Developing a shared infrastructure for personalised health ... › fileadmin › ... · Developing a shared infrastructure for personalised health and medicine research: experience

Developing a shared infrastructure for

personalised health and medicine research:

experience from the Netherlands

International Conference on Perspectives in Precision MedicineCopenhagen, 1 March 2018

Prof Alain van Gool

The Dutch way of collaborating

2 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

Source: www.waterschappen.nl

Source: www.leestekensvanhetlandschap.nl

Source: http://www.deltawerken.com

30 April 2009 A-STAR biomarker seminar, Singapore

The Dutch way of collaborating

Collaboration is key to advance in health research

Dutch CC meeting ‘Personalized Health Care”

Ede, 2 October 2013

Alain van Gool

Lecture LKCH, UMC Utrecht

29 October 2013

Alain van Gool

Knowledge

validation &

application

Knowledge

translation

Knowledge

exploitation

Fundamental

knowledge

Universities IndustryUniversity medical

centers

Applied Research

Institutes


Collaboration is key to advance in health research


Ede, 2 October 2013

Alain van Gool


29 October 2013

Alain van Gool

Knowledge

validation &

application

Knowledge

translation

Knowledge

exploitation

Fundamental

knowledge

Universities IndustryUniversity medical

centers

Applied Research

Institutes


https://www.google.nl/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiLsvL0--jMAhWKWhQKHUFEBWMQjRwIBw&url=https://en.wikipedia.org/wiki/Leiden_University&bvm=bv.122448493,d.ZGg&psig=AFQjCNG2nD-SOcwwEdKmo9jecYe4fqRj-w&ust=1463844511999998

Money fuels collaboration


Ede, 2 October 2013

Alain van Gool


29 October 2013

Alain van Gool


Highlights discussed today

• Netherlands Genomics Initiative (NGI)

• Public Private Partnerships (TIP, CTMM, BMM)

• Topsector Life Science Health (Health~Holland)

• Dutch Techcenter for Life Sciences (DTL)

• Dutch National Research Agenda (NWA)

• Radboudumc Technology Centers (RTC)

• Large scale technology Infrastructures (X-omics)

• Dutch infrastructure for personalized

medicine and health research (Health-RI)


Funding large scale Netherlands technological networks2002-20103


Funding large public-private partnership programs

(Centre for Translational Molecular Medicine) (Top Institute Pharma)

(BioMolecular Materials)

2006-2015


Funding large public-private partnership programs

(Centre for Translational Molecular Medicine) (Top Institute Pharma)

(BioMolecular Materials)

2006-2015

Outcome:

1. Results (drugs, diagnostics, devices)

2. Culture change in Netherlands



Redefine private interest in Public-Private Partnerships

{www.rijksoverheid.nl}

{http://www.zonmw.nl/nl/roadmaps-lsh/}

Roadmap Molecular Diagnostics:

• Build an efficient biomarker development pipeline in Netherlands

• Bring all stakeholders together in a functional open innovation network based on public-private-partnerships

• Have end-users (patients) direct biomarker discovery in beginning

• Improve progress of biomarkers from discovery to clinical implementation

9 TopSectors Multiple Roadmap teams per TopSector

2011-2012

Science for Science

Science for Industry

Science for Society

Strategy building

Nico van Meeteren

Email: [email protected]

mailto:[email protected]

Ambitions

Dutch Delta

Buck Consultatnts international, 2016

Growth

2017 2017

Growth

An ‘aligned’ cluster reaching out

37 applied universities69 vocational education institutes

“If ‘I’ is replaced by ‘we’,

even illness turns into wellness”

http://new.theprophouse.com.au/wp-content/uploads/2012/08/TH0905-Orange-Carpet-Runner.jpg

Redefine private interest in Public-Private Partnerships

{www.rijksoverheid.nl}

{http://www.zonmw.nl/nl/roadmaps-lsh/}

9 TopSectors Multiple Roadmap teams per TopSector

2011-2012


DUTCH TECHCENTER FOR LIFE SCIENCESNL platform enabling cross-disciplinary research

PARTNERSHIP FOR DATA, TECHNOLOGIES & LEARNING

>100 EXPERT GROUPS INVOLVED SO FAR

Nijmegen

Amsterdam

Wageningen

Utrecht

Rotterdam

Eindhoven

Maastricht

Groningen

Leiden

Delft

Enschede

Zeist

Hanze University

University Groningen

UMCG

Hubrecht Institute

UMCU

Utrecht University

Wageningen UR

PRI

TU Twente

Radboudumc

Radboud University

Maastricht Univ.

