D2.1. Data harmonisation guidelines and standardized data ......D2.1. Data harmonisation guidelines and standardized data management/processing protocol across sites Project title:

ThisprojecthasreceivedfundingfromtheEuropeanUnion’sHorizon2020researchandinnovationprogrammeundergrantagreementNo732592.

D2.1.Dataharmonisationguidelinesandstandardizeddatamanagement/processingprotocol

acrosssites

Projecttitle: Healthymindsfrom0-100years:OptimisingtheuseofEuropeanbrainimagingcohorts

Duedateofdeliverable: 30thJune,2017Submissiondateofdeliverable: 30thJune,2017Leaderforthisdeliverable: WilliamBaaré(REGIONH)

|P a g e |1 L i f e b r a i n D e l i v e r a b l e 2 . 1 .

Healthymindsfrom0to100years:OptimisingtheuseofEuropeanbrainimagingcohorts

Contributorstothedeliverable

Name Organisation Role/Title

Deliverableleader

WilliamBaaré REGIONH

WP2Leader.Coordination.HUBUstudydataorganization/codebooks/sharedvariables/variablesofinitialinteresttolifebrain.Qualitycontrol,organization,Lifebrainsitecodebooks.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium.

Co-authors KathrineSkakMadsen

REGIONH HUBUstudydataorganization/codebooks/sharedvariables/variablesofinitialinteresttolifebrain.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium.

LouiseBaruëlJohansen

REGIONH Qualitycontrol,organization,Lifebrainsitecodebooks.DiscussionsonLifebraindataharmonization.

OlgaRigina REGIONH Qualitycontrol,organization,Lifebrainsitecodebooks.DiscussionsonLifebraindataharmonization.

HartwigSiebner

REGIONH/UniversityofCopenhagen

OverviewandfeedbackonharmonizationofLISAstudydata.

MichaelKjær REGIONH/UniversityofCopenhagen


ErikLykkeMortensen

UniversityofCopenhagen,Publichealth


EllenGarde UniversityofCopenhagen,Publichealth/REGIONH

OverviewandfeedbackonharmonizationofLISAstudydata.LISAstudydataorganization/codebooks/sharedvariables

ChristianEriksen

REGIONH LISAstudydataorganization/codebooks/sharedvariables

KristineBeateWalhovd

UiO OverviewandfeedbackonharmonizationofLCBCstudydata.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium

AndersMartinFjell


MonikaMowinckel

UiO LCBCstudydataorganization/codebooks/sharedvariables

ReneWesterhausen




LarsNyberg Umeå OverviewandfeedbackonharmonizationofBetulastudydata.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium

MikaelStiernstedt

Umeå OverviewandfeedbackonharmonizationofBetulastudydata.Betulastudydataorganization/codebooks/sharedvariables/variablesofinitialinteresttoLifebrain.

KlausEbmeier UOXF OverviewandfeedbackonharmonizationofWhitehallstudiesdata.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium

EnikoZsoldos UOXF OxfordImagingdataorganization/codebooks/sharedvariables/variablesofinitialinteresttolifebrain.GuidanceonWhitehallIIdataoverseenbyAidaSanchez

AidaSnachez UOXF/UCL WhitehallIISeniorDataManager.WhitehallIIdataorganization/codebooks/sharedvariables/variablesofinitialinteresttolifebrain

UlmanLindenberger

MPIB OverviewandfeedbackonharmonizationofBASEandBASE-IIdata.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium.

AndreasBrandmaier

MPIB StatisticaladvisorycontributionstoBASEandBASE-IIstudies.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium.

SimoneKühn MPIB BASE-IIimagingdataorganization/codebooks/sharedvariables/variablesofinitialinteresttoLifebrain.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium.

SandraDüzel MPIB BASE-IIdataorganization/codebooks/sharedvariables/variablesofinitialinteresttoLifebrain.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium.

JuliaDelius MPIB BASEdataorganization/codebooks/sharedvariables/variablesofinitialinteresttoLifebrain.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium.

MartinBecker MPIB CompilationofBASEvariablesforcodebooks.DavidBartrésFaz

UB OverviewandfeedbackonharmonizationoftheUniversityofBarcelonastudiesdata.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium

CristinaSoléPadullés

UB UniversityofBarcelonastudiesdataorganization/codebooks/sharedvariables/variablesofinitialinteresttoLifebrain.

BrendaPenninx

VMUC OverviewandfeedbackonharmonizationofNESDAstudydata.NESDAstudydataorganization/codebooks/sharedvariables/variablesofinitialinteresttolifebrain.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium

LauraNawijn VMUC NESDAdataorganization/codebooks/sharedvariables/variablesofinitialinteresttolifebrain.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium

RikHenson MRC/UCAM OverviewandfeedbackonharmonizationofCamCANstudydata.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium



RogierKievit MRC/UCAM OverviewandfeedbackonharmonizationofCALMstudydata.CALMstudydataorganization/codebooks/sharedvariables/variablesofinitialinteresttolifebrain.Discussionsonwhichvariablestoharmonizeandhow,locallyandintheLifebrainconsortium

TinaEmery MRC/UCAM CamCANandCALMdataorganization/codebooks/sharedvariables/variablesofinitialinteresttoLifebrain.

DarrenPrice MRC/UCAM AssistancewithCamCANvariablescodebookAnnieBryant MRC/UCAM AssistancewithCALMvariablescodebookPaoloGhisletta

UNIGE Advisorfordataanalyses.DiscussionsonLifebraindataharmonization.

Finalapproval

BarbaraB.Friedman UiO Finalediting,approvalandsubmission

DocumentHistory

Release DateReasonforChange

Status(Draft/In-review/Submitted

Distribution

1.0. 05.06.2017 Firstdraft SenttoreviewtotheCO

Email

2.0. 28.06.2017 Seconddraft Revision

Email

3.0. 30.06.2017 Finalversion SubmissiontothePP

Participantportal

DisseminationlevelPU Public XPP Restrictedtootherprogrammeparticipants(includingtheCommissionServices) RE Restrictedtoagroupspecifiedbytheconsortium(includingtheCommission

Services)

CO Confidential,onlyformembersoftheconsortium(includingtheCommissionServices)



Tableofcontents

TABLE OF CONTENTS ...................................................................................................................... 4

EXECUTIVE SUMMARY ................................................................................................................... 5

LIST OF ACRONYMS / ABBREVIATIONS ..................................................................................... 7

INTRODUCTION ................................................................................................................................. 8TASK2.1DESCRIPTION ............................................................................................................................... 8BACKGROUND .......................................................................................................................................... 8STATUSOFTASK/STATE-OF-THEARTINTHETOPIC ........................................................................................... 9OBJECTIVES .............................................................................................................................................. 9PERSPECTIVE .......................................................................................................................................... 10COLLABORATIONAMONGPARTNERS ........................................................................................................... 10

1. INCLUDED STUDIES PER SITE ............................................................................................. 11

2. DESCRIPTION OF ACTIVITIES ............................................................................................. 121.1. MAPPINGTHEDATA ..................................................................................................................... 121.2. SELECTIONOFVARIABLESOFINITIALFOCUS ...................................................................................... 141.3. GATHERINGSTUDYPROTOCOLSANDSITE-SPECIFICVARIABLESMETADATA ............................................. 151.4. CHECKINGCODEBOOKCONSISTENCY .............................................................................................. 161.5. PRELIMINARYDATAHARMONIZATIONPOTENTIAL .............................................................................. 17

2. NEXT STEPS ................................................................................................................................ 202.1. GENERALHARMONIZATIONPROCEDURES ......................................................................................... 212.2. DESIGNINGTHELIFEBRAINDATABASE .............................................................................................. 22

3. CONCLUSION ............................................................................................................................. 22

4. REFERENCES ............................................................................................................................. 22

5. APPENDIX ................................................................................................................................... 26



ExecutiveSummaryThedeliverableisareportontheimplementationofpartofTaskWP2.1“Dataharmonizationguidelinesandstandardizeddatamanagementplan/processingprotocolacrosssites”.This taskaims todevelopand implementharmonizationprotocols tounifyandbridge thedifferentcodingstandardsoftargetvariablesbetweensites.Inthisprocess,wewilldevelopguidelines for addressing differences in datamanagement systems and routines, andMRimagequalitycontrolproceduresacrosssitestosecureefficientapplicationandutilizationofdatatransfer,storageandprocessingsystems.Inthisdeliverablewe

1. CategorizedallavailableandinprincipleshareabledataforallLifebrainstudiesandtimepoints.

2. ProvidednecessaryinformationtotheworkdoneinotherWP2tasks:a. Task2.3“Enrichmentofexistingcohortsbyonlinedatacollection(M6-M18)b. Task2.4“Enrichmentofexistingcohortsbyhomecollectionofdriedblood

spots(DBS)”(M6–M36)c. Task2.5“Enrichmentofexistingcohortsbyadministrationofbuccalswabsfor

epigeneticanalysis”(M6–M36)d. Task2.6“GenerationofnewGWAS(genome-wideassociationstudy)dataand

harmonizationofgeneticdataacrosssamples”(M6-M24)e. Task3.2.“DevelopmentandvalidationofaposterioriharmonizationofMRI

data”,(M1-M9)3. Identifiedandselectedvariablesofinitialinterest4. Obtainedsite-specificcodebooks,containinginformationoninclusion/exclusion

criteria,standardoperatingprocedures,datacollectionmethods,andmetadataonthevariablesofinitialinterest.

5. Providedageneralevaluationofthedataharmonizationpotentialofvariablesofinitialinterestandformulategeneraldataharmonizationstrategies

Nextsteps:

1. Continuewithqualitycontrolandcompletionofsite-specificstudyprotocols.Thelatterspecificallyconcernsdocumentingtheinstructionsgiventosubjectsduringcognitivetests.

2. Continuewiththestringentqualitycontrolofthesite-specificvariablecodebooksoncompleteness,organizationandformatting.

3. Establishwork groups for a in depth evaluation of data harmonization for specificdimensionsandclustersofvariables



4. Defineandestablishvariablescodesandmeta-dataforvariablesofinitialinteresttoLifebrain.GenerateLifebrainformattedtablestemplateforsite-specificvariablestothe Lifebraindatabase,developed in Task3.1 “Developmentof adata storageandmanagementsystem”(M1-M6),anddevelopconversionscriptstopopulateLifebraintableswithsite-specificdata.



Listofacronyms/abbreviationsLifebrain Healthymindsfrom0-100years:OptimisingtheuseofEuropean

brainimagingcohorts

WP Workpackage

GA GrantAgreement

UiO UniversityofOslo

UmU UmeåUniversitet

UOXF UniversityofOxford

MPIB MaxPlankInstituteforHumanDevelopment

UB UniversityofBarcelona

REGIONH RegionHovedstaden

VUMC UniversityMedicalCenterAmsterdam

MRC MedicalResearchCouncil

UCAM UniversityofCambridge

MRI MagneticResonanceImaging

AbbreviationsoftestandquestionnairesthathavebeenemployedinLifebrainstudiesareprovidedinAppendix1.



IntroductionTask2.1description“Task2.1Establishadatamanagementandprocessingprotocolforharmonizationofdataforpooling, integration,qualitycontrolacrosssites.Lead:REGIONH;Participants:UmU,UOXF,MPIB, UB, MRC, VUMC (M1-M6) The task will develop and implement harmonizationprotocols,i.e.developtechnicalandsemanticdatastandards,andqualityprotocolstounifyandbridgethedifferentcodingstandardsoftargetvariablesbetweensites.Itwillalsodefineguidelinesforaddressingdifferencesindatamanagementsystemsandroutines,andMRimagequalitycontrolproceduresacrosssitestosecuretheefficientapplicationandutilizationofthedatatransfer,storageandprocessingsystemdevelopedinT3.1.Moreover,T2.1willfacilitatetheimplementationofthe innovativeposthocharmonizationalgorithms,developed inT3.2,tocorrect MR images for scanner-specific differences in tissue contrast and intensity, non-uniformity.Finally,T2.1willensuretheefficientimplementationandmanagementofthenewdried blood spot assays and online data collection system developed in T3.5 and 3.6,respectively.”BackgroundLifebrainisaEuropeanmulti-sitestudyaimedtocapitalizeonexistingmultidimensionalcrosssectional and longitudinal retrospectively acquired biological, behavioural and cognitive,medical,mentalhealth,andinvivoneuroimagingdata.TheobjectiveofLifebrainistoestablishasolidfoundationofknowledgeforunderstandinghowbrain,cognitiveandmentalhealthcanbeoptimizedthroughthelifespan.Identificationofdeterminantsofbrain,cognitiveandmentalhealthatdifferentstagesofliferequiresalargedatabaseofdetailedinformationaboutbrainimagingmeasures,cognitivefunction,mentalandmedicalhealth,aswellasbiologicalmeasures.Central to (large-scale) multi-site initiatives such as Lifebrain are data integration,standardizationandharmonization.TheinternationalEuropeanaspectaddsanextralayerofuniquepossibilitiesaswellaschallenges.ThecoordinatedresearcheffortswithinLifebrainallows formultiple analytic strategies (2), increase statistical power, allowmoreadvancedsubgroup analyses, enhance generalizability of findings and support cross validation orreplicationoffindingsacrossdatasets.



