ALUMNEYE NEWS

Department of Ophthalmology UT Southwestern medical center

Summer 2015

INSIDE THIS ISSUE:

2 Ball for Eye Research 3 Volunteer work at St.

John of Jerusalem Eye Hospital Group

4 Resident graduates 5-6 Fellow graduates 6-7 AlumnEye Assoc. 8-9 Faculty Grants 9 Resident awards Photo: Leukemic Retinopathy 10-11 Peer-reviewed pubs 12 Clinic contact info.

Dear Alumni:

I’m pleased to bring you this

latest issue of the AlumnEye

News, highlighting the activi-

ties of faculty, fellows and

residents in the Department

of Ophthalmology.

In this issue, you’ll read about

the recently published paper

in the American Journal of

Transplantation and our re-

searchers’ discovery of the

process behind the rejection

of second corneal transplants.

This sort of activity is made

possible in part by our annual

event, the Ball for Eye Re-

search, the proceeds of which

fund laboratory research in

the Department.

I’m also happy to report on

the future plans of our gradu-

ating residents and fellows, as

well as the important volun-

teer work carried out at the

St. John of Jerusalem Eye Hos-

pital Group in Israel by Drs.

He, Lehmann, and Kennedy.

Finally, please keep in mind

the importance of joining the

AlumnEye Association. I want

to thank current supporters of

the association, and encour-

age those of you who have

not yet joined to complete

and return the 2015-2016

form on page seven.

Have a wonderful summer.

Chair’s Message

UPCOMING EVENTS

September 26, 2015 Carol F. Zimmerman, M.D.

Lectureship in Neuro- Ophthalmology

November 15, 2015 Annual Alumni Reception

at AAO 6 to 8 p.m.

Palazzo Resort Hotel Casino

Las Vegas, NV

December 5, 2015 Ophthalmology at the

Crossroads: Seymour B. Gostin, M.D.

Lectureship

James P. McCulley, M.D. Professor and Chair

Thanks to the process known as immune privilege, first-time corneal transplants have a 90 percent success rate. Patients needing secondary transplants are three times more likely to experience rejection of transplanted corneal tissue, or a loss of immune privilege.

A recently-published study by Department of Ophthalmology researchers in the American Journal of Transplantation examines the mechanism behind this phe-nomenon.

“Understanding why these rejections occur is important to further improving the ways in which corneal transplants are performed,” said the study’s senior author, Jerry Y. Niederkorn, Ph.D., Professor and Vice Chair of Research in Ophthalmolo-gy, and Professor of Microbiology.

After studying mouse models, researchers discovered that after the first corneal transplant is accepted, T regulatory cells prevent other types of immune cells from attacking and rejecting the transplant. But severing (continued on page 2)

RESEARCH NEWS: UNCOVERING THE AUTOIMMUNE PROCESS

THAT CAUSES REJECTION OF SECONDARY CORNEAL TRANSPLANTS

AlumnEye News Page 2

On Saturday, March 28, donors to and supporters of the Department of Ophthalmology

gathered at the Dallas Country Club for the Ball for Eye Research (formerly known as the

Eye Ball), an annual gala benefitting sight-saving research in the Department. With nearly

220 attendees, the Ball grossed well over $200,000 (the highest amount since 2008); net

proceeds going directly to research were the most since the event began in 2001.

“I am so pleased with how this year’s Ball for Eye Research turned out,” said Dr. McCulley.

“Thanks to our dedicated event chairs and generous donors, the funds raised by the Ball

will enable our researchers to more vigorously continue building upon important discover-

ies we have made, including the identification of one of the genetic causes of a common

type of macular degeneration, as well as a significant expansion in understanding the mechanism and devel-

opment of age-related macular degeneration.”

The next Ball for Eye Research will take place on Saturday, April 2, 2016 at the Dallas Country Club. For

more information, contact Jennifer Roemer, 214-648-0347, jennifer.roemer@utsouthwestern.edu. ◊ - J.R.

