Curriculum Vitae WILLIAM ANTHONY MULLER€¦ · William A. Muller, MD, PhD School of Medical Sciences, Weill Medical College 2005- Faculty of 1000 Faculty Member, Leukocyte Development

Curriculum Vitae

WILLIAM ANTHONY MULLER

Place of Birth: New York, New York

Citizenship: United States of America

Licensure and Certification:

1983 Diplomate, National Board of Medical Examiners (No. 211701)

1986 Board of Registration of Medicine Commonwealth of Massachusetts,

License to Practice Medicine No. 650024

1987 Diplomate of the American Board of Pathology, Anatomic Pathology,

May 29, 1987

1988 - 2012 New York State, License to Practice Medicine and Surgery No.173517

2007 - State of Illinois, Licensed Physician and Surgeon, No. 036.119476

Office Address: Department of Pathology

Northwestern University

Feinberg School of Medicine

Ward Building 3-126

303 East Chicago Avenue

Chicago, IL 60611-3008

Home Address: 1423 Hinman Avenue

Evanston, IL 60201

Education:

1975 A.B. Harvard College, Cambridge, MA

Summa cum laude (Biology)

Honors Thesis: Isolation and Preliminary

Characterization of the DNA of Porphyridium aerugineum.

1981 Ph.D. The Rockefeller University, New York, NY

Dept. of Cellular Physiology and Immunology

Thesis: The Membrane Polypeptides of the Vacuolar System:

Composition and Recycling

1982 M.D. Cornell University Medical College, New York, NY

Professional Positions:

1982-83 Medical Intern, Massachusetts General Hospital,

Boston, MA

1983-87 Resident in Pathology, Brigham and Women’s Hospital,

Boston, MA

1987-94 Assistant Professor, Laboratory of Cellular Physiology and Immunology

1994-1996 Associate Professor, Laboratory of Cellular Physiology and Immunology

The Rockefeller University, New York, NY

Curriculum vitae, page

William A. Muller, MD, PhD

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1987-1995 Adjunct Assistant Professor, Department of Pathology,

Cornell University Medical College, New York, NY

1987-1995 Assistant Attending Pathologist, The New York Hospital,

New York, NY

1995-1996 Adjunct Associate Professor, Department of Pathology,

Cornell University Medical College, New York, NY

1995- 2000 Associate Attending Pathologist, The New York Presbyterian Hospital,

New York, NY

1997- 2000 Associate Professor with Tenure, Department of Pathology, Weill Medical

College of Cornell University

1997- Adjunct Professor, Laboratory of Cellular Physiology and Immunology,

The Rockefeller University, New York, NY

1998- 2000 Associate Professor, Graduate Program in Immunology, Weill Graduate

School of Medical Sciences

2001- 2007 Professor, Department of Pathology and Laboratory Medicine, Weill

Medical College of Cornell University

2001- 2007 Professor, Graduate Program in Immunology, Weill Graduate School of

Medical Sciences

2001- 2007 Attending Pathologist, New York-Presbyterian Hospital

2007 - 2016 Chairman, Department of Pathology, Northwestern Memorial Hosptial,

Chicago, IL

2007 - 2016 Magerstadt Professor and Chairman, Department of Pathology,

Northwestern University Feinberg School of Medicine, Chicago, IL

Present Position: Professor, Department of Pathology, Northwestern University Feinberg

School of Medicine, Chicago, IL 60611

Professional Memberships:

1987-2007 New York Academy of Science

1985-present American Society for Investigative Pathology

1994-present North American Vascular Biology Organization

1996-2007 Harvey Society

2006-present The Henry Kunkel Society

Awards and Honors:

1973 Jacob Wendel Scholarship, Harvard College

1975 Arthur Eugene Sutherland Prize, Harvard College

1975 American Chemical Society (Northeast Section) Research Award

1975 Phi Beta Kappa, Harvard University

1988 Pew Scholarship in the Biomedical Sciences

1988 RJR Nabisco Research Scholars Award

1990 Irvington Institute for Medical Research New Initiatives Award

1994-1999 Established Investigator, American Heart Association

1998-1999 Mentored a Finalist in the Intel Science Talent Search

2000-2001 Teaching Excellence Award, Immunology Program of the Graduate



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School of Medical Sciences, Weill Medical College

2005- Faculty of 1000 Faculty Member, Leukocyte Development Section

2005- NIH MERIT Award (R-37 HL064774)

2006- Elected to membership in the Henry Kunkel Society

2007- Magerstadt Professor of Pathology, Northwestern University Feinberg

School of Medicine

2007-2008 Mentored a Finalist in the Intel Science Talent Search

2010 Elected as a AAAS Fellow

2013 Rous-Whipple Award, American Society for Investigative Pathology

2014 Ramzi Cotran Memorial Lecture, Brigham and Women’s Hospital, Boston

2016 Karl Landsteiner Lecture, Sanquin Research Center, Amsterdam

Institutional Responsibilities (previous years at Weill Cornell Medical College):

5 % Teaching

1989-1996 Designed new Pathology Curriculum as problem-based learning. Taught

Pathology by intensive tutorial method.

1997-1998 Played a major role in designing and implementing a major new

curriculum for the second year medical students, The Basis of Disease.

1997-1998 Associate Course Director, The Basis of Disease.

1998-present Pathology Department Liason for The Basis of Disease.

2000-2001 Course Director, Graduate School Division of Immunology, Research-in-

Progress Course.

2000-present Course Director, Graduate School Division of Immunology, Advanced

Topics in Immunology Course—Leukocyte Homing and Migration.

10% Clinical Attending Pathologist on autopsy service

20% Administrative

Member, Pathology Residency Committee 1994-1997

Faculty Search Committee, 1998 – 1999

Basis of Disease administration, 1997 – present

General Faculty Council, Weill Medical College, 2000 –

Basic Science Subcommittee, General Faculty Council, 2001 –

Secretary, General Faculty Council, Weill Medical College, 2001 – 2003

Vice Chairman, General Faculty Council, Weill Medical College, 2003 – 2005

Chairman, General Faculty Council, Weill Medical College, 2005 -2007

Member, Committee of Review for Academic Promotion, Weill Medical College, 2002 –

2007

Program Director, Immunology Training Grant, Graduate School of Medical Sciences

Immunology Program, 2003 – 2007

Member, Committee on Science, Weill Medical College (2003 – present; strategic

planning; report to the Dean of the Medical College)

Member, Senior Scientist Group, Weill Medical College, 2003 – 2007



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Member, Joint Faculty and Postdoctoral Fellows Advisory Committee, 2004 – 2007

Member, Admissions Committee, Graduate Program in Immunology, 2004 – 2007

Member, Research Awards Committee, Weill Medical College, 2004 – 2007

Member, Graduate Program in Immunology Admissions Committee, 2004 – 2007

Member, Graduate Program in Immunology Qualifying Exam Committee, 2004 – 2007

Member, Conflicts Advisory Panel, 2005 – 2007

Member, Weill Medical College Benefits Committee, 2006 – 2007

Member, Weill Medical College Plan Administration Committee, 2006 – 2007

65% Research

Institutional Responsibilities: Northwestern University Feinberg School of Medicine

(FSM), Northwestern Medical Faculty Foundation (NMFF), and Northwestern Memorial

Hospital (NMH) 2007 – 2016 as CHAIRMAN OF THE DEPARMENT OF PATHOLOGY

Advisory Committee, T32 Training Grant in Transplant Surgery (2007 -

Advisory Board, Prostate SPORE (2007 – 2016)

Advisory Committee, EM and Optical Imaging Core Facility (2007 – 2010)

Chairman, Advisiory Committee, EM and Optical Imaging Core Facility (2010 – 2014)

Lurie Cancer Center Internal Advisory Committee (2007 – 2016)

Residency Committee, Department of Pathology (2007 – 2016)

Departments & Centers Advisory Committee, “One Northwestern” Strategic Plan (2007)

Northwestern Medical Faculty Foundation, Board of Directors (2007 – 2014)

Finance Committee, Northwestern Medical Faculty Foundation (2007 – 2013)

Executive Laboratory Management Committee, Northwestern Memorial Hospital (2007 –

Laboratory Liason Committee, Northwestern Memorial Hospital (2008 – 2012)

Medical Executive Committee, Northwestern Memorial Hospital (2008 – 2010)

Northwestern Medical Faculty Foundation Task Force on Productivity-Based

Compensation Models (2009 - 2010)

Northwestern University Imaging Advisory Board (2009 – present)

Northwestern University Skin Disease Research Center Executive Board (2009 – present)

Northwestern University Rheumatic Diseases Research Core Center (NURDRCC)

Executive Committee (2010 –

Search Committee for the Dean, Feinberg School of Medicine 2011

Purchased Physician Services Committee, NMH 2011 – 2013

FSM Executive Committee of the Faculty (2012 – 2016)

Northwestern Medicine Leadership Group (2013 – 2016)

Search Committee for the Director of Women’s Health, Robert H. Lurie Comprehensive

Cancer Center (2013 – 2014).



