Dokuz Eylul University Graduate School of Natural and ... Department … · [email protected] . Kadriye Ertekin : Analytical Chemistry, Chemical Sensors, Acid-Base Chemistry

Dokuz Eylul University Graduate School of Natural and Applied Sciences

Department of Chemistry

Established in 1998, Department of Chemistry offers 1-year English Preparatory School and 4-year Bachelor’s degree program in Chemistry. At undergraduate level, curriculum follows the Active Learning method, which is often synonymously called Problem Based Learning. Graduate study is also available in Chemistry both at Master’s and PhD level. Active Learning is a student-centered approach to education that brings an alternate model to the traditional teacher-centered education. The annual curriculum in Active Learning undergraduate program is composed of 14 individual modules each concentrating on different topics on Chemistry. At the end of 2-week modules, students are obliged to take a Module Evaluation (ME). In one academic year, there are fourteen MEs, two Term Evaluations (TE) for Fall and Spring terms each, and one Final Evaluation (FE) for those who can not achieve 80 Grade Point Average (GPA) at the end of the academic year. Active Learning in Chemistry (ALICE) depends on Problem Based Learning (PBL) sessions that urge students to question, discuss, and investigate the issues raised in the reading comprehension texts and worksheets given to them in each session. Related to modular topics, PBL sessions are supported by lectures and a variety of curricular activities such as Language and Writing, Laboratory Studies in Physics and Chemistry, Physics and Mathematics Lectures, Summer Practice, and Computer Aided Education. The quoted names given in parenthesis are the Turkish equivalents for the names of the curricular activities in the program. Descriptions of these curricular activities are given in Module Description Form. The language of instruction is partly in English. At the beginning of each term, students are given reading lists that comprise of the main texts essential to Chemistry as well as to Physics and Mathematics in the first year. The curriculum is based on these texts, and students are expected to develop a critical mind and analytical thinking that will enable them to deconstruct the components that make up Chemistry. The syllabi of curricular activities are also designed to provide the students with the methodology and techniques as how to combine science topics as they were followed in High Schools and develop a critical approach, promote research, and write an academic research paper on a given topic. Chairman: Prof. Dr. Kadir Yurdakoç Deputy Chairs: Secretary: Havva Kuyucu Phone: (232) 412 85 16 Postal Address: DEU Faculty of Arts and Sciences Department of Chemistry Tınaztepe Campus, Buca 35160 IZMIR Socrates Programme Coordinator: Assoc. Prof. Dr. Melek Merdivan Phone: (232) 412 86 93 Fax: (232) 453 41 88 Email: [email protected]

ACADEMICS Full Professors

Name Research interests e-mail

Kadir Yurdakoç

Physical Chemistry, Adsorption, Catalysis, Chemical Kinetics, Thermodynamics and Biophysical Chemistry

[email protected]

Associate Professors


Serap Alp Organic Chemistry, Photochemistry, Dyes and Pigments [email protected]

Melek Merdivan Analytical Chemistry, Chemometrics, Separation Methods melek.merdivan@ deu.edu.tr

M. Yavuz Ergün Organic Chemistry, Natural Compounds [email protected]

Kadriye Ertekin Analytical Chemistry, Chemical Sensors, Acid-Base Chemistry [email protected]

Mürüvvet Yurdakoç Inorganic Chemistry, Boron Chemistry [email protected]

Assistant Professors


Elif Subaşı Inorganic Chemistry, Organometalic Compounds [email protected]

M. Nalan Tüzmen Biochemistry, Biotechnology [email protected]

Instructors


Levent Çavaş Biochemistry, Marin Chemistry [email protected] Research Assistants


Zehra Bekçi Physical Chemistry [email protected] Elif Ant Bursalı Inorganic Chemistry [email protected] Güneş Çolak Günhan Physical Chemistry [email protected] Senem Karahan Inorganic Chemistry [email protected] Özlem Öter Analytical Chemistry [email protected] Gülsiye Öztürk Organic Chemistry [email protected] Yoldaş Seki Physical Chemistry [email protected] Serap Seyhan Analytical Chemistry [email protected] Nilgün Candan Yücel Biochemistry [email protected] Derya Topkaya Organic Chemistry [email protected]

mailto:[email protected]

GRADUATE CURRICULUM OF CHEMISTRY DEPARTMENT Güz Yarıyılı/Fall Semester

Ders Kodu Ders Adı T P L C ECTS

Credit KIM501 Advanced Analytical Chemistry 3 0 0 3 8 KIM503 Advanced Physical Chemistry 3 0 0 3 10 KIM511 Advanced Organic Chemistry 2 0 0 2 7 KIM513 Organometallic Compounds 3 0 0 3 8 KIM515 Polymer Chemistry 3 0 0 3 7

KIM519 Chromatographic Methods in the Purification and Separation of Organic Compounds 2 2 0 3 9

KIM521 Advanced Inorganic Chemistry 3 0 0 3 9 KIM523 Enzymatic Methods of Analysis 3 0 0 3 9 KIM525 Enzyme Science 3 0 0 3 8 KIM527 Immobilized Enzymes, Cells and Organelles 3 0 0 3 8 KIM529 Thermal Methods of Analysis 3 0 0 3 10 KIM531 Adsorption Surface Area and Porosity 3 0 0 3 10 KIM533 Kinetics of Complex Reactions 3 0 0 3 9 KIM535 Chemometrics 3 0 0 3 10 KIM537 Optical Sensors in Chemistry 3 0 0 3 9 KIM539 Metabolism 3 0 0 3 9 KIM601 Mass Spectroscopy 3 0 0 3 9 KIM603 Free Radical Chemistry 3 0 0 3 8 KIM605 Fast Reactions 3 0 0 3 10 KIM607 Analysis of Pesticides and Heavy Metals by Chromatographic Techniques 3 0 0 3 8 KIM609 Advanced Instrumental Methods 3 0 0 3 7 KIM611 Fundamentals of Bioprocess Engineering 2 0 0 2 9 KIM613 Enzyme Technology 3 0 0 3 8 KIM615 Methabolic Dismutation 3 0 0 3 8 KIM617 Cell Membranes 3 0 0 3 9 KIM619 Production of Industrial Salts 3 0 0 3 8 KIM621 Bioanorganic Chemistry 3 0 0 3 9 KIM623 Organic Reactions and Photochemistry 3 0 0 3 9 KIM625 Organic Dyes and Pigments 3 0 0 3 9 KİM627 Biochromatography 3 0 0 3 8 KIM629 Organic Reaction Mechanisms 3 0 0 3 9 KIM631 Reaction Mechanisms of Inorganic and Organometallic Systems 3 0 0 3 10 KIM633 Separation Methods in Analytical Chemistry 3 0 0 3 10 KIM596 C M. Sc. Seminar 0 2 0 0 5 KIM598 C M. Sc. Research 3 0 0 0 10 KIM599 C M. Sc. Thesis 0 0 0 0 20 KIM696 C Ph. D. Seminar 0 2 0 0 5 KIM698 C Ph. D. Research 3 0 0 0 10 KIM699 C Ph. D. Thesis 0 0 0 0 20 T: Theory, P: Practice, L: Laboratory, C: Credit

http://www.fbe.deu.edu.tr/bolumler/katalog.asp?ders_kodu=KIM501&program=KID































Spring Semester Ders Kodu Ders Adı T P L C

ECTS Credit

KIM504 Spectroscopic Methods of Analysis 2 0 0 2 8 KIM506 Radicals in Biochemistry 3 0 0 3 8 KIM508 Protein Purification Methods 3 0 0 3 8 KIM512 Heterocyclic Compounds 3 0 0 3 8 KIM514 Aromatic Compounds 2 0 0 2 7 KIM516 Advanced Biophysical Chemistry 3 0 0 3 8 KIM518 Stereochemistry of Organic Compounds 3 0 0 3 9 KIM520 NMR Spectroscopy 3 0 0 3 9 KIM522 Advances in Gas Chromatography and HPLC 3 0 0 3 10 KIM526 Chemistry of Transition Elements 3 0 0 3 9 KIM528 Trace Metals and Analysis 3 0 0 3 10 KIM530 Titrations in Non-aqueous Solvents 3 0 0 3 9 KIM532 Catalysis 3 0 0 3 10 KİM534 Bioanalytical Chemistry 3 0 0 3 9

KİM536 Synthesis and Structural Analysis of Inorganic and Organometallic Compounds 3 0 0 0 10

KIM602 Heterogeneous Catalysis 3 0 0 3 10 KIM604 Fuel Chemistry 3 0 0 3 8 KIM606 Advanced Chemical Process Industries 2 0 0 2 8 KIM608 Chemistry of Boron and Silisium 3 0 0 3 9 KIM610 Advanced Analytical Application of Ion Exchange Techniques 3 0 0 3 7 KIM612 Electrochemical Processes in Analytical Chemistry 3 0 0 3 8 KIM614 Radio analytical Chemistry 2 0 0 2 8 KIM616 Carbohydrates 3 0 0 3 8 KIM618 Structural Analysis Techniques of Natural Compounds 3 0 0 3 9 KIM620 Fermentation Technology 3 0 0 3 8 KIM622 Enzyme Activity Regulation 3 0 0 3 9 KIM624 Membrane Receptors and Their Formation Systems 3 0 0 3 9 KIM626 Organic Synthesis Design 3 0 0 3 9 KİM628 Xenobiotics and Metabolic Effects 3 0 0 3 8 KIM596 C M. Sc. Seminar 0 2 0 0 5 KIM598 C M. Sc. Research 3 0 0 0 10 KIM599 C M. Sc. Thesis 0 0 0 0 20 KIM696 C Ph. D. Seminar 0 2 0 0 5 KIM698 C Ph. D. Research 3 0 0 0 10 KIM699 C Ph. D. Thesis 0 0 0 0 20 C : Compulsory Courses T: Theory, P: Practice, L: Laboratory, C: Credit


























Course Code: CHEM 501 Course Title: Advanced Analytical Chemistry Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a Week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Hüsamettin Akcay Instruction Language: Turkish

PREREQUISITIES None DESCRIPTION Objectives: The course aims to provide an advanced understanding of the analytical chemistry and incorporation of computer technology (software based) with analytical chemistry

Learning outcomes:

By this course, student can remind the basic analytical chemistry topics and discuss them deeply.

To develop the students analytical thinking.

