Facility Strategies for Animal Research and Biocontainment 2018 Conference

November 5-6, 2018 The Vinoy Renaissance Resort in St. Petersburg, FL

Renovation • Data Collection • Space Utilization • Flexibility Capacity Expansion • MEP System Upgrades • Cost Reduction

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IN COOPERATION WITH:

AALAS

The surge in new planning initiatives for animal research and biocontainment facilities (renovations, technology investments, equipment upgrades, and capacity expansion) is being driven by these seven new research and performance requirements:

1. Improved room and microenvironmental data collection2. New space for emerging and highly specialized research models3. Increased facility flexibility and program adaptability4. More robust protocols for compliance and research quality5. Better utilization of existing space6. Modernized mechanical and control systems for sustainability, cost reduction, and reliability 7. Expanded capacity to accommodate new and current research programs

Attend this conference to learn HOW these new demands are being met, with WHAT RESULTS and at WHAT COST. Specifically, you’ll get the latest technologies, project details, metrics, and outcomes for new and successful initiatives involving:

• Renovation strategies that are low cost and high ROI • Digitization of cages, racks, equipment, and space• Software, systems, and sensors for data collection and monitoring• New space utilization and allocation metrics and benchmarks • Modularity for rapid response to demand, swing space, and construction• Mitigation measures for noise, vibration, and animal stress in construction environments• Equipment, systems, and protocols for regulatory and certification compliance • Improved environmental controls for lighting, acoustics, temperature, humidity • More efficient caging, IVC, and rack solutions • Highly specialized lab types • Lean/efficient process workflow and logistics• Increased capacity within existing footprint• Low cost flexibility features and equipment • Strategies for ease of maintenance• New cost-effective automation options• Equipment and policies for reduced air changes and sustaining environmental quality• Improved capital project planning and management strategies• Up-to-date capital project cost models for renovation and new construction• Equipment, systems, and protocols for reduced operations cost and sustainability

Attend this conference with your research program leaders and your project, design, engineering, and operations team to get your key decision-makers in sync with the new, efficient facility models, features, and technologies now being implemented to create more efficient, compliant, and financially sustainable research platforms.

We very much look forward to seeing you in St. Petersburg in November.

Derek Westfall President Tradeline, Inc.

Steven L. Westfall, Ph.D. Founder and CEO Tradeline, Inc.

“You guys have set the bar very high. The quality of your speakers and the organization of your conferences are far superior to most other conferences I have attended.”Bob Cowan Director of FacilitiesFred Hutchinson Cancer Research Center

Who Should Attend? This conference is the annual industry meeting for:

• Research Veterinarians • Capital Project Teams• Project Managers• Engineering Managers• Architects• Research Compliance Directors • Animal Facility Operations Managers• Space Planners• Animal Facility and Vivarium Managers• Animal Resource Managers• Biosafety Officers• Research Program Directors to benchmark their planning and management initiatives, and animal facility operations for their organizations.

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Special Pre-Conference Course

Sunday; November 4

Fundamentals of Planning and Design of Animal Research and Biocontainment Labs 7:30 a.m. – Registration/Continental breakfast 8:00 a.m. – 4:30 p.m.; (a total of 6 hours of instruction.)

Six (6) AIA Continuing Education Hours (CEHs) are available for this course. AIA HSW

What past attendees have said...

Best training program I have ever attended!

Jeffrey and Michael are extremely knowledgeable. They have given us great insight and understanding into planning these facilities.

Very informative. Good discussion points and interactions with the group.

Very informative and detailed presentation. I feel I am coming away prepared to ask the right questions of our designers and maintenance programs.

Overall excellent…good audience participation, tons of good information, excellent book as handout.

Great job!

Great training!

Very informative! A lot to take in, but totally worth all day!!

Excellent speakers and presentation material!

Enjoyed the fact that it was basic enough in its approach for those of us that are new to animal research.

Great overview of animal and BSL-3 facilities…an eye opener!

Very knowledgeable speakers.

Very easy to follow. Presenters are very knowledgeable. Well done – appreciated sharing of past experiences.

Very good presentations and appropriate topics! Thanks!

The logistics of the program were great and it was run well. Overall very good fundamentals class.

Very good info for an inexperienced person.

Great overview of the material – very knowledgeable of the topic.

Outstanding!

A job well done by speakers. Provided very clear feedback to group.

Very good speakers with practical experience. Will definitely recommend.

Well done! Great presentation.