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Search Committee for the Director of the Robert H. Lurie Comprehensive Cancer Center

(2014)

Search Committee for the Chair, Department of Pediatrics (2014 – 2015)

Advisory Committee, Center for Advanced Microscopy (2015 – present)

Advisory Committee, Nikon Imaging Center at Northwestern University

Internal Scientific Advisory Board, Northwestern Program Project Grant on “Integrating

Mechanistic Insights from Diverse Models to Prevent CMV Reactivation following

Transplantation.” (2015 – 2019)

Institutional Responsibilities: Northwestern University Feinberg School of Medicine

(FSM), since 2016 (Since stepping down as Chairman of the Department of Pathology.)

Advisory Committee, Center for Advanced Microscopy (2015 –

Advisory Committee, Nikon Imaging Center at Northwestern University (2014 -

Executive Laboratory Management Committee, Northwestern Memorial Hospital (2007 –

2019)

Advisory Committee, T32 Training Grant in Transplant Surgery (2007 – 2019)

Northwestern University Skin Disease Research Center Executive Board (2009 – present)

Innovation and New Ventures (INVO) Faculty Advisory Board (2016 - 2018)

Feinberg School of Medicine, Driskill Graduate Program, Program Committee (2018 –

Feinberg School of Medicine, MSTP Admissions Committee (2018 –

Associate Program Director for Basic Science, T32 Vascular Surgery Scientist Training

Program (2019 -



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Research Support:

Total DIRECT costs

Past: Pew Scholarship in the Biomedical Sciences 4 years - $50,000/yr

RJR Nabisco Research Scholars Award 3 years - $75,000/yr

Irvington Institute for Medical Research 2 years - $50,000/yr

New Initiatives Award

NIH Program Project (Cell Mediated Immunity) 4 years - $339,717

American Heart Association Established Investigatorship 3 years - $225,000

Amgen, Inc. Collaborative Research Agreement #1 2 years - $250,000

Amgen, Inc. Collaborative Research Agreement #2 2 years - $607,750

Cornell Arthritis and Musculoskeletal Disease Center 2 years - $ 80,000

NIH HL09722-01 (NRSA) Award to Postdoctoral Fellow 3 years - $ 74,908

American Heart Association, Grant-in-Aid 3 years - $150,000

Berlex Biosciences Collaborative Research Agreement 2 years - $134,035

Charles H. Revson Foundation Fellowship (to postdocs) 6 years - $210,000

NIH 1P01 HL072942-01 PPG: The Atherogenic Microenvironment

(P.I.= David Hajjar)

Project 3 Differentiation and Fate of Monocytes in Atherosclerosis

Total Direct Costs of Project 3 $1,125,000

Dates of Grant: 04/01/03 – 03/31/08

Principal Investigator William A. Muller – Effort 30%

NIH T32 AI007621-06-10 Immunology Research Training Program

Total Direct Costs: Approx. $1,375,000 (stipend levels increase yearly)

Dates of Grant: 09/01/04 – 08/31/09

Principal Investigator: William A. Muller – No effort charged

Genzyme Corporation Production of CD99-deficient mice

Total Direct Costs $508,944

Dates of Grant 07/01/03 – 06/30/06

Principal Investigator William A. Muller – No effort charged

AHA #0920014G Adhesion Molecules, Calcium Flux, and Targeted

Recycling: Interrelationships Among Factors Regulating Diapedesis

Total Direct Costs: $90,772 (Postdoctoral fellowship for Fei Han)

Dates of Grant: 01/01/09 – 12/31/10

Principal Investigator William A. Muller (no effort charged)

NIH F32 AI084454 Isolation of the LBRC and characterization of its

protein components

Total Direct Costs: $92,428 (Postdoctoral fellowship for David

Sullivan)

Dates of Grant: 08/01/09 – 07/31/11




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AHA 10POST2650016 How PECAM and CD99 enter and function in the

Lateral Border Recycling Compartment: Prerequisites for transmigration

Total Direct Costs: $95,224 (Postdoctoral fellowship for Gong Feng)

Dates of Grant: 01/01/10 – 12/31/11


NIH R21 HL102519 Identifying the membrane proteins of the LBRC, a

key regulator of inflammation

Total Direct Costs: $275,000

Dates of Grant: 04/01/10 – 03/31/12

Principal Investigator: William A. Muller – Effort 10%

AHA 12PPRE9460038 The molecular motors involved in targeted recycling

of the lateral border recycling compartment

Total Direct Costs: $52,000 (Predoctoral fellowship for Bita Cyrus)

Dates of Grant: 01/01/12 – 12/31/13


AHA 12PPRE9330014 Sequential cell signaling events during leukocyte

transendothelial migration

Total Direct Costs: $52,000 (Predoctoral fellowship for Evan Weber)

Dates of Grant: 01/01/12 – 12/31/13


Evan Weber/Predoctoral AHA Fellowship

AHA-14PRE18550021

Sequential Cell Signaling Events During Leukocyte Transendothelial Migration

1/1/14 – 12/31/14

$26,000

Bita Cyrus/Predoctoral NRSA

Motors Regulating Targeted Recycling of the Lateral Border Recycling

Compartment

6/1/13 – 5/31/18

$36,127/year

Richard Watson/Predoctoral NRSA

F30HL116100

The Role of CD99 in Leukocyte Transendothelial Migration in vitro and in vivo

6/1/13 – 5/31/17

$47,676

Ryan Winger/Predoctoral AHA Fellowship

AHA-15PRE22710025



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Mechanisms of leukocyte transendothelial migration at the blood-brain barrier in

vivo.

1/1/15 – 12/31/16

$26,000

R.H. Lurie Cancer Center Lefkofsky Innovation Research Award

Total Costs: $75,000 direct costs only

Dates of Grant: 06/01/18 – 05/31/19

Principal Investigator: William A. Muller – Effort 1%

Current:

R01 HL046849 (Muller-PI) 06/01/16 – 05/31/20 2.4 Calendar Months

NIH/NHLBI $267,235 direct costs

The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration

The Aims of this proposal are to define how PECAM signals to the calcium channel TRPC6 to

promote transmigration, to define the role of IQGAP1 in targeted recycling of the LBRC and to

define the role of kinesin 1 light chain variant 1 (KLC1c) in recruiting the LBRC and

transendothelial migration. Mechanisms will be worked out using in vitro models and validated

in vivo in mouse models of ischemia/reperfusion injury

Role: PI

R01 HL064774 A1 (Muller-PI) 04/01/00 – 11/30/20 3.0 Calendar Months

NIH/NHLBI $280,102 direct costs

Beyond PECAM: Mechanisms of Transendothelial Migration

The Aims of this proposal are to understand the mechanism behind the sequential control of

transmigration by specific adhesion molecules, to uncover how CD99L2 functions in

transendothelial migration in humans and in mice, and to define the signaling pathways

downstream of CD99 that are relevant for transmigration. These will be investigated by

intravital microscopy and in murine models of myocardial infarction.

Role: PI

R01 CA236904 (Muller-PI) 04/01/19 – 3/31/24 3.0 Calendar Months

NIH/NCI $274,452 direct costs per year

How Circulating Melanoma Cells Usurp the Leukocyte Transmigration Mechanism for

Successful Metastasis

The goals of this proposal are to determine to what extent melanoma cells in circulation use the

LBRC to cross into tissues and whether this gives them a survival advantage in setting up

metastatic colonies. We will use in vitro and in vivo models to test this hypothesis and also

identify the mechanism(s) that tumor cells use to recruit the LBRC.

Role: PI

T32 HL094293 (Eskandari-PI) 07/01/19 - 06/30/24 0.36 Calendar Months

NIH/NCI $305,304 directs



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Vascular Surgery Scientist Training Program

The major goal of this project is to support vascular surgeons who want to establish independent

careers as physician/scientists. I serve as Associate Program Director for basic science.

Role: Associate Program Director

U54 HL119810-07 (G Vince-PI) 08/01/19 - 07/31/20 0.48 Calendar Months

Cleveland Clinic Lerner College of Medicine CWRU

$175,000 direct costs

A first-in-class therapeutic to block ischemia/reperfusion injury following acute myocardial

infarction

The Aims of this grant application are to perform pharmacokinetic and pharmacodynamics

studies on the Tat-KLC1c peptide and to test its efficacy in ischemia/reperfusion models in mice

and pigs in order to bring this closer to a therapy that would be considered for clinical trials.

Role: Subcontract PI

Accelerator Award 11/01/19 – 10/31/20 0.12 Calendar Months

Chicago Biomedical Consortium $100,000 direct costs

A first-in-class therapeutic to block ischemia/reperfusion injury following acute myocardial

infarction

The Aims of this grant application are to optimize the dosing schedule for the peptide so that we

can achieve the best possible outcomes and move this closer to a therapy.

