FINAL PROGRAM

Dear Colleague,Welcome to the 17th International Conference on Continuous Renal Replacement Therapies.The CRRT Conference continues to provide a comprehensive coverage of the rapidly developingfield of Critical Care Nephrology and CRRT. It highlights the recent advances in our understand-ing of pathophysiology of critical illness, acute kidney injury, emerging strategies in themanagement of sepsis, multiorgan failure, development and use of biomarkers, technical advances inCRRT and the appropriate utilization of these techniques.

This year's program presents exciting new developments and evidence for hemodynamic monitoring,fluid management, dialysis timing, and extracorporeal support for critically ill patients. A mix ofinvited lectures, pro-con debates, interactive workshops, tutorials, poster sessions and paneldiscussions are planned to continue the tradition of multidisciplinary interactions.

Again this year we are offering a Pre-Conference AKI Workshop titled: “Changing Paradigms inAcute Kidney Injury: From Mechanism to Management”. The workshop will provide a com-prehensive review of the most recent developments in the field. Topics include, mechanisms, pathwaysof AKI and its effects on other organs, biomarkers and their applications and the findings from therecent clinical trials. We hope that this course will provide participants an opportunity to interactwith experts in the field and emerge with a better understanding of this rapidly evolving area.

2012 Conference Topic Highlights:• Organ Dysfunction in the Critically Ill Patient

Emerging Concepts in Organ Cross-talk, Sepsis, Microcirculation &Oxidative Stress, Infections• Acute Kidney Injury (AKI)

Pathophysiology, Microcirculation, Mechanisms of Injury and Repair, Biomarkers Targets forEarly Intervention, Cardiorenal and Hepatorenal Syndrome, Long Term Outcomes

• Controversies in Management of the Critically Ill PatientFluid Management, Augmented Renal Clearance, Risk Stratification, Non-Invasive Monitoring, Blood gas and Electrolyte Disorders, End-Of Life Care

• Challenges and Controversies in Renal Support & CRRTWhen to Start and Stop, What Dose of Dialysis, Fluid Management, Type of Anticoagulant, Pharmacokinetics of Antimicrobials, Nutritional Support, Quality Measures, New Techniques, Acid Base Problems, Intradialytic Hypotension

• Biomarkers for Management of Critically Ill Patients Risk Stratification, Surveillance, Diagnosis, Targeted Intervention and Prognosis

• Special Sessions for Nurses and Allied PersonnelCompetency Assessment, Ethical Dilemmas and End of Life Care

• Special Pre and Post Conference WorkshopsFundamentals of CRRT, Emerging Research in AKI, Hands On training for CRRT Devices,Organization of CRRT Programs, Pediatric Hands-On Workshop, Hemodynamic Monitoring, Ultrasound and Vascular Access Placement

As always, we hope to provide the right environment to foster learning and mutually beneficial com-munications and collaborations. We are pleased that you have joined us to share your knowledge andexperience, as it is through multidisciplinary interactions that we will gain a better understanding of crit-ical illness and it is only through our collective efforts that we will improve the lives of our patients.

On behalf of the organizing committee we are happy to welcome you to San Diego for ourSeventeenth Anniversary of the CRRT Conference.

Ravindra L Mehta, MBBS MD DM FACP FRCP(UK)Chairman, Organizing Committee

ACKNOWLEDGEMENTS of EDUCATIONAL GRANTS AND CORPORATE CONTRIBUTIONS

Alere San Diego IncorporatedAstute Medical

CytoPherx IncorporatedSpectral Diagnostics Incorporated

FELLOWS IN TRAINING SUPPORT

NxStage Medical Incorporated

SEVENTEENTH INTERNATIONAL CONFERENCE ON CONTINUOUS RENAL REPLACEMENT THERAPIES

CRRT 2012

USASteven R. Alexander, MDLinda Awdishu, PharmD

Joseph V. Bonventre, MD, PhDTimothy E. Bunchman, MD

Jorge Cerda, MD, FACP, FASNWilliam R. Clark, MDStuart Goldstein, MD

Thomas A. Golper, MDAndre A. Kaplan, MD

John Kellum, MDEileen Lischer, MA, BSN, RN, CNN

William L. Macias, MD, PhDBruce Mueller, PharmD, FCCP

Emil P. Paganini, MD, FACP, FRCPDavid M. Ward, MD, FRCP

SOUTH AMERICAEmmanuel Burdmann, MD, PhD

Raul Lombardi, MD

CANADANoel Gibney, MD

Martine Leblanc, MD, FRCPCRonald Wald, MD

EUROPEBernard Jean-Marie Canaud, MDAndrew Davenport, MD, FRCP

Patrick Honore, MDClaudio Ronco, MD

Miet Schetz, MD, PhDRaymond Vanholder, MD, PhD

JAPANTadao Akizawa, MD

Hiroyuki Hirasawa, MD, PhDKazo Kaizu, MD

AUSTRALIAIan Baldwin, RN, MN, ACCCNRinaldo Bellomo, MD, FRACP

ORGANIZING COMMITTEECHAIRMAN

Ravindra L. Mehta, MBBS MD DM FACP FRCP(UK)

On-site Registration Fees Begin February 10 - 17, 2012Registration Opens (5:00-8:00 pm) Monday, February 13, 2012Conference Workshops and Plenary Sessions February 14 - 17, 2012Poster Mounting and Viewing February 14 & 15, 2012Pre-Conference AKI Workshop - PW1 (see separate handout) February 14, 2012Elective Workshops February 14 and 17, 2012

HW1 Fundamentals of CRRT (full day) Tuesday, February 14, 2012HW2 GAMBRO Hands-on Physicians (No CME) Tuesday, February 14, 2012HW3 Pediatric Hands-On Workshop Friday, February 17, 2012HW4 Hemodynamic Monitoring and Use of Drugs Friday, February 17, 2012HW5 Essentials for Developing, Nurturing and Friday, February 17, 2012

Growing a CRRT ProgramHW6 Introduction to Critical Care Ultrasonography Friday, February 17, 2012

IMPORTANT CONFERENCE DATES

Endorsed by

The International Society of Nephrology

Acute Kidney Injury Network

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INDIAVijay Kher, MD, DM, FAMS, FISN, FIMSA

Rajasekara Chakravarthi, MD, DNB

Participating Faculty ………………………………………………………………………2General Conference Information …………………………………………………4, 5 & 6 Program

Industry Workshops ……………………………………………………………………7Elective Workshop (Tuesday, HW1, HW2) ……………………………………………8Plenary Sessions and Standard Workshops (Tuesday through Friday) ……………9Elective Workshops (Friday, HW3, HW4, HW5, HW6) ……………………………13

Poster List …………………………………………………………………………………14Hotel Maps …………………………………………………………………………16 & 17Acknowledgements …………………………………………………………… Back Cover

TABLE OF CONTENTS

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PARTICIPATING FACULTYEric Adler, MDAssociate Clinical ProfessorMedical Director, Cardiac TransplantDivision of CardiologyUniversity of California, San Diego School of MedicineSan Diego, CA USA

Anupam Agarwal, MDDivision of Nephrology, THT 647University of Alabama at BirminghamBirmingham, AL USA

Steven Alexander, MDProfessor of PediatricsChief, Pediatric NephrologyLucile Packard Children's Hospital at StanfordStanford University Medical CenterStanford, CA USA

Amelia Allsteadt, BSN,RN,CNNNurse Manager, Texas Childrens HospitalHouston, TX USA

Luis Alvarez, MD, PhDPalo Alto Medical FoundationStanford Medical CenterMenlo Park, CA USA

David Askenazi, MDChildren's of AlabamaUniversity of Alabama at BirminghamDivision of Pediatric NephrologyBirmingham, AL USA

Linda Awdishu, PharmD, MASAsst. Clinical Professor of Pharmacy and MedicineThe Skaggs School of Pharmacy andPharmaceutical Sciences, UCSDAsst. Clinical Professor, School of Pharmacy, UCSFSan Diego, CA USA

Sean Bagshaw, MD, MSc, FRCPCDivision of Critical Care MedicineUniversity of AlbertaEdmonton, Al CANADA

Charanjit Bahniwal, MDCleveland Clinic FoundationSolon, OH USA

Vishal Bansal, MD, FACSUCSD Department of SurgeryDivision of Trauma, Surgical Critical Care and BurnsSan Deigo, CA USA

Jonathan Barasch, MD PhDColumbiaNew York, NY USA

Roland Blantz, MDUniversity of California, San DiegoVeterans Affairs San Diego Healthcare SystemSan Diego, CA USA

Josée Bouchard, MDHopital du Sacre-Coeur de MontrealUniversite de MontrealMontreal, Qu CANADA