Leaders:Perkins + WillJeff Zynda – Principal and Academic Science Practice LeaderR.G. Vanderweil Engineers, LLPMichael Walsh, PE, LEED AP BD+C – Senior Mechanical Engineer and Principal

What you will learn: Participants will come away with a basic understanding of the terminology, concepts, processes, standards, numbers, types of equipment, and furniture (as applicable) involved in the planning and design of animal research and biocontainment labs including related mechanical, electrical and plumbing systems. The course also serves as primer for the two-day conference that follows and will be highly interactive with Q&A throughout. AIA HSW

Who should attend: This course is designed for those involved in the planning, design, construction, or operation of animal research and biocontainment laboratories including project managers, architects, facility engineers, construction engineers, facility managers, facility planners, biosafety professionals, EH&S personnel, veterinarians, and researchers employed at colleges and universities, medical facilities, pharmaceutical facilities, A/E/C firms, government health centers, and public health labs.

Cost for this course: $1,140 Fundamentals Course only

$1,000 with registration to the two-day conference November 5-6

(Fees include course materials, continental breakfast, refreshment breaks, and lunch.)

Space is limited and enrollment is subject to approval.

Facility Site Tour

Wednesday, November 7Site Tour: H. Lee Moffitt Cancer Center Vivarium and The Small Animal Imaging Laboratory (SAIL) Check-in at tour desk in hotel lobby at 8:15 a.m.; Departs hotel at 8:30 a.m.; Bus drops off at Tampa International Airport terminals by 12:30 p.m.; Returns to hotel by 1:15 p.m.

H. Lee Moffitt Cancer Center Vivarium Supporting the research program in Moffitt’s 256,000-gsf interdisci-plinary research space is a 29,000-gsf AAALAC accredited Specific Pathogen Free (SPF) small rodent (Rats/Mice) barrier facility (vivarium), (with interstitial floor for vivarium MEP infrastructure) located on the ground floor of the Stabile Research Building (SRB). The entire facility is outfitted with security cameras and card access. Additional card access is required to access the Small Animal Imaging Core, Gene Targeting Core and the housing/procedure rooms for NSG mice. AIA

The Small Animal Imaging Laboratory (SAIL) The Small Animal Imaging Laboratory (SAIL) provides advanced and multi-modality imaging services including consultation, imaging, and image analysis for both basic and translational research. The SAIL facility contains state-of-the-art instrumentation including a 7T MRI, multimodal PET/SPECT/CT, ultrasound, bioluminescence, and fluorescence modalities. The facility’s instrumentation and services have been largely employed to evaluate tumor development, progression, metastasis, and response to therapy in mouse and rat models of cancer, as well as the development of imaging biomarkers, contrast agents, and high-resolution anatomical imaging of human specimen. AIA

IMPORTANT SITE TOUR NOTES:• YOU MUST SIGN UP IN ADVANCE (SEE REGISTRATION FORM) AND

HAVE WRITTEN CONFIRMATION FROM TRADELINE IN ORDER TO ATTEND THE TOUR(S). • Site tour attendance is limited. Space on the site tour(s) will be filled on a first-registered, first-served basis.• No more than 5 people per organization will be confirmed on a tour.

• Failure to check-in at the tour desk in the lobby 15 mins. prior to departure time may result in your seat being forfeited to those on the stand-by list.• All tour participants must arrive at the site on the tour bus with the tour group. For security reasons, no one may meet the group at the tour site. • A $25 bus transportation fee will be charged to your registration fee. This fee is non-refundable for cancellations made within two weeks of the tour date.

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Facility Site Tour Conference Participants

Speakers• AAALAC International• AALAS• Aircuity• Chernoff Thompson Architects• Cornerstone Commissioning, Inc.• CRB • Edstrom• EwingCole• Henry Ford Health System• Lab Animal Consultants• Matachana USA• Memorial Sloan Kettering Cancer

Center & Weill Cornell Medicine• Memorial University Newfoundland• Perkins + Will• PRI Bio• R.G. Vanderweil Engineers, LLP• South Dakota State University

• Stony Brook Medicine• Tecniplast USA, Inc.• The Clark Enersen Partners • The ElmCos Group• The University of Alabama at

Birmingham School of Medicine• The Whiting-Turner Contracting

Company• Translational Research Institute• University of Calgary• University of Houston• Vium Inc.

Exhibitors• Aircuity Inc.• Allentown Inc.• Animal Care Systems, Inc.• Arcoplast, Inc.

• BASF Corporation• Edstrom, Inc.• Getinge, Inc.• Life Science Products, Inc.• Matachana USA• NuAire, Inc.• Phoenix Controls• PRI Bio• Res-Tek, Inc.• Siemens Building Technologies, Inc.• Tecniplast USA, Inc.• The Whiting-Turner Contracting Co.• Trespa North America• Tuttnauer USA Co. Ltd.• Vium, Inc.

Special Event Hosts• Strobic Air, a CECO Environmental

Company

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Sunday, November 4Registration Sign-in/Continental Breakfast for Fundamentals Course 7:30 a.m. – 8:00 a.m.

