Forensic Drug Detection - Neogen Toxicologytoxicology.neogen.com/pdf/catalogs/forensic_catalog_15.pdf · • Synthetic Cathinones (Methcathinone) • Designer Benzodiazepines

Forensic Drug Detection

ELISA Test Kits and Reagents

Oral Fluid Collection System

Automated Equipment

Simple Sensitive Solutions

To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: www.neogen.com/toxicology2

Neogen Corporation develops, manufactures, and markets a diverse line of products used to provide solutions for drug detection, and food and animal safety. Founded in 1982, Neogen (NASDAQ: NEOG) has grown to more than 1,000 employees with multiple U.S. and international locations, and a worldwide presence.

Neogen’s more than 30 years spent developing and manufacturing enzyme-linked immunosorbent assay (ELISA) test kits has produced the highest quality, most dependable reagents with excellent reproducibility and sensitivity.

Our comprehensive line of drug detection assays includes more than 115 ELISA kits that can be used to screen more than 300 drugs and/or their metabolites in a wide range of forensic matrices. Our test kits are qualitative one-step kits intended as screening devices for the detection of drugs and/or their metabolites in forensic samples only. Suspect samples should be confirmed by a quantitative method, such as GC/MS.

Our easy-to-use protocols are designed for high and low volume laboratories as they can be run manually or easily automated on a wide range of immunoassay instruments. Neogen’s experienced technical support staff is available to discuss your testing and automation requirements to find a system that will work best for your applications. With our experienced research and development teams, and flexible operations, Neogen can quickly respond to rapidly evolving needs in the forensic market.

Neogen believes that maintaining earned trust is a combination of innovation and a continuous commitment to quality. Neogen’s quality management system is ISO 9001 certified, which communicates to the company’s worldwide customer base that it understands the quality standards customers expect, and is firmly committed to achieving those quality standards.

Neogen’s continuing record of exceptional performance has earned it increasing recognition, including being repeatedly named as one of Forbes Magazine’s Best Small Companies in America; being named to Fortune Magazine’s prestigious list of 40 Stocks To Retire On; and being selected to NASDAQ’s top tier of companies, the NASDAQ Global Select Market.

Neogen’s drug detection product line offers:• More than 100 drug detection test kits• Validation for forensic matrices: whole blood, urine, hair, oral fluid,

serum, plasma, meconium, breast milk and others• High sensitivity• Excellent reproducibility• Automated and semi-automated equipment packages• Reagent Rental Program• Customized single-line reporting software• More than 30 years of ELISA experience

Neogen offers products for multiple drug panels:• Stimulants• Anabolic Steroids/Beta-Agonists• Hallucinogens and Anesthetics• Antidepressants/Sedatives• Narcotic Analgesics• Anti-Inflammatories• Antipsychotics• Other Prescription Drugs• Workplace Testing• Designer Drugs

Your Complete Forensic Drug Detection Source

To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: www.neogen.com/toxicology 3

Stimulants• Amphetamine• Amphetamine Specific• Amphetamine Ultra• Benzylpiperazine (BZP)• Caffeine/Pentoxifylline• Cocaine/BZE• Cotinine• Doxapram• Mazindol/Mazindol Metabolites• Methylphenidate• Methamphetamine/MDMA• Nikethamide• Synthetic Cathinones (Methcathinone)

Anabolic Steroids/Beta-AgonistsAnabolic Steroids• 16ß-Hydroxystanozolol• Boldenone• Nandrolone• Stanozolol• Trenbolone

Beta-Agonists• Bronchodilator Group• Clenbuterol• Ractopamine• Theophylline

Hallucinogens & Anesthetics• Dextromethorphan• Ketamine• Lidocaine• LSD• Mepivacaine• PCP• Procaine• THC• Synthetic Cannabinoids

Antidepressants/Sedatives• Azaperone• Barbiturate Group• Benzodiazepine Group (Oxazepam/Clonazepam)• Buspirone• Citalopram• Detomidine• Flunitrazepam• Fluoxetine• Hydroxyzine• Reserpine• Sertraline• Trazodone• Tricyclics Group• Zolpidem

Narcotic Analgesics• Alfentanil• Anileridine• Buprenorphine• Buprenorphine/Norbuprenorphine• Butorphanol• Carfentanil• Diprenorphine• Etorphine• Fentanyl• Hydromorphone• Levallorphan• Lofentanil• Meperidine Enhanced• Methadone• Methadone/LAAM• Naltrexone/Nalbuphine• Opiates• Oxycodone/Oxymorphone• Pentazocine• Propoxyphene• Sufentanil• Tramadol

