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JointMeetingofthe
EASDIsletStudyGroup&BetaCellWorkshop
WestinBellevue,Dresden,May7-10th,2017
SUNDAY,MAY7th2017
From16:00h
REGISTRATIONANDDISTRIBUTIONOFMEETINGMATERIAL
18:30h
18:45h
OPENING
MicheleSolimena(fortheBCW)(Dresden,DE)
PierreMaechler(fortheEASD)(Geneva,CH)
KEYNOTELECTURE
Chair:PierreMaechler(Geneva,CH)
Phasetransition-drivenproteinassembly:anewviewonintra-cellular
compartimentalization
AnthonyHyman(Dresden,DE)
19:30h WELCOMERECEPTION
MONDAY,MAY8th2017
From8:00h
REGISTRATIONANDPOSTERMOUNTING
8:30h-10:30h
8:30h
9:00h
9:30h
10:00h
10:15h
10:30h
SESSION1:BETACELLDEVELOPMENT
Chair:LeifGroop(Malmö,SE)
Nkx2.2actsdownstreamofNeurog3tospecifypancreaticendocrine
lineages
LoriSussel(Denver,CO)
Beyondtranscriptionfactorsinthelineageselectionand
differentiationofpancreasprogenitors
AnthonyGavalas(Dresden,DE)
Myelintranscriptionfactorsrepressprecociousstressresponsesfor
thefunctionandsurvivalofpancreaticbetacells
GuoqiangGu(Nashville,TN)
Phosphoinositide3Kinase(PI3K)regulatesendocrinecellmotility
andpancreaticisletmorphogenesis(ShortTalk)
RobinKimmel(Innsbruck,AT)
Synaptotagmin13regulatesendocrinecelldelaminationduring
pancreasdevelopment(ShortTalk)
MostafaBakhti(Munich,DE)
COFFFEEBREAK
MONDAY,MAY8th2017
11:00h-13:00h
11:00h
11:30h
12:00h
12:30h
12:45h
13:00h
SESSION2:BETACELLMATURATIONANDREGENERATION
Chair:ChristopherWright(Nashville,TN)
Generatingfunctionallymaturebetacellsfromhumanstemcells
MatthiasHebrok(SanFrancisco,CA)
Glucotoxicblockofbetacellregeneration
YuvalDor(Jerusalem,IS)
mTORsignalingregulatesthemetabolicprogramingofbetacells
leadingtofunctionalmaturation
AnilBhushan(SanFrancisco,CA)
HeterogeneousNFkBactivitybalancesproliferationandfunctionin
agingbetacells(ShortTalk)
SharanJanjuha(Dresden,DE)
Transcriptomeanalysisofpancreaticcellsacrossdistantspecies
highlightsnovelimportantregulatorgenes(ShortTalk)
BernardPeers(Liège,BE)
LUNCH
MONDAY,MAY8th2017
14:00h-16:00h
14:00h
14:30h
15:00h
15:30h
16:00h
SESSION3:BETACELLFUNCTIONI
Chair:ShantaPersaud(London,UK)
NewandunexpectedrolesforSNAREproteinsinthepreservationof
functionalbetacellmass
DebbieThurmond(LosAngeles,CA)
Longitudinalinvivoimagingofisletsrevealsadominantroleofbeta
cellfunctionindiabetespathogenesis
StephanSpeier(Dresden,DE)
Regulationofbeta-cellfunctionandfatebyinsulin
JamesJohnson(Vancouver,CA)
Reversalofhumanbetacellfunctionaldamageinducedbylipo-
glucotoxicconditionsortype2diabetes
PieroMarchetti(Pisa,IT)
COFFEEBREAK
MONDAY,MAY8th2017
16:30h-18:30h
16:30h
17:00h
17:30h
18:00h
18:15h
18:30-20:30h
SESSION4:BETACELLFUNCTIONII
Chair:HindrikMulder(Malmö,SE)
Whyarelargeisletsunresponsivetoincretins?