Statusoftask/state-of-theartinthetopicInJune2016,theinternationalJournalofEpidemiologypublishedthe“MaelstromResearchguidelinesforrigorousretrospectivedataharmonization”(2).Overanine-yearperiod,using“aphonesurveywith34majorinternationalresearchinitiatives,aseriesofworkshopswithexperts,andcasestudiesapplyingtheproposedguidelines”theauthorsdevelopedgenericguidelines for successful retrospective data harmonization that include severalinterdependentsteps:“

1. Definetheresearchquestion,objectivesandprotocol2. Assemblepre-existingknowledgeandselectstudies3. Definetargetedvariablesandevaluateharmonizationpotential4. Processdata5. Estimatequalityoftheharmonizeddataset(s)generated6. Disseminateandpreservefinalharmonizationproducts”

Thecurrentdeliverableprimarilyconcernssteps2and3.OverallLifebrainresearchquestionshavebeenoutlinedinthegrantapplicationandaredetailedinWP4:Demonstration.Steps4,5and6areoutofthescopeofthecurrentdeliverableandarethemainsubjectofotherworkpackages.ObjectivesThe overall objective of the deliverable is to provide a solid foundation for establishing aLifebraindatabaseconsistingofavailablebehavioural,cognitive,medicalandmentalhealth,neuroimaging and biological data, in-depth data harmonization and development andimplementationofguidelines forstandardizeddatamanagementandprocessingprotocolsacrosssites.Wewill:

• CategorizeavailabledataforallLifebrainstudiesandtimepoints• Identifyaninitialsetofvariablesofinterest• Acquire site-specific code books containing information on study design, standard

operating procedures, data collection methods, and metadata on variables e.g.variablenames,variabledescription,datatype,dataformat,allowablevaluesetc.

• Identifycommonalitiesinavailabledataacrosssites,evaluategeneralharmonizationpotentialandformulategeneraldataharmonizationstrategies



PerspectiveDetails and implementationofexactdataharmonization techniquesand theevaluationoftheirapplicabilityandqualityaredependentonthespecificresearchquestionsformulatedinWP4andwhatstudieswillbetargetedData harmonization, data management and proper documentation will requires constantfocusandeffortthroughoutthelifespanofLifebrain.Collaborationamongpartners ThelargenumberofLifebrainresearchersthathavecontributedtothedeliverablereflectsthestrong,transparentandfocussedcollaborativeframeworkthatLifebrainprovides.EachsitedesignatedateamconsistingofthestudyPIsanddedicatedresearchpersonneltodiscussand specify thedimensionsandvariablesof interestaswell asdataharmonizationand toprovidedetailed informationon study setup andprotocols, andmetadata for variables ofinterestaswellasexpertiseandexperienceindataorganizationandharmonization.



1. Includedstudiespersite UiO LCBC:LifespanChangesinBrainandCognition

(consistofsubjectofHukommelseProsjekt,NeurocognitiveDevelopment,NeurocognitivePlasticity,andMorogBarn)(3timepoints)

UmU Betula-Aging,MemoryandDementia(2timepoints)UOXF WhitehallII:Imaging(1timepoint)MPIB BASE(BerlinAltersstudie,8timepoints) BASEII(BerlinAltersstudie,2timepoints)UB WAHA(Walnutinterventionstudy:3timepoints)

MSA(Multi-SystemicAtrophy:1timepoint)PD(Parkinson'sDisease:3timepoints)GABA(GABASpectroscopy:1timepoint)iTBS(Theta-burststimulation:1timepoint)CR(CognitiveReserve:1timepoint)

REGIONH HUBU(“HjernensUdviklinghosBørnogUnge“;Brainmaturationinchildrenandadolescents:12timepoints)

LISA(LiveActiveSuccessfulAgeing:1timepoint)VUMC NESDA(NetherlandsStudyofDepressionandAnxiety:6time

points)MRC CamCan(CambridgeCentreforAgeingandNeuroscience:3time

points)UCAM CALM(CentreforAttention,LearningandMemory:1timepoint)InFigure1.weprovidethetotalnumberofsubjectsandobservations.AcompleteoverviewofthetotalnumberofuniqueparticipantsandobservationswithbehaviouraldataonlyandwithbehaviouralandMRIdataforallindividualLifebrainstudiesisprovidedinAppendix2.

FIGURE1.NUMBEROFSUBJECTSANDOBSERVATIONSINLIFEBRAIN



2. Descriptionofactivities The groundwork for the Lifebrain data harmonization effort was laid down in the grantapplicationandduringtheLifebrainKick-offmeetingheldinBrussels,January16-18,2017.Duringthefirst6monthsofLifebrain,theWP2.1 leader,RegionH,anddataharmonizationteamsofindividualLifebrainsitescommunicatedthroughemail,Slack,OneDrive,Skypeandtelephonetodiscussandorganizeallnecessaryinformation.1.1. Mappingthedata

ThefirsttaskwastomapalldataavailableandinprincipleshareablewithinLifebrain.Based on the discussion at the kick off meeting a spread sheet was created containingidentifieddimensionsandvariables.Thisspreadsheetwasthanpopulatedandifnecessaryextended by each site with information on data availability, and used tests, protocols,questionnairesetc.ThedimensionsthatwereincludedaredisplayedinFigure2.AdetailedoverviewofthevariableswithineachofdimensionsisprovidedinAppendix3.



FIGURE2.LIFEBRAINDATADIMENSIONS



1.2. Selectionofvariablesofinitialfocus

Based on the detailed overview of in principle shareable data it has been decided,whichvariablestoinitialfocuson(seeFigure3).Thedecisionwasinformedbyobservedavailabilityof data across sites, the focus of the research in WP4, specifically Task 4.2 “Analysis ofindividual pathways/mediator variables in relation to risk formental health problems andresilience” (M18-M48),andTask4.3“Analysis of individualpathways/mediator variables inrelation to risk for poor cognitivefunction and decline versusresilience”(M18-M48).Thedecisionwastofocusoureffortsonthedimensions:

• Studysetup/participants• Demographics• PhysicalMeasures• PhysicalHealth• MentalHealthand• CognitiveTests.

ThelevelofdetailobtainedfortheMRI,Biomarkers,andDNAdatadimensionswassufficienttoinformthespecifictasksonthesedimensionsi.e.

• Task3.2.“DevelopmentandvalidationofaposterioriharmonizationofMRIdata”(M1-M9);

• Task2.4“Enrichmentofexistingcohortsbyhomecollectionofdriedbloodspots(DBS)”(M6–M36);

• Task2.5“Enrichmentofexistingcohortsbyadministrationofbuccalswabsforepigeneticanalysis”(M6–M36);and

• Task2.6“GenerationofnewGWAS(genome-wideassociationstudy)dataandharmonizationofgeneticdataacrosssamples”(M6-M24).

FIGURE3.DIMENSIONSANDVARIABLESOFINITIALFOCUS



DataharmonizationoftheMRI,BiomarkerandDNAdataiscloselycoupledtotheworkinthesetasks. 1.3. Gatheringstudyprotocolsandsite-specificvariablesmetadata

Next,spreadsheetsweredevelopedforgatheringdetailedinformationonrespectivelystudyprotocols, i.e. employed inclusionandexclusion criteria and theorder inwhichbiological,physical, behavioural and cognitive, and neuroimaging assessments were performed (seeFigure 4), and variablemeta-data i.e. site-specific information on variable name, variabledescription,allowablevalues,datatype,dataformat,allowablevalues,valuedescription,andcodingofmissingdata(seeFigure5).

FIGURE4.EXAMPLESPREADSHEETLAYOUTFORGATHERINGSITESPECIFICSTUDYPROTOCOLS



1.4. Checkingcodebookconsistency

All sitesprovided the required information in study inclusion/exclusion criteria and studyprotocols.Organizationof the informationon the specific instructions subjectsweregivenduringcognitivetests,partofthestudyprotocols,isongoing.All sites provided information on variable metadata for the variables of initial focus. Astringent quality control of the site specific variable code books on consistency andcompleteness,withrespecttoreportedinformationinthegeneralsharedvariablesoverview,organizationandformattingisongoing.TheprovidedvariabledataallowedustoassessdataavailabilityaswellthelevelofdetailinwhichdimensionsandvariablesofinterestwereassessedandsampledacrossLifebrainsites.Thelatterallowedustoperformanoverallevaluationofthedataharmonizationpotentialofthedifferenttypesofvariables.

FIGURE5.EXAMPLESPREADSHEETFORGATHERINGSITESPECIFICVARIABEMETADATA



1.5. Preliminarydataharmonizationpotential AdetailedoverviewofthedataavailableinLifebrainisprovidedinAppendix3.1-3.3.Inwhatfollows,anoverallevaluationofdataharmonizationpotentialofdimensionsandclusterofvariablesisgiven.1. Dateofassessments,timeofassessments,investigatordoingtheassessment,andsubject

sex,birthdate,birthmonth,birthyear,calculatedage,andgeneralinfoonmortality,anddateofdeath.

Thisdatadoesnotneedharmonizationinthesensethatscores,exceptfor"Investigatordoingtheassessment"havethesamemeaningacrosssites.Sexwillberecodedtofemale,male.Overall,forallvariablesthatwillbeusedinLifebrain,wewillimposeastringentcodingregimei.e.organizationandformattingofthemetadataassociatedwithLifebrainvariables.WestrivetofollowinternationalstandardsandstandardsusedinotherlargeconsortiacomparabletoLifebraininscoopandfocus,inordertoenableefficientfuturecouplingofLifebraindatatothatofotherconsortia.2. Subject,mother,father,guardian,personaccompanyingchildeducationalLifebrain has a good coverage of subject education. The available data will allow twostrategies:

a. RecordhighestattainededucationandconverttoyearsofeducationfollowingtheInternationalStandardClassificationofEducation(currentversion2011)(3a,b).

b. Re-categorizeavailabledataintoapproximatelyfourcategories(seeforexample,3).Additionally,wewillstatisticallyaccountforpossiblecohortandcountryeffects.Whilenotavailableinallstudies,importantly,informationonparenteducationisavailableoravailableinprincipleinstudiesincludingpartially(LCBC)orexclusively(HUBU,CALM)children.Ofnote,inCALM,educationwasregisteredforthepersonwhoaccompanied thechild.Educationofmother/father/guardian/other canberetrievedfromthisdata.

3. SubjectoccupationInformation is inprincipleavailable formostof the studies. If feasible,wewill recordandconvertacquireddatausingInternationalStandardClassificationofOccupations(ISCO)08(4).



4. IncomeData isnot available in all studies.Harmonizationof and/or including income in statisticalmodelsforfuturespecificresearchquestionsisnotstraightforwardandneedtoaccountfornationaldifferencesine.g.costofdailyliving,housingprices,taxes,inflationetc(5).5. MaritalandrelationshipstatusHarmonizationwillincludere-categorisationtoensureuniformcoding.6. Weight, Weight at birth, Height, Grip strength, Waist circumference, Blood pressure,

HandednessDataharmonizationonthesevariableswillinprincipleonlyrequiresre-coding.However,weneedtoaccountfordifferencesbetweensitesintheprotocolsandmethodsusedtoderivethesemeasures(e.g.Weightmeasuredusingaweightbalanceorreported;Bloodpressuremeasuredsitting,lyingdown,orboth,...).7. AlcoholMostsitesassessedalcoholuse.However,assessmentsdiffersubstantialinthelevelofdetailof acquired information (e.g. typical/ heavy drinking, type of alcohol beverage, quantity,frequency, drinking pattern, reference period) and instruments used. Successfulharmonization/modellingofalcoholconsumptionwilldependonwhichstudiesareincludedinspecificinvestigations.Culturalandcohortdifferencesneedtobeaccountedfor(6).8. SmokingMostsitesassessedsmokinghabits.However,assessmentsdiffergreatlyinthelevelofdetailofacquired information (type:cigarettes,cigars,pipe,quantity, frequency, referencetime,ageofstarting/stopping).Categorizationssuchas"never","current","notcurrent"oreversmoked "yes/no" might be possible. Depending on the studies included in specificinvestigationsdefinitionofvariablesonquantity/frequencymaybefeasible(7).9. SubstanceuseSubstanceusehasbeenassessedinseveralstudies.However,assessmentsdifferinthelevelofdetail(e.g.status,typeofdrug,frequency,agestarted/stopped).Dependingonstudiesandthenumberof subjects thathaveused substancesofabuse,wemaybeable tomodel itspossible effects, for example using a categorical variable "never, "current, "not current"and/orexcludesubjectsfromanalyses.



10. PhysicalactivityMostsitesassessedphysicalactivity.However,thelevelofdetailofacquiredinformation(e.g.leisure,occupational, transport,daily living,organized, type,duration, regularity, intensity,frequency, MET or Calories equivalents) differs across sites as well as the assessmentinstrumentsthatwereused.Westrivetoharmonizeonintensity,frequency,duration,and/oracategoricalvariableforlevelofactivity(8,9).11. MedicationMostsitesassessedmedicationuse.However,levelofdetail(e.gmedicationhistory,typesofmedication,medication codes, frequency, doses) andassessments instrumentsuseddiffergreatlyacrosssites.Dataharmonizationlikelywillinvolvecategoricalvariables.12. SleepMostsitesassessedsleep.EightstudiesusedthePittsburghSleepQualityIndex.Othersusedin-house questionnaires. The data harmonization potential is deemed good and allowsidentifyingcommonvariables.13. Anxiety,DepressionandMoodMost studies assessed anxiety and depression and mood variables. However, there isconsiderablevariationinthespecificassessmentinstrumentsthatwereusedaswellasthenumberofinstrumentsusedineachindividualstudy.Moreover,notallstudiescanprovideitemleveldata.Wewillidentifycommonvariables,andassessthefeasibilityofimplementinge.g.latentfactormodels,itemresponsetheory(IRT)(9,10).14. Memory self-assessment and Everyday memory, Stress, Life events and experience,

PersonalityThesedimensionswereassessedinseveralstudies.However,thereisconsiderablevariationinthespecificassessmentinstrumentsthatwereusedaswellasthenumberofinstrumentsusedineachindividualstudy.Moreover,notallstudiescanprovideitemleveldata.Wewillidentify common variables, and assess the feasibility of implementing e.g. latent factormodels,itemresponsetheory(IRT)(9,10,11).