Peter Brindley, MDUniversity of Alberta HospitalEdmonton, AL CANADA

Emmanuel Burdmann, MD, PhDAssociate Professor, Division of NephrologyUniversity of Sao Paulo Medical SchoolSao Paulo, SP BRAZIL

Jorge Cerda, MD, FACP, FASNClinical Professor of MedicineAlbany Medical CollegeCapital District Renal PhysiciansAlbany, NY USA

Lakhmir Chawla, MDAssociate Professor of MedicineGeorge Washington University Medical CenterWashington DC, DC USA

William Clark, MDVice President, Medical Strategy and Therapy DevelopmentGambro Renal Products, Intensive CareClinical Assistant Professor of MedicineIndiana University School of MedicineIndianapolis, IN USA

Rolando Claure, MDAssistant Professor of NephrologyUniversidad del ValleSchool of MedicineCochabamba, Ce BOLIVIA

Todd Costantini, MDDepartment of SurgeryUniversity of California San DiegoSan Diego, CA USA

Maureen Craig, MSN, RN, CNNUC Davis Medical CenterCarmichael, CA USA

Dinna Cruz, MD, MPHDepartment of NephrologyInternational Renal Research Institute VicenzaSan Bortolo HospitalVicenza, VI ITALY

Helen Currier, BSN, RN, CNN, CENPDirector, Renal & Pheresis, Vascular Access and Wound Ostomy Care ServicesNursing Research Scholar, Center for Clinical ResearchTexas Children's HospitalHouston, TX USA

Andrew Davenport, MD, FRCPConsultant NephrologistHonorary ReaderRoyal Free HospitalUniversity College London Medical SchoolLondon, ENGLAND (UK)

Daniel De Backer, MDDepartment of Intensive CareBrussels, BELGIUM

Zheng Dong, Ph.D.Georgia Health Sciences University andCharlie Norwood VAMCAugusta, GA USA

Zoltan Endre, MD, PhDUniversity of New South WalesUniversity of Otago - ChristchurchSydney, Ne AUSTRALIA

Geoffrey Fleming, MDVanderbilt University Medical CenterDepartment of PediatricsDivision of Critical CareNashville, TN USA

James Fortenberry, MD, FCCM, FAAPDepartment of PediatricsEmory University School of MedicineChildren's Healthcare of Atlanta at EglestonAtlanta, GA USA

Benjamin Freda, DOTufts University School of MedicineBaystate Medical CenterRenal DivisionWestern New England Renal and Transplant AssociatesLongmeadow, MA USA

Noel Gibney, MB FRCP(C)Professor and DirectorDivision of Critical Care MedicineFaculty of Medicine and Dentistry, University of AlbertaEdmonton, CanadaEdmonton, AB CANADA

Stuart Goldstein, MDProfessor of Pediatrics, University ofCincinnati College of MedicineDivision of Nephrology and Hypertension &The Heart InstituteDirector, Center for Acute Care NephrologyCincinnati Children's Hospital Medical CenterCincinnati, OH USA

Thomas Golper, MDVanderbilt University Medical CenterProfessor of Medicine/NephrologyMedical Director, Medical Specialties Patient Care CenterNashville, TN USA

Patty Graham, RN, MS, CCRN, CSUCSDSan Diego, CA USA

Hiroyuki Hirasawa, MDDepartment of Emergency and Critical Care MedicineChiba University Graduate School of MedicineChiba, Ch JAPAN

Patrick Honoré, MDHead of ClinicsIntensive Care departmentUZ BrusselVUB University,Brussels, BelgiumJette, Br BELGIUM

Ben Humphreys, MD, PhDBrigham and Women's HospitalHarvard Medical SchoolHarvard Stem Cell InstituteBoston, MA USA

Can Ince, PhDDept. of Intensive Care MedicineErasmus Medcial CenterErasmus University of RotterdamRotterdam, So THE NETHERLANDS

Rajiv Jalan, MD, PhDThe UCL Institute of HepatologyUniversity College LondonLondon, UNITED KINGDOM

Oliver Joannes-Boyau, MDAnesthesiologist and IntensivistConsultant in ICUConsultant in Hemofiltration, Sepsis and Organ Support TherapiesUniversity Hospital of BordeauxPessac, FRANCE

Luis Juncos, MDDivision of NephrologyUniversity of Mississippi Medical CenterJackson, MS USA

Kazo Kaizu, MDSocial Insurance Yokohama Chuo HospitalYokohama, Ka JAPAN

Shyamala Karuvannur, MDRSF, CA USA

Kianoush Kashani, MDMayo ClinicRochester, MN USA

John Kellum, MDProfessor, Critical Care MedicineUniversity of Pittsburgh School of MedicinePittsburgh, PA USA

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PARTICIPATING FACULTYJolyn Kleinholz, RNCincinnati, OH USA

Edwin Lee, MDMayo ClinicRochester, MN USA

Andrew Lewington, MDRenal AssociationLeeds, YK UNITED KINGDOM

Jeffrey Lipman, MDIntensive Care UnitRoyal Brisbane and Womens' HospitalUniversity of Queensland, AustraliaBrisbane , Qu AUSTRALIA

Eileen Lischer, MA, BSN, RN, CNNAdministrative Nurse IV Acute DialysisUCSD Medical CenterSan Diego, CA USA

Zhi-Hong Liu, MDDirector,Research Institute of Nephrology,Vice President, Jinling Hospital,NanjingUniversity School of MedicineAcademician, Chinese Academy of EngineeringNanjing, CHINA

Etienne Macedo, MD, PhDUniversity of Sao PauloSao Paulo, SP BRAZIL

William Macias, MD, PhDLilly Research LaboratoriesEli Lilly and CompanyIndianapolis, IndianaIndianapolis, IN USA

Alan Maisel, MDProfessor of MedicineUniversity of California, San DiegoSan Diego, CA USA

Martin Matejovic, MDCharles University Medical SchoolTeaching Hospital PlzenPlzen, CZECH REPUBLIC

Javier Maynar, MDDepartment of Intensive Care MedicineSantiago HospitalBasque Public Health SystemVitoria, Ba SPAIN

Peter McCullough, MD, MPHNorthville, MI USA

Ravindra Mehta, MBBS, MD, DM,FACPProfessor of Clinical MedicineUniversity of California, San Diego School of MedicineAssociate Chair for Clinical Research,Department of Medicine; Director, Clinical Nephrology and Dialysis ProgramsUCSD Medical CenterSan Diego, CA USA

Bruce Molitoris, MDProfessor of MedicineDirector, Indiana Center for Biological MicroscopyIndiana University School of MedicineIndianapolis, IN USA

Bruce Mueller, PharmD, FCCP,FASNAssociate Dean for Academic Affairs andProfessor, Dept. of Clinical, Social &Administrative Sciences, College of PharmacyAssociate Director, Department of Pharmacy Services, University Hospital, University of MichiganAnn Arbor, MI USA

Mark Okusa, MDDivision of NephrologyUniversity of VirginiaCharlottesville, VA USA

Emil Paganini, MD, FACP, FRCPProfessor Emeritus - Clinical MedicineSenior Advisor - ICU NephrologyCleveland Clinic FoundationChesterland, OH USA

Alisa Palazzolo, BSN, RNCincinnati Childrens Hospital Medical CenterLawrenceburg, IN USA

Heather Patton, MDUniversity of California, San Diego Health SystemSan Diego, CA USA

Didier Payen, MDPARIS, FRANCE

Peter Pickkers, MD, PhDRadboud University Nijmegen Medical CentreDept. Intensive Care MedicineNijmegen, NETHERLANDS

Hamid Rabb, MDProfessor & Vice ChairmanDepartment of MedicineMedical Director, Kidney TransplantJohns Hopkins University School of MedicineBaltimore, MD USA

Claudio Ronco, MDDirector, Department of NephrologySt. Bortolo HospitalVicenza, ITALY

Mitchell Rosner, MDDivision of NephrologyUniversity of VirginiaCharlottesville, VI USA

Robert Safirstein, MDProfessor of Medicine University of Arkansas Little Rock, AR USA

Paul Sanders, MDBirmingham VA Medical CenterBirmingham, AL USA

Navparkash Sandhu, MDUCSDVA Med Center SDSan Diego CA USA

Miet Schetz, MD, PhDAssociate Professor of MedicineDepartment of Intensive CareUniversity HospitalUniversity of LeuvenLeuven, BELGIUM

Kai Schmidt-Ott, MDMax Delbrueck Center for Molecular MedicineExperimental and Clinical Research Center andDepartment of NephrologyCharité - Universitätsmedizin BerlinBerlin, GERMANY

Robert Schrier, MDUniversity of Colorado School of MedicineAurora, CO USA

Nick Selby, MDDepartment of Renal MedicineRoyal Derby HospitalDerby, 0 UK

Andrew Shaw, MD FRCADuke UniversityDurham, NC USA

Vishnu Bhotla Sivakumar, MD, DM,DNB, FISN, FRProfessor of NephrologyHODDept of NephrologySVIMSTirupati, AN INDIA