* Fundamentals of Planning and Design of Animal Research 8:00 a.m. – 4:30 p.m. and Biocontainment Labs

Hosted Reception; Registration Sign-In 7:30 p.m. – 8:30 p.m.

Monday, November 5Registration Sign-in/Continental Breakfast 8:00 a.m. – 8:30 a.m.

General Session 8:30 a.m. – 10:55 a.m.

Conference Overview Speakers: Memorial Sloan Kettering Cancer Center & Weill Cornell Medicine; Lab Animal Consultants; Memorial University Newfoundland; Translational Research Institute

Concurrent Forum Sessions 11:10 a.m. – 12:05 p.m.

A. An industry ripe for massive disruption: Animal facility operating processes and design overhaul

B. Cost data, budget, and project planning: Tools to aid biocontainment facility project design, construction, and operation

C. The critical construction details: Animal facility construction and renovation

Hosted Luncheon 12:05 p.m.

Concurrent Forum Sessions 1:10 p.m. – 2:05 p.m.

D. 4D operational modelling tech unlocks improved vivarium planning and operations E. Upgrading to the modern vivarium: Digitally enabled and super energy/water efficient F. + Capacity, density, and revenue: New rodent housing designs and micro-level technology

for facility upgrades

Concurrent Forum Sessions 2:20 p.m. – 3:15 p.m.

G. The next level: A guide to planning a net-zero, Designated Pathogen Free (DPF) animal facility

H. Securing quality data with the Digital Vivarium: Videos and sensors for complete, objective, robust data

I. Two benchmarks: Focused and flexible animal facilities for emerging research programs (germ free, barrier, biocontainment)

General Session 3:45 p.m. – 4:45 p.m.

Speakers: Stony Brook Medicine; Henry Ford Health System / AALAS

Reception Hosted by (Guests Welcome) 4:45 p.m. – 5:45 p.m.

* Additional cost to attend + Presented at this time only.

Register with payment by Oct. 5 and Save $200

TradelineInc.com

Agenda at a Glance

Register Now!

Special Events and Features:

Hosted Pre-Conference ReceptionSunday; November 4, 7:30 p.m. Light appetizers and dessert. Attendees may sign in and pick up their conference materials at this time. Guests welcome.

Hosted ReceptionMonday; November 5, 4:45 p.m. - 5:45 p.m. Guests welcome.

Food and BeverageRegistered attendees will be provided with lunch and refreshment breaks on both meeting days.

A continental breakfast will be served on the first meeting day and a full breakfast will be served on the second meeting day.

Please Note The FollowingDress for this conference is business casual. It is our goal to maintain the temperature of the meeting rooms at an acceptable level for all attendees. However, for your maximum comfort we suggest that you plan to dress in layers.

Audio or video recording devices are not permitted at this conference.

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Agenda at a Glance

* Additional cost to attend + Presented at this time only.

Tradeline is a Registered Provider with The American Institute of Architects Continuing Education Systems. Credit earned on completion of this event will be reported to CES Records for AIA members by Tradeline. Certificates of Completion for non-AIA members are available upon request.

There are a maximum of 15 Continuing Education Hours (CEHs) available at this conference. Sessions marked with the AIA CES logo AIA have been registered with the AIA/CES Record. Sessions marked with HSW qualify for HSW credit.

Tuesday, November 6Hosted Breakfast 7:15 a.m. – 8:00 a.m.

Concurrent Sessions 8:05 a.m. – 9:00 a.m.

C. The critical construction details: Animal facility construction and renovation G. The next level: A guide to planning a net-zero, Designated Pathogen Free (DPF)

animal facility J. + Go beyond average sustainability and cost savings with new sterilization processes

General Session 9:15 a.m. – 10:10 a.m.

Speakers: The University of Alabama at Birmingham School of Medicine; AAALAC International

Concurrent Forum Sessions 10:35 a.m. – 11:30 a.m.

A. An industry ripe for massive disruption: Animal facility operating processes and design overhaul

B. Cost data, budget, and project planning: Tools to aid biocontainment facility project design, construction, and operation

H. Securing quality data with the Digital Vivarium: Videos and sensors for complete, objective, robust data

Concurrent Forum Sessions 11:45 a.m. – 12:40 p.m.

D. 4D operational modelling tech unlocks improved vivarium planning and operations K. + Validation of effluent treatment systems: New decision-making criteria

Hosted Luncheon 12:40 p.m.

Concurrent Forum Sessions 1:45 p.m. – 2:40 p.m.

E. Upgrading to the modern vivarium: Digitally enabled and super energy/water efficient I. Two benchmarks: Focused and flexible animal facilities for emerging research programs

(germ free, barrier, biocontainment)

General Session 2:55 p.m. – 3:40 p.m.