Role: PI

F31 HL131355 Nakisha Rutledge Predoctoral NRSA

The Role of CD99L2 in Leukocyte Transendothelial Migration in vitro and in vivo

Total Costs: $188,330

Dates of Grant: 06/01/16 – 05/31/21

F30 HL134202 Prarthana Dalal Predoctoral NRSA

Defining the Role of IQGAP1 in Leukocyte Transendothelial Migration in vitro

and in vivo

Total Costs: $242,880

Dates of Grant: 09/15/16 – 09/14/21

Extramural Professional Activities:

1987-present Served as peer reviewer frequently, especially for the following journals:

Journal of Cell Biology, Journal of Immunology, American Journal of Pathology,

Circulation, Proceedings of the National Academy of Sciences, Journal of

Cellular Physiology, The Journal of Biological Chemistry, Science, Nature,

Nature Immunology, Cell Reports, Science Signaling.



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1990-1994 Member of the Vascular Wall Biology Study Section for the American Heart

Association, National Grant-in-Aid review

1993-1996 Assistant Editor, The Journal of Experimental Medicine

1996-present Editor, The Journal of Experimental Medicine

1996 Chairman, CD31 Section, VIth International Workshop on Leukocyte

Differentiation Antigens, Kobe, Japan November 10-14

1997-2000 Member, Inflammation Study Section, National Arthritis Foundation

1996-present Ad hoc reviewer, NIH NHLBI study sections (various)

1998-2000 Member, American Society for Investigative Pathology (ASIP) Program

Committee.

2000-2002 Chairman, ASIP Program Committee

Member, ASIP Council

Member, ASIP Education Committee

Member, ASIP Finance Committee

2002-present Associate Editor, Cell Communication and Adhesion

2002-2003 Chairman, NAVBO (North American Vascular Biology Organization) Program

Committee for the 2003 Meeting.

2003-2004 President-Elect, North American Vascular Biology Organization (NAVBO)

2004-2005 President, NAVBO

2004 – 2008 Editorial Board, Laboratory Investigation

2004 – 2006 ASIP Nominating Committee

2005-2009 Editorial Committee, Annual Review of Pathology: Mechanisms of Disease

2005-2008 Charter Member, NIH Study Section on Atherosclerosis and Inflammation in

the Cardiovascular System (AICS).

2005 - Faculty of 1000 Member of the Leukocyte Development subsection of the

Immunology Faculty.

2007 – 2008 Scientific Advisory Board, International Vascular Biology Meeting, Sydney

Australia, June 2008



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2008 – 2009 Scientific Advisory Committee, International Society on Thrombosis and

Hemostasis, 2009 Meeting, Boston, MA, July 2009.

2009 - 2012 Councilor, North American Vascular Biology Organization

2009 - 2015 FASEB Science Policy Committee representative of ASIP

2011 - Editorial Board, Analytical Cellular Pathology

2011 – 2012 International Advisory Board for the 17th

International Vascular Biology Meeting,

Wiesbaden, Germany, June 2-5, 2012.

2012 - Secretary/Treasurer of the North American Vascular Biology Organization

2011 - 2013 ASIP Nominating Committee

2013 - ASIP Public Affairs Working Group (became Research and Science Policy

Committee)

2014 – 2016 Organizing Committee for Pathobiology for Investigators, Students, and

Academicians (PISA) meeting for ASIP.

2014- 2016 Program Committee, 19th

International Vascular Biology Meeting, Boston, MA

October 30 – November 3, 2016.

2016 - Chair, ASIP Research and Science Policy Committee

ASIP Finance Committee

ASIP Council

2017 – 2018 Co-Organizer, Vascular Biology 2018 (NAVBO Annual Meeting), Vascular

Inflammation Workshop.

2019 – 2020 Organizer, Vascular Biology 2020 (NAVBO Annual Meeting), Vascular

Inflammation Workshop.



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Invited Lectures (since 2010)

2010

•Cleveland Clinic, All roads lead to the LBRC: A common mechanism for leukocyte

transendothelial migration January 29, 2010

•Keystone Symposium on Atherosclerosis, All roads lead to the LBRC: A common mechanism

for leukocyte transendothelial migration. February 10, 2010

•U. of Tennessee, How Endothelial Cells Regulate Transendothelial Migration of Leukocytes.

March 31, 2010

•Experimental Biology 2010, The Role of the Endothelial Lateral Border Recycling

Compartment in Transcellular and Paracellular Migration, April 26, 2010

•CNIC, Madrid (Spain), How endothelial cells control leukocyte diapedesis: Role of the Lateral

Border Recycling Compartment, May 25, 2010

•Northwestern (several) ,

•International Vascular Biology Meeting, Los Angeles, CA New Insights into the Mechanisms

Regulating Leukocyte Transendothelial Migration. June 21, 2010

•Northern Illinois University, How endothelial cells regulate transendothelial migration of

leukocytes, September 24, 2010

•University of Chicago, The Endothelial Cell Lateral Border Recycling Compartment Regulates

Transendothelial Migration of Leukocytes, October 19, 2010

2011

•Arizona State University, Cancer Cell Motility and Metastasis Meeting, The Endothelial Cell

Lateral Border Recycling Compartment Regulates Transendothelial Migration of Leukocytes(and

tumor cells?) May 20, 2011

•Northwestern Cancer Center Grand Rounds, How vascular endothelial cells regulate leukocyte

influx in inflammation, May 27, 2011.

•Brigham and Women’s Hospital, Michael Gimbrone Symposium, The role of the endotheium in

leukocyte transendothelial migration: Even more dynamic than we thought. June 11, 2011

•Northwestern FSM (grand rounds), The Regulation of Leukocyte Transendothelial Migration in

the Inflammatory Response, November 12, 2010

•Korean Association of Immunologists, Seoul Korea, November 19, 2010 How endothelial cells

regulate transendothelial migration of leukocytes.

•University of Arizona, PSOC Program Seminar, How endothelial cells regulate leukocyte

transmigration: Application to cancer metastasis. November 3, 2011

•University of Illinois, Chicago, Pulmonary Division Seminar, Targeted trafficking of membrane

from the LBRC controls leukocyte transendothelial migration November 15, 2011

•Plenary Symposium Speaker, ASVP/ASCVP Joint Annual Meeting, Nashville, TN Regulation

of Leukocyte Transmigration December 5, 2011

2012

•Ralph Steinman memorial symposium, The Rockefeller University, New York, Membrane

recycling: Still essential after all these years. May 14, 2012

•Lillehei Heart Institute Seminar, University of Minnesota, How endothelial cells regulate

leukocyte transmigration. May 16, 012



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•International Vascular Biology Meeting, Wiesbaden, Germany, June 2-5, How the endothelial

cell Lateral Border Recycling Compartment Regulates Leukocyte Transmigration, June 2, 2012

2013

•Vanderbilt University School of Medicine, Vascular Biology Seminar Series, March 20, 2013,

“Regulation of Leukocyte Transmigration by the Endothelial Cell LBRC.”

•ASIP Annual Meeting at Experimental Biology 2013, Boston, MA, Rous-Whipple Award

Lecture, Boston, MA, April 21, “How Endothelial Cells Regulate Transmigration of Leukocytes

in the Inflammatory Response.”

•Keynote Speaker, UPMC Department of Pathology Annual Retreat, May 22, 2013, “Sequential

Molecular Interactions that Regulate Leukocyte Transendothelial Migration: Studies in vitro and

in vivo.”

•Northwestern University Feinberg School of Medicine, Rheumatology Grand Rounds, May 27,

2013, “Sequential molecular interactions in endothelial cells that regulate transmigration of

leukocytes.”

•Ludwig-Maximilians-Universitat Munchen, School of Medicine, Munich Germany, June 19,

2013, “How Endothelial Cells Regulate Diapedesis of Leukocytes in Inflammation.”

•Barts and The London School of Medicine and Dentistry, William Harvey Research Institute,

London, England, June 21, 2013, “How Endothelial Cells Regulate Diapedesis of Leukocytes in

Inflammation.”

2014

Yale Cardiovascular Research Center/NAVBO Symposium on Cardiovascular Inflammation

and Remodeling, May 8-10, 2014. “Novel mechanisms regulating transendothelial

migration.”

Ramzi Cotran Lecture, Department of Pathology, Brigham and Women’s Hospital, Boston.

May 19, 2014. “New insights into the regulation of transendothelial migration by endothelial

cells.”

Chicago Biomedical Consortium Vascular Biology Workshop, Chicago, IL. June 14, 2014.

“The Lateral Border Recycling Compartment and the Regulation of Transendothelial

Migration.”

American Heart Association Annual Meeting, November 15-19, Chicago, IL. Session on

Novel Mechanisms of Inflammatory Regulation of Cardiovascular Disease. “Novel

Endothelial Signaling Pathways that Regulate Transendothelial Migration of Leukocytes.

