Dulal_Mahato_Research_paper_published

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Optimization of microwave, ultra-sonic andsupercritical carbon dioxide assisted extractiontechniques for curcumin from Curcuma longa

P.S. Wakte , a, , B.S. Sachina, A.A. Patila, D.M. Mohatoa, T.H. Banda and D.B.

Shindea

a Pharmaceutical Technology division, Department of Chemical Technology, Dr.

Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India

Received 30 August 2010; revised 27 October 2010; accepted 19 March 2011. Available

online 31 March 2011.

Abstract

A bio-active phytochemical, curcumin, was isolated from dried rhizomes of Curcuma longa

using Soxhlet, microwave, ultra-sonic and supercritical carbon dioxide assisted extraction

techniques. The quantification of curcumin in resultant extracts was performed using pre-

validated HPLC methodology. The critical parameters viz . effect of pre-irradiation and

soaking solvent on the curcumin yield were studied. The extraction efficiency of all the

above described techniques was established in terms of percent curcumin yields and

extraction rate constants. Prior to extraction, microwave and ultra-sonic irradiation of dry

curcuma powder resulted in 68.57 and 40.00% curcumin yield, respectively, whereas water

soaked irradiated curcuma powder yielded 90.47 and 71.42% curcumin recovery

respectively, during a total extraction period of five minutes. The maximum extraction rate

constant of 47.49 × 10−2 min−1 was observed when using microwave assisted acetone

extract of water soaked curcuma rhizomes. The comparison of Soxhlet, microwave, ultra-

sonic and supercritical carbon dioxide assisted extraction in terms of percent yield and

required extraction period showed that microwave assisted extraction technique was more

efficient for the curcumin extraction from powdered C. longa rhizomes.

Graphical abstract

Highlights

► Curcumin was extracted efficiently from Curcuma longa rhizomes. ► Microwave, ultra-

sonic and supercritical CO2

assisted extractions were compared. ► Microwave assisted

extraction resulted in 90.69% curcumin yield within 5 min.

Keywords: Curcumin; Microwave assisted extraction; Soxhlet assisted extraction;

Supercritical carbon dioxide assisted extraction; Ultra-sonic assisted extractionAbbreviations: MAE, microwave assisted extraction; SAE, Soxhlet assisted extraction; SC

CO2E, supercritical carbon dioxide extraction; UAE, ultra-sonic assisted extraction

Article Outline

1. Introduction

2. Experimental procedures

2.1. General

2.2. HPLC method for curcumin analysis

2.3. Soxhlet assisted extraction (SAE)

2.4. Microwave assisted extraction (MAE)

Separation and Purification Technology Volume 79, Issue 1, 19 May 2011, Pages 50-55

doi:10.1016/j.seppur.2011.03.010 | How to Cite or Link Using DOI

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6/24/2011http://www.sciencedirect.com/science/article/pii/S1383586611001602



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2.5. Ultra-sonic assisted extraction (UAE)

2.6. Supercritical carbon dioxide extraction (SC CO2E)

2.7. Extraction rate constant

2.8. Statistical analysis

3. Results and discussion

3.1. Soxhlet assisted extraction (SAE)

3.2. Microwave assisted extraction (MAE)

3.2.1. Effect of microwave irradiation

3.2.2. Effect of soaking solvent

3.3. Ultra-sonic assisted extraction (UAE)

3.3.1. Effect of ultra-sonic irradiation

3.3.2. Effect of soaking solvent

3.4. Supercritical carbon dioxide extraction (SC CO2E)

3.5. Extraction rate constant

3.6. Comparison of SAE, MAE, UAE and SC CO2E on the basis of curcumin yield and

extraction time

4. Conclusion

References

Corresponding author. Tel.: +91 240 2403307; fax: +91 240 240013.

Copyright © 2011 Elsevier B.V. All rights reserved.

Separation and Purification Technology Volume 79, Issue 1, 19 May 2011, Pages 50-55


6/24/2011http://www sciencedirect com/science/article/pii/S1383586611001602

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