ERYTHROPOEISIS

Hemocytoblast Proerythroblast Erythroblast Basophilic Polychroma-

tophilicErythroblast

Orthochroma-tophilic

ErythroblastNuclearExtrusion

Reticulocyte

RBC

PluripotentialStem Cell

1. dispersedchromatin

2. nucleoli

3. cytoplasmic

1. clumpedchromatin

2. no nucleoli

3. maximum

1. condensedchromatin

2. grey-greencytoplasm

(hemoglobinsynthesis)

1. condensedeccentricnucleus

2. pinkcytoplasm

1. anucleate

2. spherical

3. slight basophilia

basophilia basophilia (free ribosomes)

Erythropoeisis- Several Stages

MYELOPOEISIS (granulopoeisis)

Hemocytoblast (multipotential)

Myeloblast (multipotential)

Promyelocyte (multipotential)

1. loss of cytoplasmicbasophilia

2. dispersed chromatin

Eosinophilopoeisis Neutrophilopoeisis Basophilopoeisis

EOSINOPHILOPOEISIS Eosinophilic

MyelocyteEosinophilic

Metamyelocyte Eosinophil(band cell)

Specific andMetachromatic Granules

Eosinophilopoeisis- Several Stages

NEUTROPHILOPOEISIS NEUTROPHILIC

MYELOCYTENEUTROPHILIC

METAMYELOCYTE NEUTROPHIL

MYELOPOEISIS (Several Stages)

Neutrophilic and Eosinophilic Band CellsNutrophilic Band and

Eosinophilic Metamyelocyte

BASOPHILOPOEISIS Basophilic Myelocyte

Basophilic Metamyelocyte Basophil

THROMBOPOEISIS

Hemocytoblast

Endomytosis(w/o karyokinesis

(w/o cytokinesis)

Reserve Megakaryocyte (megakaryoblast) Platelet-Forming Megakaryocyte

Platelet-Shedding

(fusion ofplasma membrane)

PlateletsResidual Megakaryocyte

MEGAKARYOCYTES

BONE MARROW

Decalcified Bone and Marrow Cavity

Marrow

Fat Cells

Bone

Marrow

Megakaryocyte

AdipocyteDiapedesis

HemopoeticCompartment

EndothelialDiscontinuity

Endothelial Cells

BloodSinusoid

ReticularFibers

Bone Marrow

Bone Marrow in Decalcified Bone Bone Marrow Smear