15. PhysicalExaminationPhysical examinations were performed in several studies. However, level of detail andassessments instruments used differ greatly across sites. Information on general health,cardiovasculardisease,diabetes,longstandingillness,stroke,vascularriskfactorsorsicknessabsenceseemsavailable.Westrivetoidentifycommonvariablesandexplorethepossibilityofcreatingcategoricalvariables.16. IQ or equivalent, Working memory, Verbal and visual memory, Mini Mental State

Examination,VerbalfluencyMoststudiesassessedthesevariables.However,studiesdifferbythespecificteststhatwereemployedaswell asby thenumberof testused ineach individual study.Wewill identifycommonvariables,andassessthefeasibilityof implementinge.g. latentfactormodels(10,13,14).TheMiniMentalStateExaminationcanbereadilyharmonized.Assessedletterand/orsemanticfluency,whiledifferinginusedprotocols,willlikelyallowustonormalizedscoresforthisvariable.Mostsitesassessedletterand/orsemanticfluencyallowingustogeneratecommonvariablesandpossiblyusenormalizedscores.17. ProcessingspeedSeveralsitesassessedprocessingspeed.However,studiesdifferbythespecificteststhatwereemployedaswell asby thenumberof testused ineach individual study.Wewill identifycommonvariables,andassessthefeasibilityof implementinge.g. latentfactormodels(10,13,14).Ofnote,moststudiesemployedversionsofthetrailmakingtask,makingitfeasibletousenormalizedscores.

2. Nextsteps Wecontinuewithqualitycontrolandcompletionofsite-specificstudyprotocols.Thelatterspecificallyconcernsdocumenting the instructionsgiven tosubjectsduringcognitive tests.Additionally,wecontinuewithstringentqualitycontrolofthesite-specificvariablecodebooksoncompleteness,organizationandformatting.Lifebrainwillallowfordifferentapproachesdependingonthespecificresearchquestionsandhypotheses.Itwillallowforcentralizedanalysesbycreatingonedatasetforanalyses,whichrequiresharmonizationoftargeteddatasets,orcoordinatedindependentanalyses(1).



2.1. Generalharmonizationprocedures Thecurrentdeliverablegatheredandorganized informationaboutall variablesof interestacrosscohortsinLifebrain.Whileharmonizationofsomeofthedimensions/variableswillbestraightforward,otherdimensions/variableswillrequiremoreefforttoharmonisegiventhelarge variation in assessment instruments used for some of the dimensions. In our dataharmonizationeffortswewillbuildonother initiatives,suchasEPOSA(16),andBIOSHARE(17)(seeFigure6).Intheautumnof2017,wewillestablishspecificworkgroupsfordataharmonizationofspecificdimensions/variables.Thetaskgroupswillgenerateguidelinesonhowtoharmonizespecificdimensions/variables,andonwhatanalyticapproachesarefeasibleand/orrecommendable.It is importanttodeterminewhethereachofthedimensions/variablesmeasuresthesameconceptinorderfortheharmonizationtoproceed.Ifthevariabledoesnotmeasurethesameconcept,harmonizationofthedatawillnotbepossible.Ifthevariabledoesmeasurethesameconcept,thentheharmonizationprocedurescanproceed.Anotherimportantstepistodeterminewhetherresponsecategoriesoverlap.Iftheydonotoverlap,variableswillbematchedoncategories,e.g.smokingyes/no.Iftheydooverlap,thetaskgroupwilldeterminepossibleharmonizationalgorithmsthatallowsforaslittle lossofinformationaspossible.

FIGURE6.SCHEMATICPRESENTATIONOFTHEHARMONIZATIONPROCESSFORALLDIMENSIONS/VARIABLESADAPTEDFROM

(16)



2.2. DesigningtheLifebraindatabase

Intheautumnof2017andinparallelwiththedataharmonizationeffortswewillstartwithdesigningtheLifebraindatabasetablesthatwillultimatelypopulatetheLifebraindatabaseusing the infrastructure developed in Task 3.1 “Development of a data storage andmanagementsystem”(M1-M6),anddevelopconversionscriptstopopulateLifebraintableswithsite-specificdata.

3. ConclusionTheobjectivesofthecurrentdeliverablewerefulfilledasdetailedbelow:

• MapandcategorizeavailabledataforallLifebrainstudiesandtimepoints:Completed• Identifyaninitialsetofvariablesofinterest:Completed• Obtainsitespecificcodebooks,whichcontaininformationonstudyspecificdesigns,

standardoperatingprocedures,datacollectionmethods,andmetadataonvariablese.g.variablenames,variabledescription,datatype,dataformat,allowablevaluesetc.

o Site-specificcodebooks,whichcontaininformationonstudyspecificdesigns,standard operating procedures were generated. Gathering the instructionsgiventosubjectsduringtestisinprogress.

o All sites provided information on variable metadata. The detailed qualitycontrol of the site specific variable code books on consistency andcompleteness, with respect to reported information in the general sharedvariablesoverview,andformattingisstillinprogress.

• Evaluatecommonalitiesacrosssitesandoverallharmonizationpotentialo Preliminary data harmonization potential of initial variables of interest has

beenevaluated

4. References(1) HoferSM,PiccininAM.Integrativedataanalysisthroughcoordinationofmeasurement

andanalysisprotocolacrossindependentlongitudinalstudies.PsycholMethods.2009;14(2):150-164.

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(3a)http://ec.europa.eu/eurostat/statistics-Explained/index.php/International_Standard_Classification_of_Education_(ISCED)(3b)http://ec.europa.eu/eurostat/web/products-manuals-and-guidelines/-/KS-06-14-246(4)http://www.ilo.org/public/english/bureau/stat/isco/(5)CanberraGroup(2011)HandbookofHouseholdIncomeStatistics.SecondEdition2011.Geneva:UnitedNations.(6)AgrawalA,FreedmanND,ChengYC,LinP,ShafferJR,SunQ,TaylorK,YaspanB,ColeJW,CornelisMC,DeSensiRS,FitzpatrickA,HeissG,KangJH,O'ConnellJ,BennettS,BookmanE,BucholzKK,CaporasoN,CroutR,DickDM,EdenbergHJ,GoateA,HesselbrockV,KittnerS,KramerJ,NurnbergerJI,Jr.,QiL,RiceJP,SchuckitM,vanDamRM,BoerwinkleE,HuF,LevyS,MarazitaM,MitchellBD,PasqualeLR,BierutLJ.Measuringalcoholconsumptionforgenomicmeta-analysesofalcoholintake:opportunitiesandchallenges.AmJClinNutr.2012;95(3):539-547.(7)http://www.dynamo-hia.eu/dsresource?type=pdf&disposition=inline&objectid=rivmp:230417&versionid=&subobjectname=(8)WarrenJM,EkelundU,BessonH,MezzaniA,GeladasN,VanheesL.Assessmentofphysicalactivity-areviewofmethodologieswithreferencetoepidemiologicalresearch:areportoftheexercisephysiologysectionoftheEuropeanAssociationofCardiovascularPreventionandRehabilitation.EurJCardiovascPrevRehabil.2010;17(2):127-139.(9)PetteeGabrielKK,MorrowJR,Jr.,WoolseyAL.Frameworkforphysicalactivityasacomplexandmultidimensionalbehavior.JPhysActHealth.2012;9Suppl1:S11-18.(10)McArdleJJ,GrimmKJ,HamagamiF,BowlesRP,MeredithW.Modelinglife-spangrowthcurvesofcognitionusinglongitudinaldatawithmultiplesamplesandchangingscalesofmeasurement.PsycholMethods.2009;14(2):126-149. (11)vandenBergSM,deMoorMH,McGueM,PetterssonE,TerraccianoA,VerweijKJ,AminN,DerringerJ,EskoT,vanGrootheestG,HansellNK,HuffmanJ,KonteB,LahtiJ,LucianoM,MattesonLK,ViktorinA,WoudaJ,AgrawalA,AllikJ,BierutL,BromsU,CampbellH,SmithGD,ErikssonJG,FerrucciL,FrankeB,FoxJP,deGeusEJ,GieglingI,GowAJ,GruczaR,HartmannAM,HeathAC,HeikkilaK,IaconoWG,JanzingJ,JokelaM,KiemeneyL,LehtimakiT,MaddenPA,MagnussonPK,NorthstoneK,NutileT,OuwensKG,PalotieA,PattieA,PesonenAK,PolasekO,PulkkinenL,Pulkki-RabackL,RaitakariOT,RealoA,RoseRJ,Ruggiero



D,SeppalaI,SlutskeWS,SmythDC,SoriceR,StarrJM,SutinAR,TanakaT,VerhagenJ,VermeulenS,VuoksimaaE,WidenE,WillemsenG,WrightMJ,ZgagaL,RujescuD,MetspaluA,WilsonJF,CiulloM,HaywardC,RudanI,DearyIJ,RaikkonenK,AriasVasquezA,CostaPT,Keltikangas-JarvinenL,vanDuijnCM,PenninxBW,KruegerRF,EvansDM,KaprioJ,PedersenNL,MartinNG,BoomsmaDI.HarmonizationofNeuroticismandExtraversionphenotypesacrossinventoriesandcohortsintheGeneticsofPersonalityConsortium:anapplicationofItemResponseTheory.BehavGenet.2014;44(4):295-313.(12)DuzelS,VoelkleMC,DuzelE,GerstorfD,DreweliesJ,Steinhagen-ThiessenE,DemuthI,LindenbergerU.TheSubjectiveHealthHorizonQuestionnaire(SHH-Q):AssessingFutureTimePerspectivesforFacetsofanActiveLifestyle.Gerontology.2016;62(3):345-353.(13)BrandmaierAM,vonOertzenT,McArdleJJ,LindenbergerU.Structuralequationmodeltrees.PsycholMethods.2013;18(1):71-86.(14)BenderAR,PrindleJJ,BrandmaierAM,RazN.Whitematterandmemoryinhealthyadults:Coupledchangesovertwoyears.Neuroimage.2016;131:193-204.(15)CostaA,BakT,CaffarraP,CaltagironeC,CeccaldiM,ColletteF,CrutchS,DellaSalaS,DemonetJF,DuboisB,DuzelE,NestorP,PapageorgiouSG,SalmonE,SikkesS,TiraboschiP,vanderFlierWM,VisserPJ,CappaSF.TheneedforharmonisationandinnovationofneuropsychologicalassessmentinneurodegenerativedementiasinEurope:consensusdocumentoftheJointProgramforNeurodegenerativeDiseasesWorkingGroup.AlzheimersResTher.2017;9(1):27.(15)SachdevPS,LipnickiDM,KochanNA,CrawfordJD,RockwoodK,XiaoS,LiJ,LiX,BrayneC,MatthewsFE,StephanBC,LiptonRB,KatzMJ,RitchieK,CarriereI,AncelinML,SeshadriS,AuR,BeiserAS,LamLC,WongCH,FungAW,KimKW,HanJW,KimTH,PetersenRC,RobertsRO,MielkeMM,GanguliM,DodgeHH,HughesT,AnsteyKJ,CherbuinN,ButterworthP,NgTP,GaoQ,ReppermundS,BrodatyH,MeguroK,SchupfN,ManlyJ,SternY,LoboA,Lopez-AntonR,SantabarbaraJ.COSMIC(CohortStudiesofofMemoryinanInternationalConsortium):aninternationalconsortiumtoidentifyriskandprotectivefactorsandbiomarkersofcognitiveageinganddementiaindiverseethnicandsocioculturalgroups.BMCNeurol.2013;13:165.(16)SchaapLA,PeetersGM,DennisonEM,ZambonS,NikolausT,Sanchez-MartinezM,MusacchioE,vanSchoorNM,DeegDJ.EuropeanProjectonOSteoArthritis(EPOSA):methodologicalchallengesinharmonizationofexistingdatafromfiveEuropeanpopulation-basedcohortsonaging.BMCMusculoskeletDisord.2011;12:272.



