CONTENTS

04 MOVIN’ ON UP! - DCAT becomes an independent association with new headquarters in iconic Empire State Building

05 DCAT Celebrates Diamond Anniversary in 1965

08 DCAT Highlights - Holds first Industry Symposium - Honors Charter Members at 37th Annual Dinner

11 1960-1970: A Decade of Scientific Invention - Roche introduces Librium and Valium, heralding a new class of drugs - Important discoveries in vaccines and vaccine production - New regulations to ensure pharmaceutical safety and quality

13 DCAT’s Past Presidents 1960-1970

14 DCAT’s Executive Secretary

ISSUE 05

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From its founding in 1890 until 1961, the DCAT organization was a section of the New York Board of Trade (a local chamber of commerce). This changed when DCAT received its certificate of incorporation on May 2, 1961, allowing DCAT to function as a separate, independent membership association. DCAT remained in the Board of Trade offices until the completion of its contract and in June 1963 established headquarters in the iconic Empire State Building.

At the time of its independence, DCAT had a roster of 800 firms in all branches of the drug, chemical and allied trades in 39 states, Mexico and Canada. DCAT’s membership actually outnumbered all of the other industries’ memberships in the New York Board of Trade, including Mercantile, Insurance, Textile, International Trade, Transportation, Securities and General. DCAT leaders felt that separating from the New York Board of Trade could more

accurately reflect the organization’s international status and could more effectively serve the interests of its members. Their vision was to build DCAT into “one of the most influential organizations of its kind in the country”. (We think they’d be pleased to know we achieved this and more – DCAT is now the premier business development association for the global pharmaceutical manufacturing industry!)

MOVIN’ ON UP!

Doors to DCAT’sEmpire State Building Office

DCAT becomes an independent association with headquarters in the Empire State Building

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DCAT Celebrates Diamond Anniversary in 1965

Similar to how we are celebrating DCAT’s 125th Anniversary throughout the year by honoring our history, DCAT members celebrated the 75th Anniversary at many events in 1965, including the Annual Fall Meeting, DCAT Annual Dinner and a Reunion Luncheon that honored members for their past service.

One event of particular note was when DCAT honored the association’s oldest living member, George R. Tomkins, formerly of Parke, Davis & Co. (a founding member company). Mr. Tomkins was presented with a scroll on his 94th birthday by DCAT Past President (1953) Lloyd I. Volckening and DCAT Executive Secretary Helen Booth.

See next page for some photos we found of DCAT members enjoying anniversary festivities. >>

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DCAT Highlights

1961 Holds First Industry Symposium(Pictured Above)

In the 1960s, the DCAT organization began taking important steps to expand the benefits of membership. One important benefit was the addition of an Industry Symposium in conjunction with the Annual Dinner. DCAT felt that providing members the opportunity to hear from government officials and learn from industry leaders would strengthen knowledge and members’ ability to deal with the future of the industry. The first Industry Symposium was held on the afternoon of Thursday, March 2, 1961, prior to the 35th Annual Dinner. Take a look at the brochure to see the speakers and topics at the 2nd Annual Industry Symposium. >>

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1963 DCAT Honors Charter Members(Pictured Left)

At the 37th Annual Dinner, DCAT honored 16 member companies who were among the original 50 who founded DCAT in 1890. Of these 16 member companies, ten were still operating under the same name, while the other six were “direct descendants” of founding members.

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1961 DCAT Surveys Members on Salesmen’s Compensation

See a survey from 1961 in which DCAT members answer questions on their salesmen’s compensation. Results to the survey are also included! How much was the median compensation for salesmen in 1961?

1963 DCAT Headquarters Moves to the Empire State Building

In an effort to increase DCAT’s image as an independent, international association, DCAT moved its office from the New York Board of Trade’s building on Liberty Street into the world’s tallest building* - the iconic Empire State Building!

*The Empire State Building was the tallest in the world until the completion of the World Trade Center’s North Tower in late 1970.