Anti-Inflammatories• Carprofen• Celecoxib• Corticosteroid Group• Dexamethasone• Flunixin• Ibuprofen• Ketorolac• Methylprednisolone• Phenylbutazone• Salicylates• Triamcinolone Acetonide• Zomepirac

Antipsychotics• Droperidol• Fluphenazine• Haloperidol• Haloperidol Metabolites• Promazine Group• Tricyclics Group

Other Prescription Drugs• Amphetamine• Amphetamine Specific• Amphetamine Ultra• Barbiturate Group• Benzodiazepine Group (Oxazepam/Clonazepam)• Buprenorphine• Buprenorphine/Norbuprenorphine• Butorphanol• Carisoprodol• Fentanyl• Hydrocodone• Hydrochlorothiazide• Hydromorphone• Ketamine• Meperidine Enhanced• Methadone• Methadone/LAAM• Methamphetamine/MDMA• Methylphenidate• Naltrexone/Nalbuphine• Opiate Group• Oxycodone/Oxymorphone• Pentazocine• Phenytoin• Propoxyphene• Tramadol• Trazodone• Zolpidem

Workplace Testing• Amphetamine• Amphetamine Specific• Amphetamine Ultra• Barbiturate Group• Benzodiazepine Group• Buprenorphine• Cocaine/BZE• Methadone• Methamphetamine/MDMA• Opiates• Oxycodone/Oxymorphone• PCP• Propoxyphene• THC

Designer Drugs• Synthetic Cannabinoids (JWH-018)• Synthetic Cannabinoids (JWH-250)• Synthetic Cannabinoids (UR-144/XLR-11)• Synthetic Cathinones (Methcathinone)• Designer Benzodiazepines

FOR FORENSIC USE ONLY

Drug Detection ELISA Panels


16β-Hydroxystanozolol 103519Acetaminophen 132419Alfentanil 103619Amphetamine 105219-1Amphetamine Specific 132319Amphetamine Ultra 130819Anileridine 105519Apomorphine/Apocodeine 109119Azaperone 100919Barbiturate Group 130619Benzodiazepine Group

(Oxazepam/Clonazepam) 130119Benzylpiperazine 108319Boldenone 101019Bronchodilator Group 100319Bumetanide 103719-1Buprenorphine 131919Buspirone 108719Butorphanol 101119Caffeine/Pentoxifylline 106419Carfentanil 103919Carisoprodol 132519Carprofen 181119Celecoxib 180719Citalopram 132719Clenbuterol 101219Clonidine/Romifidine 180119Cocaine/Benzoylecgonine 130319Corticosteroid Group 100419Cotinine (Serum) CT-96-SCotinine (Urine) CT-96-UCreatinine 133319Cromoglycate 105819Dantrolene 106319Detomidine 181319Dexamethasone 101519Dextromethorphan 131419Diprenorphine 106119Doxapram 106219Droperidol 101619Ethacrynic Acid 101719-1Etorphine 101819Fenspiride 108419Fentanil Group 100519Fentanyl 131519Fexofenadine/Terfenadine 181419Flunitrazepam 109519Flunixin 101919Fluoxetine 107619Fluphenazine 104119Furosemide 104219-1Glycopyrrolate 102019Guanabenz 109219Haloperidol 104319-1Haloperidol Metabolites 102119Hydrochlorothiazide 180319Hydromorphone 132219Hydroxyzine 105719Ibuprofen 180219Ipratropium/Atropine 107119Isoxsuprine 102219

Ketamine 131719Ketoprofen 108219Ketorolac 105619Levallorphan 102319Lidocaine 106719-1Lofentanil 102419LSD 130219Mazindol/Mazindol Metabolites 102519Meperidine Enhanced 133119Mephentermine 107219Mepivacaine 102719Meprobamate 133419Metaraminol 107919Methadone 131619Methadone/LAAM 132919Methamphetamine/MDMA 130919Methocarbamol 108019Methotrexate 107519Methylphenidate 133219Methylprednisolone 104519Naltrexone/Nalbuphine 133019Nandrolone 104619Nikethamide 109919Opiate Group 130419Oxycodone/Oxymorphone 130719Pentazocine 103119Phencyclidine (PCP) 130519Phenylbutazone 104719-1Phenytoin 132119Procaine 103219Promazine Group 100719Propoxyphene 131119Propranolol 107319Pyrilamine 105919Ractopamine 106519Reserpine 104819Salicylates 133619Sertraline 131319Stanozolol 103319Sufentanil 104919Sulfamethazine 103419