SusumuSeino(Kobe,JP)
Fromabsencetohyperactivityofglutamatedehydrogenaseandthe
hypotohyperinsulinsim
PierreMaechler(Geneva,CH)
Geneticandnutritionalcontrolofbetacellconnnectivity
GuyRutter(London,UK)
Glucosedependentgranuledockinglimitsinsulinsecretionandis
decreasedinhumantype2diabetes(ShortTalk)
NikhilGandasi(Uppsala,SE)
Primaryciliadysfunctiondisruptsglucosetoleranceandbetacell
function(ShortTalk)
FrancescoVolta(Munich,DE)
POSTERPRESENTATIONSESSIONA(ODDNUMBERS)AND
REFRESHMENTS
TUESDAY,MAY9th2017
8:30h-13:00h
CITYTOURDRESDENWITHEXHIBITIONNEWMASTERSOROLD
MASTERS
13:00h
14:00h
14:45h-15:45h
14:45h
15:15h
15:45h
LUNCH
KEYNOTELECTURE
Chair:StefanBornstein(Dresden,DE)
Frommembraneraftstolipidomics:alife-longjourney
KaiSimons(Dresden,DE)
SESSION5:BETACELLMASSVS.DEDIFFERENTIATIONINT2D
Chair:GilLeibowitz(Jerusalem,IS)
Betacelllossintype2diabetesisnotaccountedforby
dedifferentiation
PeterButler(LosAngeles,CA)
Whenbetacellsfail:lessonsfromdedifferentiation
DomenicoAccili(NewYork,NY)
COFFFEEBREAK
TUESDAY,MAY9th2017
16:15h-18:15h
16:15h
16:45h
17:15h
17:45h
SESSION6:GENETICS&EPIGENETICSOFBETACELLSINT2D
Chair:MaureenGannon(NashvilleTN)
Usinghumangeneticsandgenomicstounravelcausalmechanisms
fordiabetes
AnnaGloyn(Oxford,UK)
Systemsbiologyonorgandonorandsurgicalpancreasspecimens
definesatranscriptomicsignatureoftype2diabeticislets
AnkeSchulte(Frankfurt,DE)
Non-codingRNAsandbetacellfunction
LenaEliasson(Malmö,SE)
Monogenicdiabetesasmodelsofbetacellorganelledysfunctionin
type2diabetes
MiriamCnop(Brussels,BE)
18:15h-20:15h
POSTERPRESENTATIONSESSIONB(EVENNUMBERS)AND
REFRESHMENTS
WEDNESDAY,MAY10th2017
9:00h-10:30h
9:00h
9:30h
10:00h
10:15h
SESSION7:THESOCIALENVIRONMENTOFTHEBETACELLS
Chair:EduardMontanya(Barcelona,SP)
Sharingiscaring:howbetacellfunctiondependsontheislet
environment
AlejandroCaicedo(Miami,FL)
Molecularandfunctionalinterplaybetweenalpha-andbeta-
cellularclocksinmouseandhumanmodels
CharnaDibner(Geneva,CH)
Elucidatingtheroleofpancreaticpericytesindiabetes-associated
betacelldysfunction(ShortTalk)
LimorLandsman(TelAviv,IS)
PYYmodulatespancreaticisletsecretoryfunctionandactsasaDPP-
IVsubstratetoregulateinsulinsecretion(ShortTalk)
ClaudiaGuida(Oxford,UK)
10:30h
COFFEEBREAK
WEDNESDAY,MAY10th2017
11:00h-13:00h
11:00h
11:30h
12:00h
12:30h
SESSION8:BETACELLTHERAPY
Chair:OleMadsen(Copenhagen,DK)
Reconstructinghumanpancreaticorganogenesis
RaphaelScharfmann(Paris,FR)
Drugdesignforbetacellprotectionindiabetesmellitus:NMDA
receptorantagonists
EckhardLammert(Düsseldorf,DE)
Advancesinpharmacologictherapyforhumanbetacell
regeneration
AndrewStewart(NewYork,NY)
Currentstatusandfutureperspectivesindiabetestherapy-from
cells,pills,andchimera
BarbaraLudwig(Dresden,DE)
13:00h
LUNCH
WEDNESDAY,MAY10th2017
14:00h-16:00h
14:00h
14:30h
15:00h
15:30h
15:45h
SESSION9:BETACELLIMMUNEINTERACTION
Chair:EzioBonifacio(Dresden,DE)
Theresidentphagocytesofpancreaticisletshaveaseminalrolein
isletdevelopmentandinflammation
EmilUnanue(St.Louis,MO)
Complexitiesofbetacellfailureintype1diabetes
ClaytonMathews(Gainsville,FL)
Coordinatedanalysisusingcomplementarymethodologiesrevealsa
viralsignatureanddemonstratesalowlevelenteroviralinfectionin
thepancreasintype1diabetes
TeresaRodriguez-Calvo(Munich,DE)
Anovel,highlyproliferativepopulationofisletendocrinecellsin
adolescentandadulthumanpancreata(ShortTalk)
JakeKushner(Houston,TX)
Exosome-mediatedtransferofmicroRNAsfromlymphocytestobeta
cellscontributestotype1diabetesdevelopment(ShortTalk)
ClaudianeGuay(Lausanne,CH)
16:00h
COFFEEBREAK
WEDNESDAY,MAY10th2017
16:30h-17:30h
16:30h
17:00h
17:30h-18:30h
17:30h
19:30h-24:00h
SESSION10:THEROLEOFALPHACELLSINISLETFUNCTION
Chair:AndersTengholm(Uppsala,SE)
Betacellreconstitutionbymodulationofisletcell-type
interconversion
PedroHerrera(Geneva,CH)
Somatostatinmediatesglucagonostaticeffectofinsulin
PatrikRorsman(Oxford,UK)
KEYNOTELECTUREANDCLOSINGREMARKS
Chair:MicheleSolimena(Dresden,DE)
Controlofpancreatichormonesecretionbybrainglucosesensing
networks
BernardThorens(Lausanne,CH)
FAREWELLDINNERAT“SCHLOSSALBRECHTSBERG”
Thursday,MAY11th2017
9:00h-17:00h
DEPARTUREOROPTIONALTOURSTO…
…DresdenMuseums
…CityofMeissen
…PillnitzCastle
…SaxonianSwitzerland