Scott SutherlandLucile Packard Children's HospitalStanford University Medical CenterStanford, CA USA

Jordan Symons, MDDivision of Pediatric NephrologySeattle Children's HospitalSeattle, WA USA

Pam Taub, MDAssistant Professor of MedicineUCSD Division of CardiologySan Diego, CA USA

Ashita Tolwani, MDProfessor, Division of NephrologyUniversity of Alabama at BirminghamBirmingham, AL USA

James Tumlin, MDUniversity of Tennessee College of MedicineChattanooga, TN USA

Volker Vallon, MDDepartments of Medicine and PharmacologyDivision of Nephrology & HypertensionUC San Diego and VASDHCSSan Diego, CA USA

Henry Wang, MD, MSUniversity of Alabama at BirminghamBirmingham, AL USA

David Ward, MD, FRCPUniversity of California San DiegoSan Diego, CA USA

Hector Wong, MDUniversity of Cincinnati College of MedicineDepartment of PediatricsCincinnati, OH USA

Michael Zappitelli, MD, MScMcGill University Health CenterMontreal Children's HospitalMontreal, QC CANADA

Kurt Zinn, DVM, Ph.D.The University of Alabama at BirminghamDept. of RadiologyBirmingham, AL USA

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CONFERENCE DATES AND LOCATIONThe inclusive dates for all scientific sessions of the SIXTEENTH INTERNATIONALCONFERENCE ON RENAL REPLACEMENT THERAPIES (CRRT) are February14-17,2012. There will be elective workshops held on Tuesday, February 14 & Friday, February 17,2012. The Conference will be held at the Hilton San Diego Bayfront, 1 Park Boulevard, SanDiego, California, USA 92101, Tel: 1-800-HILTONS, Fax: 1-619-564-3344

Please note: Program Schedule may be subject to change

REGISTRATION INFORMATIONAll participants must register and pay the appropriate fee. Conference registrants will haveaccess to all scientific sessions and poster sessions. The registration fee includes general sessions,conference workshops, CME accreditation, conference syllabus, continental breakfasts onThursday and Friday, coffee breaks, receptions on Tuesday and Wednesday and lunches onWednesday and Thursday. Registration will begin on the evening of Monday, February 13,2012. Poster Viewing will begin on Tuesday evening February 14, 2012. For additionalregistration times see the program.

REGISTRATION FEES On-Site RegistrationFeb. 10 thru Feb. 17, 2012

Physicians/Other (MD, PhD, etc.) $ 795

Nurses/Dieticians/Pharmacists/Residents*/Fellows* $ 595 *with letter of verification from department head

Industry $ 795

Conference Registration Fee Includes: Access to all general sessions (Wednesday-Friday),workshop lectures (Wednesday-Thursday), Exhibit Area, Welcome Reception & PosterSession (Tuesday), Exhibit Reception (Wednesday), two lunches (Wednesday/Thursday) andall conference breaks. Conference Registration Fee DOES NOT include Elective Workshopson Tuesday or Friday (see page 4 for list) or a printed syllabus.

ONLINE MULTIMEDIA PRESENTATIONS $295This year we have teamed up with Bluesky Broadcast to capture PLENARY SESSIONS andselected STANDARD WORKSHOPS for post-conference viewing online. Purchase of thispackage enables you to review presentations in a state-of-the-art format that includes streamingaudio and video, and synchronized slides. Make this purchase when during the conference andSAVE significantly over post-conference purchase of individual plenary sessions and work-shops. Please visit the conference website for details regarding the presentation list, contentsample and purchase details. AKI and Fundamentals Workshops also available!

MEET THE EXPERT (limited to 20 delegatesper session) $30These sessions (choose from 2 on Wed. & Thurs.) allow participants to meet and interact withinternationally renowned experts in an informal setting over breakfast. This is an excellentopportunity to ask questions, learn how these experts manage patients, get guidance for projectsand network. See program for times and participating experts.

GENERAL INFORMATION

ConferenceRegistration Feedoes not include

Elective Hands-OnWorkshops

New!

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GENERAL INFORMATIONPRE-CONFERENCE AKI & ELECTIVE WORKSHOPSTUESDAY - Full Day WorkshopsTuesday, February 14 8:00am-5:30pm (includes lunch, AM & PM breaks and Tues. Reception)

PW1: Changing Paradigms in Acute Kidney Injury:

$250 / $220From Mechanisms to Management (see separate handout for schedule) Acute Kidney Injury is a rapidly evolving area where several advances have been made in understanding themechanisms and pathways of AKI and its effects on other organs. Recent identification of biomarkers has pro-vided new tools and techniques to characterize this disorder. This pre-course will provide a comprehensivereview of the most recent developments in the field and describe emerging knowledge from basic and trans-lational research applicable to clinical care.

CRRT Conference Registration NOT Required for this workshop** A $30 discount will be given to attendees that register for the CRRT Conference (valid for full price reg-istrations only.)

HW1: Fundamentals of CRRT $185This workshop offers an introduction to CRRT techniques and is developed to provide a core set of informa-tion on the principles and practice of CRRT. The operating characteristics of CRRT techniques for solute andfluid management, drug management will be discussed along with the potential applications of these tech-niques. Requirements for developing a successful CRRT program and selecting machines will also bedescribed.____________________________________________________________________TUESDAY - Half Day Hands-On Elective Workshop $110Tuesday, February 14 8:00am-12:30pm (includes AM break & 12:30 lunch)HW2: GAMBRO Hands-On Physician’s Workshop:

Practical CRRT - The Nuts and BoltsThrough case studies, lecture and Prismaflex System hands-on practice, this workshop will provide prac-tical approaches to prescribing and delivering CRRT with Gambro’s leading CRRT system. CME credits do not apply to HW2Presented by: Luis Alvarez, MD, PhD, Stanford University Medical Center ___________________________________________________________________________FRIDAY - Post-Conference Elective Workshops (choose one) $110 eachFriday, February 17 2:00pm-5:30pm - HW6 Starts at 1:30 (includes 1:00pm lunch & PMbreak )

HW3: Pediatric Hands-On Workshop This workshop will focus upon the practical aspects of care including clinical program development, dis-cussion of various models of ICU and Nephrology medical nursing care and hands on machine setup andoperation.

HW4: Hemodynamic Monitoring and Use of DrugsCritically ill Patients require frequent assessments and monitoring of hemodynamic and respiratory param-eters to optimize stability and guide ventilator support. Several techniques are now available and utilizedto manage patients including devices to assess the microcirculation, volume responsiveness and cardiacperformance. This workshop will cover the principles and strategies for hemodynamic and microcircula-tory monitoring in critically ill patients.

HW5: Essentials for Developing, Nurturing and Growing a CRRT ProgramSuccessful CRRT programs require careful planning, nurturing and ongoing monitoring for growth andeffectiveness.. This workshop will cover the key elements for building and enhancing a program. Topics tobe covered include developing a multidisciplinary team, creating tool kits for training, assessments andmonitoring effectiveness of the program, dealing with administration, financial considerations and strate-gies for program growth.

HW6: Introduction to Critical Care Ultrasonography (starts at 1:30)CCUS or critical care ultrasonography is an ultrasonography examination performed and interpreted by inten-sivist at the bedside to establish the diagnosis and guides procedures, locate a target organ or a disease specificcondition. It serves as a complement to CXR, CT, MRI, Echo or other imaging modalities. This intro workshopis a 3.5 hour workshop that includes a 1 hour intro lecture, 1 hour reviewing normal and abnormal images,and a 1.5 hour hands-on section. The components of this workshop are: abdominal (kidney, bladder, IVC andaorta); thoracic( lung and pleural space); vascular (vascular access and DVT).

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GENERAL INFORMATION

CRRT 2013Hilton San Diego Bayfront San Diego, California

February 12-15, 2013

Mark Your Calendar!

GUEST FEE $185Includes: Access to Exhibit Area, Welcome Reception (Tuesday), Exhibit Reception (Wednesday) and twoLunches (Wednesday & Thursday). Guests are not admitted to the General Sessions or Workshops. Guestsare not eligible to receive CME Credits.

SOCIAL ACTIVITIESPoster Review and Reception Tuesday, February 14, 2012 6:00pm-7:30pmAll attendees are invited to review the CRRT poster presentations including fellows in training and meetthe presenters and faculty. This is a great opportunity to pick-up credentials, register on-site, organize yourworkshops and prepare for the upcoming CRRT meeting.

Exhibit Reception and Poster Session Wednesday, February 15, 2012 6:30pm-8:00pmMeet and interact with the CRRT poster presenters while you review the latest in equipment and productsin the exhibit area. This is a great opportunity to network and meet your colleagues.