Synthetic Cannabinoids (JWH-018) 133519Synthetic Cannabinoids (JWH-250) 133719Synthetic Cannabinoids

(UR-144/XLR-11) 133919Synthetic Cathinones (Methcathinone) 181819THC 131019Theophylline 106019Tramadol 131819Trazodone 132819Trenbolone 109719Triamcinolone Acetonide 105119Tricyclics Group 132019Zolpidem 132619Zomepirac 109619Zopiclone/Eszopiclone 133819

Hair ELISA Kits* Product No. Cocaine/BZE 140119Methamphetamine 140219Opiates 140319Synthetic Opiates 140419PCP 140519THC 140619

*Not sold in the U.S.

Oral Fluid ELISA Kits Product No.Cocaine/BZE 120119Methamphetamine 120219Opiates 120319PCP 120419THC 120519Multi-Analyte Calibrator Set 128100

ELISA Test Kits Product No. ELISA Test Kits Product No. ELISA Test Kits Product No.


New kits

Ready-to-use (RTU) Assay

Matrix specific calibrators included Other kits include positive and negative controls

Neogen’s ready-to-use or RTU test kits require no pre-dilution of conjugate prior to assay set-up.

Neogen’s Ready-to-Use (RTU) Forensic Assays

Neogen offers forensic assays that are ready to use and that do not require pre-dilution of reagents prior to assay setup. Matrix specific quantitative calibrators or qualitative positive or negative controls are assay-specific. See the product list or contact a forensic representative for details regarding a specific kit.

Drug Detection ELISA Kits


NeoSal™ Oral Fluid Collection System

Neogen is proud to announce the release of our NeoSal™ Oral Fluid Collection System. Our oral fluid collection system is designed for maximum ease-of-use at the collection site and testing laboratory.

Intended UseThe NeoSal Oral Fluid Collection System is intended for the collection and transportation of oral fluid samples. Oral fluid samples collected with the NeoSal can be screened for drugs of abuse using Neogen’s ELISA test kits, or other drug monitoring kits validated by the testing laboratory.

NeoSal Key Features:• Sample Volume Adequacy Indicator (SVAI)• Stimulant-free collection pad• Quick collection, typically 1-2 minutes• Unique collector handle fits directly into buffer tube• No additional sample processing required• Automation friendly, buffer tube fits onto 12 x 75 sample racks• Consistent drug recovery

Oral Fluid ELISA KitsNeogen has expanded its forensic drug detection product line by adding panel of oral fluid ELISA kits for Cocaine/BZE, Methamphetamine, Opiates, PCP and THC.

Features of Neogen’s Oral Fluid ELISA Kits:• Optimized with the NeoSal Oral Fluid Collection System• High sensitivity• Excellent reproducibility• Compatible with automated and semi-automated equipment• Available in 96 and 480 well assay

Neogen’s Oral Fluid ELISA KitsKit Name Product No.

Cocaine/BZE 120119

Methamphetamine 120219

Opiates 120319

PCP 120419

THC 120519

Multi-Analyte Calibrator Set 128100


NeoSal 25 Pack Product #128101-25


Neogen's Hair ELISA KitsKit Name Product No.

Cocaine 140119

Methamphetamine 140219

Opiates 140319

Synthetic Opiates 140419

PCP 140519

THC 140619Not sold in the U.S.


Hair ELISA Drug Kits

Neogen has expanded its forensic drug detection product line by adding hair testing ELISA kits for the most commonly abused drugs on the illicit market—Cocaine, Methamphetamine, Opiates, Synthetic Opiates, PCP, and THC. Using hair samples to detect drugs of abuse has become common practice because of its advantages over traditional sample types. Advantages include:

• Hair is easy to handle and store• Collection is far less invasive than urine and blood• Brief periods of non-use do not affect test results • A larger window of drug detection• Simple retesting• Difficult to adulterate test resultsThese advantages have led hair samples to be extensively used in workplace testing, as well as in other areas, such as legal cases, occupational and traffic medicine, and for historical research.

Intended UseFor the determination of trace quantities of drug analytes in human hair samples.