2015 BALL FOR EYE RESEARCH

Dr. McCulley

welcoming guests to

the 2015 Ball

corneal nerves, which occurs during the first transplantation procedure, releases high levels of the neuropeptide Substance P. The resulting high Substance P levels disable the T regulatory cells needed for acceptance of subsequent corneal trans-plants. This inactivation results in rejection of more than 90 percent of the second corneal transplants in mice and helps to explain the curiously high risk for corneal graft rejection in patients who receive a second corneal transplant.

Researchers found that the high Substance P levels can be blocked with drugs to restore the eye’s immune privilege and promote the acceptance of second corneal transplants. Future research will focus on pharmacological strategies for restoring T regulatory cell function and promoting the survival of second corneal transplants. Other studies will determine if these findings can be extended to enhancing the immune response to cancers.

“In the future,” said Dr. Niederkorn, “ophthalmologists may be able to implement processes, and eventually prescribe medications, that can lower rates of rejection.”

The study is supported by grants from the National Eye Institute and Research to Prevent Blindness. More information is available in Paunicka KJ, Mellon J, Robert-son D, Petroll M, Brown JR, Niederkorn JY: Severing corneal nerves in one eye in-duces sympathetic loss of immune privilege and promotes rejection of future cor-neal allografts placed in either eye. Am J Transplant 2015 Jun;15(6):1490-501. (Parts excerpted from UTSW news release, “Ophthalmologists uncover auto-immune process that causes rejection of secondary corneal transplants.”). - ◊ J.R.

REJECTION OF SECONDARY CORNEAL TRANSPLANTS (CONT’D.)

R esearchers

found that

the high

Substance P

levels can be

blocked with

drugs to restore

the eye’s

immune

privilege and

promote the

acceptance of

second corneal

transplants.

AlumnEye News Page 3

It was a busy week in early May for three ophthalmologists who travelled to Jerusalem,

Israel, to volunteer at the St. John of Jerusalem Eye Hospital Group. James Lehmann,

M.D., residency and cornea fellow alumnus from San Antonio, David Kennedy, M.D., cor-

nea fellow, and Yu-Guang He, M.D., Associate Professor of Ophthalmology, saw under-

privileged patients in clinic, gave lectures, and performed surgeries.

In 2001, the Department began its working relationship with the hospital, which provides

eye care to nearly 70,000 people in need each year in the West Bank, Gaza, and East Je-

rusalem, regardless of ethnicity, religion, or ability to pay.

“What we saw from the start of this relationship,” said Dr. McCulley, a Commander with

the Order of St. John, “was an opportunity to give some of our fellow surgeons intensive surgical experience at a first-class

hospital abroad, while supporting a worthwhile cause.” Despite unsettled political conditions in Israel interrupting the pro-

gram’s earlier years, volunteers returned as soon as the climate became more favorable.

Dr. Lehmann, a member of the Order of St. John, who has participated in volunteer trips to the

hospital since 2005, is impressed with the progress made in subspecialty training available at St.

John and in Israel. This is important, because the needs of patients are great: “The level of pathol-

ogy in these patients is much higher than we see at home,” said Dr. Lehmann. “There is much

more trauma, much more infection, and patients present much later.”

In addition to the flagship site in Jerusalem, the Eye Hospital Group operates outreach clinics in

Gaza, Hebron, and Anabta, and has a mobile outreach team that targets isolated communities.

The Jerusalem hospital is also home to an eye bank, an ophthalmology training program, and a

nursing school, and is affiliated with the U.K.-based international

charity of St. John, whose 25,000 worldwide members carry out

philanthropic activities in more than 40 countries. The charity is also recognized by the U.N.

Along with seeing patients, Drs. Lehmann and Kennedy transported 21 donor corneas to the

hospital, and demonstrated surgical transplantation techniques for physicians. Dr. Kennedy

also presented a talk on “DMEK: Tips for Your First Case.”

