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Drugs effecting the digestive organs
function
Lector prof. Posokhova K.A.
Among substances that influence on functioning of digestive organs there are
following groups of drugs:Drugs which influence on appetite;
Emetic and antiemetic drugs;
Drugs which are used in case of disturbed function of gastric glands;
Drugs effecting liver function;
Drugs used in case of disturbed excretory function of pancreas;
Laxative agents;
Drugs which influence on motor function of intestines
Drugs which influence on
appetite:
Drugs which improve appetite
Drugs which depress appetite
Гіркоти
Полин гіркий
Золототисячник малий
Деревій звичайний
PhepranonumForm of production - 0,025 g tablets
Mechanism of action of emetic and antiemetic drugs
Metoclopramide, reglan and cerucalFrom of production: 0,01 g tablets, ampoules with 2 ml of 0,5 % solution.
MotiliumForm of production: 0,01 g tablets
Drugs which stimulate gastric secretion:
With diagnostic aim: caffeine, histamine, gastrin.With treating aim: plantain juice, plantaglucide, natural gastric juice, pepsin, hydrochloric acid.
Drugs which depress gastric secretion:
Drugs which block choline receptros:M-cholinoblockers (nonselective cholionolyutics): atropine sulfateM1-cholinoblockers with selective action (selective cholinolytics): gastrozepinganglioblockers: pirilen, benzohexonium
Drugs which block histamine-Н2-receptors: cimetidine, renitidine, famotidine, nizatidine, rexatidineInhibitors of proton pump: omeprazole, controlokProstaglandines and their synthetic derivatives: misoprostolAntacid drugs:
System: sodium hydrocarbonateNonsystem: aluminum hydroxide, magnesium oxide, almagel, maalox, renni
Gastroprotectors:Drugs which form mechanic protection of mucous membrane of stomach: sucralfate, de-nolDrugs which increase protective function of mucous barrier and stability of mucous membrane towards action of damaging factor: carbenoxolon, misoprostol
Atropine sulfate (Atropini sulfas). Powder for preparation of 0,5 % and 1 % eye drops, 1% eye
ointment, 0,0005 g tablets, ampoules with 1 ml of 0,1 % solution.
Gastrozepin (Gastrocepinum) Forms of production: 0,025 g and 0,05 g tablets; ampoules
with 0,01 g of dry substance.
Cimetidine Form of production: 0, 2 g tablets.
Ranitidine (Ranitidin) Forms of production: 0,15 g and 0,3 g tablets and ampoules with 2 ml of
2,5 % solution.
FamotidinForms of production: 0,02 g and 0,04 g tablets.
Omeprazole Form of production – 0,02 g capsules.
Antaciddrugs
Systemantacids
Nonsystemantacids
AlmagelCombined drug which contains gel of aluminum hydroxide,
magnesium oxide and D-sorbit. Form of production: 170 ml bottles.
Antacid drugs
Maalox Combined rugs which contains gel of aluminum hydroxide,
magnesium oxide.
Sucralfate Form of production: 1 g tablets
De-nolForm of production: 0,12g tablets.
Pylobact Omeprazole + Clarythromycin + Tinidazole
Schemes of combined treatment of gastric ulcer
De-nol + amoxycillin
De-nol + metronidazole
Omeprazole + amoxycillin + clarythromycin
De-nol + clarythromycin + metronidazole
De-nol + controlok + amoxycilin + clarythromycin
Drugs which influence on functioning of digestive organs
Part 2
Among substances that influence on functioning of digestive organs there are
following groups of drugs:Drugs which influence on appetite;
Emetic and antiemetic drugs;
Drugs which are used in case of disturbed function of gastric glands;
Hepatotropic drugs;
Drugs used in case of disturbed excretory function of pancreas;
проносні засоби;
Drugs which influence on motor function of intestines
Hepatotropicdrugs
Jaundice (?)
Liver protectors
Cholelytholytic
Classification of жовчогінних drugs: Drugs which stimulate bile ptoduction (choleretics,
cholesecretors)Drugs which increase secretion of bile and stimulate production of
bile acids (true choleretics)а) drugs which include bile acids (allochol, cholenzyme)б) synthetic drugs (nicodine, oxafenamide)в) drugs of plant origin (безсмертник піщаний, кукурудзяні
приймочки, pepper mint, піжмо, dog-rose, cholagol)Drugs which increase secretion of bile primarily due to water
component (hydrocholeretics: mineral waters, valerian drugs)Drugs which stimulate bile secretion
(cholekinetics) drugs which cause increasing of gall-bladder tone and decreasing
of bile ducts tone (cholekinetics: magnesium sulfate, sorbit, barberries). drugs which cause relaxation of bile ducts tone
(cholespasmolytics: M-cholinoblockers, euphyllin, nitroglycerine).
Allochol (Allocholum)
Drugs of plant origin
Кукурудзяні
приймочкиБезсмертник
піщаний Dog-rose
Cholagol
Pharmacodynamics of magnesium sulfate depending of way of administration
Clinical classification of antioxidants Antioxidants of direct action
Drugs which contain vitamin E (tocopherole acetate, aevit).Vitamin C drugs (acrobatic acid, galascorbin, ascorutin).Bioflavonoids (legalon, flamin, flakumin, sylibor, convaflavin).Drugs which include thiol groups (unithiol, thiosulfate sodium).
Antioxidants of indirect actionDrugs which regulate phospholipid contents of cell membranes (essentiale, lipin, retinol, aevit).Precursors of pyridine nucleotides (nicotinic acid, nocotinamid).Precursors of glutation (metionin, cystein, glutamic acid).Drugs which induct glutationperoxydase (selenium containing drugs).Other drugs which increase antioxidating potential of blood and tissues (lipoic acid, lilamid, organic drugs of liver).
Tocopherole acetate (Tocopheroli acetas)Vitamin E is produced in many forms: 5 %, 10 % and 30 % oil solution in 10, 20 and 50 ml bottles; elastic capsules with 0,1 and 0,2 ml of 50 % solution in oil; ampoules with 1 ml of 5
%, 10 % and 30 % oil solutions.
Розтропша плямиста
Carsil Legalon
Mechanism of action of legalon
Essentiale Is produced in 5 ml ampoules and in capsules
Lipostabil
Pancreatin (Panсreatinum) Is produced in 0,25 g and 0,5 g dragee (tablets).
Panzynorm forte
Festal, Enzistal, Mezym-forte
No-spa, nicospan
Baralgin
Крушина звичайна
Bisakodil
Guttalax
Bil-berries St. John’s wort
Pepper mint Chamomile
Imodium