Town Hall Knowledge Roundup

Adjourn 3:40 p.m.

Wednesday, November 7

* Facility Site Tour (must be pre-registered to attend) 8:15 a.m. – 1:15 p.m.

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Monday, November 5

Emerging rodent models: Specialized facility demands and altered space metrics Memorial Sloan Kettering Cancer Center & Weill Cornell MedicineNeil S. Lipmann, VMD – Professor & Executive Director, Center of Comparative Medicine & PathologyNewly emerging models in oncology, stem cell biology, and infectious disease, plus the revealed importance of the microbiome in biological processes and diseases, is generating increasing demand for highly specialized rodent models – highly immunocompromised, germ free, or gnotobiotic – which add unique and demanding environmental, housing, and support requirements. Neil Lipman details how highly immune compromised mice, such as the NSG and NOG strains, as well as axenic and gnotobiotic models can disrupt existing vivarium operating models and alter space planning metrics. He offers short- and long-term solutions using newly developed caging systems for maintaining gnotobiotic rodent models outside of flexible film isolators.

Recording and reporting of room and microenvironmental data: Latest developments Lab Animal ConsultantsJohn J. Hasenau, DVM, DACLAM – PrincipalThe ability to accurately record room and microenvironmental data is becoming more important in the understanding of study reproducibility and the impacts these variables have on study data; variability from the quality of the data collected, how the data is collected, when it is collected and where it is collected. John Hasenau examines what the industry is doing to address these challenges including the role of digital technology and new reporting guidelines, more efficient caging, IVC and rack solutions, and what it takes to leverage them in your organization for improved repeatability and rigor of study outcomes.

Closing the instability gap on outdated facilities: Cost-effective consolidation solutions for sustainable operations Memorial University NewfoundlandJennifer Keyte, DVM – Director, Animal Care Services and University VeterinarianMemorial University’s state-of-the-art multi-species Animal Resource Centre replacement facility centralizes animal care in a collaborative, efficient, inspiring work space, with a modern facility design and equipment that will benefit both people and animals. Jennifer Keyte charts the increasing gap between outdated vivarium facilities and the need to deliver sustainable and viable biomedical research activities and degree certifications. She details the new facility feature set to support rodent production and housing, small and large animal surgery, physiological testing, behavioral testing in an Animal Containment Level 2 environment, as well as all related support and admin areas, and design solutions that allow for future expansion.

5-year findings on Specific Pathogen Free facility plans, and repurposing for gnotobiotics Translational Research InstituteTess Vogts – Core Facilities CoordinatorThe Translational Research Institute’s Specific Pathogen Free (SPF) vivarium has generated five years’ worth of facility design and operational wisdom, a collection of findings and best practices now being further expanded with the addition of gnotobiotic space. Tess Vogts provides critical details for success in anticipating customer base needs, re-derivation of mouse lines, animal imaging equipment and processes, and optimizing procedure and support space ratios. She scopes out the effect that increasing demand for gnotobiotics is having on animal research facilities, and what it takes to repurpose existing space to support the program requirements.

Monday and Tuesday, November 5-6

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Unconventional reuse solutions for advanced animal imaging: Low cost, high quality, and researchers love it Stony Brook MedicineGlen Itzkowitz, MA, MBA – Associate Dean, Research Facilities & OperationsSophisticated animal imaging capability is in high demand, but the cost and timelines for brick-and-mortar solutions can be prohibitive and drive investigators to other institutions. No more! Glen Itzkowitz details Stony Brook Medicine’s cost-effective space repurposing initiative to install 7.0- and 9.4-Tesla small animal MRIs in prefab facilities under a pedestrian plaza. He illustrates solutions for daunting logistical problems, building systems integration, imaging equipment upgrades and support requirements (cooling, venting, shielding), animal transport and handling processes. He charts project costs, intramural and extramural funding streams, and highlights unexpected project successes.

Facility solutions for seizing new research opportunities and reducing LAR cost Henry Ford Health SystemJennifer C. Smith, DVM, DACLAM – Director, Bioresources Department, and 2018 AALAS PresidentTo respond to new priorities in research funding and demands for cost reduction and sustainability, research organizations are upgrading facilities with new technology, modernizing and expanding space and equipment, and cultivating a high-productivity, lean workforce. Jennifer Smith provides a “state of the industry” report based on her tenure as AALAS President and illustrates what Henry Ford Health System is doing in terms of facility renovation and modernization projects to meet newly emerging program requirements. She examines the impact of equipment and technology changes on vivarium operating models, and what it takes to recruit, train, and retain operators and support staff.