But the learning process went both ways, said Dr. Kennedy: “While it’s valuable for us to be

able to come here and feel like we’re helping patients, we’ve learned so much about some

of the really rare conditions seen here.”

The quality of medical care, facilities, and equipment at the Eye Hospital “are just as good as

what we have in the U.S.,” said Kennedy.

Dr. He, a retina subspecialist, examined patients in clinic at the hospital for, among other

things, signs of diabetic retinopathy, and travelled to a village in the West Bank with the out-

reach clinic. He also gave two lectures for physicians at the hospital, including “Impact of

Mobile Health on macular Surveillance – Where We Are” and “Necrotizing Herpetic Retinop-

athies.”

“This trip was fascinating and far exceeded any expectations I had,” said Dr. He, reflecting on

his first trip to the St. John hospital. “I really enjoyed every minute of it.” ◊ -J.R.

HELPING THE NEEDIEST: VOLUNTEERING AT ST. JOHN OF JERUSALEM EYE HOSPITAL

Yu-Guang He, M.D., with some of the

patients he examined during his trip to

Israel

T he level of

pathology

in these patients

is much higher

than we see at

home. There’s

much more

trauma, much

more infection

and the patients

present later.

— James

Lehmann, M.D.

David Kennedy, M.D., with a

clinic patient

AlumnEye News Page 4

Juan Arciniega, M.D., received his M.D. from the University of Carabobo in Valencia, Venezuela. He completed a postdoctoral cornea research fellowship at UT Southwestern, followed by his PGY1 year at John Peter Smith Hospital in Fort Worth. Dr. Arciniega will join Gulf Coast Eye Institute in McAllen, TX following graduation.

Vinay Dewan, M.D., received his M.D. from Washington University in St. Louis, and completed his PGY1 year in the Department of Internal Medicine at Washington University. Dr. Dewan will enter the glaucoma fellowship program at UT Southwestern following graduation.

Julie Linden Soto, M.D., completed her M.D. at the University of Oklahoma in Oklahoma City, after which she completed her PGY1 year at the Virginia Mason Medical Center in Seattle, WA. Dr. Soto plans on joining a group practice in Dallas upon graduation.

Erwin Puente, M.D., Ph.D., received his M.D. and Ph.D. from Washington University in St. Louis. He went on to complete his PGY1 year at UT Southwestern. Following graduation, Dr. Puente will take up an assistant instructor position at UT Southwestern.

Brittany Ransom, M.D., received her M.D. from LSU School of Medicine in New Orleans; she remained in New Orleans for her PGY1 year at Tulane University. Dr. Ransom will join a group practice in Jacksonville, FL following graduation.

Kruti Dajee, M.D., completed her M.D. at UT Southwestern, and her PGY1 at Presbyterian Hospital/Texas Health Resources in Dallas. After graduation, Dr. Dajee will commence a vitreoretinal fellowship at UT Southwestern.

Patrick Ford, M.D., received his M.D. from the University of Oklahoma in Oklahoma City, and completed his PGY1 year at St. Mary Mercy Hospital in Livonia, MI. Following graduation, Dr. Ford will move to Anchorage, AK, and join a group practice at the Alaska Native Medical Center.

Ross Lynds, M.D., attended UT Medical Branch in Galveston, followed by his PGY1 year at Presbyterian Hospital/Texas Health Resources in Dallas. After graduation, Dr. Lynds will take up a vitreoretinal fellowship at UT Southwestern.

2015 GRADUATING RESIDENTS

Ivan Vrček, M.D., received his M.D. from UT Southwestern, followed by his PGY1 year at Baylor University Medical Center in Dallas. After he graduates, Dr. Vrček will commence an oculofacial plastic and reconstructive surgery fellowship with Texas Oculoplastic Consultants in Austin.

