ECML/PKDD-2005 Workshop on Discovery Challenge

Guide to the Hepatitis Dataset

Shusaku Tsumoto Shoji Hiranotsumoto@computer.org hirano@ieee.org

Department of Medical Informatics,Faculty of Medicine,Shimane University, Japan

Hepatitis Dataset: Basic Information

Donators Dr. Katsuhiko Takabayashi and Dr. Hideto Yokoi

Department of Medical Informatics, Chiba University Hospital, Japan

Subjects 771 patients of type B and C chronic virus hepatitis who took exami

nations at Chiba University Hospital during 1982 and 2001.

Contents Biopsy information: dates and results

stage of fibrosis, virus activity Period of applying interferon therapy Laboratory Examinations

Blood tests (Biochemical, Hematological, DNA), Urinalysis Basic information of patients

MID (masked ID), Sex, Date of Birth

Hepatitis Dataset: Structure

7 tables in CSV format An MID (masked ID) is used to relate information in different table

Description of Examinations (459)Description of Examinations (459)

Stationary data Temporal data

MID

In-hospital Exam Results (1,565,876)

In-hospital Exam Results (1,565,876)

Out-hospital Exam Results(31,040)

Out-hospital Exam Results(31,040)

Basic Patient Information (771)Basic Patient Information (771)

Interferon AdministrationInformation (198)

Interferon AdministrationInformation (198)

Biopsy Information (961)Biopsy Information (961)

*Added on July 4, 2003.

Results of Hematological Analysis (42,914) *

Results of Hematological Analysis (42,914) *

Goals of the Challenge

Evaluate whether the laboratory examinations can be used to estimate the stage of liver fibrosis. If possible, it can be used as an alternate of invasive biopsy.

Discover the differences in temporal patterns between hepatitis B and C.

Evaluate whether the interferon therapy is effective or not. High-cost therapy; but it is not effective for all patients. Can we forecast its effectiveness in advance using the results of

laboratory examinations ?

Validate the following hypothesis regarding GOT and GPT. (GOT or GPT) x (time) = (stage of liver fibrosis)