Development of VIRTUAL LAB solutions through ICT on Microwave Biosensors Applications towards Early & Efficient

Diagnosis of Health Risks in Rural Zones of India.

Pilot proposal submitted toMinistry of Human Resource Development

Under the Scheme on“National Mission on Education through Information and Technology”

Dr. K. S. DayaMicrowave Physics Laboratory

Department of physics & Computer ScienceDayalbagh Educational Institute

Dayalbagh, Agra –282 110

NON-INVASIVE PLANAR MICROWAVE SENSOR for BLOOD GLUCOSE DETECTION

RAPID DETECTION MICROWAVE SENSOR FOR THE PRESENCE OF PATHOGENIC BACTERIA IN DRINKING WATER

Virtual Lab realisation on

Design objective

- Design & development of biosensors.- Developing a device by integrating the developed sensor, data analyser & the data converter.- Fusing the developed device to a communication gadget.

Present proposal aims to develop Virtual Lab solutions using devices based on simple microwave structures for effective early diagnosis of health risks.

Technology advancements in the field of healthcare and biological sciences has overwhelmingly influenced our lifestyle

and lifespan. However, advanced technologies today seem incomplete -due to the complexity of the biological systems -for its drawbacks in providing easy and fast information as it requires

# highly priced consumables,# considerable time # skilled manpower,

none of which are easily available.

Motivation

Motivation- Cont…

Hence…understanding the health risks and the health status of individuals in the rural India has not been viable till date.Over half the population of India are inhabited in rural or geographically challenging locations, thus any statistics available on the health is incomplete.

Working Principle

• Interaction between microwaves and matter • the electric field passes through the dielectric

medium, • electric field affects medium parameter called

permittivity (dielectric constant)• Measuring the dielectric properties of a material can

indirectly measure other properties that have a correlation to the material

For Eg:- Dielectric constant of blood increases with increase in glucose level in blood

• Microwave sensors are very sensitive to change in dielectric constant and most of biological substances either have high dielectric proteins or are dielectric proteins themselves.

• Microwave sensor does not require any reagents or chemical, thus an indigenous solution without interdependencies

• Unlike biological methods, results are immediate.

Advantages

• Easy to use • No technical expertise required• Can be a completely portable systems• No reagents or chemical required, thus

eliminating the need of supply chain for transporting chemicals to remote locations

• Gives autonomy to the user resulting in better health safety concern

Other Benefits

Non Invasive Blood Glucometer

Low cost, NO-PRICK and easy to use solution for continuous self monitoring of blood glucose .

Sensor Design & Development

Thus there is an immediate need for a easy and safe solution which will overcome:-

The psychological hassle to a prick.Blood related safety concerns (infections)Requirement of skilled manpower.Requirements of consumables of conventional ready to use

invasive gluco-meters.

And …

Provides with an indigenous and user friendly self monitoring systems to the under privileged and elderly

Rapid Pathogen Sensor

Sensor Design & Development

Low cost, user friendly and easy to use solution for consistent monitoring of bacterial pathogens in water.

There is an immediate need for a easy and rapid solution which will overcome:-

Cost Prolonged TAT Result related problems on consistency / repeatability & reproducibility Requirement of skilled manpower. Requirement for instruments. Requirements of consumables for conventional and test kits.

Microstrip line type sensor

Sensitivity : 8.71 mg/dl per MHz % Error : 15%

Proof of Principle

0 20 40 60 80 100 120 140 160 1800

50

100

150

200

250

300

350

400

Shift in Frequency (MHz)

Blo

od G

luco

se L

evel

(m

g/dl

)

Frequency shift and Glucose level in blood

Sample - Simulation Results

Base Architecture• Hand held device (Mobile phone) used by a patient.• Conversion of microwave data• Test Value displayed. • Data Interpretation and advice on future course of

action. (through voice, preferably in local language) • Simultaneously transmits the information to a Physician / Hospital / Repository

Realising the VIRTUAL LAB Solution

Architecture for realising Virtual Lab Non-Invasive Glucometer

(SMS)

(VOICE)

Architecture for realising Virtual Lab Rapid Bacterial Sensing

Personal information fed into the device

Calibration (automated)

Test (finger against the sensor)

Data conversion

Result interpretation

Advice to patients

Communication (SMS) to Health care personnel

Information to a

Database

Calibration (automated)

Test

Data conversion

Result interpretation

Information to a Database

Alike models

• DIAdvisor – Ongoing project titled the PERSONAL HEALTH SYSTEMS through ICT under the Seventh Framework Programme (FP7) of the European Union (EU).

• Project duration – 2008 to 2012• Project cost - €9,300,000

Timeline & Deliverables for thePILOT PHASE

Time Line Deliverable Milestones

0th month Project kick off

3rd Month Designing of resonator

6th Month Identifcation of suitable dielectric material and simulation of glucometer sensors

9th Month Spiking studies for the presence of bacteria.

1st Miles stone

12th Month Live testing of gluco sensors.

2nd Mile stone.

Non-Recurring INR 1.28 Crore

Recurring INR 0.441 Crore

Total INR 1.73 Crore

Proposed Budget forPILOT PHASE

Details of Proposed Non -Recurring Budget

S.No.

ITEM Cost in Lakhs (in INR)

1 Site Preparation 5

2 Bax DUPONT PCR based detection system 40

3 Laminar Air Flow Bench 3

4 Biosafety Cabinet 5

5 Deep Freezer 10

6 Incubators 3

7 Glass wares 5

8 Millipore filter Assembly with Vaccum pump 2

9 Analytical Balance 2.0

10 Refrigerator 1.0

11 Books & Journals 15

12 Autoclave 1.5

13 Other software 15.0

14 Microscope 10

15 Hot air oven 1.0

16 Spinner 1.0

17 Millipore water purification system 5

18 Microwave Connectors 5

19 Other equipments 7.5

Total Non Recurring Cost 128.2

Details of Recurring Budget

Thank You