Join the AlumnEye

Association:

Sign up now for the

2015-2016 academic

year

(see page 7)

AlumnEye News Page 5

S. Serdar Dogan, M.D., completed medical school and his residency training at Ankara University Medical School in Turkey. In 2014, he completed a cornea fellowship at UT Southwestern. Currently concluding his pediatric ophthalmology fellowship, Dr. Dogan will commence his PGY1 year in surgery at Methodist Hospital in Dallas, before starting his residency at UT Southwestern in 2016.

Justin Gutman, M.D., received his M.D. at SUNY Upstate in Syracuse, NY, and completed his residency at SUNY Downstate in Brooklyn. Following his vitreoretinal fellowship, Dr. Gutman will join Coastal Eye Group in Myrtle Beach, SC.

Dayane C. Issaho, M.D., completed medical school at Faculdade Evangelica do Paraná in Curitiba, Brazil and her residency at the clinical hospital of the Federal University of Paraná. She went on to her first pediatric ophthalmology fellowship at the Federal University of São Paulo in Brazil. At the conclusion of her current pediatric ophthalmology fellowship, Dr. Issaho will return to Brazil to both practice at the Hospital de Olhos do Paraná in Curitaba and join the faculty at the Federal University of São Paulo as an assistant professor.

Austin Lash, M.D., received his M.D. at LSU School of Medicine in Shreveport, LA, and completed his residency at LSU Health Science Center in Shreveport. At the conclusion of his cornea fellowship, Dr. Lash will join Eye Associates of East Texas in Tyler.

Prashanthi Giridhar, M.D., attended Texas Tech University School of Medicine in Lubbock, where she also completed her residency. At the conclusion of her pediatric ophthalmology fellowship, Dr. Giridhar will join Pediatric Eye Specialists in Fort Worth.

Geoffrey Hill, M.D., attended medical school at St. Louis University in St. Louis, MO, and completed his residency at John H. Stoger, Jr. Hospital of Cook County in Chicago. Dr. Hill will join Hill Vision Services in St. Louis at the conclusion of his cornea fellowship.

David Kennedy, M.D., completed his M.D. at LSU School of Medicine in New Orleans, and his residency at UT Southwestern. Following his cornea fellowship, Dr. Kennedy will join Gulf South Eye Associates in Metairie, LA.

2015 GRADUATING FELLOWS

Deepak Sobti, M.D., attended medical school at the University of Rochester School of Medicine and Dentistry in New York, and completed his residency at the University of Arizona in Tucson. At the conclusion of his neuro-ophthalmology/oculoplastics fellowship, Dr. Sobti will remain in Dallas and go into private practice.

Robert Reinauer, Jr., M.D., received his M.D. at UT Health Science Center in San Antonio, and completed his residency at the Kresge Eye Institute at Wayne State University in Detroit, MI. Following his vitreoretinal fellowship, Dr. Reinauer will join New Vision Eye Center in Vero Beach, FL.

Michelle Nguyen, M.D., attended medical school at the UCLA David Geffen School of Medicine in Los Angeles, CA, and completed her residency at Montefiore Medical Center/Albert Einstein College of Medicine in Bronx, NY. Dr. Nguyen will join Eye Health Partners in Nashville, TN following her neuro-ophthalmology/oculoplastics fellowship.

Richard Moore, M.D., received his M.D. from the University of Texas Medical School at Houston, and went on to complete his residency at Eastern Virginia Medical School in Norfolk, VA. Following his glaucoma fellowship, Dr. Moore will join the DeHaven Eye Clinic in Tyler, TX.

AlumnEye News Page 6

Ahmed Soliman, M.D., attended medical school in Cairo, Egypt at Cairo University Hospitals, where he also completed his residency. Prior to his cornea fellowship at UTSW, Dr. Soliman undertook two other fellowships: medical retina at Harvard Medical School – Joslin Diabetes Center in Boston, MA and pediatric ophthalmology at the University of Minnesota in Minneapolis. Dr. Soliman will return to Cairo this summer, and take up a faculty position at Cairo University Hospitals.