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5. Appendix Appendix1:AbbreviationsoftestandquestionnairesthathavebeenemployedinLifebrainstudies(PDF)Appendix2:Numberofsubjectsandobservations(PDF)Appendix3.1:DetailedoverviewofthedataavailableinLifebrain(PDF)Appendix3.2:DetailedoverviewofthedataavailableinLifebrain(PDF)Appendix3.3:DetailedoverviewofthedataavailableinLifebrain(PDF)

Abbreviations Fullname(ChildandParents) Indicatesthatboththeparticipantandparentshavefilledoutaversionofthequestionnaire(Parents) Indicatesthattheparentsfilledoutthequestionnaire4D5Q,4DKL(inGerman) TheFour-DimensionalSymptomQuestionnaireAC AlcoholConsumptionACE-R AddenbrookesCognitiveExaminationRevisedAGORA AngoraphobiaAH4 non-verbalreasoningpartoftheAliceHeimGroupAbilityTestANT,EmotionalANT AttentionNetworksTestASEBA AchenbachSystemofEmpiricallyBasedAssessmentASI AddictionSeverityIndexAUDIT AlcoholUseDisordersIdentificationTestBAECKE BaeckePhysicalActivityQuestionnaireBAI BeckAnxietyInventoryBASEactivityquestionnaire BerlinAgeingStudyactivityquestionnaireBasecog BerlinAgeingStudyCognitivetestbatteryBDI BeckDepressionInventoryBIGfive Thefive-factormodelofpersonalityBIS-11 Barrett'sImpulsivenessScaleBIS/BAS BehaviouralInhibition/ApproachSystemBNT-60 BostonNamingTestBPRS BriefPsychiatricRatingScaleBRIEF BehaviourRatingInventoryofExecutiveFunctionBrugha akaTheListofThreateningExperiences(LTE)CAGE Acronymcreatedfrom4alcoholdependencequestions(Ewing,1984)CAMB CopenhagenAgingandMidlifeBiobankCAMT CimbiaffectivememorytaskCASE ChildandAdolescentSurveyofExperiencesCASP control','autonomy','pleasure'and'self-realization';qualityoflifemeasureinolderageCC3000 CambridgeCentreforAgeingNeuroscience3000sampleCDDR CustomaryDrinkingandDrugUseRecordCDQ CognitiveDysfunctionquestionnaireCERAD TheConsortiumtoEstablishaRegistryforAlzheimer’sDiseaseCES-D CentreforEpidemiologicalStudiesDepressionScaleCHAMPS CHAMPSPhysicalActivityQuestionnaireforOlderAdultsCIDI CompositeInternationalDiagnosticInterview(WHO)CIS-R ClinicalInterviewSchedule–RevisedCLOX ClockdrawingtaskCN / 10MQ 10memoryself-reportquestionsCPT ContinuosPerformanceTestCVA CerebroVascularAccidentCVLT CaliforniaVerbalLearningTestDAST-20 DrugAbuseScreeningTestDE DependenceSymptomsDHEA-5 Dehydroepiandrosterone5mgDKEFS Delis-KaplanExecutiveFunctionSystemDMS(Cantab) DelayedMatchingtoSampleDSM-III-R DiagnosticandStatisticalManualofMentalDisordersIIIrevisedE2 EstradiolEFIT EmotionalfaceidentificationtaskEHI EdinburghhandednessinventoryEMO Emotionalgo/nogotaskEMQ Everydaymemoryquestionaire(Sunderlandetal.1983)EPI Echo-PlanarImagingEPIC EuropeanProspectiveInvestigationintoCancerandNutritionEPICEPAQ-2 EPICPhysicalActivityQuestionnaireERQ EmotionRegulationQuiestionnaireF-HAM FamilyhistoryassessmentmoduleFAB FrontalAssessementBatteryFCSRT FreeandCuedSelectiveRemindingTest(Buschke)FEAR FEARQuestionnaireFFQ FoodFrequencyQuestionnaireFraminghamCHD FraminghamCoronaryHeartDiseaseriskscoreFraminghamCVD FraminghamcardiovasculardiseaseriskscoreFTF FivetofifteenFTND theFagerströmTestforNicotineDependenceGAD GeneralizedAnxietyDisorderGDS GeriatricDepressionScale(Yesavage)GHQ GeneralHealthQuestionnaireGMS-A/B GeriatricMentalState(GMS),VersionA/B(Copelandetal.,1988)HADS HospitalAnxietyandDepressiveScaleHAMD HamiltonDepressionScaleHASitems HistoryandAetiologyScheduleHC HeadcoilHDRS HamiltonDepressionRatingScaleHiPIC HierarchicalPersonalityInventoryforChildrenHNC Head-neckcoilHSP HighlySensitivePersonHU HarmfulalcoholUseHVLT-R HopkinsVerbalLearningTest-RevisedIADL InstrumentalActivitiesofdailyLiving(Lawton&Brodfy1969)ICU InveotoryofCallous-UnemotionaltraitsIDS InventoryofdepressivesymptomatologyIPAQ InternationalPhysicalActivityQuestionaireIPAQ-S InternationalPhysicalActivityQuestionnaireshortversion2002IST-2000-R IntelligensStrukturTest2000RevisedJ-EPQ JuniorEysenckpersonalityquestionnaireJenskins JenkinsSleepQuestionnaireJLO JudgementofLineOrientationKSQ KarolinskaSleepQuestionnaireLOT-R LifeOrientation-RevisedLTE-Q ListofThreateningExperiencesquestionnaireMACA MacArthurstressreactivityquestionnaireMADRS Montgomery-AsbergDepressionRatingScaleMASQ MoodandAnxietySymptomQuestionnaireMB Multi-bandMDI MajordepressioninventoryMDQ MoodDisorderQuestionnaireMEMPR Multi-EchoMPRAGEMET MetabolicEquivalentTotalMFQ MemoryFunctioningQuestionnaire(MFQ)(Gilewski1990)MID MajordepressioninventoryMIDI MidlifeDevelopmentInventory(MIDI)ScaleMillHill MillHillvocabularyscaleMMSE MiniMentalStateExaminationMNA MiniNutritionalAssessmentMOCA MontrealCognitiveAssessmentMPRAGE Magnetization-PreparedRapidGradientEchoMTCF ModifiedTaylorComplexFigureTestN-back WorkingMemoryTestNA(VUMC) NegativeAffectNART NationalAdultReadingTestNeo-Pi-R NEOPersonalityInventory-RevisedNEO-FFI NeuroticismExtraversionOpennessFive-FactorInventoryNEPSY aneuropsychologicalassessmentinstrumentNEPSYVA NEPSY-VisualAttentionsubtestNPI NeuropsychiatricInventory(Cummings)PA PanicDisorderPA(VUMC) PositiveAffectPAL PairedAssociatedLearning(visualmemoryandlearning)CANTABPASE PhysicalActivityScalefortheElderlyPGCMS The Philadelphia Geriatric Center (PGC) Morale ScalePHQ-9 PreceivedHealthquestionnairePING PediatricImaging,Neurocognition,andGeneticsPSQI PittsburghSleepQualityIndexPSS PreceivedStressScalePSWQ Penn-StateWorryQuestionnaireultrabriefversionRAVLT ReyAuditoryVerbalLearningTestRCFT ReyComplexFigureTestRey-0 Rey–OsterriethcomplexfiguretestROCF Rey-OsterreichcomplexfigureRQ TheRelationshipQuestionnaire(Bartholomew&Horowitz,1991)RTI(CANTAB) CambridgeNeuropsychologicalTestAutomatedBatteryReactionTimetouchscreenversion

RVP RapidVisualInformationProcessing(CANTAB)SA(VUMC) SomaticArousalSCD-Q SubjectiveCognitiveDeclineQuestionnaire(Ramietal.,2014)SCID-I StructuredClinicalInterviewforDSM-IV-TRAxisIDis-ordersSCL-90 SymptomChecklist90itemsSDMT SymbolDigitModalitiesTestSDQ StrenghtanddifficultiesquestionaireSF-36 36-ItemShortFormHealthSurveSHBG SexHormoneBindingGlobulinSOC(CANTAB) StockingsofCambridgeSOEP GermanSocio-EconomicPanelStudy(SOEP)SPSRQ-CR SensitivitytoPunishmentandSensitivitytoRewardQuestionnaire-ChildRevisedSST(CANTAB) Stop-SignalTaskSTAI StateandTraitAnxietyInventorySTAI-C StateTraitAnxietyInventoryforChildrenSTW SpotthewordSWLS TheSatisfactionWithLifeScaleSWM(CANTAB) SpatialWorkingMemoryTCF TaylorComplexFigureTestTCI TemperamentandCharacterInventoryTFEQ ThreeFactorEatingQuestionnaireTMTA,B TrailMakingTestA,BTMT-A TrailMakingTestpartATMT-B TrailMakingTestpartBTOPF TestofPremorbidFunctioningTOT TipofTheTongueUCLA UCLAUniversityofCalifornia,LosAngeles)LonelinnessScaleUPSIT UniversityofPennsylvaniaSmellIdentificationTestVOSP VisualObjectandSpacePerceptionBatteryWAIS WechslerAdultIntelligenceScale

WAIS-IVDS,DCDigitSpan(DS)andCoding(DC)testsfromtheWechslerAdultIntelligenceScale-FourthEdition(WAIS-IV;

WASI WechslerAbbreviatedScaleofIntelligenceWHIIS Women’sHealthInitiativeInsomniaRatingScaleWHODAS WorldHealthOrganizationDisabilityAssessmentScheduleWISC WechslerIntelligenceScaleWMSIII WechslerMemoryScale-3rd edWPPSI WechslerPreschoolandPrimaryScaleofIntelligenceWQ WomensquestionnaireYoung YoungManiaRatingScale

AbbreviationsoftestandquestionnairesthathavebeenemployedinLifebrainstudiesAppendix 1

Lifebrain:overviewofthetotalnumberofuniqueparticipantsandobservations

Lifebrain Site UiO UmU UOXF VUMC MRC UCAM

Allstudies Study LCBC BetulaWhitehallIIImaging

BASE BASEII WAHAMSA_PS

PPD GABA iTBS CR HUBU LISA NESDA CamCAN CALM

Numberoftimepoints

3 3 1 8 2 3 1 3 1 1 1 12 1 6 3 1

12527Totalunique

subjects1677 376 800 516 2200 82 24 46 33 27 49 94 450 2981 2690 482

7327 Behaviouronly 39 25 516 1755 2680 2057 255

5200 MRI+Behavior 1638 376 775 445 82 24 46 33 27 49 94 450 301 633 227

27972 Totalobservations 2533 707 800 1402 2527 229 24 105 33 27 49 817 450 14860 2927 482

19873 Behaviouronly 39 25 1402 1755 52 60 14228 2057 255

8099 MRI+Behavior 2494 707 775 772 177 24 105 33 27 49 817 390 632 870 227

MPIB UB REGIONH

Appendix 2

390

90

7387

5140

subvar_seq

include Categories Variables Subvar

1 1 UiO UMU UOXF VUMC MRC UCAM

2 1 Study Study Studyname LCBC Betula: WhitehallII BASE BASE-II WAHA MSA_PSP PD GABA iTBS CR HUBU LISA NESDA CamCAN CALM

3 1 Study Study Timepoints 3 2 1 8 2 3 1 3 1 1 1 12 1 6 3 1

5 1 Study Study Dateofassessments 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

6 1 Study Study Timeofassessments 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

7 1 Study StudyInvestigatordoingthe

assessment1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

8 1 Study Subject Sex 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

9 0 Study Subject AgeRange(specify) Apr/92 25-85 60-84 70-95+24-40/61-

8163-80 38-81 36-81 60-79 61-83 48-89 Jul/22 62-70 18-74 18-102 5-18

10 1 Study Subject Birthdate 0 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0

11 1 Study Subject Birthmonthandyear 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1

12 1 Study Subject Birthyear 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1

13 1 Study Subject Calculatedage 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

1 1 Study Subject Generalinfomortality 0 0 0 1 1 0 0 0 0 0 0 0 0 1 0 0

2 1 Study Subject Dateofdeath 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Demographics Language Languageoftests(specify) Norwegian Swedish English German German Spanish Spanish Spanish Spanish Spanish Spanish Danish Danish Dutch English English

2 0 Demographics Language Mothertongue/native 1 1 1 0 1 1 0 1 0 0 0 1 1 0 1 1

3 0 Demographics Language assessedBilingual 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 1

4 0 Demographics Language assesedSecondlanguage 1 0 0 0 0 1 0 0 1 1 1 0 0 0 1 1

5 0 Demographics Languageaskedgenerallytolist"otherlanguagesspokenathome"

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

6 0 Demographics Language Basicethnicityinfo 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

7 0 Demographics Language CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1

8 0 Demographics LanguageCognitivereserveSolé-Padullés

etal.,20090 0 0 0 0 1 0 0 1 1 1 0 0 0 0 0

9 0 Demographics LanguageMayer,K.U.,Maas,I.,&Wagner,M.(1999).

