1991).

Effects of acetylsalicyclic acid (aspirin) and naproxen sodium on ovulation

28

in the rabbit. Proceedings of the 47th Annual Meeting of the American Fertility Society, Orlando, FL, Abstract # O-177 (S75)

39. Keenan, D.L., Dasko, L.M., Dharmarajan, A.M., Wallach, E.E. and Zacur,

H.A. (1991). Effects of dietary carrot on steroidogenesis in the rat and rabbit. Proceedings of the 47th Annual Meeting of the American Fertility Society, Orlando, FL, Abstract # P-015 (S87)

40. Takehara, Y., Dharmarajan, A.M., Kaufman, G., Kokia, E., Adashi, E.Y.

and Wallach, E.E. (1992). The effect of interleukin-1βon ovulation, oocyte maturation, and fertilization in the in vitro perfused rabbit ovary. Proceedings of the 39th Annual Meeting of Society for Gynecologic Investigation, St. Antonio, TX. Abstract # 242.

41. Murray, D.L., Wallach, E.E. and Dharmarajan, A.M. (1992). The effect of

GnRH analogue on progesterone production in the pseudopregnant rabbit. Proceedings of the 39th Annual Meeting of Society for Gynecologic Investigation, St. Antonio, TX. Abstract # 386.

42. Kaufman, G., Dharmarajan, A.M., Takehara, Y., Cropp, C.S. and Wallach,

E.E. (1992). The effect of protein kinase C inhibition on gonadotropin-in-duced ovulation in the in vitro perfused rabbit ovary. Proccedings of the Society for the Study of Reproduction, North Carolina, NC, Abstract # 475

43. Moutos, D., Schryer, B., Hurn, P. and Dharmarajan, A.M. (1992). The

effect of exogenous estrogen on corpus luteum blood flow in the pseudopregnant rabbit. Proceedings of the IX Ovarian Workshop. Abstract # 49

44. Zanagnolo, V.L., Hesla, J, Dharmarajan, A.M. and Wallach, E.E. (1993).

Effects of an analog of gonadotropin releasing hormone on rabbit Fovarian function. Proceedings of the 40th Annual Meeting of Society for Gyne-cologic Investigation, Toronto, Canada. Abstract # P-015 (S87)

45. Chen, S.H., Zanagnolo,V.L., Preutthipan, S., Roberts, K. and Dharmarajan,

A.M. (1993). Insulin-like growth factor-I (IGF-I) potentiates estradiol-stimulated progesterone production by the rabbit corpus luteum. Proccedings of the Society for the Study of Reproduction, Denver, CO, Abstract # 161

46. Hesla, J.S., Preutthipan, S., Chen, S.H., Chang, T.S.K., Wallach, E.E. and

Dharmarajan, A.M. (1993). The role of nitric oxide in hCG-induced ovulation in the rabbit. Proceedings of the 49th Annual Meeting of the American Fertility Society, Montreal, Canada, Abstract # P261

47. Wallach, E.E., Dharmarajan, A.M., Kaufman, G., Takehara, Y. (1993).

Cytokines and signalling pathways in the periovulatory interval. Journal of Assisted Reproduction and Genetics (suppl) 10(6) PS2.

29

48. Preutthipan, S., Chen, S.C., Maguire, M.P., Chang, T.S.K., Tilly, J.L., Wallach, E.E., Dharmarajan, A.M. (1994). Role of nitric oxide in rabbit corpus luteum maintenance. Proceedings of the 41st Annual meeting of Society for Gynecologic Investigation, Chicago, IL, Abstract # 051.

49. Dharmarajan, A.M., Goodman, S.B., Tilly, K.I., Tilly, J.L. (1994). Role of

Apoptosis in functional luteolysis in the pseudopregnant rabbit. Proceedings of the 41st Annual meeting of Society for Gynecologic Investigation, Chicago, IL, Abstract # 072.