Tuesday, November 6

Combined renovation/modular solution adds capacity and support for highly specialized models The University of Alabama at Birmingham School of MedicineKarl Kraebber – Director of Xenotransplantation OpsCombining renovation with modular construction is proving to be an expedient strategy for accommodating short-term programs, expanding capacity, and supporting highly specialized animal models. Karl Kraebber sets out the facility capability, capacity, and support requirements associated with UAB’s designated pathogen free (DPF) and genetically modified animal production requirements. He profiles a multi-phase initiative to renovate an existing CMU animal vivarium and double capacity using modular construction methods, including details on much needed upgrades, modular facility site selection, facility flow, project budgeting, and lessons learned.

AAALAC accreditation: An integral component of your construction projectsAAALAC InternationalGary Borkowski, DVM, MS, DACLAM – Senior DirectorAAALAC International is a voluntary accreditation organization for animal care and use programs, and there are currently over 1000 accredited units in over 45 countries worldwide. The physical plant (vivarium) is a critical component of animal care and use programs, and understanding AAALAC expectations during planning, design and construction can facilitate the accreditation process for institutions. Dr. Gary Borkowski presents an overview of how an institution applies for, achieves, and maintains accreditation, with an emphasis on subjects germane to the physical plant components. He highlights AAALAC’s primary standards and reference resources and identifies common physical plant deficiencies seen during AAALAC site visits.

Town Hall Knowledge RoundupFacilitator: Tradeline, Inc.Derek Westfall – PresidentThis closing session is where key ideas, new developments, and findings that have been revealed over the course of the entire two-day conference (including sessions you may have missed) get clarified, expanded upon, and affirmed or debated. This is also the opportunity to get answers from industry leaders and the entire audience to specific questions on key and challenging issues.

Attend all of the General Sessions below

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Monday and Tuesday, November 5-6

AIA Sessions qualify for AIA credit. HSW Sessions qualify for HSW credit

A. An industry ripe for massive disruption: Animal facility operating processes and design overhaul The ElmCos GroupChris Cosgrove – Principal

University of HoustonDavid W. Brammer, DVM – Executive Director Animal Care Operations

Current operating processes: Inefficient. Existing facilities: Expensive, inflexible, and unsustainable. Yesterday’s benchmarks: Obsolete. Action item: Embrace the continuous improvement culture before it’s too late. Dr. David Brammer and Chris Cosgrove demonstrate the transformative effects that Lean process improvement is having on animal facility operations today, and on new modernization, renovation, and new construction plans. They lay out change management strategies, operational knowledge prerequisites, process refinement methods, budget planning metrics, and the results to expect: Increased capacity, enhanced program flexibility and scalability, reduced space requirements, lower operating costs, and improved sustainability. AIA HSW

Monday 11:10 a.m. – 12:05 p.m. | Tuesday 10:35 a.m. – 11:30 a.m.

B. Cost data, budget, and project planning: Tools to aid biocontainment facility project design, construction, and operation South Dakota State UniversityJane Hennings – Director, South Dakota Animal Disease Research and Diagnostic Laboratory

The Clark Enersen Partners Andrew Stepp, AIA – Senior Principal

Cornerstone Commissioning, Inc.Dan Frasier, PE – Principal, Director of Commissioning

Before you start your next renovation or new construction project, attend this session to get up-to-date data on costs, new project processes, and equipment requirements for modern biocontainment facilities. Session leaders distill valuable findings from a case study of South Dakota Animal Disease Research and Diagnostic Laboratory and they demonstrate risk analysis based design solutions, efficient space configurations, critical facility capabilities, key equipment investments, and diagnostic protocols for flexibility, biosafety, and biosecurity. They illustrate layout and programming strategies to satisfy research, education, and outreach missions, and they provide guidance for phased expansion/renovation without down-time. AIA HSW

Monday 11:10 a.m. – 12:05 p.m. | Tuesday 10:35 a.m. - 11:30 a.m.

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Forum Sessions

C. The critical construction details: Animal facility construction and renovation The Whiting-Turner Contracting CompanyLuke Redmond – Project Manager Kevin Schaefer – Superintendent

Warning: Animal facility construction and upgrade initiatives are particularly vulnerable to going off the rails during construction. From site prep issues, imprecise infrastructure fabrication and installation processes, well-intentioned but mis-informed on-site changes, inadequate trades/vendor communication… the list of potential failure points is long, and remediation can be difficult, expensive, or impossible. Don’t let that happen to your project! Equipped with over two decades of hard-earned wisdom in constructing animal research facilities, session leaders deliver a quality-control recipe for success from the constructor’s viewpoint including project team composition, stakeholder engagement, scheduling, change orders, computer model management, communication, and more. AIA HSW

Monday 11:10 a.m. – 12:05 p.m. | Tuesday 8:05 a.m. – 9:00 a.m.