2015 GRADUATING FELLOWS (CONT’D.)

ALUMNEYE ASSOCIATION

The Department of Ophthalmology thanks the

following 2014-2015 Association members for

their gracious support of its continuing education

activities:

Shawn Agee, M.D. (Birmingham, AL) Ronald Barke, M.D. (Arlington, TX) Carol Boren, M.D. (Brownwood, TX) David Burk, M.D. (Bay City, MI) Anthony W. Evangelista, M.D. (Arlington, TX) Sidney Gicheru, M.D. (Irving, TX) Michael Halsted, M.D. (Omaha, NE) Sylvia Hargrave, M.D. (Dallas, TX) Alfred L. Humphrey, M.D. (Arlington, TX) John David Jones, M.D. (Lubbock, TX) R. Galen Kemp, M.D. (Waxahachie, TX) Rebecca Kurzon, M.D. (Winter Park, FL) James Lehmann, M.D. (San Antonio, TX) Mark B. Lindsay, M.D. (Bryan, TX) Rajiv M. Rugwani, M.D. (Waxahachie, TX) David Stager, Jr., M.D. (Plano, TX) Frank Terrell, M.D. (Stephenville, TX) Jacob Thomas, M.D. (Springfield, MO) Alan Twer, M.D. (Philadelphia, PA) Steven M. Verity, M.D. (Dallas, TX) James T. Walker, M.D. (Abilene, TX) David Whiting, M.D. (St. Louis Park, MN) Jess T. Whitson, M.D. (Dallas, TX)

Acknowledgment in the next

issue of the AlumnEye News,

and on Alumni Day

A reduced price for your dinner

on Alumni Day

Reduced costs for CME credit

and lectureship courses

One free drink ticket at the

alumni reception on November

15, 2015 during the AAO

meeting

Join the AlumnEye

Association and

receive….

Roger A. Velasquez, M.D., received his M.D. from UT Health Science Center in San Antonio, where he stayed on for his residency. Dr. Velasquez will return to San Antonio following his glaucoma fellowship and join the faculty at UT Health Science Center as an assistant professor.

DEPARTMENT OF OPHTHALMOLOGY AlumnEye Association

2015 - 2016 Membership Application SEPT. 1, 2015 – AUG. 31, 2016

Total Due: $100

Name:

Graduation year:

Organization:

Address:

E-mail:

Dues: $100 Please make checks payable to UT Southwestern Ophthalmology AlumnEye Association Mail application and check to: UT Southwestern Medical Center Department of Ophthalmology ATTN: Ryan Myers 5323 Harry Hines Boulevard Dallas, TX 75390-9057 [please include ‘+4’ zip code]

AlumnEye News Page 8

ACTIVE FACULTY GRANTS AND AWARDS

Investigator Grant title Agency Type

R. Wayne Bowman, M.D. Post Approval Study of AcrySof IQ Toric IOL

Models SN6AT6-SN6AT9

Alcon Research

Igor Butovich, Ph.D. Biochemistry and Biophysics of Preocular Tear

Film

NIH R01

Yu-Guang He, M.D. Low-cost home vision self-test Vital Art & Science,

Inc./TX State Subct

James P. McCulley, M.D. RPB Unrestricted Research Grant Research to

Prevent Blindness

V. Vinod Mootha, M.D. Genetics and Genomics of Fuchs Endothelial

Corneal Dystrophy

NIH R01

Jerry Y. Niederkorn, Ph.D. Core Grant for Vision Research - Entire Project NIH P30

Jerry Y. Niederkorn, Ph.D. Immunobiology of Corneal Allografts NIH R01

Jerry Y. Niederkorn, Ph.D. Immunological Modulation of Ocular Tumor

Metastases

NIH R01

Jerry Y. Niederkorn, Ph.D. Transplant and Tumor Rejection Processes

Within the Eye

NIH R01

W. Matthew Petroll, Ph.D. Assessment of Corneal Fibroblast Biomechani-

cal Behavior

NIH R01

Danielle M. Robertson, O.D., Ph.D. Interactive Effects of OSA and T2DM on Cor-

neal and Ocular Surface Disease

NIH R21

Danielle M. Robertson, O.D., Ph.D. Effects of Systemic Disease on Corneal Epithe-

lial Pathophysiology

NIH R01

Rafael Ufret-Vincenty, M.D. Phase 3 Study of Lampalizumab Admin IV to

Pts with Geographic Atrophy Secondary to

Age-Related Macular Degeneration

Genentech, Inc.

Rafael Ufret-Vincenty, M.D. Role of Complement Factor H and Immunity in

AMD.: Novel Transgenic Model

NIH R01

Serena X. Wang, M.D. Pediatric Eye Disease Investigator Group: Am-

blyopia Treatment Study, subcontract

Jaeb Center for

Health Research,

Inc.

Serena X. Wang, M.D. Study of Loteprednol Etabonate Ophthalmic

Gel 0.5% vs. Prednisolone Acetate Ophthalmic

Suspension 1% for Intraocular Inflammation

Following Surgery for Childhood Cataract

Bausch & Lomb,

Inc.

AlumnEye News Page 9

ACTIVE FACULTY GRANTS AND AWARDS (CONT’D.) Investigator Grant title Agency Type

Serena X. Wang, M.D. Effect of OMS302 Added to Standard Irrigation

Solution on Intraoperative Pupil Diameter and

Acute Postoperative Pain in Children through 3

Yrs

Omeros Corp.

David R. Weakley, Jr., M.D. Infant Aphakia Treatment Study (IATS), subcon-

tract

Emory

University

Two Ophthalmology residents claimed the first and second prizes in the Texas Ophthalmological Association’s (TOA) resident paper com-petition, held during

the annual TOA Meeting May 1-2. Xihui “C.C.” Lin, M.D., (r.) a second-year resident, received first place for his paper, “Ocular Manifestations and Manage-ment of Graft versus Host Disease.” Second place went to third-year resident Erwin Puente, M.D., Ph.D., (l.) for his paper, “Choroidal Melanoma Metas-tasis if Modulated by Kupffer Cells.”

“We are extremely proud of the quality of our resi-dents’ annual research projects,” said Preston H. Blomquist, M.D., Residency Program Director and Vice Chair of Education. “Drs. Lin and Puente did a superb job representing UT Southwestern through their clinically relevant topics.”

All ophthalmology residency programs in Texas can nominate up to two resident papers. Four to five are selected by TOA for presentation at the organization’s annual meeting. ◊ -J.R.

RESIDENT PAPER AWARDS AT TOA

A 17-year-old adolescent boy presented with

blurred vision for several weeks. Indirect

ophthalmoscopy revealed dilated and tortuous

vessels with diffuse retinal infiltrates and

intraretinal hemorrhages as well as a macular

leukemic infiltrate. Visual acuity was 20/400 OD and

20/20 OS, the white blood cell count was 521 400

cells/μL (to convert to x109/L, multiply by 0.001),

and a bone marrow biopsy supported a diagnosis of

chronic myelogenous leukemia. In this composite

fundus image of the right eye with decreased visual

acuity, peripheral intraretinal hemorrhages with

cotton-wool spots are apparent in addition to a

large leukemic infiltrate in the macula.

— Johnathan D. Warminski, M.D. (UTSW Residency

2012; UTSW Vitreoretinal Fellowship 2014) and

Eduardo Uchiyama, M.D. (UTSW Residency 2011;

UTSW Vitreoretinal Fellowship 2013).

Source: JAMA Ophthalmol. 2015 Jan;133(1):73.

LEUKEMIC RETINOPATHY

AlumnEye News Page 10

*Since the last issue of the AlumnEye News newsletter

2014

Blomquist P: Is it time to adopt vision screening for ophthalmology residency program applicants? J Acad Ophthalmol 2014 7:e1-e2.

Bratton ML, He YG, Weakley DR: Dexamethasone intravitreal implant (Ozurdex) for the treatment of pediatric uveitis. J AAPOS 2014 Apr;18(2):110-3.

Butovich IA, Lu H, McMahon A, Ketelson H, Senchyna M, Meadows D, Campbell E, Molai M, Linsenbardt E: Biophysical and morphological evaluation of human normal and dry eye meibum using hot stage polarized light microscopy. Invest Ophthalmol Vis Sci 2014 Jan 7;55(1):87-101.

Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL: ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein. Chem Biol 2014 Nov 20;21(11):1564-74.

Chun SG, Iyengar P, Gerber DE, Hogan RN, Timmerman RD: Optic neuropathy and blindness associated with crizotinib for non-small-cell lung cancer with EML4-ALK translocation. J Clin Oncol 2015 Feb 10;33(5):e25-6.

Ding Z, Joy M, Bhargava R, Gunsaulus M, Laskshman N, Miron-Mendoza M, Petroll M, Condeelis J, Wells A, Roy P: Profilin-1 Downregulation has Contrasting Effects on Early vs. Late Steps of Breast Cancer Metastasis. Oncogene 2014; 33:2065-74.

Fung DS, Whitson JT: An evidence-based review of unoprostone isopropyl ophthalmic solution 0.15% for glaucoma: place in therapy. Clin Ophthalmol 2014 Mar 10;8:543-554.

McMahon A, Lu H, Butovich IA: A Role for ELOVL4 in the Mouse Meibomian Gland and Sebocyte Cell Biology. Invest Ophthalmol Vis Sci 2014 May 1;55(5):2832-40.

Miller AM, Chandler DL, Repka MX, Hoover DL, Lee KA, Melia M, Rychwalski PJ, Silbert DI; Pediatric Eye Disease Investigator Group, Beck RW, Crouch ER 3rd, Donahue S, Holmes JM, Quinn GE, Sala NA, Schloff S, Wallace DK, Foster NC, Frick KD, Golden RP, Lambert SR, Tien DR, Weakley DR Jr: Office probing for treatment of nasolacrimal duct obstruction in infants. J AAPOS 2014 Feb;18(1):26-30.

Mootha VV, Gong X, Ku HC, Xing C: Association and Familial Segregation of CTG18.1 Trinucleotide Repeat Expansion of TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci 2014 Jan 2;55(1):33-42.

Wladis EJ, Wu AY, Shields JA, Shields C, Shinder R: Bilateral lacrimal gland disease: clinical features of 97 cases. Ophthalmology 2014 Oct;121(10):2040-2046.

Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS: CD8(+) cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome. Mucosal Immunol 2014 Mar;7(2):417-27.

Zhou C, Petroll WM: MMP regulation of corneal keratocyte motility and mechanics in 3-D collagen matrices. Exp Eye Res 2014 Feb 14;121C:147-160.

2015 Aredo B, Zhang K, Chen X, Wang CX, Li T, Ufret-Vincenty RL: Differences in the distribution, phenotype and gene expression of subretinal icroglia/macrophages in C57BL/6N (Crb1(rd8/rd8)) versus C57BL6/J (Crb1(wt/wt)) mice. J Neuroinflammation 2015 Jan 15;12(1):6.

Chun SG, Iyengar P, Gerber DE, Hogan RN, Timmerman RD: Optic Neuropathy and Blindness Associated With Crizotinib for Non-Small-Cell Lung Cancer With EML4-ALK Translocation. J Clin Oncol 2015 Feb 10;33(5):e25-6.

Hartmann EE, Stout AU, Lynn MJ, Yen KG, Kruger SJ, Lambert SR: Infant Aphakia Treatment Study Group; Infant Aphakia Treatment Study Group. Stereopsis results at 4.5 years of age in the infant aphakia treatment study. Am J Ophthalmol 2015 Jan;159(1):64-70.e2.