TOURS Tours are based on availability and subject to change.The Gaslamp Segway® Tour Adults/Children 10 or older*: $95.00Wednesday, February 15, 2012 10:00am-12:30pm Segway tours are the ideal way to see San Diego because you will cover so many areas in less time andwithout exhaustion. On The Gaslamp Segway® Tour, you will explore the historic Gaslamp Quarter; viewthe great Victorian-era architecture, cruise along the Embarcadero and glide up the hills to beautiful BalboaPark. Come join us on this fun journey through America’s Finest City!*Must be at least 10 years of age AND weigh at least 90 lbs. Must wear comfortable, flat soled shoes.

San Diego Bay Cruise Adults: $27.00 Children ages 3-12: $14.00Thursday, February 16, 2012 10:00am -12:30pm Join us on a memorable, professionaly narrated two-hour tour of San Diego Bay! Sit back, relax and soakup the gorgeous scenery as you cruise around taking in the famous sights of San Diego. Highlights includeeverything from sea lions to Navy SEALS. You'll see the Navy Submarine base, the Star of India, cruiseunder the spectacular Coronado Bridge and view the famous Hotel Del Coronado.

CONFERENCE CANCELLATION POLICYIf your registration must be cancelled, your fee, less $100 U.S. for administrative costs, will be refundedupon your written request. No refunds will be made after January 17, 2012. Allow 6-8 weeks for refund.

CONFERENCE OFFICE / INFORMATIONRES Seminars. Phone: 858-272-1018 Conference Website:4425 Cass Street, Suite A Fax: 858-272-7687 www.crrtonline.comSan Diego, CA 92109 USA Email: res@crrtonline.com

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PROGRAM

TUESDAY AFTERNOONGROUP 1 SIMULTANEOUS WORKSHOPS (see page 8 for full group list)4:00-5:30 I01 CRRT Systems I (C,N,AP)

I. B. Braun - CRRT SystemsDevice demonstrations of features, setup, operation, monitoring and discontinuation.

WEDNESDAY MORNING GROUP 2 SIMULTANEOUS WORKSHOPS (see page 9 for full group list)8:15-9:45 I02 CRRT Systems II (C,N,AP)

I. NxStage Medical Device demonstrations of features, setup, operation, monitoring and discontinuation.

GROUP 3 SIMULTANEOUS WORKSHOPS (see page 9 for full group list)10:00-11:30 I03 CRRT Systems I (C,N,AP)

I. B. Braun - CRRT SystemsDevice demonstrations of features, setup, operation, monitoring and discontinuation.

LUNCHES

11:30-1:00 Gambro Focus Group Luncheon Looking for an Expert Opinion? Overview of the KDIGO Guideline for AKIHear an up-to-date expert consensus on AKI treatment with a focus on the evidence-based application of CRRT in the ICU.

11:30-1:00 ALERE Luncheon Plasma NGAL Updates: The Cardiorenal Syndrome and Next Generation AssaySpeakers will present new information about applications of an extended range plasma NGAL assay including its use for more timely diagnosis in the early phases of the Cardiorenal syndrome, for risk stratification of those at increased risk of short-term adverse heart failure related outcomes and on the utility of a next generation plasma NGAL assay for improved diagnosis in critically ill patients.

THURSDAY MORNINGGROUP 4 SIMULTANEOUS WORKSHOPS (see page 11 for full group list)8:00-9:00 I04 CRRT Systems II (C,N,AP)

I. NxStage Medical Device demonstrations of features, setup, operation, monitoring and discontinuation.

LUNCHES

12:40-2:00 Industry Forum Luncheon Regulatory Requirements for Dialysate/Infusate Solutions for CRRTSeveral new solutions are now available for CRRT however they are subject to regulatory requirements that often influence the their utilization and introduction in the market. This session will explore the key factors that detremine regulatory approval of solutions for CRRT.

12:40-2:00 Gambro Focus Group LuncheonGetting the MOST out of Your CRRT SystemLearn how new options with the Prismaflex System are creating opportunities to provide your patients with Multi-Organ Support Therapy.

INDUSTRY WORKSHOPS AND LUNCHESEach of these three Industry Workshops will be presented twice in different time slots. They runsimultaneously with the standard workshops (see corresponding Group numbers on pages 8, 9 and 11.

PLEASE NOTE: CME Credits DO NOT apply to Industry Presentations.

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MONDAY, FEBRUARY 13

TUESDAY, FEBRUARY 14

TUESDAY AFTERNOON, FEBRUARY 14

PROGRAM5:00-8:00pm Conference Registration Open - Indigo W. Foyer

7:00am Conference Registration Open - Indigo W. Foyer

PRE-CONFERENCE AKI FULL DAY WORKSHOP

8:00-5:30 PW1 Changing Paradigms in Acute Kidney Injury: From Mechanisms to ManagementSee separate hand-out for schedule and info. regarding lunch & breaks

ELECTIVE FULL DAY WORKSHOP8:00-5:30 HW1 Fundamentals of CRRT

See separate hand-out for schedule and info. regarding lunch & breaks

ELECTIVE HALF DAY WORKSHOP8:00am-12:30pm HW2 GAMBRO Hands-On Physician’s Workshop:

Practical CRRT - The Nuts and BoltsCME credits do not applySee separate hand-out for schedule and info. regarding lunch & breaks

STANDARD WORKSHOPS (open to all participants - applicable to physicians, nurses and allied personnel)(Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = of interest to nurses and allied personnel)

Workshops presented in a series are marked with a “1” for a primary discussion and “2” for a more complexor advanced discussion in the topic. Series workshops 1 and 2 can be taken subsequently (following eachother) or independently (e.g. workshop 1 can be taken without taking workshop 2 and vice versa).

4:00-5:30pm GROUP 1 - SIMULTANEOUS STANDARD WORKSHOPS

A01 Assessing the MicrocirculationRolando Claure, MD, Can Ince, PhD, Etienne Macedo, MD, PhD

Techniques of monitoring and interpretation of microcirculatory alterations in critical illness as measured by direct sublingual observation. Strategies to assess microcirculatoryalterations in the critically ill patients will be presented and discussed.

B02 Plasma Exchange Therapy and Hybrid TechniquesHiroyuki Hirasawa, MD, David M. Ward, MD, FRCP

Principles of catheter choice, Principles of plasma exchange, sorbent based and hybrid therapies for extracorporeal support. Case based discussion of practical application of plasma exchange, sorbent based and hybrid therapies for extracorporeal support.

C03 Critical Care Pharmacology: Vasopressors, and InotropesJeffrey Lipman, MD, Peter Pickkers, MD, PhD

Pathophysiology of shock and the principles and practical use of vasopressors, ionotropes, vasodilators in critically ill patients.

D04 Biomarkers 1: Principles and ApplicationsZoltan Endre, MD, PhD, William L. Macias, MD, PhD

Principles and classification of biomarkers and their application for diagnosis and management of diseases. Criteria for using biomarkers as surrogate end points.

E05 Liver and the Kidney 1: Principles of Hepatic DysfunctionRajiv Jalan, MD, PhD, Heather Patton, MD

Pathophysiology of hepatic failure and rationale for use of different techniques forextracorporeal support techniques (Cell based systems, MARS, CRRT) for hepatic support.

F06 Competency Assessment in CRRTPatty Graham, RN, MS, CCRN, CS, Eileen Lischer, MA, BSN, RN, CNN

Description on training requirements, core curriculum and skills assessment for CRRT care delivery.

G07 Fluids and Solutions in the Critically Ill 1Daniel De Backer, MD, Andrew D. Shaw, MD FRCA

How to select and use colloids, crystalloids and blood products.H08 Preventing and Managing Complications of Dialysis 1: Intradialytic Hypotension

Andrew Davenport, MD, FRCP, Nick Selby, MDDefinitions and pathophysiology of intradialytic hypotension. Strategies for prevention and management.

I01 See page 7 for non CME Industry Workshops

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6:00-7:30pm Reception and Poster Review - For All Conference Attendees

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WEDNESDAY MORNING, FEBRUARY 15

8:15-9:45am GROUP 2 - SIMULTANEOUS STANDARD WORKSHOPS A09 Vascular Access /Membrane and Circuit C, N, AP

Luis Juncos, MD, Emil P. Paganini, MD, FACP, FRCPPrinciples of catheter choice, placement, maintenance, recognition and management of complica-tions, selection and use of membranes for different applications, circuit design, setup and monitoring.

B10 Dialysis Dose Prescription and Delivery (C, N, AP)William R. Clark, MD, Rolando Claure, MD, Claudio Ronco, MD

Operational characteristics influencing solute removal in CRRTC11 Critical Care Management: Nutrition Assessment and Delivery (I, N, AP)

Oliver Joannes-Boyau, MD, Miet Schetz, MD, PhDPathophysiology of malnutrition in critically ill patients. Principles of nutritional assessment and support and adjustments for RRT.