D. 4D operational modelling tech unlocks improved vivarium planning and operations CRB Niranjan S Kulkarni, PhD – Director of Operations Improvement Kevin J Chriswell, AIA – Senior Project Architect

New modeling and simulation techniques are delivering a goldmine of actionable information for making complex animal research facility planning decisions and reducing construction, operations, and equipment costs. Session leaders illustrate the use of 4D Operations Improvement Modeling in conjunction with Building Information Modeling (BIM) to engage designers, owners, end users, and equipment suppliers in data-enhanced facility planning. They chart the iterative simulation process and the results including smart optimal flexibility investments, improved personnel movement, improved energy use, smarter caging decisions (disposable vs. reusable), and streamlined cage wash processes. AIA HSW

Monday 1:10 p.m. – 2:05 p.m. | Tuesday 11:45 a.m.– 12:40 p.m.

E. Upgrading to the modern vivarium: Digitally enabled and super energy/water efficient EdstromClement Feng – Vice President Marketing, Strategy

University of HoustonDr. David Brammer, D.V.M.; DACLAM – Executive Director of Animal Care Operations

AircuityPete Hmelyar – Vice President of Sales

AAALAC InternationalDr. Gary Borkowski, DVM, MS, DACLAM – Senior Director

New data gathered from emerging vivarium IoT technologies is providing fresh operational insights into hidden waste and helping to identify opportunities for deep resource savings. In this session presenters explore new technologies and renovation strategies that enable healthier vivarium workplaces and reduce water consumption and energy use by up to 50%. They deliver study findings from the University of Houston comparing the use of Demand Controlled Ventilation (DCV) to constant airflow in non-human primate and rodent rooms, and they illustrate the cost benefits and improved environments for human and animal health. AIA HSW

Monday 1:10 p.m. – 2:05 p.m. | Tuesday 1:45 p.m. – 2:40 p.m.

F. Capacity, density, and revenue: New rodent housing designs and micro-level technology for facility upgrades TecniplastBrian Geyer – Vice-President Sales

Common obstacles facing animal research organizations today: 1) outdated facilities and equipment cannot keep up with demands for research capacity growth, 2) aging equipment has reached its design lifecycle, and 3) new decisions on upgrade strategies are needed to increase space utilization, workflow, operational efficiency, and sustainability. Brian Geyer highlights the latest advances in environmental technology enhanced rodent housing, and the new possibilities for increasing housing density in existing space and compensating for HVAC inadequacies. He demonstrates expected ROI and examines key considerations in selecting equipment and technology to promote cost-effective operational efficiency and overall sustainability. AIA HSW

Monday 1:10 p.m. – 2:05 p.m.

“You run a fabulous conference. Your team’s attention to detail, and also how you engage each participant to make it meaningful for them, is laudable and exemplary. I wish other conferences worked this way.”Rajesh S. Mangrulkar, M.D.Associate Dean for Medical Student EducationUniversity of Michigan Medical School

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G. The next level: A guide to planning a net-zero, Designated Pathogen Free (DPF) animal facility EwingColeJennifer Wampler, AIA, LEED AP – Principal Kate Mondock, PE, LEED AP – HVAC Engineer

It is possible: Energy intensive ABSL facilities can be brought into line with organizational sustainability commitments. In this session, Jennifer Wampler and Kate Mondock examine strategies for minimizing energy demand and maximizing on-site renewables to deliver a net zero energy DPF animal facility that meets current best practices. They illustrate technologies and strategies to reduce energy use and improve overall energy performance including on-site and building-mounted photovoltaic arrays, a high-performance building envelope and surface materials, sequence of operations facility monitoring and air change reduction, and integrated lighting and building control systems. AIA HSW

Monday 2:20 p.m. – 3:15 p.m. | Tuesday 8:05 a.m. – 9:00 a.m.

H. Securing quality data with the Digital Vivarium: Videos and sensors for complete, objective, robust data Vium Inc.Laura Schaevitz, PhD – Chief Scientific Officer

The efficacy of animal models in drug development is being called into question, in part, due to the measures available for monitoring animals within the cage, housing system, and vivarium. This session examines the rise of the Digital Vivarium: A combination of existing monitoring technologies with data science, environmental design, and cloud infrastructure to address the historical imperfections of in-vivo research. Laura Schaevitz illustrates how traditional animal housing systems are being upended and outfitted with video and sensor technologies to provide more complete, objective, and robust data sets, and the streamlined data collection processes that reduce labor costs and improve study reproducibility. AIA HSW

Monday 2:20 p.m. – 3:15 p.m. | Tuesday 10:35 a.m. – 11:30 a.m.

