Initials of patient: R.A Date of Admission: Age: 48 y.o Diagnosis: Cerebral malaria Sex: Male Date medication started: DRUG MECHANISM OF ACTION INDICATION CONTRAINDICATION EFFECTS NURSING RESPONSIBILITIES Generic Name: Doxycycline Brand Name: Vibramycin Classification: Anti-infective, tetracycline Dosage: 1 cap (100 mg) Route: Per orem Frequency: BID Form: Capsule Color: Sky blue Is primarily a bacteriostatic. It enters the gram negative bacteria by passive diffusion through the porin channels and gram positive channels and gram positive bacteriaand other organisms by energy- dependent active transport. It is concentrated intracellularly by vulnerable cells. Tetracyclines after entering the cell are bound reversibly to the 30S subunit of the ribosomes of Doxycycline is drug of choice for treatment of suspected or proven Rocky Mountain spotted fever. Doxycycline is used for treatment of falciparum malaria resistant to chloroquine, acne vulgaris, community- acquired pneumonia, lymphogranuloma venereum etc. Doxycycline can also be used for prophylaxis of malaria and leptospirosis.. Hypersensitivity to any of the tetracyclines. Children less than 8 years of age. Pregnancy and lactation Porphyria Severe hepatic dysfunction Adverse effects: CNS: benign intracranial hypertension (higher in children) GI: esophagitis, hepatotoxicity, pancreatitis. Derm: rashes Hemat: blood dyscrasias. Local: phlebitis at IV site. Misc: hypersensitivit y reactions, superinfection. Side effects: GI: diarrhea, nausea, vomiting Derm: photosensitivit y Pre- administration Check doctor’s order Observe 10 Rs Intra- administration Administer 1 hr or 2 hrs after meals. May be taken with food if GI irritation occurs Administer with a full glass of liquid and at least 1 hr before going to bed to avoid esophageal ulceration. Avoid administration of calcium, zinc, antacids,
Initials of patient: R.ADate of Admission: Age: 48 y.oDiagnosis:
Cerebral malariaSex: MaleDate medication started:DRUGMECHANISM OF
ACTIONINDICATIONCONTRAINDICATIONEFFECTSNURSING RESPONSIBILITIES
Generic Name:Doxycycline
Brand Name:Vibramycin
Classification:Anti-infective, tetracycline
Dosage:1 cap (100 mg)
Route:Per orem
Frequency:BID
Form:Capsule
Color:Sky blueIs primarily a bacteriostatic. It enters the gram
negative bacteria by passive diffusion through the porin channels
and gram positive channels and gram positive bacteriaand other
organisms by energy-dependent active transport. It is concentrated
intracellularly by vulnerable cells. Tetracyclines after entering
the cell are bound reversibly to the 30S subunit of the ribosomes
of bacteria. Here the aminoacyl-tRNA is prevented from attaching to
the acceptor site which is present on the ribosomal complex of
mRNA. This leads to inhibition of the process of adding amino acids
to the emerging peptide.The carrier involved in the active
transport is absent in the mammalian cells and also tetracyclines
do not bind to mammalian 60S or 30S ribosomes. These two factors
are responsible for the selective toxicity of tetracyclines to the
microbes.Doxycycline is drug of choice for treatment of suspected
or proven Rocky Mountain spotted fever. Doxycycline is used for
treatment of falciparum malaria resistant to chloroquine, acne
vulgaris, community-acquired pneumonia, lymphogranuloma venereum
etc. Doxycycline can also be used for prophylaxis of malaria and
leptospirosis.. Hypersensitivity to any of the tetracyclines.
Children less than 8 years of age. Pregnancy and lactation
Porphyria Severe hepatic dysfunction
Adverse effects:CNS: benign intracranial hypertension (higher in
children)GI: esophagitis, hepatotoxicity, pancreatitis. Derm:
rashesHemat: blood dyscrasias. Local: phlebitis at IV site. Misc:
hypersensitivity reactions, superinfection.Side effects:GI:
diarrhea, nausea, vomitingDerm: photosensitivityPre-administration
Check doctors order Observe 10 RsIntra-administration Administer 1
hr or 2 hrs after meals. May be taken with food if GI irritation
occurs Administer with a full glass of liquid and at least 1 hr
before going to bed to avoid esophageal ulceration. Avoid
administration of calcium, zinc, antacids, magnesium- or
aluminum-containing medications, sodium bicarbonate, or iron
supplements within 1-3 hr of oral tetracyclines.Post
administration: Document Observe for adverse reactions
