Dolghii Xenia

Dr. Melania Macarie

EPIDEMIOLOGICAL AND CLINICAL FEATURES OF LIVER CIRRHOSIS

Faculty of Medicine, UMPh Tîrgu MureșDepartment of Gastroenterology I, Faculty of Medicine, UMPh Tîrgu Mureș

• Cirrhosis is a liver disease defined by extensive fibrosis with regenerative nodule formation and distorsion of liver structure.

• It is an ireversible condition that also has serious complications including ascites, variceal hemorrhage,hepatic encephalopathy, hepatocellular carcinoma and hepatorenal syndrome.

• Alcohol abuse and viral infection are the worldwide most common causes of cirrhosis.

Introduction

• The aim of this study is to establish the main epidemiological and clinical aspects of this disease in our geographical area.

Aim

• A retrospective study was performed which included patients with liver cirrhosis admitted in Gastroenterology department of Tîrgu Mureș Emergency County Hospital between 01.01.2013-31.12.2013.

• The readmissions were excluded.• According to age the patients were stratified into 2

groups: under the age of 50 years old and the ones aged over 50 years old.

• Data were collected with Microsoft Excel program and analyzed with GraphPad InStat program. Categorical data analysis was conducted with Fisher Exact Test.

Material and Method<50

YEARS OLD

>50 YEARS OLD

• During the studied period 302 cirrhotic patients were admitted in the Gastroenterology division of Tîrgu Mureș Emergency County Hospital.

• There were included in the research 239 patients with a median age of 58.13 years old.

Results

Total239

patients

<50 years old

49 patients

>50 years old190

patients

Mean Age 58,13 42,20 62,27

Urban 111 21 90

Rural 128 28 100

Gender( M/F)

149/90 35/14 115/75

Demographical Data

Distribution by gender• Male prevalence of cirrhotic patients (M/F ratio of

1.65/1).

62%

38%male

female

(149)

(90)

<50 years old >50 years old0

20

40

60

80

100

120

14

75

35

115

femalemale

p>0,05

Distribution by gender and age

Male prevalence of cirrhotic patients in “<50 years old”. (Ratio of 2.5/1).

Series10.00%

10.00%

20.00%

30.00%

40.00%

50.00%

60.00%

70.00%62.34%

27.19%

9.62%

Toxic etiologyHCVHBV

Distribution by etiology• Prevalence of toxic etiology (n=149 patients), followed

by viral etiology (HCV) (n=65 patients) and HBV (n=23).

<50 years old >50 years old0

20

40

60

80

100

120

38

112

8

56

4

19

Toxic etiolgyHCVHBV

Distribution by etiology and age

<50 years old >50 years old0.00%

10.00%

20.00%

30.00%

40.00%

50.00%

60.00%

70.00%

80.00%

90.00%

100.00%Столбец1

77,55%

58,94%p<0,05

• Predominance of toxic etiology in “<50 years old” sample.

• Prevalence of Variceal bleeding among cirrhotic patients in “<50 years old ”vs “>50 years old” samples.

<50 years old>50 years old

0

20

40

60

80

100

120

140

160

13(26,5%) 41(21,5%)

36

149

UGI bleed(+)UGI bleed (-)

p>0,05

Other clinical data(I)

<50 years old>50 years old

0

20

40

60

80

100

120

140

160

180

8(16,3%) 25(13,1%)

41

165

Hepatic En-cephalopathy(+)Hepatic En-cephalopathy(-)

p>0,05

• Prevalence of hepatic encephalopathy among cirrhotic patients in “<50 years old ”vs “>50 years old” samples.

Other clinical data(II)

• Cirrhosis is a common end result of liver damage ( Mostly caused by alcohol and viral hepatitis)

• Cirrhosis is a frequently encountered disease even among the young population.

• Cirrhosis prevalently affects male population.• In its terminal stages, cirrhosis is frequently associated

with other diseases and may have fatal complications.

Conclusions

THANK YOU!