D12 Biomarkers 2: Application in AKI (I, N, AP)Josée Bouchard, MD, Dinna Cruz, MD, MPH, Zoltan Endre, MD, PhD

Development and qualification of structural and functional biomarkers for AKI. Current performance characteristics and application for diagnosis, management and prognostication in AKI.

E13 Liver and the Kidney 2: Principles of Extracorporeal Hepatic Support (A, N)Andrew Davenport, MD, FRCP, Rajiv Jalan, MD, PhD

Pathophysiology of hepatic failure and rationale for use of different techniques for extracorporeal support techniques (Cell based systems, MARS, CRRT) for hepatic support.

F14 Therapeutic Modalities: IHD, SLED, PD (C, N, AP)Emmanuel Burdmann, MD, PhD, Thomas A. Golper, MD, Vishnu Bhotla Sivakumar, MD

Comparisons of operational characteristics including anticoagulation, membranes, solutions and flows and approaches for ongoing and future research

G15 Fluids and Solutions in the Critically Ill 2: Solutions for CRRT (C, N, AP)Linda Awdishu, PharmD, MAS, Sean Bagshaw, MD, MSc, FRCPC

Solutions for CRRT: What's available and applications for Electrolyte and Acid Base Balance.H16 Preventing and Managing Complications of Dialysis 2: Operation, Fluids,

Electrolytes and Acid Base (C, N)Maureen Craig, MSN, RN, CNN, Javier Maynar, MD, Nick Selby, MD

Definitions and explanation of operation, fluids, electrolytes and acid base.I02 See page 7 for non CME Industry Workshops

10:00-11:30am GROUP 3 - SIMULTANEOUS STANDARD WORKSHOPS A17 Anticoagulation: Mechanisms and Techniques (C, N, AP)

Emmanuel Burdmann, MD, PhD, Oliver Joannes-Boyau, MD, Ashita Tolwani, MDAnticoagulation regimens: Mechanisms, selection, prescription, monitoring and implementation

B18 Fluid Management (C, N, AP)Ravindra L. Mehta, MBBS, MD, DM, FACP, Didier Payen, MD

Principles of volume assessment, fluid removal and fluid regulation with different CRRT equipmentC19 Acid Base and Electrolyte Problems in the Critically Ill 1 (I)

John A. Kellum, MD, Mitchell H. Rosner, MDPrinciples for evaluating and managing acid base and electrolyte problems in critically ill patients using case studies.

D20 Extracorporeal Techniques for Sepsis 1: Pathophysiology and Targets (A)Patrick M. Honoré, MD, Martin Matejovic, MD

Pathophysiology of sepsis and rationale for use of extracorporeal support in treatment of sepsis.Experimental models for high permeability membranes, HVHF, VHVHF and hybrid therapies

E21 Heart Failure and Cardio-renal Syndrome 1: Pathophysiology (I)Alan Maisel, MD, Claudio Ronco, MD

Pathophysiology, recognition and management strategies for cardiac and renal failure in the critically ill patient.

F22 Ensuring Patient Safety and Quality Measures for RRT in AKI 1: Water Standards, Infection Control (C, N, AP)Thomas A. Golper, MD, Eileen Lischer, MA, BSN, RN, CNN

Discussion of the recent developments in ensuring quality and patient safety for acute dialysis delivery.

G23 Pediatric CRRT: The Basics (I, N, AP)Geoffrey Fleming, MD, Scott Sutherland, Jordan M. Symons, MD, Michael Zappitelli, MD

Technique requirement and application for use in children excluding neonates. Covering epidemiology of pediatric acute kidney injury, and a focus on the pediatric CRRTprescription (anticoagulation, fluid composition, modality, and nutrition provision), as well as outcome in pediatric CRRT.

H24 Patient Centered Care in the ICU: The Team Approach (I, N, AP)Peter Brindley, MD, Patty Graham, RN, MS, CCRN, CS

Taking good care of patients requires communication and understanding of the needs of patients and their loved ones. This workshop will discuss the principles and practice of patient centered care utilizing case studies.

I03 See page 7 for non CME Industry Workshops

7:00-4:30pm Conference Registration Open - Indigo W. Foyer

7:00-8:15 MEET THE EXPERT (elective event, see pg. 4 for details)Session 1 (ME1) - Daniel De Backer, MD and Hiroyuki Hirasawa, MDSession 2 (ME2) - Rajiv Jalan, MD, PhD and Robert Schrier, MD

11:30am-1:10pm Lunches Hosted by Conference (see following page for details)

9:45-10:00 Coffee Break - Indigo Terrace

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WEDNESDAY AFTERNOON, FEBRUARY 15

1:10-3:45 Plenary 1 MINI-SYMPOSIAOrgan Dysfunction in the CriticallyIll Patient: Emerging Concepts

Co-chairs: John A. Kellum, MDPeter Pickkers, MD, PhD

1:10-1:15 Opening RemarksRavindra L. Mehta, MBBS, MD

1:15-1:30 Sepsis and AKI: Bidirectional andSynergistic Relationship?Martin Matejovic, MD

1:30-1:45 Metabolic Derangement and Nutritional Support in Sepsis with Organ FailureHiroyuki Hirasawa, MD

1:45-2:00 Nutritional Support in ICU Patients:Does Timing and Route Matter?Miet Schetz, MD, PhD

2:00-2:15 Microcirculatory Alterations: Potential Mechanisms and Implications for TherapyDaniel De Backer, MD

2:15-2:30 The Endothelial Glycocalyx: A New Target in Critical IllnessCan Ince, PhD

2:30-2:45 The Future is Predetermined in Severe Sepsis, So What are the Implications?Didier Payen, MD

2:45-3:00 Tailored Therapeutics and Personalized Medicine: Is it Possible in Critical Illness?William L. Macias, MD, PhD

3:00-3:25 SPECIAL LECTUREEngineering Critical Care Medicine: A New Way to Protect Our PatientsPeter Brindley, MD

3:30-3:45 Panel Discussion3:45-4:15 Coffee Break: Exhibits Open

Indigo ABEF

4:15-6:30 Plenary 2MINI-SYMPOSIAAcute Kidney Injury (AKI): Pathophysiology

Co-chairs: Stuart L. Goldstein, MDKazo Kaizu, MD

4:15-4:30 Minimizing the Renal Toxicity of Iodinated ContrastPeter A. McCullough, MD, MPH

4:30-4:45 AKI in the Patient with Cancer: What Have We Learned?Ben Humphreys, MD, PhD

4:45-5:00 Genome-wide Association Studies(GWAS): Can We Apply to AKI?Robert Safirstein, MD

5:00-5:15 Marrying the Heart and Kidney with Biomarkers: Improved Understanding of the Cardio Renal Syndrome?Alan Maisel, MD

5:15-5:30 Distant Organ Responses in AKIHamid Rabb, MD

5:30-5:45 Liver-Kidney Interactions in Hepatorenal Syndrome:Who's to Blame?

The Kidney - Rajiv Jalan, MD The Liver - Robert Schrier, MD

5:45-6:00 Panel Discussion

6:00-6:30 SPECIAL SESSIONCritical Care Nephrology Jeopardy Moderator: Noel Gibney, MD Nephrology Team:Ashita Tolwani, Emil Paganini, Claudio Ronco Intensivists Team:John Kellum, Andrew Shaw, Miet Schetz

6:30 Adjourn

6:30-8:00 EXHIBIT RECEPTION ANDPOSTER SESSIONIndigo ABEF

OPENING SESSION I: PATIENT CHARACTERISTICS

11:30am-1:00pm Lunches Hosted by Conference - RSVP required, selection made during registration process.See page 7 for Industry related luncheons

Conference Luncheon

Nursing Forum LuncheonCommunication in Crisis: Improving Our "Verbal Dexterity"- Peter Brindley MDStrong verbal communication skills are key whether for establishing a shared mental model, coordinating tasks, centralizing the flow of information, or stabilizing emotions. This talk will provide a framework for understanding key concepts of verbal communications and offer practical suggestions for improving communication in critical care.