Contents: : Acid-base equilibria in aqueous and nonaqeous media, acid-base equilibria, acid-base titrations, complex formation equilibria, complexometric titrations, precipitation equilibria, precipitation titrations, oxidation-reduction equilibria, oxidation-reduction titrations, trace element analysis, instrumental methods.

TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

J. N. Miller, Modern Analytical Chemistry, Prentice Hall Int, 1993, ISBN 013 005042 3. Ed:J. Zyka, Instrumentation in Analytical Chemistry, Vol. 1-2, 1991,1992, ISBN 0,13 472218 3, 013

472226 4. J. S. Frite & C.H.Scenenek, Quantitative Analytical Chemistry, 1987, ISBN 0205 10554 8. M. S. Cresser, Flame Spectrometry in Environmental Chemical Analysis, RSC, 1994, ISBN 0

85186734 0. Ed. E.Prichard & G. Mackay, trace Analysis, RSC,1996,ISBN 0 85404417 5.

ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 503 Course Title: Advanced Physical Chemistry Level: Graduate Semester: Fall ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION Objectives: : Introduction and principles of quantum theory will be described in the first chapter. Techniques and applications of theory will be discussed. Atomic structure and atomic spectra will be outlined in detail. Molecular structure of hydrogenmolecule-ion, the structures of di- and polyatomic molecules will also be emphasized in detail.

Learning outcomes:

By this course, student can remind the basic physical chemistry topics and discuss them deeply.

Contents: : Quantum Theory: Introduction and Principles; Quantum Theory: Techniques and Applications (Translational, rotational and vibrational motions), The Harmonic Oscillator; Atomic Structure and Atomic Spectra (The structure and spectra of hydrogenic atoms, The structures of many electron atoms, The spectra of complex atoms); Molecular Structure (The hydrogen molecule-ion, The structures of diatomic and polyatomic molecules, Deocalized systems); Rotational and Vibrational Spectra (General features of spectroscopy, Pure rotational spectra, The vibrations of diatomic molecules). TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

• P. J. F Griffiths, “Calculations in Advanced Physical Chemistry”, E. Arnold; 3rd. ed. (1983). ISBN: 0713134836.

• A. Holderness, J. N. Lazonby, “Advanced Level Physical Chemistry”, Heinemann (December, 1976), ISBN: 0435654349.

• P. W. Atkins, “Physical Chemistry”, 7th ed., Oxford Univ. Press, Oxford, 2002. • Y. Sarıkaya, “Fizikokimya”, 2. Baskı, Gazi Kitapevi, Ankara, 1997.


Course Code: CHEM 504 Course Title: Spectroscopic Analysis Methods Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (2+0) Total Class Hours: 14 weeks x 2h. = 28h. Instructor: Prof. Dr. Hüsamettin Akcay Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: The course aims to provide an advanced understanding of the spectroscopic and electroanalytical techniques incorporation of electronic and computer technology.

Learning outcomes:

1. By this course, student can remind the basic analytical analysis methods and discuss them deeply.

2. To develop the students analytical thinking

Contents: : Uv-visible absorption spectroscopy, IR-spectroscopy, AAs, radiochemical methods, electrometric analysis methods.


1. H.N. Willard et. Al., Instrumental Methods of Analysis, ISBN: 0-442-24502-5, 1981. 2. Prof. Dr. T. Gündüz, Enstrümental Analiz, Bilim Kitapevi, Ankara, 1990.

ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 506 Course Title: Free Radicals in Biochemistry Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: Free radical formation and its effect on cell structure and dismutation mechanisms in metabolism are very interesting topics nowadays. Its physiological importance will be investigated in this course. Contents: Reactions of free radicals, Reduction of molecular oxygen, Superoxide radicals as a substrate, Radicals as intermediate, Radicals as reaction product, The action of radicals on copper proteins, Superoxide anion metabolism, The flavin redox-system and its biological functions. TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK 1. “Biochemie und Klinik der Superoxid Dismutase”, Perimed Fachbuch-Verlagsgesellschaft GmbH, (1985). ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 508 Course Title: Protein Purification Methods Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: Protein-enzyme purification is necessary to determine its structure properties, effect mechanisms and its clinical and industrial application. Contents: General methods for protein purification, Extract preparation, Formation of soluble proteins, Clarification of the extract, Concentration of the extract, Chromatographic methods, Electrophoretic methods. TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK 1. E. L.V. Harris and S. Angel, “Protein Purification Methods (A Practical Approach)”, IRL Press (1993). 2. M. P. Deutscher, “Guide to Protein Purification”, Methods in Enzymology (Alberson J.N, Simon M.R.) Vol.182, Academic Pres Inc. (1990). 3. S. M. Wheelwright, “Protein Purification: Design and Scale up of Downstream Processing”. ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 511 Course Title: Advanced Organic Chemistry Level: Graduate Semester: Fall ECTS Credit: 7 Status: Elective Hours a week: T. (2+0) Total Class Hours: 14 weeks x 2h. = 28h.

Instructor: Prof. Dr. Mustafa Toprak, Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: This course aims to emphasize and review the important point of organic reactions and mechanisms. Contents: Chemical Bonding and Molecular Structure; Stereochemical Principles; Conformational and Other Steric Effects; Study and Description of Organic Reaction Mechanisms; Nucleophilic Substitution; Polar Addition and Elimination Reactions; Carbanions and Other Nucleophilic Carbon Species; Reactions of Carbonyl Compounds; Aromaticity and Electrophilic Aromatic Substitution; Photochemistry; Free-Radical Reactions. TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK

• Francis A. Carey, Richard J. Sundberg, “Advanced Organic Chemistry: Structure and Mechanisms (Part A)”, Springer; 4 edition (September 30, 2004) ISBN: 0306462435.

• Bernard Miller, “Advanced Organic Chemistry”, Second Edition, Prentice Hall; 2 edition (July 1, 2003) ISBN: 0130655880.

ASSESSMENT Midterm exam 15 % Final Exam 60 % Project 25 % Total 100%

Course Code: CHEM 512 Course Title: : Heterocyclic Compounds Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Yavuz Ergün Instruction Language: Turkish PREREQUISITIES None DESCRIPTION: Objectives: This course aims to acquaint students with various types of heterocyclic ring systems and describing the preparation and properties of the heterocyclic compounds. Contents: Heterocyclic Ring Systems; Five-membered Ring Compounds with One Heteroatoms; Fıve-membered Ring Compounds with Two Heteroatoms; Six-membered Ring Compounds with One Heteroatoms; Six -membered Ring Compounds with Two Heteroatoms; Three- and Four-membered Ring Compounds. TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK

• Joule, G.F. Smith, “Heterocylic Chemstry”, Van Nostrand, Reintold Company, London (1972) • Leo A. Paquette, W.A. Benjamin, “The Principles of Modern Hetercylic Chemstry”, Inc. New York

(1970) • Katritky, J.M. Lagowski, “The Principles of Heterocylic Chemstry”, Chapman and Hall LTD. London

(1971) ASSESSMENT Midterm exam 25 % Final Exam 50 % Project 25 % Total 100%

Course Code: CHEM 513 Course Title: Organometallic Compounds Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Mürüvvet Yurdakoç Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Learning outcomes: An appreciation of the chemistry of organometallic complexes, and an ability to predict structure and reactivity in such complexes. SYNOPSIS

1. Reminder of what Organometallic Chemistry is, Revision of Electron Counting. 2. Molecular orbital picture of an octahedral complex; justification for the 18 electron rule. 3. Class I, II and III metal complexes, -donors and -acceptors and the spectrochemical series. 4. Synthetic routes to organometallic compounds. 5. Electropositive main group metal alkyls; lithium, magnesium and aluminium. 6. Transition Metal Alkyls; synthesis, stability and reactions. 7. Alkene, Alkyne, Allyl, enyl ligands, Cyclopentadienyl and cyclic aromatic ligands - metallocenes.

Objectives: The chemistry of compounds composed of metal and organic units together is called organometallic chemistry. Classification, sructural analysis, synthesis, stabilities and the chemical reactions of organometallic compouns will be investigated in this course. Contents: General look, structure and bonding fundamentals, effective atomic number rule (EAN), carbonyl ligand, π- ligands, the other important ligands. Organometallic reactions, homogeneous catalysis, transition metal-carbene and transition metal-carbine complexes and the usage of organometallic compounds in organic synthesis TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

• Gary O. Spessard, Gary L. Miessler, “Organometallic Chemistry”, Prentice Hall, 1996. • Ram C. Mehrotra, Arirudh Singh, “Organometallic Chemistry: A Unified Approach”, ISBN:

0470210192, 1991. • D. F. Shriver, P. W. Atkins, C. H. Langford, “Inorganic Chemistry”, Oxford University Press,

Oxford, 1998. • E. Huheey, “ Inorganic Chemistry of Structure and Reactivity ”, Harper & Row Publisher, N.Y.,

1978. • E. Prichard & G. Mackay, “Trace Analysis”, RSC,1996, ISBN 0 85404417 5.


Course Code: CHEM 514 Course Title: Aromatic Compounds Level: Graduate Semester: Spring ECTS Credit:7 Status: Elective Hours a week: T. (2+0) Total Class Hours: 14 weeks x 2h. = 28h. Instructor: Prof. Dr. Mustafa Toprak Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: This course aims to introduce the fundamentals and basic concept of aromatic compounds in organic chemistry Contents: Aromaticity; Electrophilic Substitution Reactions; Directive Effects in Electrophilic Substitution Reactions; Quantitative Investigation of Benzene Derivatives and Polynuclear Hydrocarbons; Nucleophilic Substitution and Elimination Reactions; Rearrangement Reactions; Synthetic Chemistry of Benzene Derivatives; Aromatic-Heterocyclic Structures. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

• Leon M. Stock, “Aromatic Substution Reactions”, Prentice-Hall, Inc. London, 1968. • Jerry March, “Advenced Organic Chemistry”, McGraw-Hill Book Company, N.Y. • Ralp Y. Fessenden, Joan S. Fessenden, “Organic Chemistry”, Brooks/Cole Publishing Company U.S.A.

1990. ASSESSMENT Midterm exam 15% Final Exam 60% Project 25 % Total 100%

Course Code: CHEM 515 Course Title: Polymer Chemistry Level: Graduate Semester: Fall ECTS Credit: 7 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Mehmet Kartal Instruction Language: Turkish PREREQUISITIES None DESCRIPTION

Learning outcomes:

To provide an in-depth introduction to the principles of polymer chemistry.

to highlight the influence of chemistry on the structure and properties of polymers.

to demonstrate the consequences of structure and properties on the applications of polymers.