Tufts Medical Center, Boston, MA. Vascular Biology Seminar, December 2, 2014. “How

Endothelial CD99 Signals though Soluble Adenylyl Cyclase to Regulate Transendothelial

Migration.”

2015

Experimental Biology 2015, “Endothelial CD99 signals through soluble adenylyl cyclase

and PKA to regulate leukocyte transendothelial migration.” Boston, MA March 28 –

April 1.

Keynote Speaker, Pathology Research Day, University of Wisconsin, August 20, 2015.

“How endothelial cell PECAM and CD99 regulate transendothelial migration.”



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Ringberg Meeting on Molecular Mechanisms of Leukocyte Traffic, Keuth, Germany.

September 13 – 17, 2015. “Novel endothelial cell signaling mechanisms that regulate

leukocyte transendothelial migration.”

Rheumatology Grand Rounds, Feinberg School of Medicine, Chicago. September 24,

2015. “Novel endothelial cell signals that regulate transendothelial migration of

leukocytes in vitro and in vivo.”

PISA Meeting, Pathways to Translational Medicine: Recent Advances in Cell Injury,

Inflammation, and Neoplasia, Baltimore, MD, October 8-10 Symposium Organizer and

Moderator, “Innate Immunity: Leukocytes, Nocioceptors, and Inflammation.”

Vascular Biology 2015, Hyannis, MA, October 18-22, “Novel endothelial cell signaling

mechanisms that regulate leukocyte transendothelial migration.”

2016

Vascular Biology Seminar, Weill Cornell Medical Center, New York, NY 10021;

January 13, 2016. “Endothelial cell PECAM and CD99 signaling pathways that regulate

transendothelial migration.”

Pathobiology Spring Seminar Series, Brown University School of Medicine, Providence,

RI, February 11, 2016. “How Endothelial Cells Regulate Egress of Leukocytes During

Inflammation.”

Oregon Health & Science University, Portland Oregon, April 7, 2016, “Coordination of

endothelial cell membrane movements that promote leukocyte transmigration.”

Gordon Conference on: Endothelial Cell Phenotypes in Health and Disease, Girona,

Spain, July 17-22, “Endothelial cell regulation of transendothelial migration.”

Landsteiner Lecture, Sanquin Research Center, Amsterdam, The Netherlands, October 4,

2016, “Endothelial cell regulation of transendothelial migration.”

PISA Meeting, Breakthroughs in Biology: From underlying pathogenesis to translational

medicine, Houston, TX, October 20-22, 2016; “Leukocyte/endothelial cell signaling

during transmigration.”

2017

Experimental Biology 2017, Symposium on Biology and Pathology of Tissue Barriers,

Chicago, IL, April 23, 2017. “Therapeutic Targeting of the Lateral Border Recycling

Compartment to Control Transendothelial migration.”

Experimental Biology 2017, Blood Vessel Club: Endothelial Cell Mechanisms that

Regulate Function and Permeability, Chicago, IL, April 24, 2017. “Endothelial Cell

Signaling that Regulates Transendothelial Migration.”

American Transplant Congress, April 29 – May 3, 2017. Transplantation in Depth: The

Endothelium as a Target of Alloimmune Attack in Transplantation. April 30, 2017.

“Mechanisms of Transendothelial Migration.”

Fourteenth International Conference on Innate Immunity, Knossos, Crete, Greece. June

19 – 24, 2017. “Molecular Regulation of Transendothelial Migration.”

Vasculata July 24 – 27, Chicago, IL. Chair, session on "Vascular Disease:

Inflammation, Atherosclerosis, Hypertension, and Tumor angiogenesis".

Vasculata July 24 – 27. Seminar, “Leukocyte-endothelial cell interactions.”



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2018

2nd

International Conference on Leukocyte Trafficking, Munich, Germany, March 14-16,

2018. “How Endothelial Cells Regulate Leukocyte Transendothelial Migration.”

20th

International Vascular Biology Meeting, Helsinki, Finland, June 3 – 6, “Is there a

Role for the PECAM/VE-Cadherin/VEGFR2 Mechanosensing Complex in Initiating

Transendothelial Migration?”

Theodor Kocher Institute, Bern, Switzerland, June 11, 2018, “How Endothelial Cells

Regulate Transendothelial Migration of Leukocytes: Adventures in the Lateral Border

Recycling Compartment,”

Tumor Environment and Metastasis Minisymposium, Evanston, IL. July 11, 2018. “The

Pathologic Basis of Tumor Metastasis.”

Vasculata 2018, St. Louis, MO. “Leukocyte-Endothelial Cell Interactions.

Vascular Biology 2018, North American Vascular Biology Organization Annual Meeting,

Newport, RI, October 14-18, 2018. “Signaling pathways that control transendothelial

migration: intravital microscopic studies in real time.”

PISA 2018, ASIP meeting, Ann Arbor, MI., October 20 – 22, 2018. “Border Crossings:

Leukocyte/Endothelial Cell Interactions During Inflammation.”

2019

The Joan and William Caro Lectureship, Department of Dermatology, Feinberg School of

Medicine, January 30, 2019. “Bench-to-Epidermis: Molecular Control of Dermal

Inflammation and Melanoma Metastasis.”

Institute of Physiological Chemistry and Pathobiochemistry, University of Münster,

Münster, Germany. February 18, 2019. “Beyond PECAM: Mechanisms of Leukocyte

Transendothelial Migration.”

Texas A&M Health Science Center, Department of Medical Physiology Seminar Series.

February 27, 2019. “Endothelial cell-intrinsic regulation of inflammation.”

Inflammation & Immunity Seminars, The Lerner Research Institute/Cleveland Clinic,

Cleveland OH. April 2, 2019. “Therapeutic treatment of inflammatory diseases and

cancer metastasis by regulation of transendothelial migration.”

Blood Vessel Club, Experimental Biology 2019, Orlando, FL, April 6, 2019. “Common

Cellular mechanisms for Breaching Blood Vessels.”

Department of Physiology and Biophysics, University of Illinois at Chicago, September

13, 2019. “Endothelial cell calcium signaling in the regulation of transendothelial

migration.”

LXIV Annual Meeting of the Argentine Society of Clinical Investigation, Mar del Plata,

Argentina, November 13 – 16, 2019. Symposium on “Vascular Imaging – From and

Function in Development and Disease.”

2020

Vascular Biology Seminar Series, Harvard Medical School, March 19, 2020

Biannual Congress of the Mexican Society for Immunology, Monterrey, Mexico, April 26

– 30, 2020.

http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=17011

http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=17011



16

Aab Cardiovascular Research Institute (CVRI) seminar series at University of Rochester

Medical Center, Rochester, NY June 3, 2020 Title to be determined.



17

BIBLIOGRAPHY

ORIGINAL REPORTS

1. Muller WA, LC Klotz. 1975. Retardation time measurements on replicating Bacillus

subtilis chromosomes: Effect of EDTA concentration. Biochim. Biophys. Acta. 378:171-

185.

2. Muller WA, RM Steinman, ZA Cohn. 1980. The membrane proteins of the vacuolar

system. I. Analysis by a novel method of intralysosomal iodination. J. Cell Biol. 86:292-

303.


system. II. Bidirectional flow between secondary lysosomes and plasma membrane. J.

Cell Biol. 86:304-314.


system. III. Further studies on the composition and recycling of endocytic vacuole

membrane in cultured macrophages. J. Cell Biol. 96:29-36.

5. Muller WA, LH Cohn, FJ Schoen. 1984. Infection within a degenerated Starr-Edwards

silicone rubber poppet in the aortic valve position. Am. J. Cardiol. 54:1146.

6. Muller WA, MA Gimbrone Jr. 1986. Plasmalemmal proteins of cultured vascular

endothelial cells exhibit apical-basal polarity: Analysis by surface-selective iodination. J.

Cell Biol. 103:2389-2402.

7. Hancock WW, WA Muller, RS Cotran. 1987. Interleukin 2 receptors are expressed by

alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine

treatment of normal human lung macrophages, blood monocytes and monocyte cells

lines. J. Immunol. 138:185-191.

8. Muller WA, CM Ratti, SL McDonnell, ZA Cohn. 1989. A human endothelial cell-

restricted, externally disposed plasmalemma protein enriched in intercellular junctions. J.

Exp. Med. 170, 399-414.

9. Newman PJ, MC Berndt, J Gorski, GC White II, S Lyman, C Paddock and WA Muller.

1990. PECAM-1 (CD31) cloning and relation to adhesion molecules of the

immunoglobulin gene superfamily. Science 247:1219-1222.

10. Albelda SM, WA Muller, CA Buck, and PJ Newman. 1991. Molecular and cellular

properties of PECAM-1 (endoCAM/CD31): A novel vascular cell-cell adhesion

molecule. J. Cell Biol. 114:1059-1068.



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11. Kumar, R, B Potvin, WA Muller, and P Stanley. 1991. Cloning of a human a(1,3)-

fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on

chinese hamster ovary cell transfectants. J. Biol. Chem. 266:21777-21783.