50. Kugu, K., Dharmarajan, A.M., Preutthipan, S., Kaufman, G., Wallach,

E.E. (1994). The effect of calcium/calmodulin-dependent protein kinase II inhibition on gonadotropin and prostaglandin-2�-induced ovulation in the in vitro perfused rabbit ovary. Proceedings of the 76th Annual meeting of the Endocrine Society, Anaheim, CA, Abstract # 453

51. Goodman, S.B., Preutthipan, S., Chen, S.H., Tilly, J.L. and Dharmarajan,

A.M. (1994). Luteal cell survival and steroidogenesis are independently regulated by luteotropins. Proceedings of the Xth Ovarian Workshop. Abstract # 24

52. Dharmarajan, A.M., (1994). Role of apoptosis during corpus luteum regression:

interaction between oxygen free radicals and nitric oxide. Proccedings of the Internationa Symposium on free radicals in biology, Chandigarh, India, Abstract # 10

53. Dharmarajan, A.M. (1995). Role of apoptosis in functional luteolysis in the

pregnant rabbit corpus luteum:evidence of a role for placental derived factors in promoting luteal cell survival. Keystone symposia, Colorado, USA, April 1995

54. Dharmarajan, A.M. (1995). Role of apoptosis in functional luteolysis.

Proceedings of the third International Union of Biochemistry and Molecular Biology, Singapiore, 1995. Abs # S31

55. Dharmarajan, A.M and Hisheh, S. (1995). Evidence of a role for oxidadtive free

radical damage in promoting luteal cell apoptosis during corpus luteum regression. Proceedings of the Australian Society for Reproductive Biology, Melbourne, 1995, abs#72.

56. Bruce, N.W., Massa, H.M., Hisheh, S. and Dharmarajan, A.M. (1995).

Apoptosis is coincident with adavanced structural regression of corpora lutea of cycling rats but not functional regression of pregnant rats. Proceedings of the Australian Society for Reproductive Biology, Melbourne, 1995, abs#131

57. Bruce, N.W., Parkinson, S. and Dharmarajan, A.M. (1995). Ovarian blood flow

in the dioestrous rat is reduced by the substrate, L-arginine, and by an inhibitor of nitric oxide synthesis. Proceedings of the Australian Society for Reproductive Biology, Melbourne, 1995, abs#136

30

58. Dharmarajan, A.M. (1995). Role of nitric oxide in ovarian function.

Proceedings of the Australian and New Zealand Society for Cell Biology, Canberra, Abs# 20.

59. Dharmarajan, A.M. (1995). Nitric oxide:function and distribution. Proceedings

of the 1st Asia-Pacific International Anatomical Conference, Singapore, Abs # 25 60. Dharmarajan, A.M. (1996). Evidence for a role of nitric oxide damage in

promoting luteal cell apoptosis during corpus luteum regression. Proceedings of the Second International Conference on “Biochemistry and Molecular Biology of Nitric Oxide”, UCLA, Los Angeles, California, USA, July 1996 Abs # I-6

61. Dharmarajan, A.M., Guo, K., Wolfe V., Saurer, S and Friis R. (1996).Signaling

during apoptosis in the mammary gland, the prostate and the corpus luteum. Proceedings of the X1th Ovarian Workshop, July 1996

62. Dharmarajan, A.M., S. Hisheh, and Sridaran R. (1996). Induction of apoptosis

by gonadotropin releasing hormone during early pregnancy in the rat. Proceedings of the X1th Ovarian Workshop, July 1996

63. Dharmarajan, A.M., Guo, K., Wolfe V., Saurer, S and Friis R. (1996). Apoptosis

in the rat Mammary gland, Prostate and corpus luteum: Detection of “cell death” associated genes using differential display cloning technique. Proceedings of Australian and New Zealand Society of Cell Biology, Canberra, September, 1996

64. Richards, A., Atiya, N., Parkinson, S.P., Singh, B, Dharmarajan, A.M. (1997).

Evidence for an interleukin converting enzyme homologue in corpus luteum apoptosis. Proceedings of the 30th annual meeting of the Society for the Study of Reproduction, Portland, OR, USA, Abs # 295

65. Dharmarajan, A.M., Atiya, N., Parkinson, S.P., Singh, B., Sabbadini, R (1997).

Role of sphingolipid signal transduction pathway in corpus luteum apoptosis. Proceedings of the 30th annual meeting of the Society for the Study of Reproduction, Portland, OR, USA, Abs # 571

66. Dharmarajan, A.M., Goodman, S.B., Atiya, N., Parkinson, S.P., Tilly, J.L

(1997). Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum (CL): evidence of a role for placental-derived factors in promoting luteal cell survival. Proceedings of the 40th annual meeting of the Endocrine Society of Australia, Canberra, Abs # 35.