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

10 0 Demographics Language witinMedicalhistory 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

11 0 Demographics Language ModifiedCAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

12 0 Demographics LanguageonlycheckedifEnglishismother

tounge0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

13 0 Demographics Languageunstructuredinterview(self

report)1 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0

14 0 Demographics Language In-housequestioinnaire 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0

1 0 Demographics Education Assessed 1 1 1 1 1 1 1 1 1 1 0 1 1 0 1 1

2 0 Demographics Education CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

5 0 Demographics Education ModifiedCAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

7 0 Demographics Education SOEP-questions 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

4 0 Demographics Education In-housequestionairre 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0

6 0 Demographics Educationunstructuredinterview(self

report)1 1 1 0 1 1 1 1 1 1 1 0 0 0 0 0

1 1 Demographics Subjecteducation Highestattained 1 1 1 1 1 1 0 0 1 1 1 0 1 1 1 0

2 1 Demographics SubjecteducationYearsofeducation(Full-

/Partime)1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 0

3 1 Demographics Subjecteducation Educationhistory 0 0 0 1 0 0 0 0 0 0 0 0 1 0 1 1

1 0 Demographics Partnereducation Highestattained 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0

2 0 Demographics Partnereducation Yearsofeducation 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

1 1 Demographics Mothereducation Highestattained 1 0 0 1 1 0 0 0 0 0 0 1 0 1 0 1

2 1 Demographics Mothereducation Yearsofeducation 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0

1 1 Demographics Fathereducation Highestattained 1 0 0 1 1 0 0 0 0 0 0 1 0 1 0 1

2 1 Demographics Fathereducation Yearsofeducation 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0

1 1 DemographicsParentaleducation(eitherfatheror

mother)Highestattained 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0

1 1 Demographics Guardianeducation Highestattained 1 0 0 1 0 0 0 0 0 0 0 1 0 1 0 1

2 1 Demographics Guardianeducation Yearsofeducation 1 0 0 1 0 0 0 0 0 0 0 1 0 1 0 0

1 0 Demographics Occupation Assessed 0 1 1 1 1 1 1 1 1 1 1 0 1 1 1 0

2 0 Demographics Occupation CC3000(Cascotcoded) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

6 0 Demographics Occupation ModifiedCAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

7 0 Demographics Occupation TIC–P 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

3 0 Demographics OccupationCognitivereservequestionnaire

(Solé-Padullés2009)0 0 0 0 0 1 0 0 1 1 1 0 0 0 0 0

4 0 Demographics OccupationDetailedcareerhistory

questionnaire(Cf.Mayeretal.,0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

5 0 Demographics Occupationin-house(Mayer,K.U.(1979).BeruflicheTätigkeit,berufliche

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

8 0 Demographics OccupationVariousstandardisedandnon-standardisedoccupational

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

9 0 Demographics Occupation Self-report 0 1 1 0 1 0 1 1 0 0 0 0 0 0 0 0

1 1 Demographics Subjectoccupation Current 0 1 1 1 1 0 1 1 1 1 1 0 1 1 1 0

2 1 Demographics Subjectoccupation Highestattained 0 1 0 1 1 1 1 1 1 1 1 0 1 0 0 0

3 1 Demographics Subjectoccupation Longest 0 0 0 1 0 0 0 0 0 0 0 0 1 0 1 0

4 1 Demographics Subjectoccupation Occupationhistory 0 0 1 1 0 0 0 0 0 0 0 0 1 1 0 0

1 0 Demographics Partneroccupation Current/Last 0 1 0 1 0 0 0 0 0 0 0 0 0 1 1 0

2 0 Demographics PartneroccupationHighestattained;before,immediatelyaftermariage

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

3 0 Demographics PartneroccupationLongest;duringmariageand

beforedevorce/death0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0

1 0 Demographics Parentoccupation OccupationMother 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

2 0 Demographics Parentoccupation Occupationfather 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

1 0 Demographics Gardianoccupation Occupationguardian 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Demographics HousingInfoontypeofhousing(e.g.private,public,appartment,

etc),residentalhistory1 1 0 1 1 0 0 0 0 0 0 0 0 1 1 0

2 0 Demographics HousingInfoongeographiclocation(e.g.

Largecity,smallcity,rural)0 1 0 1 1 0 0 0 0 0 0 1 0 1 0 0

3 0 Demographics Housing Householdcomposition 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

5 0 Demographics Housing Postalcode,combinedwithdutchgeo-data

0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 0 Demographics Housing CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

7 0 Demographics Housing diw_datadoc_2009-046.pdf 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

8 0 Demographics Housing In-house 1 1 0 1 1 0 0 0 0 0 0 1 0 0 0 0

1 0 Demographics Income assessed 1 0 0 1 1 1 0 1 0 0 0 1 1 1 1 0

2 1 Demographics Income Currency(specify) NOK 0 0 DM Euro Euro 0 Euro 0 0 0 DKK 0 Euro Sterling 0

3 1 Demographics Income Household(peryear,…) 1 0 0 1 1 1 0 1 0 0 0 1 0 1 1 0

5 0 Demographics Income Parents/Gardian(peryear,…) 1 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0

6 0 Demographics Income Partner(peryear,…) 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

7 0 Demographics Income Person(peryear,…) 1 0 0 1 1 0 0 0 0 0 0 1 0 0 0 0

9 0 Demographics Income CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

10 0 Demographics Income ModifiedCAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

11 0 Demographics Income in-houseQuestionairre 0 0 0 1 1 0 0 0 0 0 0 1 0 0 0 0

12 0 Demographics Income in-houseinterview 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

13 0 Demographics Incomeunstructuredinterview(self

report)1 0 0 0 0 1 0 1 0 0 0 0 0 1 0 0

1 0 Demographics Socialinformation Assessed 0 0 1 1 1 1 0 1 1 1 1 0 0 0 0 0

2 0 Demographics Socialinformation Champ-Qestionnaire 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

3 0 Demographics SocialinformationCognitivereservequestionnaire

(Sole-Padulles20090 0 0 0 0 1 0 1 1 1 1 0 0 0 0 0

5 0 Demographics Socialinformation LonelinessscaleRussel1984 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0

7 0 Demographics SocialinformationNumberofconfidants

(Antonucci)0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0

8 0 Demographics Socialinformation SOEP-Person-questionnaire 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

9 0 Demographics Socialinformation in-housestructuredinterview 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Demographics Socialinformation In-housequestionairre 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

10 0 Demographics Socialinformationunstructuredinterview(self

report)0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Demographics Maritalstatus assessed 0 1 1 1 1 1 0 1 0 0 0 0 1 1 1 0

1 Demographics Relationshipstatus assessed 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

1 0 Demographics FamilyInfoonfamily(e.g.#children,grandchildren,brothersand

sisters,…)1 1 0 1 1 1 0 1 0 0 0 1 0 1 1 0

1 0 Demographics Network InfoonSocialnetwork 0 1 0 1 1 1 0 1 0 0 0 0 0 1 1 0

1 0 Demographics Other InfoonHobbies 0 1 0 1 1 1 0 1 1 1 1 1 0 0 1 0

2 0 Demographics Other InfoonActivities 0 1 1 1 1 1 0 1 1 1 1 1 0 1 1 0

3 0 Demographics Other Lifeevents 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Demographics Worklife/satisfaction Assessed 0 0 0 1 1 0 0 0 0 0 0 0 0 1 0 0

2 0 Demographics Worklife/satisfaction Karasekquestionire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

4 0 Demographics Worklife/satisfaction PGCMS(15items)andothers 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

5 0 Demographics Worklife/satisfaction SWLS 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

Demographics Worklife/satisfaction wellbeing,loneliness 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

6 0 Demographics Worklife/satisfaction in-houseQuestionairre 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Physicalmeasures Weight Measured 1 1 0 1 1 1 0 1 0 0 0 1 1 1 1 1

2 1 Physicalmeasures Weightunstructuredinterview(self

report)0 0 1 1 1 1 0 0 0 0 0 0 0 1 1 1

1 1 Physicalmeasures Weightatbirth Fromrecords 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 1 Physicalmeasures Weightatbirthunstructuredinterview(self

report)0 1 0 0 1 1 0 1 0 0 0 0 0 0 1

1 1 Physicalmeasures Height Measured 1 1 0 1 1 1 0 1 0 0 0 1 1 1 1 1

2 1 Physicalmeasures Heightunstructuredinterview(self

report)0 0 1 1 1 0 0 0 0 0 0 0 0 0 1 1

1 1 Physicalmeasures Gripstrength Tested 0 1 0 1 1 0 0 0 0 0 0 0 0 1 0 0

2 1 Physicalmeasures Gripstrength Dynamometer 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

3 1 Physicalmeasures Gripstrength Hand-dynamometer 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 1 Physicalmeasures Gripstrength Jamardynamometer 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 1 Physicalmeasures Gripstrength Standardizeddynametry 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Physicalmeasures Waistcircumference Measured 0 1 0 1 1 1 0 1 0 0 0 0 0 1 0 0

1 1 Physicalmeasures Bloodpressure Measured 1 1 1 1 1 1 0 1 0 0 0 0 0 1 1 0

2 1 Physicalmeasures BloodpressureLeft/rightarmwhilesitting,liyng

&standing(TP1)0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

3 1 Physicalmeasures BloodpressureLying;sitting;standingsyst/diast.

mmHG0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

5 1 Physicalmeasures BloodpressureSittingafter1hrmentalexercise.averageof2readings.rightarm

0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

7 1 Physicalmeasures Bloodpressure supinerest 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

1 Physicalmeasures Bloodpressurerest5minutes:sittingdown,

rightarm,averageof30 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

1 Physicalmeasures Bloodpressure Sitting,1minuterest 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

1 Physicalmeasures Bloodpressurebloodpressuremonitor(lying,standing,standingafter3min)

0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

8 1 Physicalmeasures Bloodpressuresittingdown,withautomated

machine1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

1 1 Physicalmeasures Handedness Measured 0 0 1 0 1 1 1 1 1 1 1 1 1 1 1 0

2 1 Physicalmeasures HandednessBiggs1975self-report

questionnaire0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

3 1 Physicalmeasures Handedness Descriptionoflaterilazation 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 1 Physicalmeasures HandednessEdinburghHandedness

Inventory0 0 0 0 0 0 0 0 1 0 0 1 1 1 1 0

7 1 Physicalmeasures Handedness in-houseQuestionairre 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

5 1 Physicalmeasures Handednessunstructuredinterview(self

report)1 1 0 1 0 1 1 1 0 1 1 0 0 1 0 0

1 0 Physicalmeasures Dexterity Tested 0 0 1 1 1 0 0 0 0 0 0 1 0 0 0 0

2 0 Physicalmeasures Dexterity BalanceandGaittest 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

3 0 Physicalmeasures DexterityBiggs1975self-report

questionnaire0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Physicalmeasures DexterityHandcoordination-circle

drawing0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

5 0 Physicalmeasures Dexterity Pegboard 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

6 0 Physicalmeasures DexterityReitanTrailMaking,Complex

Figures0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Physicalmeasures Hearing Tested 0 1 0 1 1 0 0 0 0 0 0 0 0 0 1 0

2 0 Physicalmeasures Hearing Audiogram 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 0 Physicalmeasures HearingAudioMesterPA444’/Company:Hortmann

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

4 0 Physicalmeasures Hearing FiveMinuteHearingTest 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

5 0 Physicalmeasures HearingHearingHandicapInventoryfor

theElderly0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

6 0 Physicalmeasures HearingHearingthresholdlevel;

audiometry,frequencesfrom0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

7 0 Physicalmeasures Hearing OldenburgerInventar 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

8 0 Physicalmeasures HearingPuretonehearingthreshold(0.5

-2.0kHz;3.0-8.0kHz)0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

9 0 Physicalmeasures Hearing Siemen'sHearcheckScreener 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

10 0 Physicalmeasures Hearingunstructuredinterview(self

report)0 0 0 1 1 0 0 0 0 0 0 0 0 0 1 0

1 0 Physicalmeasures Vision Tested 0 1 0 1 1 0 0 0 0 0 0 1 0 0 1 0

2 0 Physicalmeasures Vision;acuity CC3000Snellen 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

3 0 Physicalmeasures Vision;acuityIfppcouldreadonaboardfrom

3and5meters0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Physicalmeasures Vision;acuityReadingchart/distancechart:

Snellenchartscore0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

5 0 Physicalmeasures Vision;colourColourblindnessselfreported

onVSTM0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

6 0 Physicalmeasures Vision;colour Colourtestreported 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0

7 0 Physicalmeasures Vision;colour Colourvision 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

8 0 Physicalmeasures Vision;other InfoonGlasses/contactlenses 0 1 0 1 0 0 0 0 0 0 0 0 0 0 1 0

9 0 Physicalmeasures Vision;otherInfoonGlasses/contactlenses

strenghts0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

10 0 Physicalmeasures Vision;otherNationalEyeInstituteVisionalFunctioningQuestionnaire–25

(VFQ-25)0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

11 0 Physicalmeasures Vision;otherOnlynotedifaffectedtest

performance0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

12 0 Physicalmeasures Vision;otherunstructuredinterview(self

report)0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0

1 0 Physicalmeasures Chairrise Measured 0 0 0 1 1 0 0 0 0 0 0 0 0 0 1 0

3 0 Physicalmeasures Chairrise 4-MeterGehstreckentest 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

4 0 Physicalmeasures Chairrise Timedup&goTest 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

5 0 Physicalmeasures Chairrise Tinetti 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

6 0 Physicalmeasures Chairrise in-housetest 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

1 0 Physicalmeasures Gaitassessment Measured 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0

2 0 Physicalmeasures Gaitassessment 4-MeterGehstreckentest 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

4 0 Physicalmeasures Gaitassessment Experimentaldevice 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

5 0 Physicalmeasures Gaitassessment Timedup&goTest 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

6 0 Physicalmeasures Gaitassessment Tinetti 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

1 0 Physicalmeasures Lungfunction Measured 0 0 0 1 1 0 0 0 0 0 0 0 0 1 0 0

2 0 Physicalmeasures Lungfunction Diagnostic&measurement 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

3 0 Physicalmeasures Lungfunction Peakflow 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

1 0 Physicalmeasures Hipcircumference Measured 0 1 0 1 1 0 0 0 0 0 0 0 0 1 0 0

1 0 Physicalmeasures Footdominence Tested 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

2 0 Physicalmeasures Footdominence CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

1 0 Physicalmeasures Bodycomposition(fat,muscle)

Tested 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Physicalmeasures Bodycomposition(fat,muscle)

Impedance(InBody,Adultsonly) 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 HealthQs ADLActivitiesofDailyLiving

Measured 0 0 0 1 1 0 1 1 0 0 0 1 0 1 1 0


ADL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0


Baltes,M.M.,Maas,I.,Wilms,H.-U.,Borchelt,M.,&Little,T.D.