MUMC+

CTMM

TUe

ErasmusMC

Generade

LUMC

Leiden University

Naturalis

TUDelft

AMC

AMOLF

CWI

NLeSC

NKI

SURFSARA

University of Amsterdam

VU University Amsterdam

VUMC

TNO

20

17

44

13 115

6

4

5

1

9Technology & data

hotels

Access to high-tech

expertise & facilities

Wetlab & data facilities

Collections of

biosamples/cohorts

Public and private labs

Training & education

High-quality

experimental design

measuring

data stewardship


Enabling Technology Hotels

program

www.dtls.nlwww.zonmw.nl

• Explore and use the DTL network• 4 rounds of funding 30k projects• Total 4,2M euro• 5 page proposals• 50% success rate


FOCUS ON CRITICAL COMPONENT: THE DATA

{Wilkinson et al, Nature Scientific Data, 2016}

Data capture

Data stewardship (FAIR)


FAIR EVOLVING RAPIDLY INTO A GLOBAL MOVEMENT

Rapid acceptance and endorsement process

✓ The conference

✓ The Website

✓ Research Data Alliance endorsement

✓ DTL flagship project

✓ FORCE11 international partner

✓ Articles accepted in NATURE

✓ NIH accepts FAIR compliance in Life Sciences Commons

✓ DTL Data lead Prof. Barend Mons Chair High Level Expert Group EC

✓ The Personal Health Train Initiative started

✓ EC announces European Open Science Cloud with FAIR as leading principle

World 2017


ALSO THE G20 HAS RECENTLY ADOPTED FAIR!

“We support appropriate efforts to promote open science and facilitate

appropriate access to publicly funded research results on findable, accessible,

interoperable and reusable (FAIR) principles.” (Statement 12)

http://europa.eu/rapid/press-release_STATEMENT-16-2967_en.htm


Personal Health Train



Redefine public needs: Dutch National Research Agenda

2ND intl Pharma-Nutrition Conference

Singapore, 17 April 2013

Alain van Gool


29 October 2013

Alain van Gool

https://wetenschapsagenda.nl/?lang=en

2016

• 12.000 questions from citizens• Summarized in 140 cluster questions• Addressed in 16 routes• Translated into National Research Agenda• Presented to government

Highlights discussed today

• Netherlands Genomics Initiative (NGI)

• Public Private Partnerships (TIP, CTMM, BMM)

• Topsector Life Science Health (Health~Holland)

• Dutch Techcenter for Life Sciences (DTL)

• Dutch National Research Agenda (NWA)

• Radboudumc Technology Centers (RTC)

• Large scale technology Infrastructures (X-omics)

• Dutch infrastructure for personalized

medicine and health research (Health-RI)


www.radboudumc.nl


Genomics

Bioinformatics

AnimalResearch Facility

Stemcells

Translationalneuroscience

Image-guided treatment

Imaging

Microscopy

Biobank

Healtheconomics

Mass Spectrometry

RadboudumcTechnology

Centers

Investigationalproducts

Clinicalstudies

Health Data

Biostatistics

Humanperformance

Datastewardship

Molecule

Flowcytometry

3D lab

100+ technology experts working in 19 Technology Centers, ~1800 users (internal, external), ~150 consortiawww.radboudumc.nl/research/technologycenters

31

Build biomarker validation pipelines

Standardisation, harmonisation, knowledge sharing in:

1. Assay development

2. Clinical validation

www.biomarkerdevelopmentcenter.nl

Rainer BischoffTheo Luider,

Alain van Gool and


http://www.erasmusmc.nl/index.htm

Collaboration towards Good Biomarker Practices

{van Gool et al, Nature Reviews Drug Discovery, Apr 2017}

COST action CA16113 http://clinimark.eu


Fund large scale scientific infrastructures

www.nwo.nl

2016:• Inventory• Clustering• Communicating

2017:• 1st call for proposals

(100M)

2018:• Funding

2019:• 2nd call for proposals

(100M)


The Netherlands X-omics Initiative

www.x-omics.nl

2018-2023 ?