67. Abdo, M.A. and Dharmarajan, A.M. (1997). Role of tumor necrosis factor-

alpha in corpus luteum regression. Proceedings of the 8th annual combined biological sciences meeting, Perth, Abs # 16.

68. Roughton, S., Dharmarajan, A.M. and Bittles, A. (1997). Role of Fas and FasL

in apoptosis during luteolysis. Proceedings of the 8th annual combined biological sciences meeting, Perth, Abs # 16.

31

69. Dharmarajan, A.M. (1998). Molecular regulation of corpus luteum apoptosis.

Proceedings of the 4th national congress on Assisted Reproductive Technology. Chennai, India, Abs 46-47.

70. Balaraman, P., Lareu, R. and Dharmarajan, A.M. Regulation of Apoptosis by

Steel factor during Folliculogenesis. Proceedings of the 29th Australian Society for Reproductive Biology, Perth, August, 1998, Abs # 13.

71. Singh, B.R., Sabbadini, R. and Dharmarajan, A.M. The comet assay-A method

for detecting DNA fragmentation. Proceedings of the 29th Australian Society for Reproductive Biology, Perth, August, 1998, Abs # 34.

72. Abdo, M.A., Singh, B.R., Hisheh, S., Parkinson, S.P. and Dharmarajan, A.M.

The Role of Tumor Necrosis factor-alpha in Corpus Luteum Apoptosis: Interleukin-1beta-Converting enzymes (ICE) implicated. Proceedings of the 29th Australian Society for Reproductive Biology, Perth, August, 1998, Abs # 45.

73. Bradley, C.K., Lareu, R. and Dharmarajan, A.M. Characterisation and cloning

of an Inhibitor of Apoptosis Protein (IAP) in the rat corpus luteum. Proceedings of the 29th Australian Society for Reproductive Biology, Perth, August, 1998, Abs # 12.

74. Junk, S.M., Murch A, Dharmarajan, A.M. and Yovich J.L. Cytogenetics analysis

of in vitro matured mouse oocytes. Proceedings of the 11th world congress on In vItro Fertilization and Human Reproductive Genetics, Sydney, May, 1999, Abs # P-109

75. Junk, S.M., Dharmarajan, A.M. and Yovich J.L. Comparison of PZD and IVF

Fertilization rates of in vitro matured mouse oocytes. Proceedings of the 11th world congress on In vitro Fertilization and Human Reproductive Genetics, Sydney, May, 1999, Abs # P-111.

76. Junk, S.M., Dharmarajan, A.M. and Yovich J.L. In vitro maturation of immature

mouse oocytes following freezing and subsequent thawing of ovarian tissue. Proceedings of the 11th world congress on In vItro Fertilization and Human Reproductive Genetics, Sydney, May, 1999, Abs # P-139.

77. Hughes R., Zuvela, E., Mableson, J., Bruce, N., Dharmarajan, A.M. and Matson,

P.L. The survival of human spermatozoa frozen by three different protocols. Proceedings of the 11th world congress on In vItro Fertilization and Human Reproductive Genetics, Sydney, May, 1999, Abs # 349

78. Gameau, L.J., Bell, M.C., Carroll, J.L., Patil, R., Dharmarajan, A.M. and Mathis,

J.M. Analysis of a human frizzled related gene, FRPAP, in apoptosis and cancer. The Ray A. Barlow Scientific Symposium on Gene Therapy in Cancer. Shreveport, LA; January, 1999: Abstract 28.

32

79. Gameau, L.J., Bell, M.C., Carroll, J.L., Patil, R., Dharmarajan, A.M. and Mathis, J.M. Analysis of a human frizzled related gene, FRPAP, in apoptosis and cancer. American Association for Cancer Research Ninetieth Annual Meeting. Philadelphia, PA; April 1999: Abstract 4061.