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SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE

9:45-12:40 Plenary 3 MINI-SYMPOSIAControversies in Management of the Critically Ill Patient: Fluid Management

Co-chairs: Hamid Rabb, MD

9:45-10:00 Do Vasoactive Drugs and Fluids Improve Renal Perfusion?Daniel De Backer, MD

10:00-10:15 Saline is Really Bad for You. Hard to Believe. Impossible to Ignore!John A. Kellum, MD

10:15-10:30 What Blood Pressure Should We Target for Patients with AKI?Ravindra L. Mehta, MD

10:30-10:45 What We Do in the OR When You're Not Looking!Andrew D. Shaw, MD FRCA

10:45-11:00 Water, Water, Everywhere: Sodium and Water Balance and the Injured BrainDidier Payen, MD

11:00-11:15 Blood Transfusions are Importantfor the Resuscitation of the Critically Ill PatientCan Ince, PhD

11:15-11:30 Fluid Management in the Critically Ill: The "5B" ApproachClaudio Ronco, MD

11:30-11:45 Thinking Outside of the Box: ANovel Strategy to Prevent Shock Induced AKITodd Costantini, MD

11:45-12:10 SPECIAL LECTUREFluid Management in the Critically Ill: Is the Kidney at Risk?Robert Schrier, MD

12:10-12:30 Panel DiscussionNoel Gibney, MB FRCP(C)

12:30-12:40 Top Abstract Awards

12:40-2:00 Lunches Hosted by Conference(see following page for details)

THURSDAY MORNING, FEBRUARY 167:00-4:30pm Conference Registration Open - Indigo W. Foyer7:00-8:00 Continental Breakfast - Indigo ABEF

7:00-8:00 MEET THE EXPERT (elective event, see pg. 4 for details)Session 3 (ME3) - John A. Kellum, MD and Peter A. McCullough, MD, MPHSession 4 (ME4) - Didier Payen, MD and Claudio Ronco, MD

Indigo CDGH (all Plenary Sessions)

8:00-9:30am GROUP 4 - SIMULTANEOUS STANDARD WORKSHOPS A25 Drug Management in CRRT (C, N, AP)

Jeffrey Lipman, MD, Bruce A. Mueller, PharmD, FCCP, FASNDrug Dosing principles for critically ill patients and adjustments in extracorporeal support techniques.

B26 Starting and Stopping RRT for AKI: Principles and Practice (A)Etienne Macedo, MD, PhD, Ravindra L. Mehta, MBBS, MD, DM, FACP

Principles of determining when to start and stop RRT. Case based discussion of various approaches.

C27 Acid Base and Electrolyte Problems in the Critically Ill 2 (A, N)Andrew Lewington, MD, Mitchell H. Rosner, MD

Principles for evaluating and managing acid base and electrolyte problems incritically ill patients using case studies.

D28 Extracorporeal Techniques for Sepsis 2 (A)Hiroyuki Hirasawa, MD, Patrick M. Honoré, MD, Oliver Joannes-Boyau, MD

Technical considerations and practical application of extracorporeal support techniques for sepsis. Results of human studies for use of high permeability membranes, HVHF, VHVHF and hybrid techniques for sepsis.

E29 Heart Failure and Cardio-Renal Syndrome 2: Management Strategies and Case Studies (I, N, AP)Eric Adler, MD, Dinna Cruz, MD, MPH, Emil P. Paganini, MD, FACP, FRCP

Technical considerations, practical application and results of different methods to treat heart failure and cardio-renal syndrome

F30 Ensuring Patient Safety and Quality Measures for RRT in AKI 2: Dialysis Adequacy, Monitoring, Nursing Issues (C, N, AP)Eileen Lischer, MA, BSN, RN, CNN, Javier Maynar, MD, Ashita Tolwani, MD

Discussion of the principles of a systems based approach to implementing and monitoring quality to reduce errors in therapy prescription and delivery.

G31 CRRT in the Newborn: Principles and Practical Issues (C, N, AP)David Askenazi, MD, Jordan M. Symons, MD

Pathophysiology and management of metabolic disorders, neonatal AKI and intoxications with CRRT.

H32 Withdrawing & Withholding Support for AKI: Ethical Issues in the ICU (I, N, AP)Rolando Claure, MD, Benjamin Freda, DO, Noel Gibney, MB FRCP(C)

Factors influencing decisions for withholding and withdrawing dialysis in the management of critically ill patients. General principles for ethical decisions and how an approach can be developed to manage patients requiring dialysis.

I04 See page 7 for non CME Industry Workshops

9:30-9:45 Coffee Break - Indigo ABEF

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2:00-3:30 Plenary 4MINI-SYMPOSIAAdvancing Clinical Care and Research in AKI; The Role of Biomarkers: Report from the 10th ADQI Conference, Dublin, Ireland, August 2011

Co-chairs: Josée Bouchard, MDBruce A. Molitoris, MD

2:00-2:15 Biomarkers in AKI: Current Status and NeedsLakhmir S. Chawla, MD

2:15-2:30 Diagnosis of AKI: Can We Improve Recognition with Biomarkers?Claudio Ronco, MD

2:30-2:45 Differential Diagnosis of AKI: Can Biomarkers Help?Zoltan Endre, MD, PhD

2:45-3:00 Use of Biomarkers to Assess Prognosis and Guide Management of AKIDinna Cruz, MD, MPH

3:00-3:15 Physiological and Imaging Markers of AKIMark D. Okusa, MD

3:15-3:30 Looking to the Future: Biomarker Enhanced Decision Support for AKI ManagementRavindra L. Mehta, MD

3:30-4:00 Coffee Break - Indigo ABEF

4:00-6:00 Plenary 5MINI-SYMPOSIAChallenges and Controversies in Renal Support and CRRT

Co-chairs: Emmanuel Burdmann, MD, PhDJorge Cerda, MD, FACP, FASN

4:00-4:15 Myocardial Stunning and Brain Edema: Acute Effects of DialysisNick Selby, MD

4:15-4:30 Therapeutic Drug Monitoring During Dialysis SupportJeffrey Lipman, MD

4:30-4:45 Cutting it Short: Implications of Drug Shortages in the ICULinda Awdishu, PharmD, MAS

4:45-5:00 CRRT and ECMO: Techniques and Outcomes from the ELSO RegistryDavid Askenazi, MD

5:00-5:15 Comparing RRT Modalities: Does it Matter What You Use if the Job is Done?Sean Bagshaw, MD, MSc, FRCPC

5:15-5:30 Management of Severe Heart Failure: A Role for Ultrafiltration?Eric Adler, MD

5:30-5:45 Telemedicine in the ICU: The Future is HereJeffrey Lipman, MD

5:45-6:00 Avoiding Anticoagulation forCRRT: An Update on Emerging MembranesPatrick M. Honoré, MD

6:00 AdjournFree Evening

THURSDAY AFTERNOON, FEBRUARY 1612:40-2:00pm Lunches Hosted by Conference - RSVP required, selection made during registration process.

See page 7 for Industry related luncheons

Conference Luncheon

Nursing Forum Luncheon - 2Benchmarking for CRRT: Which Parameters Should We Use? Maureen Craig, MSN, RN, CNN and Eileen Lischer, MA, BSN, RN, CNNThis session will explore the quality measures that should be implemented to assess the delivery of CRRTand for comparisons across centers.

"Late Breaking Trials" LuncheonAKI, Critical Care, Sepsis and Extracorporeal Support Therapies Chair - William Macias MDThis session provides results from recent and ongoing clinical trials in AKI, Critical Care, Sepsis andExtracorporeal support therapies to inform participants of the latest research findings in the field.

Diagnostic and Prognostic Stratification in the Emergency Department Using Biomarkers of Intrinsic Acute Kidney Injury (AKI)Jonathan Barasch, Kai Schmidt-Ott, MD

A Multi-Center Pilot Study to Assess the Safety and Efficacy of Selective Cytopheretic Device (SCD) Therapy in Patients with Acute Kidney Injury (AKI)James Tumlin, MD

Negative Results in PROWESS Shock: Implications to Clinical Practice and Clinical Research William Macias MD

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SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CAREIndigo CDGH (all Plenary Sessions)

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7:30-10:00 Plenary 6MINI-SYMPOSIAEmerging Concepts in AKI

Co-chairs: Lakhmir S. Chawla, MDOliver Joannes-Boyau, MD

7:30-7:45 Rediscovering Urine Electrolytes for Differential Diagnosis and Prognosis of AKIEtienne Macedo, MD, PhD

7:45-8:00 Measuring GFR on Demand: Ready for Prime Time?Bruce A. Molitoris, MD

8:00-8:15 Improving Outcomes from AKI: Lessons from the UK?Andrew Lewington, MD

8:15-8:30 Combined CRRT-bilibrubin Adsorption System forLiver FailureZhi-Hong Liu, MD

8:30-9:30 The Changing Face of AKI: Snapshots from Around the WorldBrazil - Emmanuel Burdmann, MDIndia - Vishnu Bhotla Sivakumar, MDJapan - Kazo Kaizu, MDCanada - Sean Bagshaw, MDAustralia - Zoltan Endre, MD, PhDUSA - Stuart L. Goldstein, MD

9:30-9:45 Alkaline PhosphatasePeter Pickkers, MD, PhD

9:45-10:00 Recent Trials in the Prevention of Contrast-Induced AKI: Importance of Emerging BiomarkersPeter A. McCullough, MD, MPH