1961 DCAT Becomes an Independent Association!

On May 2, 1961, DCAT received its certificate of incorporation, allowing DCAT to function as an independent membership association. Take a look at the certificate.

1964 DCAT Encourages Audience Participation at Industry Programs

At the Annual Fall Meeting in 1964, DCAT offered an audience participation session on various manufacturing and marketing issues faced in the industry. Read a recap article printed in the Drug Trade News publication on September 28, 1964. Seems to have been a success! >>

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1965 Reunion Luncheon Honors 700 DCAT Volunteers for Past Service

In honor of the 75th Anniversary of the DCAT organization, DCAT held a Reunion Luncheon for past presidents, directors, committee volunteers and members. It was a huge, heartwarming success. Over 700 DCAT members were in attendance. Those that could not make it offered their well wishes to the organization:

“I scarcely need tell you how proud we all are of the fine record of the DCAT, the splendid work it has done and is doing and will do; of the wonderful service it always has offered to those of us who need it occasionally. My very best regards and wishes to all my friends in the Association on this 75th year of life. I hope it will continue for a vast number more!” – Hugh Puckett, DCAT member

“I think of the DCAT frequently and the many fine people in it. All good wishes for continued success. Warm regards.” – Steven F. Urban, DCAT member

1966 DCAT Continues to Produce “Digest of Current Activities & Trends”

Read the March 21, 1966 edition of DCAT’s Digest of Current Activities & Trends to see DCAT’s new membership dues structure based on the member company’s size instead of the company’s location. DCAT uses a similar structure today! Other features in this publication include US Food and Drug Administration news, information on overseas grants and new members!

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1965 Celebrates Diamond Anniversary of the Association(Pictured Left)

DCAT celebrated its 75th Anniversary with its members during the 39th Annual Dinner. Read a letter from DCAT President Fred Coe, in which he encourages members to continue to “get to know and use DCAT.”

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1960 - 1970

INDUSTRY TIMELINE

SPAFAS, an acronym for “specific pathogen-free avian supplies,” is started in Norwich, Connecticut, by poultry producer Raymond Davis and scientist Dr. Roy Luginbuhl. The company develops and produces specific pathogen-free fertile eggs for medical research and vaccine production, an important advancement in vaccine production. Merck & Co. would later acquire the company in the 1970s.

First known as Milan, Mylan starts doing business in White Sulphur Springs, West Virginia. The company is founded by Milan “Mike” Puskar and Don Panoz.

Janssen Pharmaceutica N.V. in Belgium joins the Johnson & Johnson family of companies. Its founder, Dr. Paul Janssen, a Belgian researcher, pharmacologist, and general practitioner is recognized as one of the most innovative and prolific pharmaceutical researchers of the 20th century. His contributions include the development of the antipsychotic therapy Haldol (haloperidol), the anesthetic fentanyl, and Reasec (diphenoxylate), used for the treatment of diarrhea, which had been a disabling and sometimes fatal disease in developing countries.

The Kefauver-Harris Drug Amendments to the Federal Food, Drug and Cosmetic Act are passed to ensure drug efficacy and greater drug safety. Sponsored in Congress by Sen. Estes Kefauver (D-Tenn.) and Rep. Oren Harris (D-Ark.), the amendments, signed into law by President Kennedy on Oct. 10, 1962, established a framework that required drug manufacturers to prove scientifically that a medication was not only safe, but effective. >>

Roche introduces Librium (chlordiazepoxide), the first benzodiazepine tranquillizer, which had been developed by Dr. Leo Sternbach, a well renowned scientist at Roche contributing to more than 240 patents. With the contribution of Dr. Sternbach, three years later in 1963, Roche introduces Valium (diazepam), an improved version of Librium. Valium would become one of Roche’s top-selling drugs and was an important contribution in the benzodiazepine class of drugs.

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The decade of the 1960s is marked by several important noteworthy accomplishments in pharmaceutical development and manufacturing. In 1960, Roche introduces Librium and Valium, heralding a new class of drugs, benzodiazepines. Important discoveries in vaccine and vaccine production are made, and leading advances are made in anticancer drugs and antibiotics. Both the US and Europe advanced important regulations that ensure the quality and safety of medicines.