80. Gameau, L.J., Bell, M.C., Carroll, J.L., Patil, R., Dharmarajan, A.M. and Mathis,

J.M. Analysis of a human frizzled related gene, FRPAP, in human breast cancer. American Society of Gene Therapy Second Annual Meeting.Washington, DC; June, 1999: Abstract 786.

81. Dharmarajan, A.M. A novel Death Promoter Gene-Y81. 3rd NUS-Faculty Of

Medicine Annual Scientific Meeting-Symposia on “Apoptosis”, August, 1999. 82. Dharmarajan, A.M. Signalling Mechanisms During Apoptosis In The Corpus

Luteum. International Symposium on Molecular and Clinical Aspects of The Regulation of Ovarian Function: Impact on the Reproductive Health of Women. New Delhi, October, 1999, Abs # 09

83. Abdo, M.A., Bogoyevitch, M.A. and Dharmarajan, A.M. Existence of

Extracellular Signal-Related Kinase (ERK) and p38 mitogen activated protein kinase (MAPK) In The rat Corpus Luteum. Proceedings of the 30th Australian Society for Reproductive Biology, Melbourne, September, 1999, Abs # 92

84. Hisheh S., Srikanadakumar S., Abdo, M.A. and Dharmarajan, A.M. Apoptosis

during functional corpus luteum regression: A role for monocyte chemoattractant protein-1 implicated. Proceedings of the 81st Annual Meetings of The Endocrine Society , San Diego, CA, USA, June, 1999, Abs # P2-348

85. Gameau, L.J., Bell, M.C., Carroll, J.L., Patil, R., Dharmarajan, A.M. and Mathis,

M.J. Expression of a human frizzled related gene, FRPHE in Human ovarian tissue and ovarian cancer. Proceedings of the 42nd Endocrine Society of Australia, Melbourne, Sepetember, 1999, Abs # 79.

86. Hisheh, S., Burton, P., Dharmarajan, A.M. and Waddell, B.J. Apoptosis in rat

placenta: Zonal distribution and changes with gestational age and glucocorticoid treatment. Proceedings of the 42nd Endocrine Society of Australia, Melbourne, September, 1999, Abs # 133.

87. Roughton, S.A., Sridaran, S. and Dharmarajan, A.M. Apoptosis following

induced regression of the rat corpus luteum may involve Fas/Fas ligand system. .Proceedings of the 9th annual combined biological sciences meeting, Perth, August, 1999, Abs # 130.

88. Lareu, R.R., Lacher, M., Friis, R. and Dharmarajan, A.M. Cloning and

expression of wnts in the rat ovary undergoing apoptosis. Proceedings of the 9th annual combined biological sciences meeting, August, 1999, Perth, Abs # 131.

89. J. Torrisi, J, Burton, P., Waddell, B.J. and Dharmarajan, A.M. Telomerase-

associated protein 1 (TP1) in rat endometrium: Changes across the oestrous cycle

33

and early pregnancy and its relationship to cellular proliferation. Proceedings of the 9th annual combined biological sciences meeting, August, 1999, Perth, Abs # 129.

90. Roughton, S.A., Sridaran, R., Dharmarajan, A.M. Fas and Fas ligand in rat

corpus luteum apoptosis following induced regression. Proceedings of the 43rd Australian and New Zealand Society for Cell and Developmental Biology, September, 1999, Gold Coast, Abstract # 091

91. Rekha, M.R., Dharmarajan, A.M., Friis, R.R. and Rao A.J. Cloning and

characterization of a novel apoptotic gene in the human placenta. International Symposium on Molecular and Clinical Aspects of The Regulation of Ovarian Function: Impact on the Reproductive Health of Women. New Delhi, October, 1999. Abs # S-10

92. Abdo, M.A. and Dharmarajan, A.M. Characterization of caspase proteolytic

cascade following tumour necrosis factor-alpha induced corpus luteum apoptosis. Proceedings of the 31th Australian Society for Reproductive Biology, Canberra, April, 2000, Abs # 109

93. Abdo, M.A. and Dharmarajan, A.M. Sphingolipid signal transduction in corpus

luteum apoptosis. Similarities between rat and rabbit. Proceedings of the 33rd annual meeting of the Society for Study of Reproduction. Madison, Wisconsin, July, 2000, Abs # 72.