10:00-10:30 Coffee Break - Indigo ABEF

10:30-1:00 Plenary 7MINI SYMPOSIAEmerging Strategies in AKI Management & Extracorporeal Support

Co-chairs: Zhi-Hong Liu, MDBruce A. Mueller, PharmD

10:30-10:55 SPECIAL LECTUREWhen Enough Is Enough: The Nephrologist's Responsibility in Ordering Dialysis TreatmentsBenjamin Freda, DO

10:55-11:10 Cytokine Modulation in Sepsis: Results with the PMMA-CHDFTechniqueHiroyuki Hirasawa, MD

11:10-11:25 Ultrasound Techniques in Nephrology: Application in AKIKianoush Kashani, MD

11:25-11:40 Simulation: Success or Failure Within Ten YearsPeter Brindley, MD

11:40-11:55 Surveillance and Early Recognition of AKI: Does it Makea Difference?Nick Selby, MD

11:55-12:10 Preventing Traumatic Brain InjuryInduced Blood Brain BarrierPermeability: Novel Future TherapiesVishal Bansal, MD, FACS

12:10-12:25 Thrombocytopenia Associated Multi-Organ Failure (TAMOF): Results from the Multi-centerPediatric Plasmapheresis TrialJames Fortenberry, MD

12:25-12:55 Critical Care Nephrology: Literature ReviewNoel Gibney, MB FRCP(C)

12:55-1:00 Closing Remarks Ravindra L. Mehta, MD, FACPChairman

1:00 Conference Adjourns

FRIDAY, FEBRUARY 17

SESSION III: TECHNIQUE CHARACTERISTICS

SESSION IV: FUTURE TRENDS IN CRRT AND CRITICAL CARE

ELECTIVE HALF DAY WORKSHOP

7:00am-5:00pm Conference Registration Open - Indigo W. Foyer

1:00-2:00 Lunch Hosted by Conference for Elective Workshop ParticipantsIndigo Terrace

2:00-5:30 Concurrent Elective Workshops - See page 4 for detailsPLEASE NOTE: HW6 will start at 1:30pmHW3: Pediatric Hands-On Workshop Steven R. Alexander, MD, Amelia Allsteadt, BSN,RN,CNN, Helen Currier, BSN, RN, CNN, CENP, Geoffrey Fleming, MD, Jolyn Kleinholz, RNAlisa Palazzolo, BSN, RN

HW4: Hemodynamic Monitoring and Use of DrugsLakhmir S. Chawla, MD, Can Ince, PhD, Andrew D. Shaw, MD FRCA

HW5: Essentials for Developing, Nurturing and Growing a CRRT ProgramJorge Cerda, MD, FACP, FASN, Patty Graham, RN, MS, CCRN, CSEileen Lischer, MA, BSN, RN, CNN and Bruce A. Mueller, PharmD, FCCP, FASN

HW6: Introduction to Critical Care Ultrasonography (1:30 start)Charanjit Bahniwal, MD, Daniel De Backer, MD, Shyamala Karuvannur, MDKianoush Kashani, MD, Edwin Lee, MD, Navparkash Sandhu, MD

3:15-3:30 Coffee Break - Indigo ABEF

5:30 Workshops Adjourn

Sapphire Ballroom - KLOP (all General Sessions)

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POSTER PRESENTATIONSCME CREDIT DOES NOT APPLY FOR POSTER SESSIONS

Posters are listed with lead authors only, please see abstract in the conference syllabus oractual posters for complete author list. Viewing: Tues. 6:00-7:30pm & Wed. 6:30-8:00pm.CRRT Applications 1. Etiology and Outcome of Acute Renal Failure in147 Children: A Single Center Experience Rainer Büscher

2. Correction Rate of Hyponatremia via ContinuousVeno-Venous Hemodialysis: A Formula Based onDialysis Dose Sevag Demirjian

3. Acute Kidney Injury; The Experience from theOther Side of the World Che Rosle Draman

4. A Multicenter International Survey of RenalSupportive Therapy during ECMO: The KidneyIntervention During Extracorporeal MembraneOxygenation (KIDMO) Group Geoffrey M Fleming

5. Continuous Veno-Venous Haemofiltration (CVVH)in Infants in PICU Using the Proprietary Prismaflex®Device and HF20® Haemofilter and Circuit Glenda Fleming

6. Continuous Veno-Venous Haemofiltration (CVVH)in Infants and Children in PICU Using theProprietary Prismaflex® Device and ST60®Haemofilter and Circuit Glenda Fleming

7. Outcomes of Patients with End Stage Renal Disease(ESRD) Under Chronic Hemodialysis RequiringContinuous Renal Replacement Therapy (CRRT) andPatients without ESRD in Acute Renal FailureRequiring CRR Yeon Soon Jung

8. Correction of Severe Hypernatremia withContinuous Renal Replacement Therapy UsingRegional Citrate Anticoagulation Bethany Karl

9. Clinical Parameters to Determine the OptimalTiming of CRRT in Critically Ill Patients with AcuteKidney Injury Dong Ki Kim

10. Identifying Predictors of Outcome FollowingCRRT Discontinuation in Pediatric ICU Population Rebecca M Lombel

11. Pharmacodynamic Properties of Imipenem inContinuous Venovenous Hemodialysis (CVVHD) Milen Amde

12. Citrate Kinetics in Septic Shock Patients withLiver Dysfunction During Continuous VenovenousHemodiafiltration Filippo Mariano

13. Fulminant Wilson's Crisis: Plasmapharesis vs. MarsPrince Mohan

14. Comparison of Electrolyte Replacements with andwithout Prismasol® Replacement Fluid Kari Mount

15. Pharmacokinetics of Meropenem in ChildrenReceiving Continuous Renal Replacement Therapy Edward J Nehus

16. Evaluation of the Potential Adverse EffectsAssociated with Calcium Carbonate PrecipitateDuring Continuous Veno-Venous Hemofiltration(CVVH) David Pantaleone

17. Carboplasmapheresis and Continuous RenalReplacement Therapy (CRRT) in the Treatment ofAmanita Phalloides Poisoning Roumen Penkov

18. Clinical Profile of Patients with AKI RequiringCRRT in a Tertiary Care Multispecialty Hospital inSouthern India Sreedhar Reddy

19. Withdrawn

20. Prophylactic Peritoneal Dialysis Improves ClinicalOutcomes in Children Following Open-Heart Surgerywith Cardiopulmonary Bypass William C Sasser III

21. Efficasy of Direct Hemoperfusion using PolymyxinB-immobilized Fiber in Children Under 10kg Mariko Sawada

22. Fluid Overload and Fluid Removal in PediatricPatients on Extracorporeal Life Support Requiring Continuous Renal Replacement Therapy David T Selewski

23. Recurrent Encephalopathy in a Patient with End-Stage Renal Disease Following Excess Consumption ofEnergy Drink: Management with Continuous RenalReplacement Therapy Seok Joon Shin

24. Effects on Timing of High-Volume Hemofiltrationin Elderly Patients with Septic Shock Wang Shouhong

25. CRRT Experiences in ICU: A Single CenterStudy in Korea Young Ki Son

26. Citrate in a Small Intensive Care Unit (ICU) inthe Netherlands; The Better Way for Dialysis? Els L Van Assche

27. Ultrafiltration in Continuous Renal ReplacementTherapy: Is Prescribed Delivered? William E Weber

28. The Effect of Continuous Renal ReplacementTherapy in Patients with Acute Kidney Injury on theSerum Levels of Biomarkers Usually Used to IndicateRenal Function Zhihong Zhang

Research in AKI29. Urine Biomarkers Predict Acute Kidney Injury inTerm Neonates with Perinatal Depression David J Askenazi

30. Prevention of Acute Kidney Injury in HospitalizedChildren with Cystic Fibrosis David J Askenazi

31. Microsample Analysis of Serum and UrineCreatinine Measurements David J Askenazi

32. The Effect of Poly (ADP-Ribose) PolymeraseInhibition on Aminoglycoside-Induced Acute KidneyInjury in Rats Alexander Biro

33. Plasma NGAL is an Early Biomarker of GraftFunction, Calcineurin Inhibitor Nephrotoxicity andTubular Regeneration in Kidney Transplantationfrom Extended Criteria Donors Vincenzo Cantaluppi

34. Microvesicles Derived from EndothelialProgenitor Cells Protect Kidney from Cisplatin-Induced Acute Toxic Injury by MicroRNA-DependentReprogramming and Inhibition of Apoptosis ofTubular Cells Vincenzo Cantaluppi

35. Classification of AKI using P-Rifle Score in a Picuin Fundación Valle Del Lili, Cali, Colombia Gastón Castillo

36. Creatinine Production and CreatinineDegradation are Reduce in Patients with AcuteKidney Injury and Sepsis Rolando Claure-Del Granado