Features of Neogen’s Hair ELISA Kits:• High sensitivity• Excellent reproducibility• Compatible with automated and semi-automated equipment• Available in 96 and 480 well assay

Assay PrincipleNeogen’s competitive direct ELISAs operate on the basis of competition between the drug or its metabolite in the sample and the drug-enzyme conjugate for a limited number of specific binding sites on the precoated microplate.

The simple assay procedure includes the addition of samples, calibrators or controls to the antibody-coated microplate followed by the addition of the enzyme conjugate (HRP). During incubation, the drug in the sample and the drug enzyme conjugate compete for binding sites on the antibody-

coated microplate. After the incubation, the microplate is washed and K-Blue® Substrate (TMB) is added. After the substrate incubation, the test can be read visually or with a microplate reader. The extent of color development is inversely proportional to the amount of drug in the sample or control/calibrator. The absence of the drug in the sample will result in a blue color (yellow if acid stop is used), whereas the presence of the drug will result in decreased or no color development.


ELISA Reagents

Reagents for Immunoassays

Product Shelf Life Product Features Available Sizes Product Number

Enhanced K-Blue® 48 months when stored at 4°C

• Develops blue color in the presence of HRP• RTU (ready-to-use)• Low background• High consistency between lots

• 200 mL• 500 mL• 1 L

308175308176308177

Red Stop Solution 24 months when stored at 4°C

• Produces a dark purple-pink color for a minimum of 2 hours when added to the wells• Non-acidic solution• RTU (ready-to-use)

• 200 mL• 500 mL• 1 L

301474301475301476

EIA Buffer 12 months when stored at 4°C

• Dilutes enzyme conjugates, standards and samples• RTU (ready-to-use)

• 500 mL• 1 L

301276301277

Wash Buffer 12 months when stored at 4°C

• Washes all unbound enzyme conjugate, samples and standards from microplates• Concentrated (10x) buffer

• 500 mL• 1 L

301176301177

ß-Glucuronidase Reagent Pack

6 months when Reagent A is stored at 4°C and Reagent B is stored at -20°C

• Allows for better detection of total Lorazepam with Neogen’s Benzodiazepine Group (Oxazepam/Clonazepam) Kit

• Single Reagent Pack

301605

Neogen recognizes that additional substrates and reagents may be required for your application. Therefore, Neogen makes available the following products that are optimized with our test kits.

Assay Procedure

Plates are precoated with the antibody. The plate is ready for use. DO NOT WASH.

Well

Antibodies

A sample or control is added to each well. Next, the drug-enzyme conjugate is added and the mixture is incubated at room temperature.

Conjugate

Sample drug

Wash the p la te to remove all unbound materials.

Wash

Unbound drug and drug conjugate

The bound materials now remain in the microplate.

Bound drug and drug conjugate

Add TMB substrate to each well and allow the color to develop.

Substrate

Qualitative results are obtained by measuring the absorbance reading at 450 nm or 650 nm if no acid stop is used.

MoreAnalyte

LessAnalyte


Dynex EquipmentThe DSX Automated Four-Plate ELISA System and the DS2

Automated Two-Plate ELISA System were developed for small to medium-throughput processing of ELISAs with advanced automation and precise liquid-handling capabilities. Neogen’s specially-designed Single Line Reporting Software enhances the DSX Revelation and DS2 Matrix software’s reporting capabilities.

The DSX and DS2 automated processing systems feature:

Modular Design• Flexible configuration, simple upgrades, and quick module replacement

Process Security• Instrument self-diagnostics supports unmanned operation• Cover lock protects reagents and prevents interference

Ease of Use• Quick and easy installation, user-friendly control system, and minimal

maintenance required

Excellent Performance• Precise liquid handling capability eliminates variations

Hamilton EquipmentThe Microlab STAR line of workstations was developed based on 50 years of expertise in liquid handling for fast and efficient assay automation and sample preparation. These innovative instruments were specifically designed for regulated laboratories to ensure full GMP-compliant operation.

The Microlab STAR automated liquid handling platform features:

• High throughput processing• Advanced pipetting technology• Easy-to-use VENUS software• Flexible design to allow easy instrument configuration• Broad range of testing applications

In addition to the Microlab STAR workstation Neogen offers the STARlet (medium - large volume sample lab) and the NIMBUS (small - medium volume sample lab) automated work stations.

Neogen offers a full line of Dynex and Hamilton automated equipment for use with our ELISA test kits. The equipment is available for direct purchase or through our Reagent Rental Program, which provides laboratories access to automation with a lower initial investment.