94. Abdo, M.A. and Dharmarajan, A.M. Evidence of Tumour Necrosis Factor-

alpha receptors in the adult rat ovaray during apoptosis. Proceedings of the 11th International Congress of Endocrinology. October, 2000, Sydney, P1434

95. Gameau, L.J., Dharmarajan, A.M. and Mathis, J.M. Investigation of the Human

Frizzled Related Apoptosis Associated Protein (FRPAP) Gene in Normal Tissue and Cancer. Proceedings of the 11th International Congress of Endocrinology. October, 2000, Sydney, P869

96. Roughton, S.R., Sridaran, R. and Dharmarajan, A.M. Regulation of Molecular

markers of apoptosis following induced regression of the rat corpus luteum. . Proceedings of the 11th International Congress of Endocrinology. October, 2000, Sydney, P138

97. Berg, M.N, Dharmarajan, A.M. and Waddell, B.J. Glucocorticoids and

progesterone prevent apoptosis in the lactating mammary gland. Proceedings of the 11th International Congress of Endocrinology. October, 2000, Sydney, Abs # OR24

98. Lareu, R.L, Bradley, C.K., Lacher, M., Friis, R.R. and Dharmarajn, A.M.

Regulation and cloning of apoptosis associated proteins (IAP) in the rat corpus luteum. Proceedings of the 11th International Congress of Endocrinology. October, 2000, Sydney, P167

34

99. Abdo, M.A. and Dharmarajan, A.M. Factors involved in tumor necrosis factor-alpha-induced rat corpus luteum apoptosis. Proceedings of the 34th annual meeting of the Society for Study of Reproduction. Ottawa, Canada, July, 2001, Abs # 387.

100. Dharmarajan, A.M, Lareu, R.L. and Drake, J. The role of Y81 (A secreted

Frizzled Related Protein) in Ovulation. Proceedings of the 34th annual meeting of the Society for Study of Reproduction. Ottawa, Canada, July, 2001, Abs # .134

101. Berg, M.N., Berry, J.A., Waddell, B.J. and Dharmarajan, A.M. Expression of

Y81 (A secreted Frizzled-Related Protein) during mammary gland apoptosis in vitro. Proceedings of the 44th annual meeting of the Endocrine Society of Australia. Gold Coast, Australia, 2001, Abs # 401.

102. Drake, J.M. and Dharmarajan, A.M. Y81 is upregulated with apoptotic cell

death during ovulation. Proceedings of the 44th annual meeting of the Endocrine Society of Australia. Gold Coast, Australia, 2001, Abs # 409.

103. Hisheh, S., Dharmarajan, A.M. and Waddell, B.J. Changes in adrenal

responsiveness during rat pregnancy: the roles of ACTH receptor and StAR. Proceedings of the 45th annual meeting of the Endocrine Society of Australia. Adelaide, Australia, 2001, Abs # 314.

104. Abdo, M.A., Dalrymple, M.B and Dharmarajan, A.M. Nitric oxide-induced

corpus luteum apoptosis is independent of the tumour necrosis factor-alpha cell death pathway. Proceedings of the 32nd Society for Reproductive Biology, Gold Coast, Australia, September, 2001, Abs # 52.

105. Roughton, S.A. and Dharmarajan, A.M. Apoptosis-related proteins are regulated

following induced regression of the rat corpus luteum (CL). Proceedings of the 32nd Society for Reproductive Biology, Gold Coast, Australia, September, 2001, Abs # 53.

106. Dharmarajan, A.M. Signalling mechanisms during apoptosis. Proceedings of the

32nd Society for Reproductive Biology, Adelaide, Australia, September, 2002, Abs # 53.

107. Dharmarajan, A.M., Hisheh, S. and Abdo, M.A. Understanding signaling events

during corpus luteum apoptosis. Proceedings of the 35th annual meeting of the Society for Study of Reproduction. Baltimore, USA, July, 2002, Abs # .413.