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A Decade of Scientific Invention

Milan (which would later become Mylan) moves from Sulphur Springs, West Virginia to Morgantown, West Virginia in 1965 and begins manufacturing various over-the-counter products the next year. Success leads to a decision to switch production to generic pharmaceuticals. One year later in 1966, it receives FDA approval to market its first product, penicillin G.

Rhône Poulenc takes an equity stake in the Institut Mérieux, a research institute devoted to vaccines, which was originally founded in 1897 by Marcel Mérieux, a student of Louis Pasteur.

The first European Pharmaceutical Directive (65/65/EC) is issued requiring that all medicinal products receive a marketing authorization before being allowed on the market in the European Economic Community, the ancestor of today’s European Union.

The Basel Institute for Immunology, founded by Roche in 1968, opens in 1969. The first director is Niels Kaj Jerne, who later in 1984, shares the Nobel Prize in Physiology or Medicine with Georges J. F. Köhler (who works at the Institute from 1976 to 1984) and César Milstein for their work in advancing theories concerning the specificity in development and control of the immune system and for discoveries for the production of monoclonal antibodies.

Sandoz acquires Biochemie GmbJ in Kundl, Austria and develops large-scale production of antibiotics and substances based on biotechnology.

Baxter introduces the first commercially produced factor VIII concentrate to treat hemophilia.

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Fluorouracil is the first anticancer drug of Roche, paving the way for Roche’s activities in the field of cancer chemotherapy. One year later in 1963, Roche introduces Valium (diazepam) a benzodiazepine drug to treat anxiety and panic attacks. It would become one of the company’s top-selling drugs.

Betnovate was the first of Glaxo’s range of steroid skin disease treatments. In the mid-1960s, Smith, Kline & French also acquired RIT (Recherche et Industrie Thérapeutiques), a vaccines business.

Squibb delves into cancer research, discovering and developing hydroxyurea for leukemia and advanced ovarian cancer.

Merck & Co. introduces Rubeovax (Measles Virus Vaccine, Live, Attenuated). Four years later in 1967, the company introduces Mumpsvax (Mumps Virus Vaccine, Live) that was developed by the well-known microbiologist and Merck & Co. scientist, Dr. Maurice Hilleman, with a culture from the throat of his young daughter, Jeryl Lynn. In 1969, the company introduces Meruvax II (Rubella Virus Vaccine, Live).

Vibramycin (doxycycline hyclate), Pfizer’s first once-a-daily broad spectrum antibiotic is introduced and becomes a top seller.

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DCAT’s Past Presidents1960 - 1970

This list of DCAT’s presidents reads like a “Who’s Who” of the drug, chemical and allied industries, as all of these men were very active in the advancement of their respected companies and the industry.

If you get a chance, we recommend a quick Google search of these names – it’s amazing what you can find!

1964W. Ward Jackson, Commercial Solvents Corp.

1968-1969Wallace T. Drew, Lander Co. Inc.

1969-1970George H. Cadgene, International Flavors & Fragrances Inc.

1963F.M. Schwemmer, Pharmaco, Inc.

1967-1968C.B. William Howel, Geigy Pharmaceuticals Division Geigy Chemical Corp.

1960William W. Huisking, Charles L. Huisking & Co.

1965Fred A. Coe, Jr., Burroughs Wellcome & Co.

1961James Day, Dow Chemical Company

1966Robert K. Pfister, Sterling Drug Inc.

1962W.J. Schieffelin III, Schieffelin & Co.

1967E.S. Robson, Monsanto Company

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DCAT’s ExecutiveSecretary

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A member of the DCAT staff since 1928, Helen L. Booth assumed the role of executive secretary in 1943. She guided the organization in this role for 27 years, before handing over the reins to Joseph Madden in 1970. Ms. Booth had such an influence on the success of the organization that she remained with DCAT (serving as Mr. Madden’s secretary) until she retired in 1975 – that is 47 years with DCAT!