Further joining forces in NetherlandsTo drive personalized medicine & health research

2015


Organize a scattered landscape …

Knowledge institutes

VSNU

Beta

NFU projects

Topinstitutes

CTMM / TraIT

TI Pharma /

Mondriaan

NL Roadmap largescale research

infrastructure/ ESFRI

EATRIS-

NL/EATRIS

DTL/ELIXIR-

NL/ELIXIR

BBMRI-NL /

BBMRI

- /ECRIN

NeCEN/

INSTRUCT

PSI/Life Lines

Funding other than ESFRI

ZonMW

Various charities

BioImagingNL/Bioi

maging

IMI

RIVM

private

institutes

NKI

Sanquin

Top-sectors

Ministeries

OC&W

International community

Many different parties

BMM

Sector/cross-sector platforms

Health~Holland

NGI/NBIC

Registratie aan

de Bron

Platform Clinical Research

Horizon 2020

NWO

eScience

Center

NFU

UU LU VU UvA

3TU RUG UM

VWS

DTLBMS.NL

Partners in PPP

CRO’s

Standardisation institutes

NEN NICTIZPharma

MKB / Spin off

Patient organisations

Various patient organisations

Hospitals

Diverse andere ziekenhuizen

Suppliers

EPD’s suppliers

IT companies (IBM, Oracle,

SAS etc.)

Largescale devices (Philips

e.a.)

SURF/VANCIS

TNO

EZ

Hubrecht

Institute

UMC Utrecht LUMC VUmc AMC

RadboudMC ErasmusMC UMCG MUMC

Radboud

KNAW

(overig)

CBS


Bring together relevant initiatives …

2014

2016

- 2009 200 biobanks


Nationwide community in personalized healthcare

www.health-ri.org39 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

1-3-2018 40

http://www.alzheimer-nederland.nl/

Towards life-spanning personalized health and medicine research

Source: Nico van Meeteren, Health~Holland


The ‘funhouse mirror’ effect in Precision Medicine

• Multiple sources of your data

• EPD• Diagnostics• Wearables• Health apps• Commercial health

tests• Social media• Surrounding

• Each give an(incomplete) image of you

• Some you want to see, some you don’t

• Not technical issue• Ethical, philosophical


Acknowledgements

Hans Wessels Jolein Gloerich

Roel Tans Esther Willems

Maurice van Dael Jenneke Keizer

Dirk Lefeber Monique van

Scherpenzeel

Leo Kluijtmans Ron Wevers

Marcel Verbeek Karlien Coene

Jan Kremer Bas Bloem

Lucien Engelen Paul Smits

the Radboudumc Technology Centers

and many others

Jan van der Greef Ben van Ommen

Ivana Bobeldijk Hans Princen

Lars Verschuren Marjan van Erk

Suzan Wopereis Heleen Wortelboer

Wessel Kraaij Jildau Bouwman

Peter van Dijken and many others

Ruben Kok Barend Mons

Jaap Heringa Merlijn van Rijswijk

and many others

Anton Ussi Florence Bietrix

Laura Bermejo Andreas Scherer

Sulev Koks Marian Hajduch

Toni Andreu

and many others

Collaborators/funders

CarTarDis

[email protected]

www.linkedIn.com

www.slideshare.net/alainvangool


http://www.erasmusmc.nl/index.htm

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Developing a shared infrastructure for personalised health ... › fileadmin › ... · Developing a shared infrastructure for personalised health and medicine research: experience