To take advantage of the Reagent Rental Program, customers agree to purchase a predetermined volume of test kits per year from Neogen, based on number of samples and required drug panel. Once an agreement is reached, Neogen will provide the automated equipment to the customer as a rental. The agreement is structured so the cost of the equipment rental, service contracts and test kits are merged, and spread over the duration of the agreement.

The Reagent Rental Program has proven to be a successful way for many of our customers to meet their automation requirements, while at the same time satisfying their ELISA test kit needs.

For assistance in determining your exact needs and selecting the best automated solution for your unique situation, or more details regarding the Reagent Rental Program, contact a Neogen sales representative.

Automated Equipment

Direct Purchase and Reagent Rental Program


Acetaminophen #132419Acetaminophen 100%Procainamide 2%Ethyl p-aminobenzoate 1%Oxyphenbutazone 0.7%Penicillin G-Procaine 0.3%Procaine 0.1%Methylene Blue 0.09%

Amphetamine #105219-1d-Amphetamine 100%d-Methamphetamine 1000%N-desmethylselegiline 203%Fenfluramine 87%Ephedrine 56%Nylidrin 21%l-Amphetamine 17%Mephentermine 14%Phentermine 11%Phenethylamine 10%Benzphetamine 8%Phenylpropanolamine 6%Isoxsuprine 6%MDMA (3,4-methylenedioxymeth-amphetamine)

2%Pseudoephedrine 2%Clenbuterol 2%Fencamfamine 2%α-Ethyltryptamine 1%4-Hydroxyamphetamine 0.6%p-Hydroxymethamphetamine 0.5%Tuaminoheptane 0.5%MDA (3,4-methylenedioxy-amphetamine) 0.4%Phenylephrine 0.4%DOB 0.12%DOM 0.11%Amitriptyline 0.06%Quinidine 0.06%Tyramine 0.03%Imipramine 0.02%Glutethimide 0.01%Nortriptyline 0.01%(+/-) Octopamine 0.01% Diethylpropion <0.5%Hordenine <0.1%Pyrantel <0.1%

Amphetamine Specific #132319d-Amphetamine 100%p-Hydroxyamphetamine 162%p-Methoxyamphetamine 160%(+/-)-MDA 117%4-Fluoroamphetamine 42%α-Ethyltryptamine 5%Phentermine 1%Phenylpropanolamine 0.9%Metaraminol 0.4%S(-)-Cathinone 0.4%DOB 0.4%DOM 0.3%l-Amphetamine 0.3%Phenethylamine 0.3%2-Aminoheptane 0.2%Methylhexanamine 0.1%d-Methamphetamine 0.1%N-Desmethylselegiline 0.1%Mephentermine 0.06%p-Methoxymethamphetamine 0.03%(+/-)-MDMA 0.01%S(-)-Methcathinone 0.01%

Amphetamine Ultra #130819d-Amphetamine 100%N-desmethylselegiline 906%Fenproporex 731%d-Methamphetamine 688%(-)-Ephedrine 49%Fenfluramine 33%Mephentermine 25%Nylidrin 14%4-Fluoroamphetamine 13%l-Amphetamine 7%Phenylpropanolamine 6%Phentermine 6%meta-Chlorophenylpiperazine (mCPP) 6%Isoxsuprine 4%Benzphetamine 2%Methylhexanamine 1% R(+)-Methcathinone 1%(+/-)-MDMA 1%(+/-)-Pseudoephedrine 1%

Fencamfamine 1%α-Ethyltryptamine 0.8%S(-)-Methcathinone 0.7%S(-)-Cathinone 0.6%2-Aminoheptane 0.6%Ampedramoff 0.6%Phenethylamine 0.5%p-Hydroxyamphetamine 0.5%Selegiline 0.4%(+/-)MDA 0.4%Phendimetrazine 0.4%DOM 0.3%Clenbuterol 0.3%Metaraminol 0.2%p-Methoxymethamphetamine 0.2%Salvinorin A 0.2%p-Methyoxyamphetamine 0.1%DOB 0.1%Mephedrone 0.04%Hordenine 0.03%Pyrimethamine 0.03%Aminorex 0.03%Nicotine 0.02%Amitryptyline 0.02%Quinidine 0.02%Imipramine 0.01%Nortriptyline 0.01%(+/-) Synephrine 0.01%