12. Muller WA, ME Berman, PJ Newman, HM Delisser, and SM Albelda. 1992. A

heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule-1

(CD31). J. Exp. Med. 175:1401-1404.

13. Muller WA and S Weigl. 1992. Monocyte-selective transendothelial migration:

Dissection of the binding and transmigration phases by an in vitro assay. J. Exp. Med.

176:819-828.

14. Xie Y and WA Muller. 1993. Molecular cloning and adhesive properties of murine

platelet/endothelial cell adhesion molecule-1. Proc. Natl. Acad. Sci. USA 90:5569-5573.

15. Delisser HM, HC Yan, PJ Newman, WA Muller, CA Buck, and SM Albelda. 1993.

Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation

involves cell surface glycosaminoglycans. J. Biol. Chem. 268:16037-16046.

16. Muller WA, SA Weigl, X Deng, DM Phillips. 1993. PECAM-1 is required for

transendothelial migration of leukocytes. J. Exp. Med. 178:449-460.

17. Bogen, S, J Pak, M Garifallou, X Deng, WA Muller. 1994. Monoclonal antibody to

murine PECAM-1 (CD31) blocks acute inflammation in vivo. J. Exp. Med. 179:1059-

1064.

18. Berman, ME and WA Muller. 1995. Ligation of platelet/endothelial cell adhesion

molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity

of leukocyte CR3 (CD11b/CD18). J. Immunol. 154:299-307.

19. Haraldsen G, J Rugtveit, T Scholz, WA Muller, T Hovig, D Kvale, P Brandtzaeg. 1995.

Isolation and long-term culture of human intestinal microvascular endothelial cells. Gut.

37:225-234.

20. Liao F, HK Huynh, A Eiroa, T Greene, E Polizzi, WA Muller. 1995. Migration of

monocytes across endothelium and passage through extracellular matrix involve separate

molecular domains of PECAM-1. J. Exp. Med. 182:1337-1343.

21. Berman ME, Y Xie, WA Muller. 1996. Roles of platelet/endothelial cell adhesion

molecule-1 (PECAM-1/CD31) in natural killer cell transendothelial migration and 2

integrin activation. J. Immunol. 156:1515-1524.

22. Xie Y and WA Muller. 1996. Assignment of PECAM-1 to human chromosome bands

17q22-q23 by in situ hybridization. Cytogenetics and Cell Genetics 74:156.



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23. Xie Y and WA Muller. 1996. Fluorescence in situ hybridization mapping of the mouse

platelet endothelial cell adhesion molecule-1 (PECAM-1) to mouse chromosome 6,

region F3-G1. Genomics. 37:226-228.

24. Liao F, J Ali, T Greene, WA Muller. 1997. Soluble domain 1 of platelet-endothelial cell

adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro

and in vivo. J.Exp. Med. 185:1349-1357.

25. Christofidou-Solomidou, M., MT Nakada, J Williams, WA Muller, HM DeLisser, 1997.

Neutrophil PECAM-1 participates in neutrophil recruitment at inflammatory sites and is

down-regulated after leukocyte extravasation. J. Immunol. 158:4872-4878.

26. Ali J, F Liao, E Martens, WA Muller. 1997. Vascular endothelial cell cadherin (VE-

cadherin): Cloning and role in endothelial cell-cell adhesion. Microcirculation

4:267-277.

27. Treutiger CJ, A Heddini, V Fernandez, WA Muller, M Wahlgren. 1997 PECAM-

1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected

erythrocytes. Nature Medicine 3:1405-1408.

28. Sun Q-H, C Paddock, GP Visentin, MM Zukowski, WA Muller, P Newman. 1998 Cell

surface glycosaminoglycans do not serve as ligands for PECAM-1. PECAM-1 is not a

heparin-binding protein. J. Biol. Chem. 273:11483-11490.

29. Elias CG III, JS Spellberg, B Karan-Tamir, C-H Lin, Y-J Wang, PJ McKenna, WA

Muller, MM Zukowski, DP Andrew. 1998 Ligation of CD31/PECAM-1 modulates the

function of lymphocytes, monocytes, and neutrophils. Eur. J. Immunol. 28:1948-1958.

30. Randolph GJ, S Beaulieu, M Pope, I Sugawara, L Hoffman, RM Steinman, WA Muller.

1998. A physiologic function for p-glycoprotein (MDR-1) during the migration of

dendritic cells from skin via afferent lymphatic vessels. Proc. Natl. Acad. Sci. USA 95:

6924-6929.

31. Randolph GJ, S Beaulieu, RM Steinman, WA Muller. 1998. Differentiation of

monocytes into dendritic cells in a model of transendothelial trafficking. Science.

282:480-484.

32. Randolph GJ, T Luther, S Albrecht, V Magdolen, WA Muller. 1998. Role of tissue

factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in

vitro. Blood. 92:4167-4177.

33. Duncan GS, DP Andrew, H Takimoto, SA Kaufman, H Yoshida, J Spellberg, JL de la

Pompa, A Elia, A Wakeham, B Karan-Tamir, WA Muller, G Sendali, MM Zukowski,

TW Mak. 1999. Genetic evidence for functional redundancy of platelet/endothelial cell



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adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and

PECAM-1-independent functions. J. Immunol. 162: 3022-3030.

34. Thakker GD, DP Hajjar, WA Muller, TK Rosengart. 1999. The role of

phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling. J. Biol.

Chem. 274:10002-10007.

35. Liao F, AR Schenkel, WA Muller. 1999. Transgenic mice expressing different levels of

soluble PECAM-IgG display distinct inflammatory phenotypes. J. Immunol. 163:5640-

5648.

36. Randolph GJ, K Inaba, DF Robbiani, RM Steinman, WA Muller. 1999. Differentiation

of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity. 11:753-761.

37. Allport JR, WA Muller, FW Luscinskas. 2000. Monocytes induce reversible focal

changes in VE-cadherin complex during transendothelial migration under flow. J. Cell

Biol. 148:203-216.

38. Robbiani DF, RA Finch, D Jager, WA Muller, AC Sartorelli, GJ Randolph. 2000. The

leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3, ELC)-dependent

mobilization of dendritic cells to lymph nodes. Cell 103:757-768.

39. Corada M, F Liao, M Lindgren, MG Lampugnani, F Breviario, R Frank, WA Muller, DJ

Hicklin, P Bohlen, E Dejana 2001. Monoclonal antibodies directed to different regions

of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the

protein and modulate endothelial permeability Blood 97:1679-1684

40. Heddini A, Q Chen, J Obiero, O Kai, V Fernandez, K Marsh, WA Muller, M Wahlgren.

2001. Binding of Plasmodium falciparum-infected erythrocytes to soluble platelet

endothelial cell adhesion molecule-1 (PECAM-1/CD31): frequent recognition by clinical

isolates. Am. J. Trop. Med. Hyg. 65:47-51.

41. Qing Z, M Sandor, Z Radvany, D Sewell, A Falus, D Potthoff, WA Muller, Z Fabry.

2001. Inhibition of antigen-specific T cell trafficking into the central nervous system via

blocking PECAM1/CD31 molecule. J. Neuropathol. Exp. Neurol. 60:798-807.

42. Miller M, KL Sung, WA Muller, JY Cho, M Roman, D Castaneda, J Nayar, T Condon, J

Kim, P Sriramarao, DH Broide. 2001. Eosinophil tissue recruitment to sites of allergic

inflammation in the lung is platelet endothelial cell adhesion molecule independent. J.

Immunol. 167:2292-2297.

43. Schenkel AR, Z Mamdouh, X Chen, RM Liebman, WA Muller. 2002. CD99 plays a

major role in the migration of monocytes through endothelial junctions. Nature Immunol.

3:143-150.



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44. Burger PE, S Coetzee, WL McKeehan, M Kan, P Cook, Y Fan, T Suda, RP Hebbel, N

Novitzky, WA Muller, EL Wilson. 2002. Fibroblast growth factor receptor-1 is

expressed by endothelial progenitor cells. Blood 100:3527-3535.

45. Mamdouh Z, X Chen, LM Pierini, FR Maxfield, WA Muller. 2003. Targeted recycling

of PECAM from endothelial surface-connected compartments during diapedesis. Nature

421:748-753.

46. Ferlazzo G, D Thomas, S-L Lin, K Goodman, B Morandi, WA Muller, A Moretta, and C

Munz. 2004. The abundant NK cells in human secondary lymphoid tissues require

activation to express killer cell Ig-like receptors and become cytolytic. J Immunol

172:1455-1462.

47. Schenkel AR, Z Mamdouh, WA Muller. 2004. Locomotion of monocytes on

endothelium is a critical step during extravasation. Nature Immunol. 5:393-400.

48. Ferlazzo G, M Pack, D Thomas, C Paludan, D Schmid, T Strowig, G Bougras, WA

Muller, L Moretta, C Munz. 2004. Distinct roles of IL-12 and IL-15 in human natural

killer cell activation by dendritic cells from secondary lymphoid organs. Proc. Natl.