Objectives:

On successful completion of this module you should be able to:-

• understand the chemistry of the main types of polymer, both thermoplastic and thermoset.

• understand the synthetic routes to the polymers and plan simple syntheses.

• understand the basic mechanisms of their formation including step growth, free radical and ionic polymerisation.

• understand how polymers are characterised, including their chemical, physical, thermal and mechanical behaviour.

• appreciate the factors influencing the stereochemistry and crystallinity of polymers and how these affect their properties

Contents: Monomer, definition of polymer, classification of polymers, sources, synthesis and polymerization process, molecular weigth of polymers and its distribution, thermal methods for polymers. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

• Polymers: Chemistry & Physics of Modern Materials, 2nd Ed., J M G Cowie, Blackie, 1991.

• Polymer Chemistry. An Introduction, M P Stevens, 2nd Ed., Oxford, 1990.

• Bahattin Baysal, “Polimer Kimyası”, Çağlayan Basımevi, (1981). ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 516 Course Title: Advanced Biophysical Chemistry Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION Learning Outcomes: The student should be able to describe biological structures from the atomic to the cellular scale. Objectives: Qualitative and quantitative characterization of biochemical substances in physical chemistry bases of analysis methods will be described and explained in details. The methods for the investigation of the structures of the biological materials and their functions will be discussed. Contents: The thermodynamics of biochemical cases; the solutions of macromolecules; equilibrium in biochemical systems; transfer prosesses; diffusion; sedimentation; viscosity; absorption and emission; light scattering; circular di chroism and optical rotary dispersion ; the application of X-ray diffraction methods to macromolecules TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

• David Sheehan, “ Physical Biochemistry ” , Jon Wiley&Sons, N.Y, 2000. • Peter R. Bergethon, “ The Physical Basis of Biochemistry”, Springer Verlag, 1998. • K.E. van Holde, W.C. Johnson and P.S. Ho, "Principles of Physical Biochemistry", Prentice Hall,

1998. • C.R. Cantor and P.R. Schimmel "Biophysical Chemistry", Volumes 1-3, Freeman, 1980. • Tinoco, K. Sauer, J.C. Wang and J.D. Puglisi, "Physical chemistry: principles and applications in

biological sciences", Prentice Hall, 2002. ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 518 Course Title: Stereochemistry of Organic Compounds Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: This course aims to understand three-dimensional structure of organic molecules which is impossible to study organic chemistry without using stereochemistry. Contents: Structural isomers and stereoisomers, Symmetry and symmetry elements, Configuration, Properties of stereoisomers , Elimination of stereoisomers, Stereochemistry of Alkenes, Conformation of acyclic molecule, Conformation of cyclic molecule, Stereoselective synthesis.


1. Ernests Eliel, Samuel H. Wilen, Lewis N. Mander, “Stereochemistry of Organic Compounds” John Wiley and Sons, INC 1994

2. Francis A. Carey, Richard J. Sounberg, “Advanced Organic Chemistry” , Plenum Pres, New York, 1997 3. Wade, J.R, “Organic Chemistry” Printice-Hall, Inc.45.1987


Course Code: CHEM 519 Course Title: Chromatographic Methods in Separation and Purification of Organic Compounds

Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (2+2) Total Class Hours: 14 weeks x 4h. = 56h. Instructor: Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: This course aims to introduce various types of chromatographic methods which are the most modern and sophisticated methods of separating mixtures. Contents: Basic Topics in Chromatography and Basic Classification of Chromatographic Methods According to Separation Methods; Adsorption Chromatography; Paper Chromatography; Column,Thin and Thick Layer Column Chromatography; Ion-Exchange Chromatography; Gel-Filtration and Gel-Permeation Chromatography; High Performance Liquid Chromatography (HPLC); Electrophoresis; Gas Chromatography Techniques. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK Arnold J. Gordon, Richard A. Ford, “The Chemist’s Companion (A Handbook of Practical Data, Techniques, and References)”, John Wiley and Sons. 1972. Laurence M. Harwood, Christopher J. Moody, “Experimental Organic Chemistry (Principle and practice)”, Blackwell Scientific Publications Oxford-London. 1989. Gerhard Schomburg, “Gas Chromatography, VCH Verlagsgesellschaft GmbH, D-6940 Weinheim Germany 1990. D. D. Perrin, W. L. F. Armafego, “Purification of Laboratory Chemicals”, Pergamon Pres Inc. 1988 ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 520 Course Title: NMR Spectroscopy Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: This course aims to understand the theory of Nuclear Magnetic Resonance Spectroscopy and how to determine of organic structures by using different NMR techniques. Contents: Introduction to Spectroscopic Methods; Using Spectroscopic Data in Organic structural Analysis; Basic Principles of Magnetic Resonance Spectroscopy; Interpretation and Use of Proton and Carbon Chemical Shifts; Interpretation and Use of Proton and Carbon Coupling Constant; Multiple-pulse and Multidimentional Nuclear Magnetic Resonance Techniques; Proton and Carbon-13 NMR Applications. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

Prof.Dr. Kemal Yelekci, “Modern Nuclear Magnetic Resonance Spectroscopy and Applications”, İstanbul, Marmara Üniv. : 516, 1991. Prof.Dr. Metin Balcı, “Nuclear Magnetic Resonance”, METU Press Yayınları, Ocak 2000. Edwin D. Becker, “High Resolution NMR (Theory and Chemical Applications)”, (Second Addition) Academic Press, 1980. Abraham, P. Loftus, “Proton and Carbon-13 NMR Spectroscopy, (An integrated Approach)”, Heyden and Sons Ltd. 1980. Derek Shaw, “Fourier Transform NMR Spectroscopy (Second Ed.)” Elsevier Science Publishers B.V., Printed in The Netherlands, 1984. Philip L. Fuchs, Chaarles A. Bunnel, “Carbon-13 NMR Based Organic Spectral Problems” , John Wiley and Sons, US, 1979.


Course Code: CHEM 521 Course Title: Advanced Inorganic Chemistry Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assist. Prof. Dr. Elif Subaşı Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: The main purpose of this course is to provide the student with the background necessary to comprehend current research literature in inorganic and certain aspects of organomatallic chemistry. Many attractive aspects of inorganic chemistry will be given during this course. It is hoped that the course provide a sound basis in contemporary inorganic chemistry for the students and will stimulate their intrest in inorganic. Contents: Atomic Structure, Structure and Properties of Solids, Molecular Structure and Bonding, Group Theory, Acids-Bases and Acceptor-Donor Chemistry. Coordination Chemistry; Structures and Isomers, Bonding, Electron Spectra, Reactions and Mechanisms. Chemistry of Organometallics; Catalysis and Organometallic Reactions, The Similarities Between Main group and Organometals’ chemistry. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

F. A.Cotton, G.Wilkinson, “Advanced Inorganic Chemistry”, 6th Ed., A Wiley Interscience Publication, 2002. D. F. Shriver, P. W. Atkins, “Inorganic Chemistry”, 3rd Ed., Oxford Univ. Press, 1999. G. L. Miessler, D. A. Tarr, “Inorganic Chemistry”, Prentice-Hall, Inc., 1999. N. N. Greenwood, A. Earnshaw, “Chemistry of the Elements”, Pergamon Press, 1984.


Course Code: CHEM 522 Course Title: Advances in Gas Chromatography and HPLC Level: Graduate Semester: Spring ECTS Credit: 10 Status: Elective Hours aweek: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION Learning outcomes: To describe and evaluate the fundamentals of analytical measurement using modern instrumental methods, such as, GC, GC-MS and HPLC. Objectives: Introduction and principles of gas chromatography and HPLC will be explained in the first chapter. Techniques and instrumentation will be discussed in detail. Some applications of GC and HPLC will also be emphasized in detail. HPLC detectors, packing sand hardware will be explained. Size exclusion chromatography, reversed phase chromatography and related techniques will also be given in this lecture. Contents: Advances in GC, HPLC, GC-MS, HPLC-MS and related techniques will be given in detail in the content of this lecture. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

Gerhard Schomburg, “ Gas Chromatography”, VCH Verlag, Weinheim, 1990. Robert L. Grob, “Modern Practice of Gas Chromatography”, John Wiley&Sons, 1995. Robert L. Cunico, Karen M. Gooding, Tim Wehr, “Basic HPLC and CE of Biomolecules”, Bay

Bioanalytical Laboratory, 1998. Lloyd R. Snyder, Joseph L. Glajch, Joseph Kirkland, “Practical HPLC Method Development”, John

Wiley&Sons, 2nd Edition, 1997. ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 523 Course Title: Enzymatic Analysis Methods Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: Enzyme activity assays are very important in Biochemistry. .Determination of the suitable activity assay methods, basic criteria and problems during the procedure will be discussed. Contents: The definition and importance of enzymatic analysis, The units and abbreviations in enzymology, Reaction kinetics, Determination of Michaelis constants and inhibition constants, Determination of catalytic activity of enzymes, Determination methods of substrate concentration, Determination of metabolite concentrations by kinetic methods, Techniques for measurements. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK H. U. Bergmeyer, “ Methods of Enzymatic Analysis”, Vol. I. , Fundementals, Verlag Chemie, (1983). U. Bergmeyer, “Methods of Enzymatic Analysis”, Vol. II., Samples, Reagents, Assesment of Results, Verlag Chemie, (1983). ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 525 Course Title: Enzyme Science Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 2h. = 28h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: There-dimensional structure, catalytic activity and kinetic properties of enzymes will be investigated. Contents: Proteins and protein folding, Protein transport systems, Chemical modifications in proteins, Protein fragmentation with enzymatic and chemical methods, Mechanisms of enzymatic catalysis, Structures and mechanisms of some enzymes TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK 1."The Study of Enzyme Mechanisms" E. Zeffren, P.L. Hall, A Wiley-Interscience Publication, ISBN 0-471-98150-8. 2. "Protein Structure Analysis" R.M. Kamp, T.Choli-Papadopoulu, B. W. Liebold (Eds), Springer, ISBN 3-540-61500-8. ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 526 Course Title: The Chemistry of Transition Metals Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Mürüvvet Yurdakoç Instruction Language: Turkish PREREQUISITIES None DESCRIPTION

Learning outcomes: On successful completion of this course you should be able to:

Provide electron configurations for the 1st row transition metals, identify oxidation states, fully name complexes and deduce their structure from name or formula.