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0


Barthel-Indexplus2IADLitemsfromLawton&Brody

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0


IADL 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0


WHODASquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0


Yesterday-Interview&BASEActivitityQuestionnaire

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0


In-housePhysicalactivity(childandparent)

0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0


in-houseinterview 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0


unstructuredinterview(selfreport)

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

1 1 HealthQs Alcohol Measured 1 1 0 1 1 1 0 0 1 1 1 1 1 1 1 0

2 1 HealthQs Alcohol Auditquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

3 1 HealthQs Alcohol CAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

4 1 HealthQs Alcohol CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

5 1 HealthQs Alcohol CDDR+otherquestionnairesputtogether

0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

6 1 HealthQs Alcohol CIDI 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

7 1 HealthQs Alcohol DependenceidentifiedbySCID-IandCAGE

0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

8 1 HealthQs Alcohol GMS-A/-B 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

10 1 HealthQs Alcohol Mediterraneandietquestiostionnaire

0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

12 1 HealthQs Alcohol in-housestructuredinterview 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

11 1 HealthQs Alcohol in-housequestionnaire 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0

13 1 HealthQs Alcoholunstructuredinterview(self

report)1 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0

1 1 HealthQs Smoking Measured 1 1 1 1 1 1 0 1 0 0 0 1 1 1 1 0

2 1 HealthQs Smoking CAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

3 1 HealthQs Smoking CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

4 1 HealthQs Smoking CDDR+otherquestionnairesputtogether

0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

5 1 HealthQs Smoking FagerstromTestforNicotineDependence(FTND)

0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 1 HealthQs Smoking In-housequestionnaire 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

7 1 HealthQs Smoking in-housestructuredinterview 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

8 1 HealthQs Smokingunstructuredinterview(self

report)1 1 1 0 0 1 0 1 0 0 0 0 0 0 0 0

1 1 HealthQs Substanceuse Measured 0 1 1 1 1 0 0 0 0 0 0 1 0 1 1 0

2 1 HealthQs SubstanceuseCDDR+otherquestionnairesput

together0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

3 1 HealthQs Substanceuse DAST-20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

4 1 HealthQs Substanceuse GMS-A 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

5 1 HealthQs Substanceuse Softandharddruguse 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 1 HealthQs Substanceuse in-housestructuredinterview 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

7 1 HealthQs Substanceuseunstructuredinterview(self

report)0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0

1 1 HealthQs Physicalactivity measured 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 0

2 1 HealthQs Physicalactivityfrequencyandduration

reportedfor3intensitylevelsof0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 1 HealthQs Physicalactivity BaeckeIndex 0 0 0 0 1 1 0 1 0 0 0 0 0 0 0 0

4 1 HealthQs Physicalactivity CHAMPS 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

5 1 HealthQs Physicalactivity EPICEPAQ-2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

8 1 HealthQs Physicalactivity IPAQ 1 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0

9 1 HealthQs Physicalactivity Medicalinterview 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

10 1 HealthQs PhysicalactivityMetabolicEquivalentofTask

(MET)0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

11 1 HealthQs Physicalactivity ModifiedMinnesotascale 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

12 1 HealthQs Physicalactivity PASE 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

14 1 HealthQs PhysicalactivityCognitivereservequestionnaire

(Sole-Padulles2009)0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0

16 1 HealthQs Physicalactivity Self-reportquestionnaire 0 1 1 1 1 0 0 0 0 0 0 0 1 0 0 0

17 1 HealthQs PhysicalactivityWalking,cycling,sedentary

activity0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

6 1 HealthQs Physicalactivity In-housequestionnaire 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0

1 1 HealthQs Medication Infoonmedicationuse 1 1 1 1 1 1 0 1 1 1 0 0 1 1 1 1

2 1 HealthQs Medication In-housequestionnaire 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

3 1 HealthQs Medication GMS-A 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

4 1 HealthQs Medication Infoontypesofmedication 0 1 1 1 1 1 0 1 0 1 0 0 1 1 1 0

5 1 HealthQs Medication Medicalinterview 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

6 1 HealthQs Medication Medicationhistory 0 0 1 1 1 0 0 0 0 0 0 0 0 1 1 0

7 1 HealthQs Medication MedicationinformationrecordedforchildrenwithADHD

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

8 1 HealthQs MedicationMedicationuseaccordingtoATCcodes,frequencyand

0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

9 1 HealthQs Medication in-houseQuestionairre 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

10 1 HealthQs Medicationunstructuredinterview(self

report)1 1 1 0 1 1 0 1 1 1 0 0 1 0 0 0

1 1 HealthQs Sleep Measured 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 0

2 1 HealthQs Sleep CAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

3 1 HealthQs Sleep In-house,sleepnightbefore 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

4 1 HealthQs Sleep In-house,basedonSpiegel,1981

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

5 1 HealthQs Sleep InsomniaratingScale 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 1 HealthQs Sleep Jenkins 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

7 1 HealthQs Sleep KarolinskaSleepQuestionnaire 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

8 1 HealthQs Sleep Pittsburgsleepinventory(childandparents)

0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

9 1 HealthQs Sleep PSQI 1 0 1 0 0 1 0 1 1 1 0 0 0 0 1 0

10 1 HealthQs Sleep Sleepduration 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

11 1 HealthQs Sleep in-houseQuestionairre 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

12 1 HealthQs Sleep in-housestructuredinterview 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

13 1 HealthQs Sleepunstructuredinterview(self

report)0 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0

1 0 HealthQs Diet Assessed 0 0 0 1 1 1 0 0 1 1 1 0 1 1 1 0

2 0 HealthQs Diet (Typesof)calorieintake 0 0 0 1 0 1 0 0 0 0 0 0 0 1 1 0

3 0 HealthQs Diet Bodyimage 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

4 0 HealthQs Diet CAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

5 0 HealthQs Diet CC3000foodconsumed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

6 0 HealthQs Diet Detailedinfoondietaryhabits 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

7 0 HealthQs Diet EPICquestionnaire 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

8 0 HealthQs Diet FFQ 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

9 0 HealthQs DietFoodfrequencylist(7days

protocol)0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

10 0 HealthQs Diet In-housenutritionquestionnaire 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

11 0 HealthQs DietMediterraneandietadherence:

Schroder20140 0 0 0 0 1 0 0 1 1 1 0 0 0 0 0

12 0 HealthQs DietMNA(MiniNutritional

Assessment)0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

DetailedoverviewofthedataavailableinLifebrain

Site

MPIB UB REGIOH

Appendix 3.1

4-93 7.5-21.5

subvar_seq





1 0 Mentalhealth Attachmentstyle Measured 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0

2 0 Mentalhealth AttachmentstyleChildandparentSocialdominanceorientation+

0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

3 0 Mentalhealth AttachmentstyleParentalBondingInventory,Interpersonalrelationships

0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

1 1 Mentalhealth Anxiety Assessed 1 1 1 1 0 0 0 1 0 1 1 1 1 1 1 1

2 1 Mentalhealth Anxiety STAI-C 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

3 1 Mentalhealth Anxiety ASI 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

4 1 Mentalhealth Anxiety BAI 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

5 1 Mentalhealth Anxiety BPRS 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

6 1 Mentalhealth Anxiety CAMBquest 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

7 1 Mentalhealth Anxiety CIDI 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

10 1 Mentalhealth Anxiety FEAR 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

11 1 Mentalhealth Anxiety GHQ 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

12 1 Mentalhealth Anxiety GMS-A 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

13 1 Mentalhealth Anxiety HADS 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0

14 1 Mentalhealth Anxiety NPI 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

15 1 Mentalhealth AnxietyRevisedChildren’sAnxietyandDepressionScale-25(Chorpitaet

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

16 1 Mentalhealth Anxiety SCL-90 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

17 1 Mentalhealth Anxiety SDQ 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

18 1 Mentalhealth Anxiety STAI 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

9 1 Mentalhealth Anxiety Everbeentoldbyadoctor? 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

19 1 Mentalhealth Anxietyunstructuredinterview(self

report)0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Mentalhealth Worry Measured 0 0 1 ? 0 0 0 0 0 0 0 0 0 1 0 1

3 0 Mentalhealth Worry PennStateWorryQuestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

4 0 Mentalhealth Worry PSWQ 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

5 0 Mentalhealth WorryRevisedChildren’sAnxietyandDepressionScale-25,childself-

reportandparentreport0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

1 1 Mentalhealth Depression/mood Measured 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1

2 1 Mentalhealth Depression/mood ApathyScale(SergioStarkstein) 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0

3 1 Mentalhealth Depression/mood BDI 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

4 1 Mentalhealth Depression/mood BSI 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

5 1 Mentalhealth Depression/mood CAMBquest 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

6 1 Mentalhealth Depression/mood CES-D 0 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0

7 1 Mentalhealth Depression/mood CIDI 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

8 1 Mentalhealth Depression/mood CIS-R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

9 1 Mentalhealth Depression/mood DSM-III-R 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

11 1 Mentalhealth Depression/mood GDS 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0

12 1 Mentalhealth Depression/mood GHQ 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

13 1 Mentalhealth Depression/mood HADS 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0

14 1 Mentalhealth Depression/mood HAMD 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0

15 1 Mentalhealth Depression/mood HDRS 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

16 1 Mentalhealth Depression/mood IDS 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

17 1 Mentalhealth Depression/mood MADRS(fmrisampleonly) 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

18 1 Mentalhealth Depression/mood MASQ 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

19 1 Mentalhealth Depression/mood MDI 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

20 1 Mentalhealth Depression/mood MDQ 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0

21 1 Mentalhealth Depression/mood PGCMS 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

22 1 Mentalhealth Depression/mood PHQ-9 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

23 1 Mentalhealth Depression/moodRevisedChildren’sAnxietyandDepressionScale-25,childself-

reportandparentreport0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

24 1 Mentalhealth Depression/mood SCID-I 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

25 1 Mentalhealth Depression/mood SDQ 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

28 1 Mentalhealth Depression/mood Young 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

26 1 Mentalhealth Depression/mood in-housestructuredinterview 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

10 1 Mentalhealth Depression/mood Everbeentoldbyadoctor? 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

27 1 Mentalhealth Depression/moodunstructuredinterview(self

report)0 1 1 0 0 0 0 0 0 0 0 0 1 0 0 0

1 0 Mentalhealth Phobias Assessed 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0

2 0 Mentalhealth Phobias CIDI,SocPhob,Agora,GAD,PA 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

3 0 Mentalhealth Phobias CIS-R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Mentalhealth Phobias GMS-A 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Mentalhealth Sleepproblems/fatigue

Assessed 0 0 0 1 0 0 0 0 0 0 0 0 0 1 1 1


InsomniaratingScale 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0


PSQI 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0


RevisedChildren’sAnxietyandDepressionScale-25(Chorpitaet

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1


in-housestructuredinterview 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Mentalhealth Somaticsymptoms Assessed 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0

2 0 Mentalhealth Somaticsymptoms CIS-R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 0 Mentalhealth SomaticsymptomsComplaintList(vonZerssen,

1990)0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Mentalhealth SomaticsymptomsPresenceof20diseases,GP

records,4DKL,migraine,chronic0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

1 0 Mentalhealth Childhoodtrauma Measured 0 0 0 0 1 0 0 0 0 0 0 0 1 1 0 0

2 0 Mentalhealth Childhoodtrauma CAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

3 0 Mentalhealth ChildhoodtraumaChildhoodTraumaQuestionnaire

0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

4 0 Mentalhealth Childhoodtrauma NEMESISquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

5 0 Mentalhealth Childhoodtrauma in-housestructuredinterview 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 0 Mentalhealth Childhoodtraumaunstructuredinterview(self

report)0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

7 0 Mentalhealth Childhoodtrauma Warexperiences/SOEP 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

1 1 MentalhealthMemoryself-

assessment/Everydaymemory

Assessed 1 1 0 1 1 1 1 1 1 0 0 0 0 1 1 0



10MemorySelf-ReportQuestions

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0



CDQ 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0



Clinicalinterview 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0



Doyouhaveanycognitive/memorycomplaint?