Barbiturate Group #130619Secobarbital 100%Amobarbital 757%Phenobarbital 469%p-OH Phenobarbital 316%Barbital 239%Butabarbital 131%Allobarbital 117%Butalbital 109%Aprobarbital 98%Pentobarbital 95%Mephobarbital 0.3%Methylene Blue 0.1%Glutethamide 0.1%

Benzodiazepine Group (Oxazepam/Clonazepam) #130119Oxazepam 100%Diazepam 434%Estazolam 365%Nordiazepam 361%Alprazolam 346%Tetrazepam 264%Flurazepam 262%Lormetazepam 231%Prazepam 198%Temazepam 192%Phenazepam 190%Halazepam 173%Triazolam 171%7-amino-Flunitrazepam 147%Diclazepam 142%Nitrazepam 141%Flubromazepam 120%N-desmethyl Flunitrazepam 119%Delorazepam 115%Flunitrazepam 110%Pyrazolam 106%Etizolam 87%Bromazepam 85%Clonazepam 79%Nimetazepam 74%Lorazepam 70%Midazolam 65%Clobazam 59%7-amino-Clonazepam 39%alpha-hydroxy Alprazolam 25%Chlordiazepoxide 19%

Benzylpiperazine #108319Benzylpiperazine 100%1-(3-Trifluoromethyl)benzyl) piperazine 3%1-(4-Trifluoromethyl)benzyl) piperazine 1%Trazodone 1%Nefazodone 0.20%Doxepin 0.13%Chlorpromazine 0.07%m-CPP 0.07%Isoxuprine 0.05%Pyrantel 0.03%N-[3-(Trifluoromethyl)phenyl] piperazine 0.03%Imipramine 0.02%

Acepromazine 0.02%Orphenadrine 0.01%Amitriptyline 0.01%Nicotine 0.01%

Buprenorphine #131919Buprenorphine 100%Diprenorphine 110%Norbuprenorphine 15%Etorphine 0.22%Butorphanol 0.16%Naltrexone 0.05%Thebaine 0.02%Nalorphine 0.02%

Carisoprodol #132519Carisoprodol 100%

Celecoxib #180719Celecoxib 100%Celecoxib Carboxylic Acid 143%Deracoxib 56%

Citalopram #132719Citalopram 100%N-desmethylcitalopram 109%(S)-Citalopram 20%Acepromazine 2%Chlorpromazine 0.7%Fluoxetine 0.1%Imipramine 0.07%Amitriptyline 0.03%Paroxetine 0.03%Doxepin 0.03%Trimipramine 0.03%Nortriptyline 0.02%Fluvoxamine 0.02%Promazine 0.02%Orphenadrine 0.01%Sertraline 0.01%Duloxetine 0.01%

Cocaine/Benzoylecgonine #130319Benzoylecgonine 100%Cocaine 133%Cocaethylene 124%m-Hydroxycocaine 96%Ecgonine 0.4%Norcocaine 0.3%Ecgonine Methyl Ester 0.06%

Cotinine CT-96-U(-) Cotinine 100%(+/-) Trans-3’-hydroxycotinine 3%(R/S) Norcotinine 0.89%

Cotinine CT-96-S(-) Cotinine 100%(+/-) Trans-3’-hydroxycotinine 9%(R/S) Norcotinine 2%

Detomidine #181319Detomidine 100%Carboxydetomidine 74%Medetomidine 26%

Dextromethorphan #131419Dextromethorphan 100%3-Methoxymorphinan 118%3-Hydroxymorphinan 2%Dextrorphan 2%Promazine 0.05%Trimipramine 0.04%Orphenadrine 0.04%Imipramine 0.02%Nortriptyline 0.02%Amitriptyline 0.02%Acepromazine 0.01%Meperidine 0.01%

Fentanil Group #100519Alfentanil 100%Sufentanil 270%Norsufentanil 119%Carfentanil 88%Remifentanil 76%Fentanyl 2%Thienylfentanyl 1%α-Methylfentanyl 0.77%p-Fluorofentanyl 0.19%3-Methylfentanyl 0.08%Norfentanyl 0.04%

Fentanyl #131519Fentanyl 100%p-Fluorofentanyl 136%Thienylfentanyl 67%3-Methylfentanyl 50%Acetyl Fentanyl 42% α-Methylfentanyl 11%Carfentanil 6%Despropionylfentanyl 0.61%Lofenanil 0.20%Sufentanil 0.15%Norfentanyl 0.01%