Explain isomerism in transition metal complexes.

Describe and explain splitting diagrams for octahedral, square planar and tetrahedral crystal fields.

Appreciate the importance of chemical species present in solution of transition chemical complexes Understand how the different types of bonding influence the structure and properties of crystalline material.

Describe a range of common crystal structures in terms of their bonding and physical structures and properties.

Objectives: Investigation of the properties of 1.,2.,3. row transition elements will be given in details. Chemical reactions of these elements will also be investigated and explained. Contents: General information for first, second and third order transition metals, compounds, the chemistry dependent on oxidation degree, the complex of the metal and solution chemistry TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK F. Albert Cotton, G. Wilkinson, C. A. Murillo, M. Bochmann, “Advanced Inorganic Chemistry”, 6th Edition,

John Wiley&Sons, Inc. N.Y., Chichester, Weinheim, Brisbare, Singapore, Toronto, 1999. P. J. Durrant, B. Durrant,” Introduction to Advanced Inorganic Chemistry”, PartI-II, 2nd Edition, Longman

Group Ltd., London, 1970. A.G. Sykes,” Advances in Inorganic Chemistry”, Academic Press, London, 1999. ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 527 Course Title: Immobilized Enzymes, Cells and Organelles Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: It is very important to get more economic of application of enzymes in medicine, analytical and industrial fields. In this course, physical and chemical immobilization methods of enzymes will be discussed. Contents: Reasons of enzyme immobilization, Physical and chemical immobilization methods of enzymes, Natural and synthetic carriers: cellulose, agarose, dextran, carragenan, alginate, chitosan, gelatin, collagen, albumin, vinyl polymers, polyamides, Kinetic parameters of immobilized enzymes, Properties of immobilized cell systems, Properties of immobilized cells and organelles. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK L. Goldstein, “Immobilized Enzymes”, (K.Mosbach,Ed.), “Methods in Enzymology”, Vol. 44, Acedemic Press, 1990. O. Zaborzky, “Immobilized Enzymes” , CRS Press, 1990. Biomattiasosson, “Immobilized Cells and Organeller” , Vol. I. and Vol II, CRS Press, 1993. ASSESSMENT Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 528 Course Title: Trace Metals and Analysis Level: Graduate Semester: Spring ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Melek Merdivan Instruction Language: English PREREQUISITIES None DESCRIPTION Objectives: : In this course, the role and essentiality of trace elements in various sources and analytical methods for the determination of trace elements will be disscussed and explained in details.

Learning outcomes:

This course is expected to help the student to propose an analytical procedure for different kinds of analytical samples.

Students can develop their analytical abilities and discuss your suggestions freely.

Contents: Importance of trace elements, sampling, sample preparation, separation and preconcentration, analytical methods

TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK T.W.Clarkson, “Metals and their compounds in environment: occurance, analysis and biological relevance”, Weinheim, N.Y. 1991. C.Vandecasteele, “Modern methods for trace element determination, Chickester, N.Y., 1997 ASSESSMENT

Homework 30 % Weekly Follow-up Reports 30 % Term Paper 40 %

Total 100 %

Course Code: CHEM 529 Course Title: Thermal Methods of Analysis Level: Graduate Semester: Fall ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof.Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION Learning outcomes: Students should be familiar with: · Theory and applications of thermal methods including TGA, DTG, DTA, DSC. · Theory and applications of surface analysis including XRD, XRF XPS, UPS AES, TEM/SEM. · An approach to industrial problem solving using these techniques. Objectives: The methods of thermal analysis are almost universally applied to a large number of analytical problems in the fields of metallurgy, paint and ink science, ceramics, mineralogy, food thecnology, inorganic and organic chemistry, polymer chemistry, geochemistry and others. In this course, TG, DTG, DTA, DSC, TMA, TPO and TPR will be given in the view of intersting examples. Contents: The application of TG and DTG to a particular problem is possible if a mass change is observed on the application of heat. If no mass change is observed, other thermal techniques such as DTA, DSC, TMA and so on, may have to be used. If mass change is very small (<1%), evolved-gas analysis (EGA) may be more useful. TGA, DTA, DSC, TMA, TPR/TPO, EGA techniques and tandem with MS, FTIR related methods will be explained as thermal analysis applications.

TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK

P. J. Haines, M. Reading “ Thermal Methods of Analysis-Principles, Applications and Problems ” , Jon Wiley&Sons, ISBN: 0471986623, p.349, 1995.

Wesley William Wendlandt, “ Thermal Analysis”,3rd Edition, Springer Verlag, ISBN: 0387982620, p. 832, 1986.


Course Code: CHEM 530 Course Title: Titrations in Non-Aqueous Solvents Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Kadriye Ertekin Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: The course aims to provide understanding of equilibrium in non-aqueous media, solvent matter interactions, potentiometric, conductometric and spectrophotometric titrations in non-aqueous solvents. Contents: Non-aqueous media solvents, indicators and titrants, potentiometric, conductometric and spectrophotometric titrations in non-aqueous solvents, determination of inflection point of titration curves, non-aqueous media electrodes and electrode modifications, acidity constant calculation, applications of non-aqueous media titrations.

TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK 1. Huber, W., “Titrations in Non-Aqueous Solvents”, Academic Press, London, 1967. 2. Fritz, J. S., “Acid-Base Titrations in Nonaqueous Solvents, Allyn and Bacon Inc. Boston, 1973. 3. Gündüz, T., Kantitatif Analiz Ders Kitabı, A.Ü. Fen Fak. Yayınları, Ankara 1988. ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 531 Course Title: Adsorption, Surface Area and Porosity Level: Graduate Semester: Fall ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof.Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION Learning outcomes: At the end of the course the student should be:

Provide an account of the interfacial chemistry of any of the systems covered in the lectures including, where appropriate, diagrams and mathematical and chemical formulae Determine adsorption isotherms from experimental data and calculate properties such as surface excess concentration, monolayer coverage and surface area Describe the important structural features of solid surfaces and methods for their characterisation familiar with the definition, classification and properties of various colloidal systems and interfaces, e.g. s/l, l/l, g/s, l/g etc. familiar with various particle sizing techniques familiar with the chemical and physical adsorption of gases on non-porous solids, particularly the Langmuir and BET models.

Objectives: In this lecture, the main parameters in adsorption and catalysis will be discussed and explained in detail. Contents: Internal and external surface, B.E.T. Specific Surface Area, Classification of Pore Sizes: Micro, Macro and Transitional Pores, Adsorption Isotherm, Physical adsorption of gases by porous and non-porous solids, Langmuir, Freundlich and BET Equation, The Gibbs Adsorption Equation and adsorption from solution

TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK

S. Gregg, “Adsorption, Surface Area and Porosity”, Academic Press; 2nd Edition, (1982). ISBN:0123009561

Richard I. Masel, “Principles of Adsorption and Reaction on Solid Surfaces”, Wiley-Interscience; 1st edition, (1996), ISBN: 0471303925.

S. Lowell, Joan E. Shields, Martin A. Thomas, Matthias Thommes, “Characterization of Porous Solids and Powders: Surface Area, Pore Size and Density”, (Particle Technology Series), Springer; 1 edition, (2004), ISBN: 1402023022.


Course Code: CHEM 532 Course Title: Catalysis Level: Graduate Semester: Spring ECTS Credit:10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION Learning outcomes: Students will

• learn the chemistry, chemicals engineering, physics and materials science necessary to understand catalysis and develop the interdisciplinary research skills needed for gain an up-to-date and multidisciplinary knowledge base in surface science, homogeneous and heterogeneous catalysis.

• gain a basic grounding in the chemical engineering necessary for the understanding, design and operation of catalytic reactors.

• gain an information and skills base directly relevant to the needs of modern chemical industry. • gain an appreciation of factors which govern the applications of catalysis in real industrial situations.

Objectives: The objective of this course is to teach the general features of catalysis. Definition, preparation and characterization methods will be explained in detail. Theoretical background of the catalysis and some new methods will also be discussed. The relationship between catalysis and industry will be expressed in the sense of homogeneous and heterogeneous catalysis. Contents: Development and history of the catalysis, the relationship between adsorption and catalysis, Surface and interface chemistry, Langmuir isotherm, Freundlich isotherm, B.E.T. Isotherm, Thermodynamical aspects of adsorption and catalysis, catalyst formulation and catalyst preparation methods, and industrial catalysis will be given in detail in the content of this lecture. TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK

J. M. Thomas, W. J. Thomas, “Principles and Practice of Heteroegeneous Catalysis”, John Wiley & Sons, N.Y., 1996.

P. W. Atkins, “ Physical Chemistry” , Oxford University Press, London, 1986. I. P. Muchlenov, E. I. Dobkina, V. I. Derjuzkina, V. E. Soroko, “ Technologie der Katalysatoren”, VEB

Deutscher Verlag für Grundstoffindustrie, Leipzig, 1976. T. Dumas, W. Bulani, “Oxidation of Petrochemicals: Chemistry and Technology”, Applied Science Pub.

Ltd., London, 1974. Paul N. Rylander, “Hydrogenation Methods”, Academic Press, London, 1985.


Course Code: CHEM 533 Course Title: : Kinetics of Complex Reactions Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof.Dr. Mürüvvet Yurdakoç Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Learning outcomes: Proficiency in the quantitative analysis of kinetic data, The ability to relate a theoretical reaction mechanism to an experimentally determined rate law, The ability to explain kinetic phenomena in terms of statistically based theories. Objectives: Description and characterization of inert and labil coordination complexes, explanation of new experimental techniques in reaction kinetics (relaxation technique), substitution, oxidation-reduction reactions and kinetics of redox reactions wil be discussed in this course. Contents: Introduction, Substitution reactions, Substitution reactions in tetrahedral compounds, Substitution reactions in square-planar and octahedral complexes, Redox reactions, Oxidant-addition and reductant-elimination reactions. TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK D. F. Shriver, P. W. Atkins, C. H. Langford, “Inorganic Chemistry”, Oxford University Press, Oxford, 1998. J. E. Huheey, “Inorganic Chemistry of Structure and Reactivity”, Harper&Row Publisher, N.Y., 1978. K. F. Purcell, J. C. Kotz, “Inorganic Chemistry”, W. B. Sounders Company, N. Y., 1977. F. Albert Cotton, G. Wilkinson, C. A. Murillo, M. Bochmann, “Advanced Inorganic Chemistry”, 6th Edition, John Wiley&Sons, Inc. N.Y., Chichester, Weinheim, Brisbare, Singapore, Toronto, 1999. ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 534 Course Title: : Bioanalytical Chemistry Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assist. Prof.Dr. M.Nalan Tüzmen Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: The aim of this course is to introduce the methods used in the qualitative and quantitative determination of biological molecules and parameters of quality of data. Contents: General principles of analytical biochemistry, Separation methods, Spectroscopic and Electroanalytical methods, Radioisotopic assays, Immunological methods, Enzyme assay methods, Carbohydrate and lipid analysis, Amino acid and peptid analysis, General methods for protein quantitation TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK Holme DJ. and Peck H., Analytical Biochemistry, Third Edition, Pearson Education, 1998. Voet D., Voet J., Biochemistry, John Wiley & Sons, Inc, 1995. ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 535 Course Title: Chemometrics Level: Graduate Semester: Fall ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Melek Merdivan Instruction Language: English PREREQUISITIES

None DESCRIPTION Objectives: In this course, formal methods for the selection and optimization of analytical methods and procedures and for the interpretation of data will be discussed and explained in details.