108. Dharmarajan, A.M. Factors involved in tumour necrosis factor-alpha-induced rat

corpus luteum apoptosis. Proceedings of Apoptosis 2003. Luxembourg, Abs # 51.

35

36

INVITED PRESENTATIONS 1. "Quantitative histological and physiological studies of the rabbit corpus

luteum using in vitro perfusion system." Department of Population Dynamics, Johns Hopkins University, Baltimore, MD, January 1988.

2. "Progesterone;synthesis and secretion." Reproductive Endocrinology confer-

ence, Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, MD, March 1989

3 "Regulation of corpus luteum function." Department of Gynecology and Ob-

stetrics, University of Maryland, Baltimore, MD, June, 1990 4. "Estradiol regulation of corpus luteum function." Department of Population

Dynamics, Johns Hopkins University, Baltimore, MD, February, 1991 5. "Role of prostaglandins in follicular dynamics." Fernstrom Symposium on

Local Regulation of Ovarian Function." Malmo, Sweden, June 1991. 6. "Control of luteal function:interaction of estradiol and insulin-like growth

factor-I." Institute of Reproduction and Development, Monash University, Melbourne, Australia, April, 1993

7. "Local regulation of corpus luteum development and function." Department

of Anatomy & Human Biology, University of Western Australia, Perth, Australia, April, 1993

8. "Regulation of apoptosis (physiological cell death) during corpus luteum

regression". Department of Gynecology and Obstetrics, University of Adelaide, Australia, February, 1994.

9. "Signaling pathways during corpus luteum regression". Department of Obstetrics

and Gynecology, University of Texas Health Science Center, Houston, Texas, May, 1994.

11. "Role of Bcl-x and Bax in the regulation of corpus luteum regression.

International Conference on Apoptosis, NIH, Bethesda, August, 1994 10. "Molecular mechanism(s) underlying physiological cell death:interaction be-

tween oxygen free radicals and nitric oxide". World Congress of Biochemistry and Molecular Biology, Delhi, September, 1994.

11. "Regulation of corpus luteum apoptosis during pregnancy; role for placental

derived factor". European Society of Hematology, Kinsale, Ireland, October, 1994.

12. Role of placental extract in the prolongation of apoptosis in the corpus luteum.

Keystone Symposium on “apoptosis”, Colorado, USA, 1994

37

13. Regulation of apoptosis in the corpus luteum. Third International Union of Biochemistry and Molecular Biology Conference “Molecular Recognition”, Singapore, April 22 -April 28, 1995

14. Corpus luteum-State of the art. International workshop on “Ovulation Induction”,

Monash University, Melbourne, Australia, April 12-April 15, 1995 15. Molecular mechanisms of corpus luteum apoptosis. Organized by Madras

Gynecological Society, Madras, South India, April 17-April 19, 1995 16. Role of Nitric Oxide in Ovulation and Corpus Luteum Function. Molecular

Biology and Pathophysiology of Nitric Oxide. International Workshop, Madrid, Spain, June, 1995

17. Molecular regulation of Corpus luteum apoptosis, Department of Clinical research,

university of Bern, bern, Switzerland, June 1995 18. Regulation of corpus luteum apoptosis, Department of Biochemistry, The

University of Western Australia, July, 1995. 19. Signalling mechanisms during corpus luteum regression, Department of Pathology,

The University of Western Australia, August, 1995. 20. Role of protooncogenes in the regulation of apoptosis, Neuromuscular Research

Institute, The University of Western Australia, September, 1995. 21. Role of nitric oxide in female reproductive system. First Asia-Pacific Anatomical

Conference, Singapore, December 1995. 22. Role of apoptosis in corpus luteum regression. Department of Biology, Molecular

Biology Institute, San Diego State University, April 1996 23 . International Symposium on “Cell Death in Reproductive Physiology”, Chicago,

Illinois, USA, April 1996 24. Role of Oxidadtive stress response factors in corpus luteum apoptosis. Department

of Gynecology and Obstetrics, University of Illinois, Chicago, USA, April 1996 25. Second International Conference on “Biochemistry and Molecular Biology of