Fexofenadine/Terfenadine #181419Fexofenadine 100%Terfenadine 23%Hydroxyzine 0.97%Orphenadrine 0.20%Cetirizine 0.18%Hydroxyebastine 0.13%Carebastine 0.07%Doxepin 0.04%Amitryptyline 0.03%Imipramine 0.03%Nortriptyline 0.03%Promazine 0.03%Chlorpromazine 0.02%Ebastine 0.02%Trimipramine 0.01%

Flunitrazepam #109519Flunitrazepam 100%7-Aminoflunitrazepam 212%Diazepam 69%Clobazam 3%Clonazepam 2%Midazolam Maleate 1%7-Aminoclonazepam 0.6%N-Desmethylflunitrazepam 0.5%Halazepam 0.4%Triazolam 0.3%Nitrazepam 0.3%Nordiazepam 0.2%Methylene Blue 0.02%Trimipramine 0.01%

Fluoxetine #107619Fluoxetine 100%Norfluoxetine 67%

Haloperidol #104319-1Haloperidol 100%Bromperidol 83%Trifluperidol 0.39%Risperidone 0.12%Spiperone 0.04%Fluanisone 0.03%Benperidol 0.01%

Haloperidol Metabolites #102119Haloperidol Metabolite (II) ((+(-)-4-

(4-chlorophenyl)-α-(4-fluorophenyl)-4- hydroxy-1-piperidinebutanol) 100%

Bromperidol 157%Haloperidol 84%Haloperidol Metabolite (I) (4-(4-chlorophenyl)

-4-hydroxypiperidine) 48%Azaperone 0.002%

Hydrochlorothiazide #180319Hydrochlorothiazide 100%Trichlormethiazide 206%Chlorothiazide 8%Furosemide 0.24%Methylene Blue 0.01%

Hydromorphone #132219Hydromorphone 100%6-Acetylcodeine 143%Morphine 85%Hydrocodone 72%Dihydromorphine 56%Codeine 55%Ethylmorphine 54%Levorphanol 49%6-Acetylmorphine 44%Morphine-6-glucuronide 39%Dihydrocodeine 38%Heroin 29%Thebaine 2%Levallorphan 0.5%Morphine-3-glucuronide 0.4%Oxymorphone 0.3%

Neogen ELISA Drug DetectionCross-reactivity Data



Oxycodone 0.2%Nalorphine 0.1%Normorphine 0.1%Norcodeine 0.04%Meperidine 0.02%Dextromethorphan 0.02%Amitriptylline 0.01%Doxepin 0.01%

Ibuprofen #180219Ibuprofen 100%Flurbiprofen 0.3%Fenoprofen 0.06%Indoprofen 0.02%Suprofen 0.01%

Ketamine #131719Ketamine 100% Norketamine 5%Methoxetamine 0.08%

LSD #130219LSD 100%LAMPA 153%Fentanyl 56%Nor-/Nor-iso-LSD 36%Acetyl Fentanyl 13% Iso-LSD 3%2-oxo-3-OH LSD 2%2-oxo-3-OH LAMPA 1%Lobeline 0.08%Clenbuterol 0.07%Methylene Blue 0.06%Procaineamide 0.02%

Meperidine Enhanced #133119Meperidine 100%Normeperidine 2%Anileridine 0.12%Diphenoxylate 0.06%Chlorpromazine 0.01%

Methadone #131619Methadone 100%LAAM 113%Propiomazine 0.06%Trimeprazine 0.04%Promethazine 0.04%EDDP 0.03%Trimipramine 0.02%Imipramine 0.01%Orphenadrine 0.01%Acepromazine 0.01%Amitriptyline 0.01%Prochlorperazine 0.01%Promazine 0.01%Chlorpromazine 0.01%Methotrimeprazine 0.01%

Methadone/LAAM #132919Methadone 100%LAAM 107%Dextromethorphan 0.18%Promethazine 0.15%Trimeprazine 0.11%Trimipramine 0.09%EDDP 0.04%Promazine 0.04%Propiomazine 0.03%Acepromazine 0.03%Chlorpromazine 0.03%Imipramine 0.02%Doxepin 0.02%Orphenadrine 0.02%Amitriptyline 0.02%Prochlorperazine 0.01%Methotrimeprazine 0.01%Meperidine 0.01%

Methamphetamine/MDMA #130919d-Methamphetamine 100%PMMA (p-Methoxymethamphetamine) 1400%MDMA (3,4-Methylenedioxymethamphetamine)