Acad. Sci. USA 101:16606-16611.

49. Schenkel AR, TW Chew, WA Muller 2004. PECAM deficiency or blockade

significantly reduces leukocyte emigration in a majority of mouse strains. J. Immunol.

173:6403-6408.

50. Nolte D, WM Kuebler, WA Muller, KD Wolff, K Messmer. 2004. Attenuation of

leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine

endotoxemia. Eur. Surg. Res. 36:331-337.

51. Han H, A Stessin, J Roberts, K Hess, N Gautam, M Kamenetsky, O Lou, E Hyde, N

Nathan, WA Muller, J Buck, LR Levin, C Nathan. 2005. Calcium-sensing soluble

adenylyl cyclase mediates TNF signal transduction in human neutrophils. J. Exp. Med.

202:353-361.

52. Maslin, C.L., K. Kedzierska, N.L. Webster, W.A. Muller, and S.M. Crowe. 2005.

Transendothelial migration of monocytes: the underlying molecular mechanisms and

consequences of HIV-1 infection. Curr HIV Res 3:303-317.

53. Han H., J Roberts, O Lou, WA Muller, N Nathan, C Nathan. 2006. Chemical inhibitors

of TNF signal transduction in human neutrophils point to distinct steps in cell activation.

J Leukoc Biol 79:147-154.



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54. Schenkel, A R, TW Chew, E. Chlipala, MW Harbord, WA Muller. (2006). Different

susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic

pneumonitis. Exp Mol Pathol 81, 23-30.

55. Morandi, B, G Bougras G., WA Muller, G Ferlazzo, C Munz. 2006. NK cells of human

secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion. Eur J

Immunol 36, 2394-2400.

56. Lou, O., P. Alcaide, F.W. Luscinskas, and W.A. Muller. 2007. CD99 is a key mediator

of the transendothelial migration of neutrophils. J. Immunol. 178:1136-1143.

57. Reinke, E.K., J. Lee, A. Zozulya, J. Karman, W.A. Muller, M. Sandor, and Z. Fabry.

2007. Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens

onset of symptoms. J Neuroimmunol 186:86-93.

58. Schenkel, A.R., E.M. Dufour, T.W. Chew, E. Sorg, and W.A. Muller. 2007. The Murine

CD99-Related Molecule CD99-Like 2 (CD99L2) Is an Adhesion Molecule Involved in

the Inflammatory Response. Cell Commun Adhes 14:227-237.

59. Strowig T, F Brilot, F Arrey, G Bougras, D Thomas, WA Muller, C. Münz. 2008.

Tonsilar NK cells restrict B cell transformation by the Epstein Barr virus via IFNγ. PLOS

Pathog. 4:e27.

60. Mamdouh Z, GE Kreitzer, WA Muller. 2008. Leukocyte transmigration requires

kinesin-mediated microtubule-dependent membrane trafficking from the Lateral Border

Recycling Compartment. J. Exp. Med. 205:951-966.

61. Dufour EM, A DeRoche, Y Bae, WA Muller. 2008. CD99 is essential for leukocyte

diapedesis in vivo. Cell Commun. Adhes. 16:1-13.

62. Dasgupta B and WA Muller. 2008. Endothelial Src kinase regulates membrane

recycling from the Lateral Border Recycling Compartment (LBRC) during leukocyte

transendothelial migration (TEM). Eur. J. Immunol. 38:1-9.

63. Seidman M, T Chew, A Schenkel, WA Muller. 2009. PECAM-independent

thioglycollate peritonitis is associated with a locus on murine chromosome 2. PLoS ONE

4(1):e4316. doi:10.1371/journal.pone.0004316. PMCID: PMC2628736

64. Dasgupta B, E Dufour, Z Mamdouh, WA Muller. 2009. A novel and critical role for

tyrosine 663 in PECAM trafficking and transendothelial migration. J. Immunol.

182:5041-5051.

65. Westhorpe CLV, J Zhou, NL Webster, B Kalionis, SR Lewin, A Jaworowski, WA

Muller, SM Crowe. 2009. Effects of HIV-1 infection in vitro on transendothelial



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migration by monocytes and monocyte-derived macrophages. J. Leukoc. Biol. 85:1027-

1035.

66. Early MA, M Lishnevsky, JM Gilchrist, DM Higgins, IM Orme, WA Muller, M

Gonzalez-Juarerro, AR Schenkel. 2009. Non-invasive diagnosis of early pulmonary

disease in PECAM-deficient mice using infrared pulse oximetry. Exp Mol Pathol 87:152-

158. PMCID: PMC2753694

67. Mamdouh Z, A Mikhailov, WA Muller. 2009. Transcellular migration of leukocytes is

mediated by the endothelial lateral border recycling compartment. J. Exp. Med.

206:2795-2808.

68. Dasgupta B, TW Chew, A deRoche, WA Muller. 2010. Blocking Platelet/Endothelial

Cell Adhesion Molecule 1 (PECAM) Inhibits Disease Progression and Prevents Joint

Erosion in Established Collagen Antibody Induced Arthritis. Exp. Mol. Pathol. 88:210-

215. PMID: 19800878

69. Manes, TD, S Hoer, WA Muller, PJ Lehner, JS Pober. 2010. Kaposi's sarcoma-

associated herpesvirus K3 and K5 proteins block distinct steps in transendothelial

migration of effector memory CD4+ T cells by targeting different endothelial proteins. J

Immunol 184, 5186-5192.

70. Florey, O, J Durgan, W Muller. 2010. Phosphorylation of leukocyte PECAM and

its association with detergent-resistant membranes regulate transendothelial migration. J

Immunol 185, 1878-1886. PMID: 20581150 PMCID: PMC3099243

71. Wu J, Z Liu, C Shao, Y Gong, E Hernando, P Lee, M Narita, W Muller, J Liu, JJ Wei.

2011. HMGA2 overexpression-induced ovarian surface epithelial transformation is

mediated through regulation of EMT genes. Cancer Res. 71:349-359.

72. Privratsky, JR, CM Paddock, O Florey, DK Newman, WA Muller, PJ Newman. 2011.

Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular

integrity. J Cell Sci 124:1477-1485.

73. Jung, KC, CG Park, YK Jeon, HJ Park, YL Ban, HS Min, EJ Kim, JH Kim, BH Kang, SP

Park, Y Bae, IH Yoon, YH Kim, JI Lee, JS Kim, JS Shin, J Yang, SJ Kim, E Rostlund,

WA Muller, SH Park. 2011. In situ induction of dendritic cell-based T cell tolerance in

humanized mice and nonhuman primates J. Exp. Med. 208:2477-2488. PMID: 22025302

74. Westhorpe, CLV, EM Dufour, A Maisa, A Jaworowski, SM Crowe, WA Muller. 2012.

Endothelial cell activation promotes foam cell formation by monocytes following

transendothelial migration in an in vitro model. Exp. Mol. Pathol. 93:220-226. PMID:

22609311.



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75. Liu, G., AT Place, Z Chen, VM Brovkovych, SM Vogel, WA Muller, RA Skidgel, AB

Malik, RD Minshall. 2012. ICAM-1–activated Src and eNOS signaling increase

endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration. Blood

120:1942-1952. PMID:22806890

76. Sullivan, DP, MA Seidman, WA Muller. 2013. Poliovirus receptor (CD155) regulates a

step in transendothelial migration between PECAM and CD99. Am. J. Pathol. 182:1031-

1042. PMCID: PMC3586692.

77. Lovelace, MD, ML Yap, J Yip, W Muller, O Wijburg, and DE Jackson. 2013. Absence

of platelet endothelial cell adhesion molecule 1, PECAM-1/CD31, in vivo increases

resistance to Salmonella enterica serovar Typhimurium in mice. Infect Immun 81:1952-

1963. PMID: 23509149; PMCID: 3676038

78. Coates, BM., DP Sullivan, MY Makanji, NY Du, CL Olson, WA Muller, DM Engman,

and CL Epting. 2013. Endothelial Transmigration by Trypanosoma cruzi. PLoS One

8:e81187. PMID: 24312535; PMCID: 3846899

79. Moricoli, D., WA Muller, DC Carbonella, MC Balducci, S Dominici, R Watson, V Fiori,

E Weber, M Cianfriglia, K Scotlandi, and M Magnani. 2014. Blocking monocyte

transmigration in in vitro system by a human antibody scFv anti-CD99. Efficient large

scale purification from periplasmic inclusion bodies in E. coli expression system. Journal

of immunological methods 408:35-45.

80. Sullivan, D.P., C. Ruffer, and W.A. Muller. 2014. Isolation of the Lateral Border

Recycling Compartment using a diaminobenzidine-induced density shift. Traffic: 1016-

1029. PMID 23415828; PMCID: PMC4140980

81. Lishnevsky, M., L.C. Young, S.J. Woods, S.D. Groshong, R.J. Basaraba, J.M. Gilchrist,

D.M. Higgins, M. Gonzalez-Juarrero, T.A. Bass, W.A. Muller, and A.R. Schenkel. 2014.

Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1

deficient FVB/n mice. Experimental and molecular pathology 97:128-136.

82. Winger, R.C., J.E. Koblinski, T. Kanda, R.M. Ransohoff, and W.A. Muller. 2014. Rapid

Remodeling of Tight Junctions during Paracellular Diapedesis in a Human Model of the

Blood-Brain Barrier. Journal of Immunology 193:2427-2437. PMID: 25063869

PMCID: PMC4138548

83. Feng G, DP Sullivan, F Han, WA Muller. 2015. Segregation of VE-cadherin from the

LBRC Depends on the Ectodomain Sequence Required for Homophilic Adhesion. J. Cell

Sci. 128:576-578. PMID: 25501813

84. Maisa A, Hearps AC, Angelovich TA, Pereira CF, Zhou J, Shi MD, Palmer CS, Muller

WA, Crowe SM, Jaworowski A. 2015. Monocytes from HIV-infected individuals show



25

impaired cholesterol efflux and increased foam cell formation after transendothelial

migration. AIDS. 29 (12): 1445-57. PMID: 26244384

85. Rutledge, N.S., E.W. Weber, R. Winger, W.G. Tourtellotte, S.H. Park, and W.A. Muller.

2015. CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory

response. Exp Mol Pathol 99:455-459. PMID: 26321243

86. Watson, R.L., J. Buck, L.R. Levin, R.C. Winger, J. Wang, H. Arase, and W.A. Muller.

2015. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate

leukocyte transendothelial migration. J. Exp. Med. 212:1021-1041.

87. Weber, E.W., F. Han, M. Tauseef, L. Birnbaumer, D. Mehta, and W.A. Muller. 2015.

TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial

migration during the inflammatory response. J Exp Med 212:1883-1899. PMID:

26392222

88. Winger, RC, CT Harp, M-Y Chiang, DP Sullivan, RL Watson, EW Weber, JR Podojil,

SD Miller, and WA Muller. 2016. Cutting Edge: CD99 is a novel therapeutic target for

control of T-cell mediated CNS autoimmune disease. J. Immunol. 196:1443 – 1448.

89. Cyrus, BF and WA Muller. 2016. A Unique Role for Endothelial Cell Kinesin Light

Chain 1, Variant 1 (KLC1C) in Leukocyte Transendothelial Migration. Am. J. Pathol.

186:1375 – 1386.

90. Gonzalez, AM, BF Cyrus, WA Muller. 2016. Targeted recycling of the LBRC precedes

adherens junction dissociation during transendothelial migration. Am. J. Pathol.

186:1387 – 1402.

91. Sullivan, D., R.L. Watson, and W.A. Muller. 2016. 4-D intravital microscopy reveals

strain-dependent differences for the roles of PECAM and CD99 in leukocyte diapedesis.

Am J Physiol Heart Circ Physiol 311:H621-H632. PMCID 5142183. DOI:

0.1152/ajpheart.00289.2016

92. Early, M., W.G. Schroeder, R. Unnithan, J.M. Gilchrist, W.A. Muller, and A. Schenkel.

2017. Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

on leukocyte infiltration during contact hypersensitivity responses. PeerJ 5:e3555.

93. DeBerge, M., X.Y. Yeap, S. Dehn, S. Zhang, L. Grigoryeva, S. Misener, D. Procissi, X.

Zhou, D.C. Lee, W.A. Muller, X. Luo, C. Rothlin, I. Tabas, and E.B. Thorp. 2017.

MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After

Myocardial Ischemia Reperfusion Injury. Circ Res 121:930-940. PMCID: 5623080



26

94. Mei Y, Feng G, Rahimi N, Zhao B, Zhang J, Cao L, Yang J, Gao J, Chen Y, Sumagin R,

Muller WA, Zhang L, Ji P. 2017. Loss of mDia1 causes neutropenia via attenuated

CD11b endocytosis and increased neutrophil adhesion to the endothelium. Blood

Advances.;1:1650-6. PMID: 29296812; PMCID: PMC5728338

95. Sullivan DP, Bui T, Muller WA, Butin-Israeli V, Sumagin R. 2018. In vivo imaging

reveals unique neutrophil transendothelial migration patterns in inflamed intestines.

Mucosal Immunol. 11(6):1571-1581. PMID: 30104624

96. Wimmer I, Tietz S, Nishihara H, Deutsch U, Sallusto F, Gosselet F, Lyck R, Muller WA,

Lassmann H, Engelhardt B. 2019. PECAM-1 Stabilizes Blood-Brain Barrier Integrity and

Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During

Neuroinflammation. Front Immunol.10:711. PMCID: 6460670.

97. Klomp JE, Shaaya M, Matsche J, Rebiai R, Aaron JS, Collins KB, Huyot V, Gonzalez

AM, Muller WA, Chew TL, Malik AB, Karginov AV. 2019.Time-Variant SRC Kinase

Activation Determines Endothelial Permeability Response. Cell Chem Biol. 26:1081-

1094. PMCID: PMC6697609; doi: 10.1016/j.chembiol.2019.04.007.

98. Beckmann L, Zhang X, Nadkarni NA, Cai Z, Batra A, Sullivan DP, Muller WA, Sun C,

Kuranov R, Zhang HF. Longitudinal deep-brain imaging in mouse using visible-light optical

coherence tomography through chronic microprism cranial window. Biomedical Optics Express.

10:5235-5250. doi: 10.1364/BOE.10.005235. eCollection 2019 Oct 1.

99. Sullivan DP, Dalal PJ, Jaulin F, Sacks DB, Kreitzer G, Muller WA. 2019. Endothelial

IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of

diapedesis. J. Exp. Med. 216:2582–2601. doi: 10.1084/jem.20190008.

BOOK CHAPTERS, SYMPOSIA, INVITED REVIEWS, COMMENTARIES

1. Muller WA, RM Steinman, ZA Cohn. 1980. Membrane flow during endocytosis. In:

van Furth R, Cohn ZA eds. Mononuclear Phagocytes: Functional Aspects. Martinus

Nijhoff, The Hague, pp. 595-612.

2. Muller WA, RM Steinman, ZA Cohn. 1983. Intracellular iodination of lysosome

membrane for studies of membrane composition and recycling. In: Fleischer S, Fleischer

B eds. Methods in Enzymology, vol. 98 Biomembranes Part L. Membrane Biogenesis:

Processing and Recycling. Academic Press, New York, pp. 404-415.

3. Steinman RM, IS Mellman, WA Muller, ZA Cohn. 1983. Endocytosis and the recycling

of plasma membrane. The Journal of Cell Biology. 96:1-27.

4. Muller WA. 1992. PECAM-1: An adhesion molecule at the junctions of endothelial

cells. In: van Furth, R., Cohn, Z.A., and Gordon, S., eds. Mononuclear Phagocytes. The

Proceedings of the Fifth Leiden Meeting on Mononuclear Phagocytes. Blackwell

Publishers, London, pp. 138-148.

https://www.ncbi.nlm.nih.gov/pubmed/30104624

https://www.ncbi.nlm.nih.gov/pubmed/30104624



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5. Muller WA. 1994. Determination of cell-surface polarity by solid-phase

lactoperoxidase iodination. In: Graham, J. and Higgins, J. eds. Methods in Molecular

Biology, v. 27. Biomembrane Protocols: II. Architecture and Function. pp. 19-30. The

Humana Press, Totowa, N.J.

6. Muller WA. 1994. Biochemical methods to determine cell surface topography. In:

Graham, J. and Higgins, J. eds. Methods in Molecular Biology, v. 27 Biomembrane

Protocols: II. Architecture and Function. pp. 31-42. The Humana Press, Totowa, N.J.

7. Muller WA. 1994. PECAM-1: The all-purpose adhesion molecule. Trends in

Glycoscience and Glycotechnology. 6:367-374.

8. Muller WA. 1995. Migration of leukocytes across the vascular intima: Molecules and

mechanisms. Trends in Cardiovasc. Med. 5:15-20.

9. Muller WA. 1995. The role of PECAM-1 (CD31) in Leukocyte Emigration: Studies in

vitro and in vivo. J. Leukoc. Biol. 57:523-528.

10. Muller WA. 1995. The use of anti-PECAM reagents in the control of inflammation.

Agents and Actions Suppl. 46:147-157.

11. Muller WA. 1996. Transendothelial Migration of Leukocytes. In: G. Peltz, ed.

Leukocyte recruitment in inflammatory disease. Section I. Molecular and Cellular

Components. p. 3-18. R.G. Landes Company, Austin, TX.