Yes/Noitem0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0



EMQ 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0



GMS-A 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0



MFQ 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0



SCD-Q 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0



Selfreportedand/orobserved 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0



subjectivememorycomplaints(FrankJessen)

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0




0 1 0 0 0 0 1 1 0 0 0 0 0 0 1 0

1 0 Mentalhealth Diagnosis Assessed 0 0 0 1 1 0 0 0 0 0 0 0 0 1 1 1

2 0 Mentalhealth Diagnosis basedonself-report 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 0 Mentalhealth DiagnosisCaseReportForm(CRF)istthewholemedicalexamination,

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

4 0 Mentalhealth DiagnosisCC3000,specificdiagnosesenquiredabout:bipolar

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

5 0 Mentalhealth DiagnosisCIDI(onlymood,bipolar,

anxiety,alcohol.)0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 0 Mentalhealth Diagnosis DSM-3 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

7 0 Mentalhealth Diagnosis DSM-4-5 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 1

8 0 Mentalhealth Diagnosis ICD-10 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

9 0 Mentalhealth Diagnosis ICD-10(basedonselfreport) 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

10 0 Mentalhealth Diagnosis ICD-9 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

11 0 Mentalhealth DiagnosisReportedbyprofessionals

referringchildrentotheCALM0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

12 0 Mentalhealth Diagnosis SCID-I 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

13 0 Mentalhealth Diagnosisin-house

questionairre/interview0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

14 0 Mentalhealth Diagnosisunstructuredinterview(self

report)0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Mentalhealth Stress Assessed 0 1 1 0 1 0 0 0 0 0 0 1 1 1 0 0

2 1 Mentalhealth Stress"Howmuchstressinthepast4

weeks?"0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 1 Mentalhealth Stress 4DSQ 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

4 1 Mentalhealth Stress Brughaquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

5 1 Mentalhealth Stress CASE 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

6 1 Mentalhealth StressTICS(TrierInventoryforChronic

Stress)0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

7 1 Mentalhealth Stress DailyHasslesquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

8 1 Mentalhealth Stress MACA 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

9 1 Mentalhealth StressPerceivedstress(PerceivedStressScale,PSS)(Cohen,

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

10 1 Mentalhealth Stress PSQ 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

11 1 Mentalhealth Stress SCL-90 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

12 1 Mentalhealth StressUnstructuredinterview(self

report)0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Mentalhealth Lifeevents/experiences

Assessed 1 1 1 0 1 0 0 0 0 0 0 1 0 1 1 0


monthsbetween 30 6 3-5 0 0 0 0 0 0 0 0 12 0 12 lifetime 0


Lifetime 1 1 1 0 1 0 0 0 0 0 0 1 0 1 1 0


FTF 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0


In-housefamilyhistory 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1


Last12monthsCASE 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0


Lifeevents 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0


Lifeevents(Brown&Harris,1989;Holmes&Rahe,1967;

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0


LTE-Q 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0


NEMESISquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0


Parent-reportedCASEmadeintolifetime

0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0


TheLifetimeofExperiencesQuestionnaire

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0



0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Mentalhealth Socialcontact Measured 1 1 0 1 1 1 0 1 1 1 1 1 0 1 1 0

2 0 Mentalhealth Socialcontact ASEBA 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Mentalhealth Socialcontact Cognitivereservequestionnaire 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

5 0 Mentalhealth Socialcontact Lonelinessscale 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

6 0 Mentalhealth SocialcontactNumberofconfidants

(Antonucci)0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

7 0 Mentalhealth SocialcontactRelationshipquestionnaire-

peersandfamily0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

8 0 Mentalhealth Socialcontact Socialactivities&socialsupport 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

9 0 Mentalhealth SocialcontactSocialcontactsquestionsdevelopedbyValenzuela

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

10 0 Mentalhealth Socialcontact Socialdominanceorientation 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

11 0 Mentalhealth SocialcontactSocialNetworksinAdultLife

Questionnaire0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

12 0 Mentalhealth Socialcontact in-housestructuredinterview 0 0 0 1 0 0 0 1 1 1 1 0 0 0 0 0

13 0 Mentalhealth Socialcontactunstructuredinterview(self

report)0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Mentalhealth Retirement Assessed 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0

2 0 Mentalhealth Retirement in-houseQuestionairre 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 0 Mentalhealth RetirementWithinquestionnaireonoccupationalcareer

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Mentalhealth Qualityoflife Assessed 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0

2 0 Mentalhealth QualityoflifeSatifactionwithLifeScale(Pavot&Diener,1993),

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

4 0 Mentalhealth Qualityoflife PGCMS 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

5 0 Mentalhealth Qualityoflifeunstructuredinterview(self

report)0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Mentalhealth Personality Measured 1 0 1 1 1 0 0 0 0 1 1 1 1 1 0 0

2 1 Mentalhealth Personality BAS 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

4 1 Mentalhealth Personality BIS 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

5 1 Mentalhealth Personality BIS-11 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

6 1 Mentalhealth Personality HiPIC 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

9 1 Mentalhealth Personality J-EPQ 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

10 1 Mentalhealth Personality LOT-R 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

11 1 Mentalhealth Personality MIDI 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

12 1 Mentalhealth Personality NEO 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

13 1 Mentalhealth Personality NEO-FFI 0 0 0 0 0 0 0 0 0 1 1 0 1 1 0 0

14 1 Mentalhealth Personality NEO-P-R 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 1 Mentalhealth Personality Bigfive 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

15 1 Mentalhealth Personalitynumerousotheraspectsoftheselfandpersonality:cf.Smith,J.,

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

16 1 Mentalhealth Personality SDQ 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

20 1 Mentalhealth Personality TCI 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

1 1 Mentalhealth MMSEMiniMentalStateExamination

Assessed 1 1 0 1 1 1 1 1 1 1 1 0 0 0 1 0

1 0 Mentalhealth PsychiatricFamilyhistory

Measured 0 0 1 1 1 0 0 0 0 0 0 1 0 1 0 0


CaseReportForm(CRF)istthewholemedicalexamination,

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0


F-HAM 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0


Familyhistoryofdementias 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0


Familytreeinventory 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0


HAS-Items 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0


PING 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0



0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 Mentalhealth Behavioraldisturbances

Measured 1 0 0 0 0 0 1 1 0 0 0 1 0 0 0 1


BRIEF 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1


ERQ 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0


NPI 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0


Questionnaireoncontrolbeliefs(cf.Smith&Baltes,1999)

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0


Questionnaireoncopingstyles(in-house;Smith&Baltes,1999)

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0


Self-perceivedefficacy 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 1 Mentalhealth physicalExamination Performed 0 1 1 1 1 1 1 1 0 0 0 0 1 1 0 0

2 1 Mentalhealth physicalExamination CAMBquestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

3 1 Mentalhealth physicalExaminationCaseReportForm(CRF)istthewholemedicalexamination,

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

4 1 Mentalhealth physicalExamination CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

5 1 Mentalhealth physicalExamination FraminghamCHD 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

6 1 Mentalhealth physicalExamination FraminghamCVD 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

7 1 Mentalhealth physicalExamination FraminghamStrokeRiskScore 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

9 1 Mentalhealth physicalExamination Infooncardiovasculardisease 0 1 1 1 1 1 0 0 0 0 0 0 1 1 1 0

10 1 Mentalhealth physicalExamination Infoondiabetes 0 1 1 1 1 1 0 1 1 0 0 0 1 1 1 0

11 1 Mentalhealth physicalExamination Infoongeneralhealth 0 1 1 1 1 1 0 0 1 1 0 0 1 1 1 0

12 1 Mentalhealth physicalExamination infoonLongstandingillness 0 1 1 1 1 0 0 0 1 1 0 0 0 1 1 0

13 1 Mentalhealth physicalExaminationInfoonmedication(HTA,diabetes,dyslipmeia)

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

14 1 Mentalhealth physicalExamination InfoonSicknessabsence 0 1 0 1 1 0 0 0 1 1 0 0 0 1 1 0

15 1 Mentalhealth physicalExamination Infoonstroke 0 1 1 1 1 1 0 1 1 1 0 0 0 1 1 0

16 1 Mentalhealth physicalExamination InfoonVascularriskfactors 0 1 1 1 1 1 0 1 1 1 0 0 0 1 1 0

17 1 Mentalhealth physicalExamination Medicalassessment 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

18 1 Mentalhealth physicalExamination PASE 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

1 Mentalhealth physicalExamination VisitwithNeuropsychologist 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

23 1 Mentalhealth physicalExaminationVisitwithdoctor+Clinical

records0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0

8 1 Mentalhealth physicalExaminationIn-house(Steinhagen-Thiessen,

E.,&Borchelt,M.(1999).0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

21 1 Mentalhealth physicalExamination Inhousestructuredinterview 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

22 1 Mentalhealth physicalExaminationunstructuredinterview(self

report)1 1 0 0 0 1 0 1 1 1 0 0 1 0 0 0

19 1 Mentalhealth physicalExamination In-housequestionnaire 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

1 0 Mentalhealth Women'shealth Assessed 0 1 0 1 1 0 0 0 0 0 0 1 0 1 1 0

2 0 Mentalhealth Women'shealth CAMBquest 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 0 Mentalhealth Women'shealth CC3000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

4 0 Mentalhealth Women'shealth Children 0 1 0 1 1 0 0 0 0 0 0 0 0 1 1 0

5 0 Mentalhealth Women'shealth Contraceptivepill 0 1 0 0 0 0 0 0 0 0 0 1 0 1 0 0

6 0 Mentalhealth Women'shealth Femalesexhormone 0 1 0 0 1 0 0 0 0 0 0 1 0 1 0 0

7 0 Mentalhealth Women'shealth In-house 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

8 0 Mentalhealth Women'shealth Menopause 0 1 0 0 1 0 0 0 0 0 0 0 0 1 1 0

9 0 Mentalhealth Women'shealthOnlyforthefemaleMR-subsample,questionson

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

10 0 Mentalhealth Women'shealthQuestionintheform"Formulär

1",notintheWQ-form0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

11 0 Mentalhealth Women'shealthunstructuredinterview(self

report)0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

13 0 Mentalhealth Women'shealthWithinmedicalanamnesis(Incl.infoonmenarche,pregnancies,

0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

14 0 Mentalhealth Women'shealthWomensQuestionnaire(created

withinBetula)0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0


Site

MPIB UB REGIOH

Appendix 3.2

subvar_seq





1 1 CognitiveTests IQorequivalent Measured 1 0 1 1 1 1 1 1 1 1 1 0 1 0 1 1

2 1 CognitiveTests IQorequivalent Vocabulary(WAIS/WAIS-III) 0 0 0 0 0 1 1 1 1 1 1 1 0 0 0 0

1 CognitiveTests IQorequivalent VocabularyWISC 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

18 1 CognitiveTests IQorequivalent Vocabulary(WASI/WPPSI) 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 1 CognitiveTests IQorequivalent BASECog:g-score 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

4 1 CognitiveTests IQorequivalent BlockDesign(WASI/WPPSI) 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

5 1 CognitiveTests IQorequivalent BlocksWAIS 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

1 CognitiveTests IQorequivalent BlocksWISC 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

6 1 CognitiveTests IQorequivalent Cattell 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

7 1 CognitiveTests IQorequivalentCompositescoresusedto

estimateg0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

8 1 CognitiveTests IQorequivalent IST-2000-R 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

9 1 CognitiveTests IQorequivalent Matrix(WASI/WPPSI) 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

10 1 CognitiveTests IQorequivalentMatrixReasoning,WASI

(WechslerAbbreviatedScaleof0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

11 1 CognitiveTests IQorequivalent NART 0 0 0 0 0 1 0 0 1 1 0 0 0 0 0 0

12 1 CognitiveTests IQorequivalentPracticalproblems,figuralanalogies,letterseries(fluid

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

13 1 CognitiveTests IQorequivalent Similarities(WAIS) 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0

14 1 CognitiveTests IQorequivalent Similarities(WASI/WPPSI) 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

15 1 CognitiveTests IQorequivalent SpotTheWord 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

16 1 CognitiveTests IQorequivalent TOPF 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 CognitiveTests Attention Measured 1 1 1 0 0 1 1 1 1 1 1 1 0 1 0 1

2 0 CognitiveTests Attention Antisaccade 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 0 CognitiveTests Attention ANT 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 0 CognitiveTests AttentionBalloonsHunt,TestofEverydayAttentionforChildren2(Manly,

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

5 0 CognitiveTests AttentionBarking,TestofEveryday

AttentionforChildren2(Manly,0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

6 0 CognitiveTests Attention CPT 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

7 0 CognitiveTests Attention Exogenecuingtask 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

8 0 CognitiveTests AttentionHectorCancellation,Testof

EverydayAttentionforChildren0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

9 0 CognitiveTests Attention Memory+distraction 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

10 0 CognitiveTests AttentionRed,Blues,BagsandShoes,Test

ofEverydayAttentionfor0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

12 0 CognitiveTests AttentionSimpleReactionTime,TestofEverydayAttentionforChildren

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

13 0 CognitiveTests Attention TMT-A 0 0 1 0 0 1 1 1 1 1 1 0 0 0 0 0

14 0 CognitiveTests Attention TMT-B 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

15 0 CognitiveTests AttentionVigil,TestofEverydayAttentionforChildren2(Manly,etal.,

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

1 1 CognitiveTests Workingmemory Measured 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1

2 1 CognitiveTests Workingmemory Plus-Minus 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

3 1 CognitiveTests WorkingmemorySpatialspan(WechslerMemory

Scale)0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

4 1 CognitiveTests Workingmemory AutomatedWorkingMemoryAssessment(Alloway,2007)

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

5 1 CognitiveTests Workingmemory BASECog:memory 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

6 1 CognitiveTests Workingmemory Coding(DC)(WAIS-IV) 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

7 1 CognitiveTests Workingmemory DigitRecall 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

8 1 CognitiveTests Workingmemory DigitRecallBackward 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

9 1 CognitiveTests Workingmemory DigitRecall,AutomatedWorkingMemoryAssessment(Alloway,

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

10 1 CognitiveTests Workingmemory DigitSpan(DS) 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

11 1 CognitiveTests Workingmemory DigitSpan(DS)(WAIS-IV) 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