Nitric Oxide” UCLA, California, USA, July 1996 26. XI th Ovarian Workshop, London Ontario, Canada, July 1996. 27. Department of Gynaecology and Obstetrics, University of Ottawa, Ottawa,

Canada, July 1996. 28. Department of Biochemistry, Vanderbilt University, Nashville, TN, USA, July

1997

38

29. Department of Gynecology and Obstetrics, University of Arkansas Medical Sciences, Little Rock, AR, USA, August 1997.

30. Sattelite Symposium on Steroidogenesis, Endocrine Society of Australia,

Canberra, 1997. 31. Department of Medicine, Royal Perth Hospital, Perth, Western Australia, 1997 32. Fourth National Congress on Assisted Reproductive Technology, Chennai, India,

Feb 1998. 33. Sattelite Symposium on “Apoptosis and Steroid Hormone Action”, Australian

Society for Reproductive Biology, Perth, August, 1998. 34. Sattelite Symposium on “ Cancer and Steroid Hormone”, Australian Endocrine

Society, Perth, August, 1998. 35. Department of Endocrinology, QEII Medical Centre, UWA, Perth, Western

Australia, November 1998 36. Department of Molecular Reproduction, Development and Genetics, Indian

Institute of Science, Bangalore, India, January 1999. 37. Department of Clinical Research, University of Bern, Bern, Switzerland, February,

1999. 38. Department of Physiology, Morehouse School of Medicine, Atlanta, GA, USA,

June 1999. 39. Department of Cell Biology, Georgetown University, Washington DC, USA, June

1999. 40. 3rd National University Hospital-Faculty of Medicine Annual Scientific Meeting,

National University of Singapore, Singapore, August, 1999. 41. International Symposium on Molecular and Clinical Aspects of Regulation of

Ovarian function. Delhi, India, October, 1999. 42. National Centre for Biological Sciences, Bangalore, India, March, 2000,

November, 2000 43. Department of Physiology, All India Institute of Medical Sciences, Delhi, India,

December, 2000 44. Department of Plant Pathology, The University of Western Australia, Nedlands,

November, 2001 45. Department of Biological and Biomedical Sciences, University of Durham, July

2002

39

46. Department of Medicine/Dermatology, Vanderbilt University, Nashville, TN,

May 2002 47. Department of Gynecology and Obstetrics, University of Arkansas Medical

Sciences, Little Rock, May 2002 48. Department of Cell Biology and Biochemistry, Texas Tech Health Science Centre,

Lubbock, TX, May 2002 49. WYETH Laboratories, Philadelphia, Pennsylvania, USA, July 2002 50. Apoptosis 2003, Luxembourg, January 2003 51. Department of Molecular Biology, University of Ghent, Belgium, Feb 2003 52. Department of Gynecology and Obstetrics, University of Brussels, Feb 2003 53. Department of Human Genetics, University of Paris, Feb 2003 54. Department of OB/GYN, University of Arkansas Medical Science Center, Little

Rock, USA, July 2003 55. Department of Physiology, Morehouse School of Medicine, Atlanta, USA, July

2003 56. Department of Medicine/Dermatology, Vanderbilt University, Nashville, TN,

USA, July 2003 57. Department of Biochemistry, University of Kerala, India, 2004 58. Rajiv Gandhi Institute of Biotechnology, Trivandrum, Kerala, India 2004 59. Madras Medical Mission, Chennai, India, 2004 60. National University of Singapore, Singapore, 2005 61. Society for Reproductive Biology, Perth, 2005 62. Australian Dermatology Society, Perth, 2005 63. PG Institute of Basic Medical Sciences, University of Madras, India, 2005 64. Bharadisan University, Trichy, India, 2005 65. Stella Maris College Chennai, India, 2005 66. Ranbaxy Pharmaceutical Company, Delhi, 2006

40

67. Edith Cowan University, Perth, 2006 68. Society For Biological Chemistry, Delhi, 2006 69. Shantha Biotechnic, Hyderabad, 2006 70. University of Hyderabad, Hyderabad, 2006