Forum Sessions (continued)

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I. Two benchmarks: Focused and flexible animal facilities for emerging research programs (germ free, barrier, biocontainment)Chernoff Thompson ArchitectsRuss Chernoff, Architect AIBC, MAAA, AIA, NSAA, OAA, AAPEI – Founding Partner

University of Calgary International Microbiome CentreShaunna Huston, PhD – Director, Programs and Business

This session illustrates facility solutions for two very different research futures: One requiring flexibility and adaptability for a wide range of possible animal research program requirements, and another purpose-built around highly specialized and technically demanding research processes and reproducibility. Session leaders profile University of Victoria’s highly flexible vivarium allowing conversion of suites between conventional, barrier, and ABSL-2, and University of Calgary’s International Microbiome Center which puts people, animals, and state-of-the-art equipment in germ free and biocontainment space. They examine decisions on lab and support space, sterilization, improving the research environment, and optimizing the flow of animals, equipment, food, water, and personnel. AIA HSW

Monday 2:20 p.m. – 3:15 p.m. | Tuesday 1:45 p.m. – 2:40 p.m.

J. Go beyond average sustainability and cost savings with new sterilization processes Matachana USAWayne DeSantis – Vice President

Engineering advances in sterilization systems have reduced energy costs and water consumption over the past several years, but up to 50% more savings and major sustainability gains are still within your grasp with new processes that are coming online. In this session, Wayne DeSantis examines the burden sterilizers and autoclaves place on building utility systems (steam, water, HVAC, compressed air, electricity, and effluent disposal) and details new solutions for reducing water consumption, energy consumption, wear and tear on building infrastructure, and overall operating costs. He examines case studies where these processes have been employed and the results you might expect. AIA HSW

Tuesday 8:05 a.m. – 9:00 a.m.

K. Validation of effluent treatment systems: New decision-making criteria PRI BioGary W Schmidt – Manager Products and Process Technology

Increased regulations concerning effluent and the demanding requirements for biological validation of the process are reshaping decisions on biowaste treatment strategies for animal facility construction and modernization initiatives. Gary Schmidt sets out solutions for user-friendly, routine biological validation at reasonable costs, the pros and cons and pitfalls to avoid associated with both batch and continuous flow effluent decontamination systems (also referred to as biowaste inactivation systems). He illustrates how each strategy can drastically effect facility infrastructure first costs and lifecycle operating costs, and delivers data and findings useful for biosafety personnel, equipment specifiers, and users of effluent decontamination systems. AIA HSW

Tuesday 11:45 a.m. – 12:40 p.m.

Register at www.TradelineInc.com

AIA Sessions qualify for AIA credit. HSW Sessions qualify for HSW credit13

“Great conference! It is one of the best conferences I have been to.” Kathleen S. Matt, PhDDean, College of Health SciencesUniversity of Delaware

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Registration:Conference Registration Fees*Registration fees with payment by 10/5/18 $1890 for single registration $1740 each for groups of 2 or more

Registration fees after 10/5/18 $2090 for single registration $1940 each for groups of 2 or more

Registration fee includes: All general sessions, selection of forums, a dessert reception, two lunches, one breakfast, a wine and hors d’oeuvres reception, refreshments, and a conference workbook guide. Presentations will be made available for download to attendees.

Team Discounts! For groups of 5 or more, please call Tradeline for additional discounts available.

Pre-Conference TrainingFundamentals of Planning and Design of Animal Research and Biocontainment Labs

$1140 Stand-alone course $1000 with full conference participation

Facility Site Tour$25 Transportation Fee

Registration InformationMake checks payable to: TRADELINE, INC. Federal Tax I.D. #95-297-2863

Policy on Cancellations, Changes and Refunds All cancellations and changes to registrations must be received by Tradeline, Inc. in writing.

You may make substitutions at any time; please notify us as soon as possible.

Full refunds will be given for cancellations received in writing 14 days or more prior to the event. A $250 service fee will be charged for cancellations received between 14 and 6 days prior. No refunds will be given for cancellations received within 5 days of the event.

Hotel and Travel Information:Room ReservationsTradeline has reserved a block of sleeping rooms for this event at The Vinoy Renaissance Resort. For registrations received by October 8, 2018 Tradeline will handle and confirm room reservations [based on availability] according to your instructions on the registration form.

After October 8th please call Tradeline for room availability.

Changes: All room reservations and changes must originate through Tradeline, Inc. to obtain the special rate. If you contact the hotel directly, you may be informed that they are sold out, or you may be charged a higher rate.

Room RateThe discounted room rate for this event is $209/night, single or double occupancy. A limited number of rooms are available at the government per diem rate for U.S. federal government employees

This is a non-smoking hotel.

Room PaymentTradeline does not accept payment for room reservations. Hotel charges are paid to the hotel directly upon checkout.

Travel InformationAirport-to-Hotel Transportation

The Vinoy Renaissance Resort is 22 miles from Tampa International Airport. Taxis or shuttles are readily available from all airport terminals. Taxi fares will run $50 – $60 each way.