12. Muller WA. 1997 Assays of transendothelial migration in vitro. In: Weir, DM, L.A.

Herzenberg, C. Blackwell, L.A. Herzenberg, eds. Handbook of Experimental

Immunology, 5e. v. 2B, section 3 The Myeloid System. Chapter 164. S. Gordon, section

editor. Blackwell Scientific Publications, Inc., Cambridge, MA., p 164.1-164.6.

13. Muller WA. 1997. CD31 Workshop Panel Report. In: Leukocyte Typing VI. White

Cell Differentiation Antigens. Garland Publishing, Inc., New York, p. 362-364.

14. Muller WA, T Greene, F Liao. 1997. Transendothelial migration and interstitial

migration of monocytes are mediated by separate domains of monocyte CD31. In:

Leukocyte Typing VI. White Cell Differentiation Antigens. Garland Publishing, Inc.,

New York, p. 370-372.

15. Muller WA 1999. Leukocyte-endothelial cell adhesion molecules in transendothelial

migration. In Gallin, J, R Snyderman, D Fearon, B Haynes, C Nathan, eds.

Inflammation: Basic Principles and Clincal Correlates, Third Edition. Lippincott

Williams & Wilkins, Philadelphia, p. 585-592.



28

16. ME Berman and WA Muller 1999 Assay for the transendothelial migration of human

natural killer cells. In K.S. Campbell and M. Colonna, eds. Methods in Molecular

Biology, vol. 121: Natural Killer Cell Protocols: Cellular and Molecular Methods. The

Humana Press, Inc. Totowa, NJ., p. 115-123.

17. Muller WA 1999 The Role of PECAM-1 in Leukocyte Emigration. In Pearson, J. ed.

Vascular Adhesion Molecules and Inflammation. Birkhauser Verlag Publishing Ltd,

Basel, Switzerland, p. 125-140.

18. Muller WA and GJ Randolph. 1999. Migration of leukocytes across endothelium and

beyond: Molecules involved in transmigration and fate of monocytes. J. Leuk. Biol.

66:698-704.

19. Hajjar KA, NL Esmon, AJ Marcus, WA Muller. 2000. Vascular function in hemostasis.

In: Beutler, et al. Williams’ Hematology, 6th

Edition. Chapter 114. McGraw-Hill, New

York, NY, p. 1451-1469.

20. Nathan, C and WA Muller 2001 Putting the brakes on innate immunity: A regulatory

role for CD200? Nature Immunology (News & Views) 2:17-19.

21. Muller WA 2001 Migration of leukocytes across endothelial junctions: Some concepts

and controversies. Microcirculation. 8:181-193.

22. Muller WA 2001. New mechanisms and pathways for monocyte recruitment. J. Exp.

Med. 194:F47-F51.

23. Muller WA. 2002 CD31 (PECAM-1) In. Creighton, TE, ed., Wiley Encyclopedia of

Molecular Medicine. John Wiley & Sons, Inc., New York. p. 588-591.

24. Muller WA 2002 Leukocyte-endothelial cell interactions in the inflammatory response.

Lab. Invest. 82:521-534.

25. Muller WA 2003 Leukocyte-endothelial cell interactions in leukocyte transmigration

and the inflammatory response. Trends Immunol. 24:327-334.

26. Crowe S, Zhu T and WA Muller. 2003. The contribution of monocyte infection and

trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection. J.

Leukoc. Biol. 74:635-641.

27. Muller WA and AR Schenkel. 2005. Transendothelial Migration of Leukocytes.

Chapter 13; pp 237 – 249. In. Wedlich D, ed. Cell Migration in Development and

Disease. Wiley-VCH Verlag, Weinheim, Germany.



29

28. Maslin CLV, K Kedzierska, NL Webster, WA Muller, SM Crowe. 2005.

Transendothelial migration of monocytes: The underlying molecular mechanisms and

consequences of HIV-1 infection. Current HIV Research 3:303-317.

29. Hajjar, KA, NL Esmon, AJ Marcus, WA Muller 2006. “Vascular Function in

Hemostasis” in Williams’ Hematology. Eds. E Beutler, MA Lichtman, TJ Kipps, U

Seligsohn, K Kaushansky, JT Prchal, McGraw-Hill, New York, 7th Ed., Chap. 108, pp.

1715-1739.

30. Muller WA 2007. “PECAM: Regulating the start of diapedesis.” in Adhesion

Molecules: Function and Inhibition. Ed. K. Ley. Pp. 201 – 235. Birhhauser Publishing,

Basel, Switzerland.

31. Muller WA and FW Luscinskas 2008. “Assays of Transendothelial Migration in vitro.”

In Cheresh, D, ed., Methods in Enzymology, vol. 443 Angiogenesis: In vitro systems. Pp.

155 – 176.

32. Muller WA 2009. Mechanisms of Transendothelial Migration of Leukocytes. Circ. Res.

105:223-230.

33. Muller WA 2009. “How Endothelial Cells Regulate Transendothelial Migration of

Leukocytes: Molecules and Mechanisms.” In Ley, K, ed., Current Topics in Membranes,

vol. 64, Burlington: Academic Press. Pp. 335-355. copyright, Elsevier Publishing.

34. Hajjar, KA, NL Esmon, AJ Marcus, WA Muller 2010. “Vascular Function in

Hemostasis” in Williams’ Hematology. Eds. K Kaushansky, MA Lichtman, E Beutler, TJ

Kipps, U Seligsohn, JT Prchal, McGraw-Hill, New York, 8th Ed., Chap. 108, pp. 1715-

1739.

35. Muller WA 2011. Mechanisms of Leukocyte Transendothelial Migration. Ann. Rev.

Pathol. Mech. Dis. 6:323-344.

36. Muller WA 2012. Regulate Globally, Act Locally: Adrenergic Nerves Promote

Leukocyte Recruitment. Immunity. 37:189-191. PMID: 22921114; PMCID: 3616496

37. Muller WA 2013. Getting Leukocytes to the Site of Inflammation. Vet. Pathol. 50:7-22.

PMID: 23345459; PMCID: 3628536

38. Sullivan DP and WA Muller 2014. Neutrophil and monocyte recruitment by PECAM,

CD99, and other molecules via the LBRC. Semin. Immunopathol. 36:193-209. PMID:

24337626

39. Muller WA 2014. How Endothelial Cells Regulate Transmigration of Leukocytes in the

Inflammatory Response. Am. J. Pathol. 184:886-896. PMID: 24655376; PMCID:

PMC3969991



30

40. Muller WA 2014. Identification of a severe bleeding disorder in humans caused by a

mutation in CalDAG-GEFI. The Journal of Experimental Medicine 211:1271.

41. Hajjar, KA, AJ Marcus, WA Muller. 2015. “Vascular Function in Hemostasis.” in

Williams’ Hematology. Eds. K Kaushansky, MA Lichtman, E Beutler, TJ Kipps, U

Seligsohn, JT Prchal, McGraw-Hill, New York, 9th Ed., Chap. 115.

42. Muller, W.A. 2015. The regulation of transendothelial migration: new knowledge and

new questions. Cardiovascular research 107:310-320. PMID: 25987544

43. Muller, WA 2016. Localized signals that regulate transendothelial migration. Current

Opinion in Immunology. 38:24-29. PMID: 26584476

44. Muller, W.A. 2016. Transendothelial migration: unifying principles from the endothelial

perspective. Immunological reviews 273:61-75.

45. Muller, W.A. 2016. How monocytes guard the glomerulus. Proc Natl Acad Sci U S A

113:10453-10455. PMCID 5035906.

46. Weber, EW and Muller, WA 2017. Roles of Transient Receptor Potential Channels in

Regulation of Vascular and Epithelial Barriers. Tissue Barriers 5(2):e1331722. DOI

10.1080/21688370.2017.1331722

47. Dalal, PJ, WA Muller, DP Sullivan 2019. Endothelial Cell Calcium Signaling During

Barrier Function and Inflammation. Amer. J. Pathol. In press.

ONLINE EDITORIALS AND INVITED REVIEWS

1. Muller WA 2008. Transmigratory cups: Half-full or half-empty? Nature Immunology.

Vol. 9. Online Focus “Outstanding Questions” supplement to focus issue on Leukocyte

Trafficking. http://www.nature.com/ni/focus/trafficking/questions.html

2. Muller WA 2011. Sorting the signals from the signals in the noisy environment of

inflammation. Science Signaling 4, pe23. [DOI: 10.1126/scisignal.2002051]

PATENTS

1. Blocking leukocyte emigration and inflammation by interfering with CD99/HEC2

US 7,223,395 B2 May 29,2007

2. Methods of inhibitiong transendothelial migration of neutrophils and monocytes with

anti-CD99L2 antibodies US 1675067 US1 September 1, 2011

http://www.nature.com/ni/focus/trafficking/questions.html

Documents

Curriculum Vitae WILLIAM ANTHONY MULLER€¦ · William A. Muller, MD, PhD School of Medical Sciences, Weill Medical College 2005- Faculty of 1000 Faculty Member, Leukocyte Development