12 1 CognitiveTests WorkingmemoryDigitspanbackward

(WISC/WASI)1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

13 1 CognitiveTests Workingmemory Digitspanforward(WISC/WASI) 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

14 1 CognitiveTests Workingmemory Digitsbackwards(WAIS) 0 0 0 0 0 1 1 1 0 1 1 0 0 0 0 0

15 1 CognitiveTests WorkingmemoryDotMatrix,AutomatedWorkingMemoryAssessment(Alloway,2007)

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

16 1 CognitiveTests Workingmemory In-houseVisualShort-TermMemory

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

17 1 CognitiveTests Workingmemory Letterdigitsubstitution 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

18 1 CognitiveTests Workingmemory Letterupdating 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

19 1 CognitiveTests WorkingmemoryMentalcontrol(Wechsler

MemoryScale)0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

20 1 CognitiveTests WorkingmemoryMrX,AutomatedWorkingMemoryAssessment(Alloway,2007)

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

21 1 CognitiveTests Workingmemory N-back 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

22 1 CognitiveTests Workingmemory N-Back(2-back) 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

23 1 CognitiveTests Workingmemory N-Back(number) 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

24 1 CognitiveTests Workingmemory Spatialspanforward(WISC/WASI)

1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

25 1 CognitiveTests Workingmemory Spatialupdating 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

26 1 CognitiveTests Workingmemory SpatialworkingmemoryCANTAB

0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0

27 1 CognitiveTests Workingmemory Workingmemory(card-sorting) 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 CognitiveTests Executivefunction Measured 1 0 1 1 1 1 1 1 1 1 1 1 0 1 1 1

2 0 CognitiveTests Executivefunction BRIEF(parents) 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

3 0 CognitiveTests Executivefunction CLOX 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

4 0 CognitiveTests Executivefunction FAB 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0

5 0 CognitiveTests Executivefunction Flanker 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

6 0 CognitiveTests Executivefunction Hotel 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

7 0 CognitiveTests Executivefunction Keeptrack 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

8 0 CognitiveTests Executivefunction Local-global 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

9 0 CognitiveTests Executivefunction Multi-sourceinterference 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

10 0 CognitiveTests Executivefunction NEPSYDirectorstask 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

11 0 CognitiveTests Executivefunction Plus-minus 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

12 0 CognitiveTests Executivefunction RCFT 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

14 0 CognitiveTests Executivefunction SOC(CANTAB) 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

15 0 CognitiveTests Executivefunction SST(CANTAB) 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

16 0 CognitiveTests Executivefunction Stroop 0 0 0 0 0 1 0 1 0 1 1 0 0 0 0 0

17 0 CognitiveTests Executivefunction TMT-B 0 0 0 0 0 1 1 1 1 1 1 0 0 0 0 0

18 0 CognitiveTests Executivefunction TowerofLondon 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0

19 0 CognitiveTests ExecutivefunctionTowerTest,DelisKaplanExecutiveFunctionSystem

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

8 0 CognitiveTests Motorspeed/function ReitanTrailMaking 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

20 0 CognitiveTests Executivefunction Trailmaking 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 1 CognitiveTests Verbalmemory Measured 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

2 1 CognitiveTests Verbalmemory CAMT 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

3 1 CognitiveTests Verbalmemory CVLT 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

4 1 CognitiveTests VerbalmemoryEmotionalmemorytask,

imagingonly0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

5 1 CognitiveTests Verbalmemory FCSRT(Buschke) 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0

6 1 CognitiveTests Verbalmemory HVLT 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

7 1 CognitiveTests Verbalmemory HVLT-R 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

8 1 CognitiveTests Verbalmemory IST-2000-R 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

9 1 CognitiveTests Verbalmemory Lettermemory 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

10 1 CognitiveTests Verbalmemory LogicalMemoryWMSIII 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

11 1 CognitiveTests Verbalmemory Memoryfortext 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

12 1 CognitiveTests Verbalmemory MillHill 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

13 1 CognitiveTests Verbalmemory RAVLT 0 0 0 0 0 1 1 1 0 1 1 0 0 0 0 0

14 1 CognitiveTests Verbalmemory Recallofsentencesandwords 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

15 1 CognitiveTests VerbalmemoryStoryRecall,Children’sMemory

Scale(Cohen,1997)0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

16 1 CognitiveTests VerbalmemoryVLMT:verballearningand

memorytest0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

1 1 CognitiveTests Visualmemory Measured 1 1 1 1 1 1 0 0 1 1 1 1 0 0 1 0

2 1 CognitiveTests Visualmemory DMS(CANTAB) 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

3 1 CognitiveTests Visualmemory e.g.,PairedAssociates 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

4 1 CognitiveTests Visualmemory Facerecognition 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

5 1 CognitiveTests Visualmemory Face-professiontask 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

6 1 CognitiveTests Visualmemory In-houseEmotionalMemory 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

7 1 CognitiveTests Visualmemory Objectlocation 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

8 1 CognitiveTests Visualmemory PALCantab 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0

9 1 CognitiveTests Visualmemory ReyComplexFigureTest 1 0 1 0 0 1 0 0 0 1 1 1 0 0 0 0

10 1 CognitiveTests Visualmemory Sceneencoding 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

1 1 CognitiveTests Verbalfluency Measured 1 1 1 1 1 1 1 1 1 1 1 1 0 0 1 0

2 1 CognitiveTests Verbalfluency ACE-R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

3 1 CognitiveTests Verbalfluency BostonNamingTest(BNT) 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

4 1 CognitiveTests Verbalfluency FABfluency 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0

5 1 CognitiveTests Verbalfluency Fluency(2tasks) 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

6 1 CognitiveTests Verbalfluency Fluency(4tasks) 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

7 1 CognitiveTests Verbalfluency Letterfluency(F-A-S) 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

8 1 CognitiveTests Verbalfluency Letterfluency(P-M-R) 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0

9 1 CognitiveTests Verbalfluency Letterfluency(P) 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

10 1 CognitiveTests Verbalfluency VFLphonemic+semantic 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

11 1 CognitiveTests Verbalfluency VLFCategories(animals) 0 0 0 1 1 1 1 1 1 1 1 1 0 0 0 0

12 1 CognitiveTests Verbalfluency WASI/WPPSIVocabulary 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

13 1 CognitiveTests Verbalfluency Wordsbeginningwith"S" 0 0 0 1 1 0 0 0 0 0 0 1 0 0 0 0

1 1 CognitiveTests Processingspeed Measured 1 1 1 1 1 1 1 1 1 0 0 0 0 0 1 0

3 1 CognitiveTests Processingspeed ChoiceReactionTime 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

4 1 CognitiveTests Processingspeed Digitsymbol(Echsler) 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

5 1 CognitiveTests Processingspeed Letter-digit 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

6 1 CognitiveTests Processingspeed Perceptualspeed 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

7 1 CognitiveTests Processingspeed Rapidautomatednamingtask 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

8 1 CognitiveTests Processingspeed RVP(Cantab) 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0

8 1 CognitiveTests Processingspeed RTI(CANTAB) 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0

9 1 CognitiveTests Processingspeed SDMT 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0

11 1 CognitiveTests Processingspeed TMT-A 0 0 1 0 0 1 0 1 1 1 1 0 0 0 0 0

12 1 CognitiveTests Processingspeed Word-colorinterference 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 CognitiveTests Simplereactiontime Measured 0 0 1 0 1 1 0 0 0 0 0 1 0 1 1 1

2 0 CognitiveTests Simplereactiontime Controltask 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

3 0 CognitiveTests Simplereactiontime CPTreactiontime 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

4 0 CognitiveTests Simplereactiontime IAT 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

5 0 CognitiveTests SimplereactiontimeReactiontimetoneutralstimuliincognitivetestscanbeutlized

0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

7 0 CognitiveTests Simplereactiontime SimpleReactionTimeTest 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1

1 0 CognitiveTests Motorspeed/function Measured 0 0 1 1 1 1 1 1 1 1 1 1 0 0 1 1

3 0 CognitiveTests Motorspeed/function DKEFSTrailMakingTest 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

4 0 CognitiveTests Motorspeed/functionElectronicTappingTest(Medical

assessment)0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

5 0 CognitiveTests Motorspeed/function ForceMatching 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

6 0 CognitiveTests Motorspeed/function Handcoordination 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

7 0 CognitiveTests Motorspeed/function MotorLearning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

8 0 CognitiveTests Motorspeed/function ReitanTrailMaking 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0

9 0 CognitiveTests Motorspeed/function TMT-A 0 0 0 0 0 1 0 1 1 1 1 0 0 0 0 0

1 0 CognitiveTests Cognitivescreeningtest/globalcognition

Measured 1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1


ACE-R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0


BRIEF 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1


IST-2000-R 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0


MMSE 1 1 0 1 1 1 1 1 1 1 1 0 0 0 1 0


MOCA 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

1 0 CognitiveTests CognitiveOther Measured 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1

3 0 CognitiveTests CognitiveOther10MemorySelf-Report

Questions0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

4 0 CognitiveTests CognitiveOtherAlliteration,Phonological

AssessmentBattery(Frederickson,etal.,1997)

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

5 0 CognitiveTests CognitiveOther Approach-avoidancetask 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

6 0 CognitiveTests CognitiveOther BentonFaces 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

7 0 CognitiveTests CognitiveOther BostonNamingTest(BNT) 0 0 0 0 0 1 1 1 0 1 1 0 0 0 0 0

8 0 CognitiveTests CognitiveOther BRIEF 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

10 0 CognitiveTests CognitiveOther CimbiaffectivemeMorytask 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

11 0 CognitiveTests CognitiveOtherCN-Rep(nonwordrepetition),

Gathercole19890 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

12 0 CognitiveTests CognitiveOther Delayeddiscounting 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

13 0 CognitiveTests CognitiveOther Dexterity(Pegboard) 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0

14 0 CognitiveTests CognitiveOtherEkmanFaceEmotion

Recognition0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

15 0 CognitiveTests CognitiveOtherEmotionRegulation(inonehalf

ofpeople)(Re-appraisingnegativemovies)

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

16 0 CognitiveTests CognitiveOtherEmotionalfaceidentification

task0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

17 0 CognitiveTests CognitiveOther FaceEmotionalGo/Nogo 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

18 0 CognitiveTests CognitiveOther FamousFaces 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

19 0 CognitiveTests CognitiveOther Five-to-fifteen 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

20 0 CognitiveTests CognitiveOther Implicitassociationtest 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

21 0 CognitiveTests CognitiveOther JLO 0 0 0 0 0 0 1 1 0 1 1 0 0 0 0 0

22 0 CognitiveTests CognitiveOtherNamingSpeed,Phonological

AssessmentBattery(Frederickson,Frith&Reason,

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

23 0 CognitiveTests CognitiveOtherNumericalOperations,WechslerIndividualAchievementTestII

(Wechsler,2006)0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

24 0 CognitiveTests CognitiveOtherNumerous(e.g.,EnhancedCued

Recall;ComplexFigure)0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

25 0 CognitiveTests CognitiveOther PicturePriming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

26 0 CognitiveTests CognitiveOtherPictureSupplemented

Alliteration,PhonologicalAssessmentBattery

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

27 0 CognitiveTests CognitiveOther proverbs(frontaltest) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

28 0 CognitiveTests CognitiveOther RAN/RAS 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

29 0 CognitiveTests CognitiveOtherReadingComprehension,

WechslerIndividualAchievementTestII(Wechsler,

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

32 0 CognitiveTests CognitiveOther SDQ 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

33 0 CognitiveTests CognitiveOther Serialrecall 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0

34 0 CognitiveTests CognitiveOtherSingleWordReading,WechslerIndividualAchievementTestII

(Wechsler,2006)0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

35 0 CognitiveTests CognitiveOtherSpellingWechslerIndividual

AchievementTestII(Wechsler,2006)

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1

36 0 CognitiveTests CognitiveOtherSyntatic/SemanticComprehension

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

37 0 CognitiveTests CognitiveOther TipofTheTongue 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

38 0 CognitiveTests CognitiveOtherVOSP(numberlocationand

incompleteletters)0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

1 1 Imaging MRI Measured 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1

2 1 Imaging MRI T1-weighted 1 1 0 0 1 1 1 1 1 1 1 1 1 1 1 1

3 1 Imaging MRI T2-weighted 1 1 1 0 0 0 1 1 0 0 1 1 1 0 1 1

4 1 Imaging MRI DWI 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1

5 1 Imaging MRI rs-fMRI 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1

1 1 Biomarker Blood Measured 1 1 1 0 1 0 0 0 0 0 0 0 0 1 0 0

1 1 Biomarker Saliva Measured 1 1 0 0 0 0 0 0 0 0 0 1 0 1 1 1

1 1 Biomarker Hormones Measured 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0

1 1 Biomarker Metabilites Measured 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0

1 1 Biomarker Immunemarkers Measured 0 0 1 1 0 0 0 0 0 0 0 0 0 1 0 0

1 1 DNA Blood Measured 0 1 1 1 1 1 0 0 0 1 1 0 0 1 0 0

1 1 DNA Saliva Measured 1 1 0 0 1 0 0 0 0 0 0 1 0 1 1 1


Site

MPIB UB REGIOH

Appendix 3.3

Documents

D2.1. Data harmonisation guidelines and standardized data ......D2.1. Data harmonisation guidelines and standardized data management/processing protocol across sites Project title: