Dermatopathology: Creighton University Dept of Pathology- Published Dermatopathology Cases (2006- 2010): Deba P Sarma, MD

8/8/2019 Dermatopathology: Creighton University Dept of Pathology- Published Dermatopathology Cases (2006- 2010): Deba P Sarma, MD

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CUMC DermatopathologyCUMC Dermatopathology

publications,2006publications,2006--

Deba P Sarma, MDDeba P Sarma, MD

Professor of Pathology, Director of DermatopathologyProfessor of Pathology, Director of Dermatopathology

Creighton University Medical Center, OmahaCreighton University Medical Center, Omaha


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Man, 58, with a tumor mass in the leg amputation stump

.

Ref:

Deba P. Sarma, Thomas P. Hansen, Edward D. Adickes: Carcinoma Arising In The Leg

Amputation Stump. The Internet Journal of Dermatology. 2006. Volume 4 Number 1.

Diagnosis: Verrucous carcinoma

Fig.1Fig.2


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Male, 41, presented with disseminated subcutaneous abscesses one monthMale, 41, presented with disseminated subcutaneous abscesses one monthafter amputation for septic right leg and removal of Groshon vascular catheterafter amputation for septic right leg and removal of Groshon vascular cathetertip.tip.

Fig.1

Fig.2

Fig,3, AFB stain

Diagnosis: Dermalabscess due to

Mycobacteriumabscessus.

Ref.

Hansen TP, Sarma DP(2006): Multiple subcutaneous nodules associate with Mycobacterium

abscessus infection following removal of an infected Groshon vascular catheter tip. Dermatol

Online J 12(4):12. PMID:17083867 [PubMed - indexed for MEDLINE]


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Man, 29, with a painless slowMan, 29, with a painless slow--growing nodule of left forearmgrowing nodule of left forearm

for a year.for a year.

Fig.1

Fig.2

Diagnosis: Sinusoidal hemangioma.

Ref.

Wang B, Santos E, SarmaDP(2006). Sinusoidal hemangioma in an

adult male. The Internet J Dermatol. 4(1):2006. Indexed by Google

Scholar.


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Man, 59, phimosis, excised foreskin.Man, 59, phimosis, excised foreskin.

Fig.1

Fig.2

Diagnosis: Hemangioma.

Ref. Santos E, SarmaD(2006): Hemangioma of the prepuce. The

InternetJ Dermatol.4(1). Indexed by Google Scholar.


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Man,74, 1Man,74, 1--cm keratotic lesion of foreheadcm keratotic lesion of forehead

Fig.1Fig.2

Diagnosis: Bullousactinic keratosis

Ref.

SarmaDP, Sharma P(2006)Bullous solar keratosis. The Internet J Dermatol,4(1). Indexed by Google Scholar.


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Man,69, left cheek lesion, suspected of squamous cell carcinoma

Fig.1 Fig.2

The tumor cells were immunoreactive for EMA, BerEp-4, CK7, and, AE1/3 with variable positive stains of Androgen receptor,CK8/18, and Vimentin, but were negative for immunostains of S100, HMB45, CK20, TTF-1, RCC, and PSA. The neoplastic cellsfrom the foci of apocrine differentiation were immunoreactive for GCDFP-15 and CK8/18. Immunostains for mismatch repair genes

includnig hMLH1, hMSH2, hMSH6, PMSH2 and RT-PCR for microsatellite instability studies including MSI (T) and MSI(C) werenegative.

Diagnosis: Sebaceous carcinoma with apocrine differentiation

Ref.

Wang B, SarmaDP(2006).Sebaceous carcinoma with apocrine differentiation. The Internet J Dermatol,

4(2). Indexed by Google Scholar.


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Woman, 51, 1Woman, 51, 1--cm nodule, left armcm nodule, left arm

Diagnosis: Proliferating trichilemmal cyst

Ref.

Sharma P, SarmaDP(2006). Proliferating trichilemmal cyst of the arm. The Internet

J Dermatol,4(2), 2006. Indexed by Google Scholar.


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A 73A 73--yearyear--old woman presented with a 0.4 cm lesion on the left cheek.old woman presented with a 0.4 cm lesion on the left cheek.

Diagnosis: Squamous cell carcinoma in situ associated with osteoma cutis.

Poonam Sharma, Deba P. Sarma: Squamous Cell Carcinoma In Situ Associated With

Osteoma Cutis. The Internet Journal of Dermatology. 2006. Volume 4 Number

Ref.


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An 80An 80--yearyear--old man presented with a longold man presented with a long--standing skin lesion on his mid forehead.standing skin lesion on his mid forehead.

Diagnosis: Seborrheic keratosis with in-situ squamous cell carcinoma changes

Ref.

SharmaP, SarmaDP, Adickes ED(2006).Seborrheic keratosis with in-

situ carcinoma changes.Dermatology Online J 12(7):19.PMID:

17459305 [PubMed - indexed for MEDLINE]


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A few interesting memories from more than 30-year of dermatopathology practice

DebaP. Sarma: FromThe Diary Of A Dermatopathologist. The Internet

Journal of Dermatology. 2006. Volume 4 Number2.


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A 63A 63--yearyear--old man with a 20old man with a 20--year history of diabetes mellitus,year history of diabetes mellitus,peripheral vascular disease and hypertension presented with a nonperipheral vascular disease and hypertension presented with a non--

healing ulcer of left foothealing ulcer of left foot

Diagnosis: Verrucous carcinoma.

Ref.

Deba P. Sarma, JeffF. Wang, Chhanda

Bewtra, Lisa M. J. Lee: Verrucous CarcinomaArising In A Chronic Non-Healing Ulcer Of The Foot Of A Diabetic Patient. The Internet

Journal of Dermatology. 2007. Volume 5 Number 1.


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A69A69--yearyear--old female presented a 0.5 cm flat, pigmented skin lesion on the right dorsal forearm.old female presented a 0.5 cm flat, pigmented skin lesion on the right dorsal forearm.

Melan A stain S-100 stain

Diagnosis: Pigmented neurofibroma.

Ref.

ZenggangPan, DebaP. Sarma: Pigmented Neurofibroma OfThe Skin: A

Case Report And Review OfThe Literature. The Internet Journal of

Dermatology. 2007. Volume 5 Number 1.


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A 34-year-old woman noticed multiple slow-growing painful and itchy nodules on

her face (1 lesion) and extremities(1 on arm and 5 on both legs).

Diagnosis: Dermatofibroma.

Ref.

Mingkui Chen, Deba Sarma: Multiple Dermatofibromasinan Adult Female. The

Internet Journal of Dermatology. 2007. Volume 5 Number 1.


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Abstract

We report a case of dermal malignant melanoma that stained negatively for commonly

done immunostains, HMB-45, and Melan-A. It stained weakly positive for S-100 protein,

a less specific marker for melanocytes. The diagnosis was established by strongly

positive immunostaining by MITF ( microphthlmia-associated transcription factor). A briefreview of the MITF and its usefulness in the diagnosis of melanoma are presented.

MITF

Ref.

Jeff F.Wang, DebaP. Sarma, Pamela Ulmer: Diagnostic dilemma: HMB-45 and

Melan-A negative tumor, canit be stillamelanoma?: MITF (Microphthalmia-

associated transcription factor)stainmay confirm the diagnosis. The Internet



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AbstractAbstractAbenign adnexal skin tumor showing sebaceous and hair differentiation occurring in an 84Abenign adnexal skin tumor showing sebaceous and hair differentiation occurring in an 84--

yearyear--old man is reported. Such a tumor may be called a sebotrichoma.old man is reported. Such a tumor may be called a sebotrichoma.

Diagnosis: Sebotrichoma

Ref.

SarmaDP, Santos EE, Wang B (2007). Sebotrichoma. The Internet J Dermatol



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Abstract

A skin biopsy from a nasal lesion showed a dermal infiltrating neoplasm composed of

polygonal cells with small nuclei and abundant coarsely granular eosinophilic cytoplasm.

Light microscopic features were that of a granular cell tumor. However, the results of the

immunohistologic studies and the observations of the electron microscopic studies did

not identify the nature of the cells nor did they confirm that it was a granular cell tumor.

We interpret the lesion as a pseudogranular cell tumor of the skin.

DebaP. Sarma, Eric E. Santos, William J. Hunter, Zoran Gatalica: Pseudogranular

CellTumor OfThe Skin. The Internet Journal of Dermatology. 2007. Volume 5

Number 1.

Ref.


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A case of acquired perforating osteoma cutis occurring on theA case of acquired perforating osteoma cutis occurring on thefinger of a 43finger of a 43--yearyear--old man is reported. English literature onold man is reported. English literature on

the topic is briefly reviewed.the topic is briefly reviewed.

Diagnosis: Osteoma cutis

Ref.

Wang JF, SarmaDP(2007).Acquired perforatingosteoma cutis.The

Internet J Dermatol 5(1). Indexed by Google Scholar.


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AbstractAbstractWe are reporting a case of cutaneous leiomyosarcomaWe are reporting a case of cutaneous leiomyosarcomaoccurring on the face of a 98occurring on the face of a 98--yearyear--old woman with a briefold woman with a brief

review of the literaturereview of the literature..

Diagnosis: Leiomyosarcoma cutis.

Ref.

Eric E. Santos, DebaP. Sarma: CutaneousLeiomyosarcomaof the Face. The

Internet Journal of Dermatology. 2007. Volume 5 Number 1.

SMA stain


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I find no good reason to separate keratoacanthoma from well differentiated

squamous cell carcinoma. I am now reporting crateriform squamous

epithelial lesions (that I used to report as keratoacanthoma) as well

differentiated squamous cell carcinoma, keratoacanthoma type'. They maythen be treated as a well differentiated squamous cell carcinoma with a

superficial complete resection, and the patient is relieved of a fast-growing

lesion. A small scar is definitely acceptable!

Ref.

DebaP. Sarma: Keratoacanthoma Should Be Reported As 'Well

Differentiated Squamous Cell Carcinoma, KeratoacanthomaType': A

Dermatopathologist's View. The Internet Journal of Dermatology. 2007.

Volume 5 Number 1.


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The picture is that of the palms of a 44-year old man of Chinese heritage who

had had red hands since birth. His 74-year-old mother and his 7-year-old

daughter also had bright red palms all their life.

Diagnosis: Erythema palmare hereditarium

SarmaDP, Wang B (2007).Erythemapalmare hereditarium(Red palms):

LanesDisease.Dermatol Online J. 13(2). PMID: 17498447 [PubMed -

indexed for MEDLINE

Ref


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Abstract

A case of a wooden splinter dermatitis occurring in the foot of a 69-year old female is

reported. The clinical features, pathology and treatment of this common injury are

briefly reviewed.

Ref.

Chen M, SarmaDP(2007).Woodensplinter dermatitis.The Internet

J Dermatol 5(2). Indexed by Google Scholar.


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AbstractAbstractCutaneous ossification is as a primary event or secondary toCutaneous ossification is as a primary event or secondary to

a wide variety of inflammatory, traumatic, or neoplastica wide variety of inflammatory, traumatic, or neoplasticconditions. We describe a case of pilomatricoma withconditions. We describe a case of pilomatricoma withextensive ossificationextensive ossification

Ref.

SharmaP, SarmaDP(2007).Ossified pilomatricoma.The Internet J

Dermatol 5(2). Indexed by Google Scholar.


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AbstractAbstractWe report a case of a Merkel cell carcinoma of the dermis with a Bowen's diseaseWe report a case of a Merkel cell carcinoma of the dermis with a Bowen's disease

of the overlying epidermis arising in the left thigh in an 88of the overlying epidermis arising in the left thigh in an 88--yearyear--old Caucasianold Caucasianfemale. A brief review of the literature is presented.female. A brief review of the literature is presented.

CK20

Ref.

DebaP. Sarma, BoWang, James Shehan, LisaLinder-Stephenson:

Concurrent Merkel cell carcinomaand Bowen's disease of the thigh. The

Internet Journal of Dermatology. 2007. Volume 5 Number2.


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AbstractAbstractWe report a case of metatypical basal cell carcinoma on theWe report a case of metatypical basal cell carcinoma on thenose of a 79nose of a 79--yearyear--old woman with a brief review of theold woman with a brief review of theliteratureliterature

Ber-Ep4bcl2

Ref.

Eric E. Santos, DebaP. Sarma, Mingkui Chen, BoWang: Metatypical Basal

Cell Carcinomaof the Nose. The Internet Journal of Dermatology. 2007.

Volume 5 Number


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Abstract

Fibrofolliculoma is a very rare benign tumor of the skin that is derived from the

perifollicular sheath. Histologically, it shows a well-formed central hair follicle with a

dilated infundibulum containing laminated keratin with anastomosing epithelial strands

that radiate from the central hair follicle into the perifollicular fibrotic stroma. The

patients with multiple fibrofolliculomas have an association with Birt-Hogg-Dube

syndrome. We report a case of a solitary nasal fibrofolliculoma occurring in a 60-year-

old male and briefly review the literature.

Ref.

ZenggangPan, DebaP. Sarma: Solitary Nasal Fibrofolliculoma. The Internet

Journal of Dermatology. 2007. Volume 5 Number2.


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Abstract

A case of intramuscular angioma in the frontalis muscle of the forehead

is reported. The etiology, pathology and treatment of this rare tumor

are briefly reviewed.

Ref.

Mingkui Chen, DebaP. Sarma: Intramuscular Angiomaof the

Frontalis Muscle. The Internet Journal of Dermatology. 2007.Volume 5 Number2.


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AbstractAbstractWe report a rare case of a dermal nerve sheath myxoma of the left intranasal skin occurring in aWe report a rare case of a dermal nerve sheath myxoma of the left intranasal skin occurring in a3333--yearyear--old female. Abrief review of nerve sheath myxoma and a similar tumor, neurothekeoma, isold female. Abrief review of nerve sheath myxoma and a similar tumor, neurothekeoma, ispresented.presented.

S-100

Ref.

Jeff F.Wang, DebaP. Sarma, Eric E. Santos, BoWang: Dermal Nerve Sheath

Myxoma. The Internet Journal of Dermatology. 2007. Volume 5 Number2.


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AbstractMedical students and the trainees in dermatology and pathology have a curiosity about the names, such as,

acne vulgaris or verruca vulgaris. The word vulgaris sounds like vulgar, commonly meaning crudely indecent,

coarse, or obscene. However, the word vulgar is derived from the Latin word vulgaris, meaning of orbelonging to the common people. In medical terminology, the word vulgaris means common or ordinary.

A search through the indexes in Dermatology and Pathology text books revealed seven dermatologic

conditions with vulgaris in their names. These included very common diseases, such as, acne vulgaris and

verruca vulgaris as well as now rarely diagnosed disease, such as, lupus vulgaris. We are briefly reviewing the

seven vulgaris diseases of the skin.

Ref.

Mingkui Chen, Erin Bruno, Eric E. Santos, DebaP. Sarma: A brief review ofthe vulgarislesionsof the skin. The Internet Journal of Dermatology.

2007. Volume 6 Number 1.


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AbstractAbstractWe present a case of an 81We present a case of an 81--yearyear--old male with anold male with anasymptomatic skin nodule on his left upper cheekasymptomatic skin nodule on his left upper cheek

Ref

BoWang, DebaP. Sarma: Sebaceous Carcinomaand Mismatch Repair

Gene Expression. The Internet Journal of Dermatology. 2007. Volume 6

Number 1


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Case Report

This is a photomicrograph (Figure 1) of a biopsied asymptomatic skin nodule from the anterior neck of a

45-year-old man. There was no history of trauma or previous surgical procedure in this location. The

epidermis is somewhat raised with hyperkeratosis and acanthosis. The upper dermis shows fibrosis. A

well-circumscribed dermal tumor nodule shows no extension into the subcutis. The tumor is composedof mature hyaline cartilage with normal chondrocytes within a homogeneous basophilic stroma. The

chondrocytes show mostly single small nuclei without any significant atypia (Figure 2). There is no

necrosis or mitotic figures. Secondary ossification or calcification is not present. The periphery of the

tumor is free of any giant cell reaction, granulation tissue or any evidence of traumatic tissue reaction.

The lesion appears to be a true chondroma in the dermis.

Ref

DebaP. Sarma, Mingkui Chen, BoWang: Chondroma Cutis. The Internet



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Case presentation

We report a case of a 59-year-old woman with a cutaneous

leiomyosarcoma associated with osteoclast-like giant cells arising from the

subcutaneous artery of the leg. The nature of the giant cells is discussed in

light of the findings from the immunostaining as well as survey of the

literature.

Ref.

Sarma DP, Santos EE, Wang B (2007). Leiomyosarcomaof the skin with osteoclast-like giant cells: a case report. J

Med Case Reports 1(1):108. PMID: 18081931 [PubMed - in

process


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Abstract

Dermatomyofibroma is a rare, benign cutaneous tumor derived from

myofibroblasts. It is predominantly found in young women, and only a few

cases have been reported in males. This entity is not generally well known and

often misdiagnosed. We report such a case of dermatofibroma occurring in a

23-year-old male with a brief review of the English literature.

ZenggangPan, Edward D. Adickes, DebaP. Sarma: Dermatomyofibroma: ACase Report And Review OfThe Literature. The Internet Journal of

Dermatology. 2008. Volume 6 Number2.

SMA

Ref.

Ab t t


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Abstract

Mycobacterium mucogenicum is a recently characterized organism that rarely may cause human infections.

This rapidly growing mycobacterium is commonly identified in tap water. Both immunosuppressed and

immunocompetent patients may develop infections from Mycobacterium mucogenicum. Some patients have

experienced lethal disease, including sepsis. Infections occurring in the skin and soft tissues have been

described only after a preceding injury. We present the first case of infection with Mycobacterium

mucogenicum occurring in a patient on the TNF- antagonist etanercept and without any prior soft tissue

injury.

AFB stain

Ref.

Shehan JM, SarmaDP. (2008). Mycobacteriun mucogenicum: Report of a skininfection associated with the use of Etanercept. Dermatology Online J. 14(1): 5.

PMID: 18319022 [PubMed - indexed for MEDLINE]


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SarmaDP, Wang JF, McAllister MV, Wang B, Shehan JM. (2008)

Possible implantation carcinoma of the scalp following craniotomy

for metastatic renal cell carcinoma. Dermatology Online J

14(6):20. PMID: 18713600 [PubMed - indexed for MEDLINE

Ref.

Abstract

We report a case of a 50-year-old man who developed a possible implantation

carcinoma of the scalp within the craniotomy scar 19 months after a metastatic renal

cell tumor nodule was removed from the brain. The English literature on the

implantation carcinoma is briefly reviewed.

RCC immunostain


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Pan Z, Albertson D, Bhuller A, Wang B, Shehan JM,

SarmaDP. (2008)Angiosarcoma of the scalp mimicking a

sebaceous cyst. Dermatolgy Online J 14 (6): 13. PMID:

18713594 [PubMed - indexed for MEDLINE

Ref.

AbstractAbstractA58A58--yearyear--old Caucasian woman presented with a cystic lump behind the right earold Caucasian woman presented with a cystic lump behind the right earthat was clinically diagnosed as an infected sebaceous cyst. The lesion wasthat was clinically diagnosed as an infected sebaceous cyst. The lesion wastreated with incision and drainage followed by antibiotics for 3 months. Becausetreated with incision and drainage followed by antibiotics for 3 months. Becausethere was no resolution, a biopsy was performed that revealed a high gradethere was no resolution, a biopsy was performed that revealed a high gradeangiosarcoma. She expired 2 months later. Cutaneous angiosarcoma is anangiosarcoma. She expired 2 months later. Cutaneous angiosarcoma is anextremely aggressive tumor. Therefore early diagnosis and management is crucialextremely aggressive tumor. Therefore early diagnosis and management is crucial

in providing better patient care.in providing better patient care.

CD34

Factor VIII


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Wang JF, Wang W, Shehan JM, SarmaDP. (2008).

Acantholytic seborrheic keratosis. The Internet J Dermatol 6 (2).

Indexed by Google Scholar.

Ref.

Abstract

We are reporting a rare case of an acantholytic seborrheic keratosis and briefly

reviewing the relevant literature.


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Wang JF, SarmaDP. (2008). CD34-positive fibroma

of the lip. The Internet J Dermatol 6 (2). Indexed by

Google Scholar.

Ref.

AbstractAbstractWe are reporting a case of CD34We are reporting a case of CD34--positive fibroma of the lip. English literature is briefly reviewed.positive fibroma of the lip. English literature is briefly reviewed.

A 56-year-old female presented with a slightly raised nodule on the lower lip measuring 0.7 x 0.7 cm. This lesion was noted by the

patient for about a month. There was no history of trauma or previous biopsy at this site. An excisional biopsy was performed.

Case Report

CD34 Vimentin


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Wang JF, Wang B, Shehan JM, SarmaDP. (2008). Use of MITF

(Microphthalmia-Associated Transcription Factor) immunostain for diagnosis

of desmoplastic melanoma. The Internet J Dermatol 6 (2). Indexed by Google

Scholar.

Ref.

Abstract

We are reporting a case of desmoplastic malignant melanoma that was confirmed by

immunostaining for microphthalmia-associated transcription factor (MITF). A brief review

of utility of MITF for diagnosis of melanoma is presented.

S100 MITF


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Wang B, SarmaDP, Javadzadeh BM, Shehan JM, (2008). Solid and cystic clear

cell hidradenoma with focal intracystic carcinoma in-situ. The Internet J Dermatol


Ref.

Abstract

A rare case of a nodulocystic hidradenoma with intracystic carcinoma in-situ occurring

in the scalp of a 79-year-old man is reported.


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SarmaDP, Teruya B, Wang B (2008). Paraganglioma-like dermal melanocytic

tumor: a case report. Cases Journal 1:48. PMID: 18638402 [PubMed - in process]

Ref.

Abstract

Paraganglioma-like dermal melanocytic tumor is a rare subtype of benign dermal melanocytic tumors. Its

histopathologic features resemble those of paraganglioma, but the immunostaining characteristics are

those of melanocytic lesions.

We report a case of a 60-year-old male with a paraganglioma-like dermal melanocytic tumor of his left

cheek and briefly review the English literature.

S100


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Wang B, Wang J, Shehan J, SarmaDP.(2008). Glomus tumor of the cheek.

The Internet J of Dermatology 6 (2). Indexed by Google Scholar.

Ref.

AbstractAbstractWe are reporting two cases of glomus tumor of the cheek that we had recently encounteredWe are reporting two cases of glomus tumor of the cheek that we had recently encounteredduring the last six months. English literature is briefly reviewedduring the last six months. English literature is briefly reviewed..

Case ReportsA 51-year-old male presented with an asymptomatic red right lower cheek lesion that was clinically diagnosed as a

venous lake.


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Shehan J, Wang JF, Repertinger S, SarmaDP.(2008). Perianal squamous cell

carcinoma in-situ: a report of two human papilloma virus-negative cases. Cases J

1(1):114. PMID: 18715505 [PubMed - in process]

Ref.

AbstractWe are reporting two cases of perianal squamous cell carcinoma in-situ, negative for high-risk (HR) and

low-risk (LR) human papilloma viruses. A brief review of anal and perianal squamous cell carcinoma and the

role of HPV are presented.

IntroductionSquamous cell carcinoma, the second most common form of skin cancer, most often affects sun-exposed

surfaces. However, squamous cell carcinoma can involve skin surfaces not previously exposed to sunlight,

such as in the anal and perianal regions. Invasive perianal squamous cell carcinoma is a locally infiltrative

malignant skin tumor that exhibits destructive growth. It is a relatively uncommon tumor, which develops

from the precursor lesion anal intraepithelial neoplasia (AIN). Immunosuppression is felt to be a risk factor.


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Repertinger S, Wang J, Adickes E, SarmaDP. (2008). Melanoma in-situ

arising in seborrheic keratosis: a case report. Cases J 1 (1):263. PMID:

18947402 [PubMed - in process]

Ref.

An-86-year-old male with a history of multiple actinic keratoses and seborrheic

keratoses of the head and trunk presented with a mid-back skin lesion. The lesion

was poorly circumscribed, flat, and gray, with a pink-tan, well-circumscribed scaly

nodule within it. The biopsied lesion was composed of the usual features of

hyperkeratotic seborrheic keratosis, but with focal atypical melanocytic proliferationwith nesting along the dermal-epidermal junction. We interpreted this lesion as a

melanoma in-situ arising within a seborrheic keratosis.

MITF

Abstract


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Repertinger SK, Stevens T, Markin N, Klepacz H, SarmaDP.(2008).

Fibroepithelioma of Pinkus with pleomorphic epithelial giant cells. Dermatology

Online J 14(12):13. {Pubmed- in process].

Ref.

Abstract

Fibroepithelioma of Pinkus is a rare, indolent variant of basal cell carcinoma (BCC). The presence of pleomorphic

giant cells in such a tumor is extremely rare and to our knowledge, only one such case has been previously

reported in the literature. We report another case occurring as a pedunculated, gluteal lesion in an 82-year-old

man. The nodule was lightly pigmented, polypoid, and measured 1.0 cm in greatest dimension.

Immunohistochemical staining confirmed that the giant cells were of epithelial origin and that the proliferative rate

of these cells was low

CD68

p63

Ab t t


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Liu H, Wang J, Bewtra C, SarmaDP. (2009). Symptomatic gallbladder metastasis

from cutaneous melanoma. The Internet J Gastroenterol 7(2). Indexed by Google

Scholar

Ref.

Abstract

Although 50%-65% of metastatic gallbladder tumors come form malignant

melanoma, clinically diagnosed cases are very rare. We are reporting such a

symptomatic case of metastatic melanoma in the gall bladder occurring in a 40-year-

old man.

Figure 1: Microscopic picture ofmetastatic melanomain the gallbladder, H&E,

X20

Documents

Dermatopathology: Creighton University Dept of Pathology- Published Dermatopathology Cases (2006- 2010): Deba P Sarma, MD