Learning outcomes:

Students can learn how the experimental data are evaluated statistically.

To develop the students abilities in use of statistical programs

Students can propose a suitable statistical methods for optimization of analytical procedure

Contents: Basic approach, creating some data, basic statistics, method optimization, factorial design, calibration, curve fitting, signal processing, factor analysis, pattern recognition.

TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK J. C. Miller, J. N. Miller, “Statistics for Analytical Chemistry”, Ellis Horwood PTR, Prentice Hall, London, N.Y., 3rd edition, 1993. B. F. J. Manly, “Multivariate Statistical Methods”, Chapman and Hall, London, N.Y., 1989. ASSESSMENT

Homework 20 % Quiz 20 % Final Exam 30 % Term paper 30 % Total 100 %

Course Code: CHEM 536 Course Title: : Synthesis and Structural Analysis of Inorganic and Organometallic Compounds

Level: Graduate Semester: Spring ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assist. Prof. Dr. Elif Subaşı Instruction Language: English PREREQUISITIES None DESCRIPTION Objectives: The enormous growth of inorganic and organometallic chemistry in the last few decades has in large part been the result of improvements in the quality and speed of the characterization of new compounds, including their structure. In the first stage, the significance of the time scales of physical methods, the relative advantages and disadvantages of those methods, and their use in concert is mentioned. In the second stage well-chosen research examples illustrate the use of the techniques that the student by know has learned about in real research publications. Throughout the lecture the aim is to help the postgraduate students to interpret experimental data, to undestand the material published in modern journals of inorganic and organometallic chemistry and to make decisions about what tecniques will be the most useful in solving particular structural problems. Contents: Techniques for carrying out Reactions and Structure Determination of Inorganic and Organometallic Compounds, Applications of various spectroscopic and spectrometric methods (NMR Spectroscopy, Infrared and Raman Spectroscopy, Electronic and Photoelectron Spectroscopy, Mass Spectrometry, Diffraction Methods) to inorganic and organometallic compounds and Characterization of Their Structures. TEACHING AND LEARNING METHOS Student centered activities TEXTBOOK Ebsworth E.A.V., Rankin D.W.H., Cradock S., “Structural Methods in Inorganic Chemistry”, 4th Ed., Blackwel Scientific Publications, Oxford 1991. ASSESSMENT Midterm exam: One written exam & 40% project Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 537 Course Title: : Optical Chemical Sensors Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Kadriye Ertekin Instruction Language: Turkish PREREQUISITIES None DESCRIPTION

Objectives: The course aims to provide a general understanding of the optical chemical sensors , advantages and disadvantages of optical sensing, fields of application and analytical aspects of sensors.

Learning outcomes:

This course is expected to help the students to understand the existing sensor technologies and to bring up the students to design new sensor types.

Contents: Sensor classification, sensor components, fiber optic chemical sensors and probes, sensor configurations, fluorescence intensity based sensors, fluorescence lifetime based sensors, sensor matrix materials, immobilization techniques, sensor applications. TEACHING AND LEARNING METHOS

The principles of optical sensors and enstrumentation are taught in lectures as class presentation and discussion format. All class members are expected to present a certain (choosen) application of optical chemical sensors (Ex: CO2 sensors, cation and anion sensing, pH sensing, pharmacuitical applications of optical sensors). TEXTBOOK

Fiber Optic Chemical Sensors and Biosensors, CRC Press, Boca Raton, 1991, vols. 1 & 2. Fluorescence Spectroscopy: New Methods and Applications, Springer Verlag, Heidelberg, 1993. "The Fluorescence of Organic Natural Products", Molecular Luminescence Spectroscopy: Methods & Applications (S. G. Schulman, ed.), Wiley & Sons, New York, 1985, vol. 1.


Course Code: CHEM 539 Course Title: Metabolism Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assist. Prof. Dr. M. Nalan Tüzmen Instruction Language: English PREREQUISITIES

None DESCRIPTION Objectives: The aim of this lecture is to study metabolic processes like glycolysis, TCA cycle, β-oxidation. Contents: Biomolecules, Introduction to Metabolism, Glycolysis, Transport through membranes, Citric acid cycle, Electron transport and oxidative phosphorylation, Lipid metabolism, Amino acid metabolism

TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK Voet D., Voet J., Biochemistry, John Wiley & Sons, Inc, 1995. Elliot W., Elliot D., Molecular Biochemistry and Biochemistry, Oxford Press, 2nd Edition New York, 2001. ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 601 Course Title: : Mass Spectrometry Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h.

Instructor: Assoc. Prof.Dr. Kadriye Ertekin, Assoc. Prof. Dr. Serap Alp

Instruction Language: Turkish

PREREQUISITIES None DESCRIPTION

Objectives: The course aims to provide a general understanding of the mass spectrometry, fields of application and analytical aspects of mass spectrometry.

Contents: Introduction and Instrumentation, Introduction to mass spectrometry and mass spectrometer, sample handling system, analyzer tube, magnet, ion collector, amplifier, recorder, the mass spectrum, Reduced Strain During Evaporation, Introduction to “in-beam” ionization for Electron Impact (EI) and the “Direct Chemical Ionization” for CI, Surface Ionization Techniques, Field desorption (FD), fast atom bombardment (FAB), Plasma desorption (PD), Formation of quasi-molecular ions and side reactions, Comparison of the Techniques positive mode and Negative mode, Determination of the Molecular Formula, Determination of molecular weight and structural information and recognition of the molecular ion peak, Rearrangements(McLafferty rearrangement, Random rearrangement etc.), Mass Spectra of some Chemical Classes (Hydrocarbons, hydroxyl compounds, ethers, ketones, aldehydes, carboxylic acids, carboxylic esters, amines, aliphatic amides, aliphatic nitriles, nitro compounds, aliphatic nitrites, aliphatic nitrates, sulfur compounds, halogen compounds, heteroaromatic compounds, natural products), GC-MS, LC-MS, MS-MS TEACHING AND LEARNING METHODS

The principles of mass spectrometry and instrumentation will be taught in lectures as class presentation and discussion format. All class members are expected to present a certain (chosen) application of mass spectrometry. TEXTBOOK

Spectrometric Identification of Organic Compounds, Seventh Edition, Robert M. Silverstein Francis X. Webster and David J. Kiemle, Chapter 1, Mass Spectrometry. Principles of Instrumental Analysis von Douglas A. Skoog , FJ Holler , Timothy A. Nieman. 10 th Edn, New York, Wiley


Course Code: CHEM 602 Course Title: : Heterogeneous Catalysis Level: Graduate Semester: Spring ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION Learning outcomes: students should:

• be able to speculate sensibly about possible reaction mechanisms given experimental observations. • be able to recognize mechanistic parallels between chemical and biocatalytic processes. • be able to propose a likely mechanism for a new catalytic reaction and to propose experiments designed

to confirm or refute their proposal. • possess a realistic integrated understanding and knowledge of the basic principles of heterogeneous

catalysis. • be able to derive appropriate kinetic equations and models for catalytic reactions that may involve

complicated reaction sequences. • be aware of special effects which may influence selectivity when microporous solids are used as

catalysts. Objectives: The objective of this course is to teach the general features of heterogeneous catalysis. Definition, preparation and characterization methods will be explained in detail. Theoretical background of the catalysis and some new methods will also be discussed. The relationship between catalysis and industry will be expressed in the sense of heterogeneous catalysis. Contents: Physical and chemical adsorption; adsorption isotherms; catalysis and chemistry; the nature of the surface bond and the mechanism of heterogeneous catalytic reactions, Adsorption and catalysis on oxides, The kinetics of surface reactions, Metal-catalysed hydrogenation of unsaturated hydrocarbons, Electrocatalysis, Components of the catalyst formulation, Examples of heterogeneous catalyst preparation, catalysis and chemistry, catalytic process and proven catalysts. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

J. M. Thomas, W. J. Thomas, “Principles and Practice of Heteroegeneous Catalysis”, John Wiley & Sons, N.Y., 1996.

Charles N. Satterfield, “Heterogeneous Catalysis in Industrial Practice”, John Wiley & Sons, (2003), ISBN: 3527305742.

Gerhard Ertl, Helmut Knözinger, Jens Weitkamp , “Handbook of Heterogeneous Catalysis, 5 Volume Set” Wiley-VCH (June 27, 1997) ISBN: 3527292128


Course Code: CHEM 603 Course Title: : Free Radical Chemistry Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h.Instructor: Prof. Dr. Mustafa Toprak, Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: In Organic Chemistry, many of the rections occur by the mechanisms of radical. The mechanism is very usable in Organic Chemistry applications.In Organic Chemistry, The structure of the radicals and the reaction mechanisms provide advanced level of information. Because of this reason, this course is very essential in Organic Chemistry Education. Contents: General Concepts and Basic Principles of the Radicals are investigated in two part of this course, Structures and Stabilities; Definitions and Methods of Investigations, Carbon Radicals, Thermodynamic stability and kinetic stability, Reactions and Mechanisms; Elementary Reactions, Radical Chain Mechanisms, Non-Chain Radical Mechanisms. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK Jacques Fossey, Daniel Lefort, Janine Sorba, “Free Radicals in Organic Chemistry”, John Wiley and Sons, 1995. Thomas H-Lowry, Kathleen S. Richardson, “Mechanism and Theory in Organic Chemistry” Harper and Row, Publisherd, New York, 1981.