Registration and Accommodations

The conference will be held at:

The Vinoy RenaissanceResort501 Fifth Ave. NE St. Petersburg, FL 33701

OnlineTradelineInc.com

Fax925.254.1093 From outside the U.S. 1.925.254.1093

MailTradeline, Inc. 115 Orinda Way Orinda, CA 94563, USA

QuestionsCall 925.254.1744 ext. 112 From outside the U.S. 1.925.254.1744 ext. 112

How to Register:

* International Attendee DiscountA $250 discount will be applied to the 2-day full conference registration fee for non-U.S. residents traveling from outside of the U.S.

Use promo code INTL2018 if registering onlineRegister with payment by Oct. 5 and Save $200

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1. Please Type or Print Clearly (or register online at www.TradelineInc.com)

• Conference registration is not complete until confirmed by Tradeline, Inc. • Please confirm airline reservations only after confirmation of registration. • Only one registrant per form.

Name ___________________________________________ First Name for name badge _________________ Title/Position _______________________________________________________________________________Institution __________________________________________________________________________________Address _________________________________________________________ M/S ______________________City___________________________________ State _____ Zip Code ______Country ______________________________ Phone _____________________Fax ______________________Attendee Contact Email ______________________________________________________________________Alternate Contact Email ______________________________________________________________________

2. Register with payment before October 5th and Save $200! Payment by 10/5/18* Full price* Single Registration ❑ $1,890 ❑ $2,090 Team Registration Discount** ❑ $1,740/Attendee ❑ $1,940/Attendee

**Name of other team registrant(s) ____________________________________________________________

3. Conference Add-Ons:Sunday, November 4 Fundamentals of Planning and Design of Animal Research and Biocontainment Labs ❑ $1,140 ❑ $1,000 with registration to the full 2 day conference November 5-6

Wednesday, November 7 ❑ $25 Tour: H. Lee Moffitt Cancer Center Vivarium and The Small Animal Imaging Laboratory (SAIL)

4. Select a Method of PaymentTo receive early discount, payment must accompany registration. Payment or P.O. # must be received by conference date in order to attend.❑ Visa ❑ Mastercard ❑ AmEx Name on Card ________________________________________Card # ____________________________________________Exp. Date_________ Security Code __________Billing Address: ________________________________________________________ (If different from above)❑ CHECK: Make payable to TRADELINE, INC. Check # ____________________________________________ ❑ INSTITUTIONAL P.O. number (not eligible for early discount) ____________________________________

5. Hotel ReservationsPlease do not call the hotel directly. The special room rate below is available at The Vinoy Renaissance Resort through Tradeline only.❑ Yes, please reserve a room for me. Arrival Date: ____________ Departure Date: ___________________❑ Single occupancy ($209/night +12% room tax) ❑ Double occupancy ($209/night +12% room tax)❑ Government rate ($120/night at press time) - A limited nubmer of rooms are available for U.S. federal government employeesSpecial Requests***: _________________________________________________________________________❑ No, I will not require a hotel reservation.

Registration and Accommodations Registration Form

*International Attendee Discount: A $250 discount will be applied to the 2-day full conference registration fee for non-U.S. residents travelling from outside of the U.S.

**Team Discount pricing above applies to groups of 2 or more. For teams of 5 or more please call Tradeline for additional discount availability.

***All requests will be honored based upon availability at hotel upon time of arrival. Tradeline will inform the hotel of your preferences but cannot guarantee any special requests.

All room reservations are guaranteed. For changes or cancellations, please notify Tradeline at least 72 hours prior to your scheduled arrival. No-shows and cancellations within 72 hours of arrival are subject to a charge equal to one night’s stay.

Policy on Cancellations, Changes and Refunds: All cancellations and changes to registrations must be received by Tradeline, Inc. in writing. You may make substitutions at any time; please notify us as soon as possible. Full refunds given for cancellations received 14 days or more prior to the event. A $250 service fee will be charged for cancellations received between 14 and 6 days prior. No re-funds will be given within 5 days of the event.

Facility Strategies for Animal Research and Biocontainment 2018 November 5-6, 2018 – The Vinoy Renaissance Resort – St. Petersburg, FL

Fax925.254.1093 From outside the U.S. 1.925.254.1093

MailTradeline, Inc. 115 Orinda Way Orinda, CA 94563, USA

QuestionsCall 925.254.1744 ext. 112 From outside the U.S. 1.925.254.1744 ext. 112

Register with payment by Oct. 5 and Save $200

TradelineInc.com

Register Now!

Tradeline, Inc. 115 Orinda Way | Orinda, CA 94563 USA

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Questions?Call 925.254.1744