RECENT PEER-REVIEWED PUBLICATIONS*

AlumnEye News Page 11

Hulleman JD, Kelly JW: Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration. FASEB J 2015 Feb;29(2):565-75.

Hussein MA, Weakley D, Wirazka T, Paysse EE: The long-term outcomes in children who are not compliant with spectacle treatment for accommodative esotropia. J AAPOS 2015 Apr;19(2):169-71.

Kennedy DP, Chandler JW, McCulley JP: Ocular surface involvements in ectrodactyly-ectodermal dysplasia-cleft syndrome. Cont Lens Anterior Eye 2015 Jun;38(3):228-31.

Koppaka V, Lakshman N, Petroll WM: Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collage Matrices. Mol Vis 2015 21:502-514.

Lass JH, Riddlesworth TD, Gal RL, Kollman C, Benetz BA, Price FW Jr, Sugar A, Terry MA, Soper M, Beck RW; Cornea Donor Study Research Group: The effect of donor diabetes history on graft failure and endothelial cell density 10 years after penetrating keratoplasty. Ophthalmology 2015 Mar;122(3):448-56.

Majmudar PA, Schallhorn SC, Cason JB, Donaldson KE, Kymionis GD, Shtein RM, Verity SM, Farjo AA: Mitomycin-C in corneal surface excimer laser ablation techniques: a report by the american academy of ophthalmology. Ophthalmology 2015 Jun;122(6):1085-95.

Miron-Mendoza M, Graham E, Kivanany P, Quiring J, Petroll WM. The Role of Thrombin and Cell Contractility in Regulating Clustering and Collective Migration of Corneal Fibroblasts in Different ECM Environments. Invest Ophthalmol Vis Sci 2015 Mar 3;56(3):2079-90.

Mootha VV, Hussain I, Cunnusamy K, Graham E, Gong X, Neelam S, Xing C, Kittler R, Petroll WM: TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci 2015 Feb26;56(3):2003-11.

Nguyen A, Hulleman JD: Differential tolerance of ‘pseudo-pathogenic’ tryptophan residues in calcium-binding EGF domains of short fibulin proteins. Exp Eye Res 2015 Jan;130:66-72.

Paunicka KJ, Mellon J, Robertson D, Petroll M, Brown JR, Niederkorn JY: Severing corneal nerves in one eye induces sympathetic loss of immune privilege and promotes rejection of future corneal allografts placed in either eye. Am J Transplant 2015 Jun;15(6):1490-501.

Petroll WM, Lakshman N: Fibroblastic Transformation of Corneal Keratocytes by Rac Inhibition is Modulated by Extracellular Matrix Structure and Stiffness. J Funct Biomater 2015 Apr 14;6(2):222-40.

Petroll WM, Miron-Mendoza M: Mechanical interactions and crosstalk between corneal keratocytes and the extracellular matrix. Exp Eye Res 2015 Apr;133:49-57.

Vrcek I, Finnerty K, Ford P, Hogan RN, Mancini R: Relapsing acute lymphoblastic leukemia presenting with a rapidly enlarging and vision-threatening orbital mass. Int Ophthalmol 2015 Apr;35(2):257-60.

Vrcek I, Starks V, Mancini R, Gilliland G: Use of an ultrasonic bone curette (Sonopet) in orbital and oculoplastic surgery. Proc (Bayl Univ Med Cent) 2015 Jan;28(1):91-3.

Writing Committee for the Cornea Donor Study Research Group, Sugar A, Gal RL, Kollman C, Raghinaru D, Dontchev M, Croasdale CR, Feder RS, Holland EJ, Lass JH, Macy JI, Mannis MJ, Smith PW, Soukiasian SH, Beck RW: Factors associated with corneal graft survival in the cornea donor study. JAMA Ophthalmol 2015 Mar;133(3):246-54.

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