Course Code: CHEM 604 Course Title: : Fuel Chemistry Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Mürüvvet Yurdakoç, Prof. Dr. Mehmet Kartal


PREREQUISITIES None DESCRIPTION Learning outcomes: To be aware of the complex nature of energy production and use. - To understand the technical aspects of energy production and use. - To understand the chemistry behind energy production and use. - To be aware of the latest advances in energy production. - To be aware of current energy related environmental issues. - To be aware of the future directions/possibilities for energy production and use. Objectives: It has been well known that demand in the usage of energy sources increases year by year. However, fosil fuels are limited. The chemical properties of the fuels and alternative energy resources will be explained in this course. Contents: Classification of energy sources, Natural and syntetic solid fuels; Carbonization and gasify of the coal; The coke fabrication and its gas; Liquid fuels; Gas fuels; Production and refinery of these fuels, Usage area and Applied chemical processes. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

CHUNSHAM SONG, “Chemistry of Diesel Fuel” Taylor & Francis; 1 edition, 2000, ISBN: 1560328452

M Kuliev, “Chemistry and technology of oil and fuel additives”, National Technical Information Service, 1974, ASIN: B0006X4BH4.

K. Owen, “Gasoline and Diesel Fuel Additives (Critical Reports on Applied Chemistry, Vol 25) John Wiley & Sons Inc, 1989, ISBN: 0471922161


Course Code: CHEM 605 Course Title: : Fast Reactions Level: Graduate Semester: Fall ECTS Credit: 10 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Kadir Yurdakoç Instruction Language: English PREREQUISITIES None DESCRIPTION

Learning Outcomes: describe and understand the principles of, and methods used, in the measurement of rate constants for fast and ultrafast chemical reactions; appreciate the role of lasers in photochemistry;

explain how differential cross sections are related to rate constants and how they can be measured; deduce the qualitative outcome of a reaction from the key features of the potential energy surface and vice versa;

explain the use of order parameters in the context of liquid crystal phases and anisotropic materials and describe differences between orientational and positional distribution functions;

explain how the properties of materials and their technological application is related to their structural properties;

Objectives: Fast reactions include many of vital practical and theoretical importance. The aim of this course is to present, a way intelligible to senior undergraduates and to research workers, some of the ideas behind these techniques. Contents: Rapid chemical reactions, experimental methods, flow methods, chemical relaxation methods, competition methods, reactions of protons, electrons, and metal ions, rapid reactions in biological systems. TEACHING AND LEARNING METHODS: Lectures and following student centered activities TEXTBOOK David Norman Hague, “Fast Reactions”, John Wiley and Sons Ltd. (1971). ISBN: 0471339008. B. Levitt, “Physical Chemistry of Fast Reactions: Vol. 1: Gas Phase Reactions of Small Molecules”, Springer; 1 edition, (1973), ISBN: 0306350912. E. F. Caldin, “The Mechanisms of Fast Reactions in Solution”, Ios Pr. Inc., (2001) ISBN: 1586031031 ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 606 Course Title: : Advanced Chemical Process Industries Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Mürüvvet Yurdakoç, Prof. Dr. Mehmet Kartal


PREREQUISITIES None DESCRIPTION Learning outcomes: Students should be able to evaluate the issues facing the chemical industry in terms of for example economics, environment, and safety; discuss features of chemical processes and relate to the context within which the industry operates.

Objectives: Production, applied processes, basic application conditions and mechanisms of the chemical industrial compounds will be explained. In this sense, reactors used in the chemical industry and their problems will also be discussed. Environmental problems arieses from chemical industry will be investigated. Contents: The importance of industrial chemistry, raw materials of this industry, Principles of the chemical technology processes, Chemical reactors, Ecology problems of chemical technology, Energy problems. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK David I. Saletan, “Creative Troubleshooting in the Chemical Process Industries”, McGraw-Hill Professional, 1994, ISBN: 0075868555. Asq Chemical & Process Industries Divisi, American Society for Quality Control, “Specifications for the Chemical and Process Industries: A Manual for Development and Use”, ASQ Quality Press, 1996, ISBN: 0873893514 Jose A. Romagnoli, “Introduction to Process Control (Chemical Industries)”, Dekker/CRC Press, 2005, ISBN: 849334969 ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 607 Course Title: Pesticide and Heavy Metal Analysis By Chromatography Technique

Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a Week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Hüsamettin Akçay Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: Chromatography has been widely progressed analytically and industrially and it is interesting the use of chromatography in pesticide and trace metal analysis.

Learning outcomes:

By this course, students can progress your knowledge about chromatographic applications concerning metals or pesticides. Contents: Chromatography technique, plate theory, rate theory, peak separation mechanism, analytical and instrumental factors in peak separation, open and closed column super critical fluid chromatography, separation and analysis with SFC-MS, RPC, HPLC, pesticide and heavy metal analysis.

TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK K. Robauds, P. R. Haddad, P.E. Jackson, “Princible and practice of modern chromatographic methods”, Academic Presse, 1994. ASSESSMENT Homework 10% Midterm exam: Two written exam 30% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 608 Course Title: Chemistry of Boron and Silicon

Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a Week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Mürüvvet Yurdakoç Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Learning outcomes: Students should be able to evaluate the issues facing the chemical industry in terms of boron and silisium for example economics and importance; discuss features of chemical processes, by products and end products of boron and relate to the context within which the industry operates. Objectives: Physical and chemical properties of boron and silisium, important compounds of these elements and their application methods in chemical industry will be given in this course. Contents: Boron and boron compounds, chemistry of silisium, silisium compounds (silisium-oxygen) (silisium-hydrogen) (silisium-halogen), properties and preparations of the sol-gel, acids of silicates. TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK M. Davidson, A. K. Hughes, T. B. Marder, K. Wade, “Contemporary Boron Chemistry”, Royal Society of Chemistry, 2000, ISBN: 0854048359 L. Barton, “Introduction to the Inorganic Chemistry of Boron” John Wiley & Sons; 1st edition, 2001, ISBN: 0471246336. V. N. Alekseev, G. Heller, K. Niedenzu, N. S. Tandura, S. Trofimenko, “Structural Chemistry of Boron and Silicon (Topics in Current Chemistry)”, Springer-Verlag, 1986, ISBN: 0387158111. Sulin Taşçıoğlu, Bor ve Silisyum Kimyası, M.Ü. Fen-Ed.Fak. Yayın No:27, İstanbul, 1992. ASSESSMENT Homework 10% Midterm exam: Two written exam 30% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 609 Course Title: Advanced Instrumental Analysis Level: Graduate Semester: Fall ECTS Credit: 7 Status: Elective Hours a Week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Hüsamettin Akçay Instruction Language: Turkish PREREQUISITIES None DESCRIPTION Objectives: Analytical chemistry is one of the basic course in chemistry education and research studies. Chemical analysis takes place in all chemical research studies. In this course, chemical analysis methods are discussed.

Learning outcomes:

This course is expected to help students to remind traditional methods and to teach new techniques. Contents: Spectroscopic titration techniques, potentiometric titration techniques, organic analysis (pesticide, etc.), micro analysis, ICP-MS.

TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK D. G. Peters, J. M. Hayes and G. M. Hieftje, Chemical separations and measurements, Saunders Golden,1974. ASSESSMENT Homework 10% Midterm exam: Two written exam 30% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 610 Course Title: Advanced Analytical Applications of Ion Exchange Technique Level: Graduate Semester: Spring ECTS Credit: 7 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Hüsamettin Akcay Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: The course aims to provide an advanced understanding of the ion exchange process, developments and applications.

Learning outcomes:

This course is expected to help the student to appreciate ion determination using ion-exchange process.

Contents: Ion exchange process, ion exchange chromatography, separation with ion exchangers, new ion exchange materials, ion exchangers in water treatment, environmental pollution management with ion exchangers, ion exchangers as bio-sorbents, structure and synthesis of polymer-resin, pharmaceutical and environmental applications of ion-exchangers, ion chromatography, capillary electrophoresis.

TEACHING AND LEARNING METHOS

Lectures and following student centered activities. TEXTBOOK Progress in ion exchange, ed. P. A. Williams, ISBN 0 85404 791 3, RSC, 1997. ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 611 Course Title: Fundamentals of Bioprocess Engineering Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours aWeek: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Fikret Kargı Instruction Language: English PREREQUISITIES

None DESCRIPTION Objectives: Major objective of the course is to introduce fundamentals of bioprocess technologies for production of chemicals, foods, pharmaceuticals and waste treatment. A brief coverage of process biochemistry and microbiology will be presented. Enzymatic and microbial conversions will be covered for suspended and immobilized biocatalysts. Bioreactorconsiderations and product separation techniques will constitute major parts of the course. Contents: Objectives and the Scope, Basic Biochemistry and Microbiology, Enzymes: Structure,function and kinetics, Microbial growth and product formation, Stoichiometry of microbial growth and product formation, Bioreactors: Configuration and instrumentation, Operational modes of bioreactors, Immobilized Cell Bioreactors, Scale-up of Bioreactors, Recovery and purification of products, Some applications in chemical and food industries. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK M. L.Shuler, F.Kargi, “Bioprocess Engineering: Basic Concepts”, Prentice Hall, 1992. ASSESSMENT: Midterm exam: Two written exam. 40% Final Exam: Final written exam. 60% Total: 100%

Course Code: CHEM 612 Course Title: Electrochemical Processes in Analytical Chemistry Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Hüsamettin Akcay Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: The course aims to provide understanding of electrochemical processes, electrochemical based instrumental techniques (separation and analysis).

Learning outcomes:

This course is expected to help the student to remind and understand electrochemical techniques in details.

Contents: Oxidation-reduction reactions, redox potential, Nernst Law, Cells and electromotive force, analytical applications of electrochemical reactions, determination of acidity and equilibrium constant, conductometric, potantiometric, polarimetric, coulometric, voltametric, amperometric methods.

TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK Southampton electrochemistry group, Instrumental methods in electrochemistry, John Wiley, 1985. Electrochemical process for clean technology, K.Scott, ISBN 0 85404 506 6, RSC, 1995. A. İsfendiyaroğlu, “Elektrokimya prensipleri”, Özarkadaş Matbaası, 1978. Ed: F. J. Welcher, “Standart Methods of Chemical Analysis”, Van Nastrand, 1966. J. J. Lingane, “Electroanalytical Chemistry”, Wiley, 1958. ASSESSMENT Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 613 Course Title: Enzyme Technology Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: Technological applications of enzymes and its important criteria will be discussed. Contents: Production of intracellular microbial enzymes, Industrial applications of immobilized enzymes, Production of concentrated fructose syrup by glucose isomerase, Hydrolysis of starch by natural and immobilized glycoamylase, Industrial applications of enzymes immobilized in membrane, Immobilized enzymes and energy production, Immobilized microorganisms and steroid transformation, Applications of immobilized enzymes in medicine. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK J. S. Dordick and A. J. Russel “Enzyme Engineering XIII” Vol. 799, Annals of the New York Academy of Sciences, (1996). D. Wong, C. Cooney, A. Demain, P. Dunnill, A. Humprey, M. Lilly, “Fermentation and Enzyme Technology” John Wiley&Sons (1978). A. Wiseman “Topics in Enzyme Fermentation Biotechnology” Vol.4 John Wiley&Sons (1980). L.B.Wingard, E. Katchalski-Katzir, L. Goldstein “Enzyme Technology” Applied Biochemistry and Bioengineering Vol.2 (1979). ASSESSMENT: Midterm exam: Two written exam. 40% Final Exam: Final written exam. 60% Total: 100%

Course Code: CHEM 614 Course Title: Radioanalytical Chemistry Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hoursa Week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Hüsamettin Akcay Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION

Objectives: The course aims to provide understanding of radiation and radioactive decomposition.

Learning outcomes:

By this course, student can understand and discuss nuclear reactions and related techniques. Contents: Radioactivity, nuclear reactions, radiation-matter interaction, detection and measurement of radiation, radioactive element based analytical techniques, neutron activation analysis, isotopic dilution analysis, preparation and applications of labeled reagents, nuclear spectroscopy, environmental affects of radiation.


G.R.Choppin & J.Rydberg, Nuclear Chemistry, Pergamon Press,1980. G. Friedlander, Nuclear and Radiochemistry, John Wiley & Sons,1981. B.G. Harvey, Introduction to Nuclear Physics and Chemistry, Univ. of California, 1969. Ed:An. N.Nesmeyanor, A Gudie to Practical,Radio/Chemistry, Mir Publishers, 1980.


Course Code: CHEM 615 Course Title: Metabolik Dismutation Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a Week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: Metabolic dismutation of superoxide anion radicals is achieved by superoxide dismutase. Dismutation mechanism, assay methods and physiologic effects will be investigated. Contents: Reactive radicals, Superoxide Dismutase, Controls of free radicals reactions, Physiological free radicals’ reactions. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK G.Czapski, “Superoxide and Superoxide Dismutase”, Gordon and Breach Sci. Publs. Harwood Academic Publ. (1991). ASSESSMENT: Midterm exam: Two written exam. 40% Final Exam: Final written exam. 60% Total: 100%

Course Code: CHEM 616 Course Title: Carbohydrates Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours aWeek: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Serap Alp, Prof. Dr. Mustafa Toprak Instruction Language: Turkish

PREREQUISITIES

None DESCRIPTION Objectives: Carbohydrates are the most important part of the natural products. Mono and disaccharides, some oligo and polysaccharides are the main compounds of food. The aim of this course is to study the structure and typical reactions and the methods of preparing various derivatives of carbohydrates.

. Contents: The Structures and Shapes of Monosaccharides, The Interrelationships of Monosaccharides, Reactions and Products of Reactions at the Anomeric Center, Reactions and Products of Reactions at the Non-anomeric Carbon Atoms, Reactions of Hydroxyl Groups, Natural Products Related to and Containing Monosaccharides, Physical Methods in Structural Analysis. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

• J. Ferrier and P.M. Collins, “Monosaccharide Chemistry”, William Clowes and Sons Ltd., London, 1985.

• Natural Products Chemistry Vol. 1, 2, 3, University Sciences Books, Mill Valley, California, 1983. ASSESSMENT: Midterm exam 40 % Final Exam 60 % Total 100%

Course Code: CHEM 617 Course Title: Cell Membranes Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a Week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: Enzyme isolations or biotechnological applications in biochemistry, cell membrane properties are very critical parameters. In this course, membrane structures will be investigated. Contents: Cell- membrane lipids, Membrane models, Properties of membrane lipids, Cholesterol and cell membranes, Membrane proteins, Lipid-protein interactions in biological membrane, Transport systems, Membrane fusion, Metabolisms of membrane lipids, Membrane biogenesis. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK P.Veagle “The Membranes of Cells” Academic Press. Inc. (1987) M.E: Starzak “The Physical Chemistry of Membranes” Academic Press, New York, (1984). ASSESSMENT: Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 618 Course Title: Structural Analysis Techniques of Natural Compounds Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h.

Instructor: Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: This course aims to acquaint students with the isolation, the purification and the characterization of the natural products by chromatographic and spectroscopic techniques. Contents: Identification pathway of Natural Compounds; NMR Technique for Investigation of Complex Structures; The Usage of “Chiroptical” Properties for Identification of Natural Compounds; Application of NOE in Identification of Distance Between Nucleus of Natural Compounds; Proton and 13C NMR Detection and Modern NMR Techniques of Biologically Active Natural Compounds TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK R. Ikan, “Natural Products”, Academic Press Inc. (London) , 1969. Sanders J. K. M., Constable E. C., Hunter B. K., “Modern NMR Spectroscopy”, Oxford University Press., London, 1989. H. Duddeck, W. Dietrich, “Structure Elucidation by Modern NMR”, Steinkopff, Darmsdatt, NewYork, 1989. ASSESSMENT Midterm exam 40% Final Exam 60% Total 100%

Course Code: CHEM 619 Course Title: Production of Industrial Salts

Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x3h. = 42h. Instructor: Assoc. Prof. Dr. Mürüvvet Yurdakoç, Prof. Dr. Mehmet Kartal Instruction Language: Turkish

PREREQUISITIES

None DESCRIPTION Objectives and learning outcomes: The production of common salt is one of the most ancient and widely distributed industries in the world. Salt is produced by mining of solid rock deposits and by the evaporation of sea water, lake, playa (desert basin) and underground brines. Rock and solar salt account for roughly 50% of production each. The physical and chemical composition of salt produced from the various sources varies widely depending upon the manufacturing techniques, climatic conditions and processes adopted.

The principal salts that crystallize from sea water along with sodium chloride are the chlorides and sulphates of magnesium, calcium and potassium. The raw salt in the form of wet crystals can be washed with saturated brine to remove insoluble matter like sand and clay as well as the soluble impurities. It is then allowed to drain and dry in the sun and crushed to a coarse or fine powder as required. Crude salt produced in a properly designed salt works has a purity of 90-95% NaCl, 1% calcium salts and 1-2% magnesium salts and 5-8% water. If the salt is washed and dried its purity can be improved up to 99%.

Contents: Production methods of NaCl and Na2SO4 from sea-water and salt-lake brines in Tuz Gölü, Acı Göl and Bolluk will be explained in some respect. Evaluation of wastes of salt industry in the point of wiew of basic raw materials such as NaCl and Na2SO4 and besides these salts, K2SO4, MgCl2 and Br2 production will be introduced. Afterwards, Trona process will be investigated and also production of soda by Solvay process will be given in detail in the content of this lecture. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

H. Civelekoğlu, R. Tolun, N. Bulutcu, “İnorganik Teknolojileri”, İstanbul (1987). Mehmet Kartal, “Çamaltı Tuzlası atık çözeltilerinden potasyum tuzlarının kazanılma koşullarının incelenmesi”, Doktora Tezi, E.Ü. Fen Fakültesi, (1982). R. Norris Shreve, Joseph, A., Brink, JR., Çeviri: A. İhsan Çataltaş, Kimyasal proses ve Endüstrileri, Cilt 1.

ASSESSMENT Midterm exam 40% Final Exam 60% Total 100%

Course Code: CHEM 620 Course Title: Fermentation Technology

Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h.

Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish

PREREQUISITIES

None DESCRIPTION

Objectives: Fermentation technology will be investigated.

Contents: Metabolic coordination in microorganisms, Fermentation Kinetics, Industrial fermentation applications. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

Wang D.J.C., Cooney C.L., Demain A.L., Dunnill P., Humphrey A.E. & Lilly M.D., “Fermentation & Enzyme Technology” John Willey & Sons (1988). ASSESSMENT: Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 621 Course Title: Bioanorganic Chemistry

Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h.

Instructor: Assoc. Prof. Dr. Mürüvvet Yurdakoç Instruction Language: Turkish

PREREQUISITIES

None DESCRIPTION Objectives and learning outcomes:

The student will understand the relationships between biology and inorganic chemistry. Metals in biological systems, Metals in medicine (therapeutics, imaging), Model complexes of natural systems including metal at their active sites The student will understand the properties of metals that make them vital to natural systems with an emphasis on basic inorganic chemistry, Thermodynamics (HSAB principle, chelate effect, pka, redox potentials), Kinetics (ligand exchange rates, substitution reactions), Electronic and geometric structures of metal ions (ligand field splitting theory, d electron count) The student will understand the biomolecules commonly used for metal-binding in natural systems. Proteins and their constituents (amino acids, layers of protein structure), Intermolecular forces present in protein structure, Nucleic acids and their constituents (RNA/DNA), Prosthetic groups The student will understand the common techniques of analysis used in bioinorganic chemistry The student will understand rationale of choice uptake and assembly of metal-containing units in biology and control of metal-ion concentration in cells, Toxic/beneficial levels of metal in vivo, Regualation of concentration levels

Contents: Biological systems, Metalloporphyrins, Enzymes, Nitrogen fixation, Metal substitutions, Biochemistry of calcium and iron, Biochemistry of nonmetals, Antibiotics, Environmental problems. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

James E.Huheey, “Inorganic Chemistry”, (Harper Int. Edition) Harper and Row, Publishers, NewYork. ASSESSMENT: Midterm exam: One written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 622 Course Title: Enzyme Activity Regulation

Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: Regulation pathway of enzyme activity effective on metabolic balances will be explained. Contents: Amplification, time scale and feedback, Theoretical introduction to enzyme activity regulation, Regulation with ligand bonding, Regulation with reversible covalent modification, Signal interaction systems, Enzyme regulation in plants. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK .J.H.Ottoway “Regulation of Enzyme Activity” IRL Press (1991).. G.Weber “Advances in Enzyme Regulation” Vol.16,Pergamon Press (1978). ASSESSMENT: Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 623 Course Title: Organic Reactions and Photochemistry

Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: This course is concerned the emphasis on the photochemistry of organic compounds that produces overall chemical change. The purpose of this course is to provide the wider photochemical context and the terms, definitions and some of the general features of photochemical reactions. Contents: Introduction to Energy Derivatives, Thermal Rearrangements and Eliminations, Photochemical Excitation, Introduction to Photochemical Reactions, Study of the Mechanism of Photochemical Reactions, Molecular Orbital Symmetry and the Stereochemistry of Concerted Unimolecular Reactions, Cycloaddition. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK John D.Coyle, “Introduction to Organic Photochemistry”, John Wiley and Sons Ltd.1986 Charles H.Depuy, Orville L. Chapman, “Molecular Reactions and Photochemistry,, Prentice-Hall. Inc. 1972 Paul Suppan, “Chemistry and Light”,The Royal Society of Chemistry 1994. ASSESSMENT: Midterm exam 40 % Final Exam 60 % Total 100%

Course Code: CHEM 624 Course Title: Membrane Receptors and Formation System

Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Prof. Dr. Leman Tarhan Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: Structural properties and functions of membrane receptors will be explained. Contents: Receptor theories, Characterization methods for membrane receptors, Stereo selectivity in membrane receptor and ligand interactions, Localization of receptors in tissue and cells, Identification of molecular structure of membrane receptor, Cell-cell signal interactions, Extracellular chemical signal interactions, Cell-cell electrochemical signal interactions. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

Repke H., Liebmann C., “Membranreseptoren und Ihre Effektorsysteme”, VCH Verlagsgesellschaft GmbH. ASSESSMENT: Midterm exam 40 % Final Exam 60 % Total 100%

Course Code: CHEM 625 Course Title: Organic Dyes and Pigments


Instructor: Assoc. Prof. Dr. Serap Alp Instruction Language: Turkish

PREREQUISITIES

None DESCRIPTION Objectives: The purpose of this course is to introduce the classes of organic colorants and to give the information about their properties, technological uses and applications of different area. Contents: Colour of Organic Compounds; Polyene, Polymethine, Di- and Triarylmethine Dyes and Their Aza Analogues; Aza[18]annulenes, Nitro ve Nitroso Dyes, Azo Dyes and Pigments; Carbonyl Dyes and Pigments; Fluorescent Dyes; Application of Dyes and Organic Pigments; Photo-, Thermo- and Electrochemical Reactions of Colour Compounds; Colorants for Imaging and Data Recording Systems; Dyes in Biochemistry, Biology, Medicine and Analytical Chemistry. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

Heinrich Zollinger, “Color Chemistry”, John Wiley and Sons, Wiley-VHC ISBN: 3 906 39023 3, (2002). ASSESSMENT: Midterm exam 40 % Final Exam 60 % Total 100%

Course Code: CHEM 626 Course Title: Organic Synthesis Design Level: Graduate Semester: Spring ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Serap Alp, Prof. Dr. Mustafa Toprak Instruction Language: Turkish

PREREQUISITIES

None DESCRIPTION Objectives: This course aims to acquaint students with suggest an analytical approach to the design of the organic synthesis. Contents: Synthons in the Synthesis of Carbon Chains and Carbocycles; Selective Functional Group Interconversion; Retro-Synthetic Analysis of Simple Organic Compounds; Methods in the Construction of Complex Molecules. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

S. Warren, “Organic Synthesis; The Disconnection Approach” John Wiley & Sons, 1984. J.Fuhrhop, G. Penzlin “Organic Synthesis; Concepts, Methods, Starting Materials” Verlag Chemie GmbH. 1983. P.Sykes, “A Guidebook to Mechanism in Organic Chemistry” Longman Scientific & Technical, 1990.

ASSESSMENT: Midterm exam 40 % Final Exam 60 % Total 100%

Course Code: CHEM 627 Course Title: Biochromotograpy Level: Graduate Semester: Fall ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h.

Instructor: Assist. Prof. Dr. M. Nalan Tüzmen Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: The aim of this lecture is to introduce advenced techniques used in isolation and purification of biomolecules. Contents: Introductory remarks, Matrix properties, Choice of affinity ligand, Biospecific affinity chromatograhy, Cell affinity chromatograhy, Dye-Ligand chromotography, Metal chelate affinity chromatography, Hydrophobic interaction chromatography, Related techniques TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK Mohr P., Pommerening K., “Affinity Chromatography, Practical and Theoretical Aspects”, Marcel Dekker, Inc. New York and Basel, 1986. ASSESSMENT: Midterm exam: Two written exam 40% Final Exam: Final written exam 60% Total: 100%

Course Code: CHEM 628 Course Title: Xenobiotics and Metabolic Effects

Level: Graduate Semester: Spring ECTS Credit: 8 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assist. Prof. Dr. M. Nalan Tüzmen Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: The aim of this course is to introduce xenobiotics which are not a natural component of the organism and to investigate its metabolism and biological effects. Contents: Xenobiotic, transition to ecosystem, xenobiotics dispersion rules, classifications, influence mechanisms, metabolic effects, reactions with DNA. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK Voet D., Voet J., Biochemistry, John Wiley & Sons, Inc, 1995

Environmental Toxicology: Impacts of Environmental Toxicants on Living Systems (Lewis Publishers) by Ming-Ho Yu. 2001. [ISBN: 1-56-670474-X]

Introduction to Environmental Toxicology: Impacts of Chemicals Upon Ecological Systems (Lewis Publishers) by Wayne G. Landis and Ming-Ho Yu. Third Edition. 2004. [ISBN: 1-56-670660-2]


Course Code: CHEM 629 Course Title: Mechanism of Organic Reactions Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h.

Instructor: Assoc. Prof. Dr. M. Yavuz Ergün Instruction Language: Turkish PREREQUISITIES

None DESCRIPTION Objectives: This course aims to acquaint students with molecular rearrangement which involve changes at carbon skeletons, and also condensation reactions in organic chemistry. Contents: Molecular Rearrangement Reactions; Free Radical and Anionic Rearrangements, Sigmatropic and Electrocyclic Rearrangements, Condensation Reactions, Condensation Reactions in Carbonyl Components, Condensation reaction in Carboxylic Acid Derivatives. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK J. B. Hendrickson, D. J. Cram, G. S. Hammond “Organic Chemistry” Third Edition McGraw-Hill Kogagusha LTD. (1970). S. H. Pine, J. B. Hendrickson, D. J. Cram, G. S. Hammond “Organic Chemistry” Third Edition McGraw-Hill Series in Chemistry (1980). J. March “Problems in Advanced Organic Chemistry” Marcel-Dekker INC. NewYork (1971). ASSESSMENT: Midterm exam 40 % Final Exam 60 % Total 100%

Course Code: CHEM 631 Course Title: Reaction Mechanisms of Inorganic and Organo-metallic Systems


Instructor: Assist. Prof. Dr. Elif Subaşı Instruction Language: English

PREREQUISITIES

None DESCRIPTION Objectives: Synthesis involving inorganic and organometallic compounds or intermediates is a large, diverse and important field, which is growing rapidly at the present time. Research in this field has received a major stimulus from the discovery of several important industrial processes involving organometallic reagents and catalysts. The bonding concepts used for non-metal compounds are extended to interpret the special magnetic and electronic properties of transition metal complexes in coordination chemistry sections are devoted to the topologies and stereochemistries of this class of compounds. It is useful in interpreting spectral and magnetic properties of coordination complexes and in predicting and interpreting the structural problems in coordination chemistry. Contents: Transition Metal Complexes; Isomerism, Reaction Mechanisms and Methods of Synthesis, Electron transfer Reactions, Substitution Reactions, Molecular Rearrangements. Organometallic Compounds; Synthesis, Structure and Bonding , Metal Carbonyl Complexes, π-Complexes of Carbocyclic Ligands, Insertion and Elimination Reaction Mechanisms, Oxidative-Addition and Reductive-Elimination Reactions, Electrophilic and Nucleophilic attack on Organometallic Complexes. TEACHING AND LEARNING METHODS Lectures and following student centered activities TEXTBOOK

R.B. Jordan, “Reaction Mechanisms of Inorganic and Organometallic Systems”, Oxford Universty Pres, 1991. Purcell K.F., Kotz J.C., “Inorganic Chemistry” W.B. Saunders Company, 1977. A.W.Adamson, P.D.Fleischauer, “Concepts of Inorganic Photochemistry” R.E.Krieger Publishing Company, US, 1984. Elschenbroich C., Salzer A., “Organometallics- A Concise Introduction” 2nd Ed., VCH, Weinheim, 1992. Lukehard C.M., “Fundamental Transition Metal Organometallic Chemistry”, Brooks/ Cole Publishing Company Monterey, California, 1985.


Course Code: CHEM 633 Course Title: Separation Methods in Analytical Chemistry Level: Graduate Semester: Fall ECTS Credit: 9 Status: Elective Hours a week: T. (3+0) Total Class Hours: 14 weeks x 3h. = 42h. Instructor: Assoc. Prof. Dr. Melek Merdivan Instruction Language: English PREREQUISITIES None DESCRIPTION Objectives: Clarifying the importance of separation methods in chemical analysis. Theoretical fundamentals and applications of non-chromatographic analytical methods: precipitation, coprecipitation, extraction, membrane separation, flotation, solvent extraction, on solid sorbents, microwave, supercritical. Theoretical fundamentals and applications of liquid chromatography, gas chromatography, planar chromatography as well as capillary electrophoresis.

Learning outcomes: By this course, student can be able to critically evaluate the analytical process.

Contents: Nature of the separation process, distillation, solvent extraction, solid phase extraction, basic principles of a chromatographic separation, Principles of and instrumentation for GC and HPLC analysis, Planar chromatography, Electrophoresis, Supercritical fluid extraction (SFE).

TEACHING AND LEARNING METHODS Student centered activities TEXTBOOK

Miller, J. M., (1975), “Separation methods in chemical analysis”, New York, Wiley. Rouessac, F., Rouessac, A., (2000), “Chemical analysis: Modern Instrumentation, methods and techniques”, John Wiley and Sons.

ASSESSMENT

Homework %25 Weekly Follow-up Reports %35 Term Paper %40

Documents

Dokuz Eylul University Graduate School of Natural and ... Department … · [email protected] . Kadriye Ertekin : Analytical Chemistry, Chemical Sensors, Acid-Base Chemistry