Extramural Funding Activities at NIH related to SSIB

ChristopherJ.Lynch,Ph.D.ExecutiveSecretary,NIHNutritionResearchTaskForce

Director,OfficeofNutritionResearchChief,NutritionResearchBranch,DDN

NIDDK,NIH

Outline

• IntroducingOfficeofNutritionResearch• CurrentFOAsandInitiativesrelatedtoSSIB

– Rgrants– UgrantsandSBIR– SPARC

• ForwardLookingOpportunities– NutritionResearchStrategicPlan

NIHInitiativesRelatedtoIngestiveBehavior,

ResearchProjects

• UnderstandingFactorsinInfancyandEarlyChildhood(Birthto24months)ThatInfluenceObesityDevelopment (R01:PA-16-169)Methodologicalresearchgapsand/orcharacterizeinfantandearlychildhoodphenotypesthatmayincreaseormitigateriskforobesity.

• HealthyHabits:TimingforDevelopingSustainableHealthyBehaviorsinChildrenandAdolescents(R01:PA-14-177,R21:PA-14-176)Innovativeresearchtoidentifymechanismsofinfluenceand/orpromotepositivesustainablehealthbehavior(s)inchildrenandyouth(birthtoage2).

• AncillaryStudiestoIdentifyBehavioraland/orPsychologicalPhenotypesContributingtoObesity (R01:PAR-16-304) Supportstheadditionofmeasuresofpsychologicaland/orbehavioralconstructsorweight-relatedvariablestoexistingornewresearchstudiesinhumans

NIHInitiativesRelatedtoIngestiveBehavior-ResearchProjects

• ResearchontheMechanismsand/orBehavioralOutcomesofMultisensoryProcessing (R01:PA-15-347).Elucidatethemechanismsand/orbehavioraloutcomesofmultisensoryprocessing,theintegrationorprocessingofatleasttwodistincttypesofsensoryinputasdefinedbydistinctreceptor-typetransduction,neuralpathwaysandcognateperceptualquality.

• SystemsScienceandHealthintheBehavioralandSocialSciences (R01:PAR-15-048,R21:PAR-15-047).Appliedand/orbasic(includingmethodologicalandmeasurementdevelopment),haveahumanbehavioraland/orsocialsciencefocus,andemploymethodologiessuitedtoaddressingthecomplexityinherentinbehavioralandsocialphenomena,referredtoassystemssciencemethodologies.

NIHInitiativesRelatedtoIngestiveBehavior-ResearchProjects

• MethodologyandMeasurementintheBehavioralandSocialSciences (R01:PAR-16-260,R21:PAR-16-261).Aimedatimprovinganddevelopingmethodologyinthebehavioralandsocialsciencesthroughinnovationsinresearchdesign,measurement,datacollectionanddataanalysistechniques.

• MetabolicContributionstotheNeurocognitiveComplicationsofDiabetes:AncillaryStudies (R01:PAR-16-333).Humanstudiestoelucidatetheetiologyandpathogenesisoftheincreasedriskforneurocognitiveimpairmentassociatedwithtype2diabetes.

NIHInitiativesRelatedtoIngestiveBehavior-ResearchProjects

NIHInitiativesRelatedtoIngestiveBehavior,

SBIRandCooperativeAgreements

SBIRandCooperativeAgreements• LabtoMarketplace:ToolsforBiomedicalandBehavioralResearch (R43/R44:PA-15-052)Encouragesthetranslationoftechnologiesforbiomedicalorbehavioralresearchfromacademicandothernon-smallbusinessresearchsectorstothemarketplace

• LabtoMarketplace:ToolsforBrainandBehavioralResearch (R43/R44:PA-14-250).Encouragesthetranslationoftechnologiesforbrainorbehavioralresearchfromacademicandothernon-smallbusinessresearchsectorstothemarketplace.

SBIRandCooperativeAgreements• IntensiveLongitudinalAnalysisofHealthBehaviors:

LeveragingNewTechnologiestoUnderstandHealthBehaviors(U01:RFA-OD-17-004).Researchprojectsthatseektoexplainunderlyingmechanismsandpredicthealthbehaviorswithinindividualsovertimeutilizingintensivelongitudinal,within-personprotocolsthatleveragerecentadvancesinmobileandwirelesssensortechnologiesandbigdataanalytics.

• PredictiveMultiscaleModelsforBiomedical,Biological,Behavioral,EnvironmentalandClinicalResearch (U01:PAR-15-085).Interagencyfundingopportunitytosupportthedevelopmentofmultiscalemodelstoacceleratebiological,biomedical,behavioral,environmentalandclinicalresearch

SPARC - Stimulating Peripheral Activity to Relieve Conditions

~$238 million investment over 7 years

Opportunity: Neuromodulationoforganfunctionholdspromiseintreatingmanydiseases.

Challenge: Themechanismsofactionforneuromodulationtherapiesremainpoorlyunderstood.

ProgramGoals: Provideascientificfoundationthatenablesbetterunderstandingoftheneuralcontroloforganfunction,spurringdevelopmentofthenext-generationoftherapeuticclosed-loopneuromodulationdevices.

• RFA-RM-17-009 (OT1,a.k.a.”pre-application”)

• RFA-RM-17-010 (OT2,a.k.a.“application”)

• QuarterlyOT1receiptdates– nextdateisAugust1,2017

• ApplicantswhoseOT1pre-applicationsarefoundtobemeritoriousandprogrammaticallyrelevantwillbeinvited tosubmitafullOT2application

• OT2applicationsareinvitation-only

SPARC2 – Funding Opportunitieshttps://commonfund.nih.gov/sparc/grants

TechnologiestoUnderstandtheControlofOrganFunctionbythePeripheralNervousSystem

Application Processhttps://commonfund.nih.gov/sparc/OtherTransac

Discuss

• Optional,butencourageddiscussionwithSPARCprogramstaff

OT1application

• Emailsix-pageOT1applicationbyreceiptdateinRFA-RM-17-009

• MustproposetoaddressaPrioritylistedforthisreceiptdate

Feedback

• WewillprovidefeedbackonyourOT1application

• SomeapplicationswillbeinvitedtosubmitanOT2application

Discuss

•RequireddiscussionoffeedbackwithSPARCprogramstaff

OT2app

•Invitationspecifiesdeadlineandotherrequirements

•FollowRFA-RM-17-010tosubmitOT2applicationtoGrants.gov

Negotiate

•SPARCwillnegotiatebudget,benchmarks,anddeliverableswithselectedapplicants

Award

•NIHwillawardanOtherTransactionAward(OT2)aftersuccessfulnegotiation