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POSTER PRESENTATIONS37. AKI Superimposed on CKD after Cardiac SurgeryNeeds Different Cutoff Value of Plasma NGALKent Doi

38. The ICNARC Model is Predictive of HospitalMortality in Critically Ill Patients Supported byAcute Dialysis Ying-Jheng Jhuang

39. KDIGO Criteria: Is Better in Diagnosing andPredicting Prognosis of Acute Kidney Injury inCritically Ill PatientsFen Jiang

40. The SAFE-T Consortium: A CollaborativeApproach for the Qualification of Novel KidneyBiomarkers with the Regulatory Authorities Joe F Keenan

41. SAPS3 Score as Mortality Rate Predictors inPatients Treated with Continuous Renal Replacement Therapy Jin Kuk Kim

42. Initiation of Acute Renal Replacement Therapy inICU Patients based on AKIN Criteria in the Absenceof Conventional Indications Fails to Improve Survival Cynthia C Lim

43. Formation of the Kidney Intervention DuringExtracorporeal Membrane Oxygenation (KIDMO)Pediatric Study Group David T Selewski

44. Acute Kidney Injury in Asphyxiated NewbornsTreated with Therapeutic Hypothermia David T Selewski

45. Serial Measurement of Urinary NGAL forPredicting AKI Worsening/Recovery in ICU Maki Tsukamoto

46. Transfusion Related Acute Kidney Injury: Resultof a Prospective Cohort Study Ladan Zand

Epidemiology and PatientCharacteristics47. Tubulointerstitial Nephritis and Uveitis Syndrome,with Genetic Fingerprint of SLE Alexander Biro

48. Association of Commonly Used Medications withPrevalence and Renal Recovery after PostoperativeAcute Kidney Injury Shahab Bozorgmehri

49. Retrospective Analysis of Acute Kidney Injury inNon Renal Solid Organ Transplant Recipients:Incidence, Outcome and Impact on Residual Renal Function Vincenzo Cantaluppi

50. Case Report of Renal Replacement Therapy in a 1-Year Old Patient with AKI Gastón Castillo

51. Survival and Mortality Risk Factors in MexicanPatients with Acute Kidney Injury Luis A Evangelista-Carrillo

52. The Impact of the Daily Presence of theNephrology Resident in the Postoperative CardiacIntensive Care Unit César Flores-Gama

53. A New Clinical Score to Predict Acute KidneyInjury After Cardiac Surgery in Chinese Elderly Patients Penghua Hu

54. The Impact of Acute Kidney Injury on In-HospitalMorbidity and Mortality Among Patients With andWithout Baseline Chronic Kidney Disease Mira T Keddis

55. Clinical Study of 72 Pediatric Patients who werePerformed Extracorporeal Membrane Oxygenationwith CRRTHirotsugu Kitaymaa

56. Acute Kidney Injury Does Not Contribute TowardsMortality in Intensive Care Unit Patients Harbir S Kohli

57. The Usefulness of AKIN Criteria Predict LongTerm Outcome of Hospital-Acquired Acute Kidney Injury Soon Hyo Kwon

58. The Impact of Mitochondrial DNA Haplogroupson the Mechanical Ventilation Weaning of CriticallyIll Patients Yi Yang

Technique Characteristics59. A Comparison of Filter Patency in CVVHD vsPre–Dilutional CVVH in High Blood Flow CRRT Systems Gaurav Agarwal

60. Saturation Coefficient Estimate of Peramivir in aPatient Receiving Continuous Veno-VenousHemodiafiltration Michael L. Bentley

61. A Retrospective Review of Transfusion Reductionand Cost Savings Using the Circuit to CircuitExchange Technique in Blood Primed CRRT Circuits Dawn M Eding

62. Treatment of Hyperlipidemia in ResistantNephrotic Syndrome: The Effect of CombinedTherapy Using Double Filtration Plasmapheresis andOral Statins Dehua Gong

63. BUN/Cr Change Ratio (BUN/Cr CR) as a NewDelta Check Strategy for Dialysis Sample You Kyoung Lee

64. Sustained Low Efficiency Dialysis (SLED) inIndia: A More Practical Alternative to CRRTRajiv Medanki

65. A Comparison of Estimated Creatinine Clearenceand Measured Glomerular Filtration Rate(Tc99mDTPA clearance) in Indians Rishi Nigam

66. First Intention Continuous Veno-VenousHemodiafiltration in Young Children with Hemolyticand Uremic Syndrome Paul Nolent

67. Post Filter Ionized Calcium Levels with DiluteRegional Citrate Anticoagulation: Do We Need ToFollow Them? Rajesh Speer

68. Heparin Anticoagulation in Powdered SorbentPheresis in Septic ICU Patients RY Tan

69. Plasma and Tissue Pharmacokinetics ofMeropenem in Critically Ill Patients on ContinuousRenal Replacement Therapy Julie M Varghese

70. Direct Visualization of Cortical PeritubularCapillary Flow Affected by Carbon Dioxide–InducedPneumoperitoneum usinig Intravital Microscopy Tokunori Yamamoto

71. Regional Citrate Plus Low Dose of Low MolecularWeight Heparins:A Safe and More EfficacyAnticoagulation Protocol for Continuous Veno-VenousHemofiltration Kaiyue Zhang

RRT Research72. Continuous Venovenous Hemodialysis (CVVHD)Effluent Imipenem Levels Predict Plasma FreeImipenem Levels Seth R Bauer

continued

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HOTEL MAPSINDIGO LEVEL 2

73. Perfluorocarbon Protects Kidney TubularEpithelial Cells by Septic Plasma-Induced Apoptosisand Promotes CD133+ Renal Progenitor CellDifferentiation: Relevance for Bioartificial RenalAssist Devices Vincenzo Cantaluppi

74. A Multiscale Model of Citrate Dynamics duringCitrate Regional Anticoagulation for CRRTSteven A Conrad

75. Pharmacokinetics of Imipenem in ContinuousVenovenous Hemodialysis (CVVHD) are Related toSeverity of Illness and Dialyzer Type William H Fissell

76. The Relationship between Thyroid Hormone andCorrected QT Interval and QT Dispersion in Non-diabetic Hemodialysis Patients Hyung-Jong Kim

77. The “U-shaped” Association between TemporalTiming of Renal Replacement Therapy Initiation andIn-hospital Mortality in Postoperative Acute Kidney Injury Szu-Ying Lee

78. The Affect Prescription and Absorption on Anti-epileptic Concentrations in Ex Vivo CRRT Model Paul J McCarthy

79. Mode and Dose of Continuous Renal ReplacementTherapy (CRRT) Affect Estimation of PlasmaPiperacillin Levels from CRRT Effluent Ashita J Tolwani

Nursing Issues80. CRRT Super Users to the Rescue Linda Ford

81. Electronic CRRT Flowsheet: Decreasing Errorsand Increasing Nurse Recruitment Troy Gideon

82. How is it Possible to Mobilize Patients Treated with CRRTAnna Kraegpoeth

83. RN Staffing in a Pediatric CRRT Program Scott Ludes

84. Nursing Knowledge of Pediatric CRRT Princliplesand Troubleshooting Scott Ludes

Targeted Intervention85. Non-invasive Hemodynamic Monitoring Used toDetermine Rate of Fluid Removal with ContinuousRenal Replacement Therapy Christopher J Burdick

86. Therapy in Patients with Acute Kidney InjuryAdmitted to the Cardiac Surgery Intensive Care Unitbetween January 2006 and January 2011 Jesús A Carrillo Rojas

87. Mars System for Acute Liver Failure due toHepatitis A, Complicated y Acute Renal Failure. Case Presentation Janette Estefan-Garfias

88. The Hemodynamic Effects During Sustained Low-Efficiency Dialysis versus Continuous Veno-VenousHemofiltration for Patients with IntracranialHypertension in a Cross Over Study Chih-Chin Kao

89. MARS Benefits Patients with Liver FailureComplicated by AKI Amay Parikh

90. Impact of Albumin Dialysis on Albumin Binding Function Jan Stange

POSTER PRESENTATIONS

17

HOTEL MAPS

AQUA LEVEL 3

SAPPHIRE LEVEL 4

COBALT LEVEL 5

ACKNOWLEDGEMENT of EXHIBITORS

The Seventeenth International Conference on

Continuous Renal Replacement Therapies would like to acknowledge the following exhibitors:

B. Braun Medical Incorporated

Gambro

NxStage Medical Incorporated

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Argutus Medical Ltd

Otsuka America Pharmaceutical Incorporated

Thrasos Innovation Incorporated

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AbViser Medical

Alere San Diego Incorporated

Amgen

Clinical Nephrology

Covidien

FAST BioMedical

Fresenius Medical Care

Fresenius Medical Care Apheresis Services

Karger Publishers

Ortho Biotech

Terumo BCT