212%p-Hydroxymethamphetamine 77%l-Methamphetamine 69%MDEA (Methylenedioxyethylamphetamine) 54%Mephentermine 13%Methoxyphenamine 8%

Fenfluramine 7%N-desmethyselegiline 7%PMA (p-Methoxyamphetamine) 4%Ephedrine 3%4-Fluoroamphetamine 2%Mephedrone 2%MDA (3,4-Methylenedioxyamphetamine) 2%Pseudoephendrine 1%4-Hydroxyamphetamine 0.6%d-Amphetamine 0.6%Phenethylamine 0.5%α−Ethyltryptamine 0.2%(+/-) Synephrine 0.2%Phentermine 0.2%Hordenine 0.2%Methylhexanamine 0.1%Nortriptyline 0.1%PPA (Phenylpropanolamine) 0.1%Penicillin G-Procaine 0.04%Fenproporex 0.04%Procaine 0.02%Doxepin 0.01%

Methylphenidate #133219Methylphenidate 100%Ritalinc Acid 0.53%

Naltrexone/Nalbuphine #133019Naltrexone 100%Nalbuphine 202%Naltriben 41%Butorphanol 28%Nalmefene 26%6ß-Naltrexol 7%3-Methoxynaltrexone 6%Naloxone 4%Nalorphine 1%Pentazocine 0.3%Codeine 0.02%

Opiate Group #130419Morphine 100% 6-Acetylcodeine 195%Codeine 190%Morphine-3-Glucuronide 154%Heroin/Diacetylmorphine 154%6-Acetylmorphine 146%Hydrocodone 122%Ethylmorphine 110%Nalorphine 76%Hydromorphone 66%Morphine-6-Glucuronide 37%Desomorphine 22% Thebaine 11%Levallorphan 7%Naloxone 2%Oxycodone 2%Levorphanol 2%Oxymorphone 1%Imipramine 0.4%Norcodeine 0.3%Trimipramine 0.3%Normorphine 0.2%Naltrexone 0.2%Acepromazine 0.05%Meperidine 0.02%Chlorpromazine 0.02%Promazine 0.01%

Oxycodone/Oxymorphone #130719Oxycodone 100%Oxymorphone 88%Hydrocodone 27%Hydromorphone 21%Ethylmorphine 7%Codeine 5%Thebaine 3%6-Acetylcodeine 3%Noroxycodone 3%6-Acetylmorphine 2%Levorphanol 2%Heroin 2%Morphine 1%Noroxymorphone 0.2%Meperidine 0.03%

Pentazocine #103119Pentazocine 100% Carfentanil 0.01%

Phencyclidine (PCP) #130519Phencyclidine 100%4-Hydroxyphencyclidine 2%Venlafaxine 0.18%Cyclobenzaprine 0.12%Orphenadrine 0.04%Amitriptyline 0.03%Promazine 0.03%Nortriptyline 0.02%Chlorpromazine 0.02%Imipramine 0.02%Doxepin 0.01%Methoxetamine 0.01%Methylene Blue 0.01%Trimipramine 0.01%Acepromazine 0.01%

Phenytoin #132119Phenytoin 100% Hydroxyphenytoin 61%

Propoxyphene #131119Propoxyphene 100% Norpropoxyphene 30%

Salicylates #133619Salicylic Acid 100%4-aminosalicylic Acid 121%Diflunisal 52%Gentisic Acid 37%Salicyluric Acid (2-Hydroxyhippuric Acid) 2%

Sertraline #131319Sertraline 100%N-Desmethylsertraline 50%Methylene Blue 4%Fluoxetine 0.7%Pyrilamine 0.4%Paroxetine 0.3%Promazine 0.2%Chlorpromazine 0.2%Amitriptyline 0.2%Acepromazine 0.2%Nortriptyline 0.2%Doxepin 0.1%Pyrethamine 0.1%Trimipramine 0.1%Imipramine 0.1%Phenothiazine 0.02%

Synthetic Cannabinoids (JWH-018) #133519JWH-018 100%JWH-073-N-(4-hydroxybutyl) metabolite 980%JWH-018 N-5-hydroxypentyl 754%JWH-200 613%JWH-018- N-pentanoic acid 613%JWH-073 490%AM 2232 446%JWH-073 N-butanoic acid 426%(±) JWH-018-N-(4-hydroxypentyl) metabolite 392%AM 2201 350%AM 1220 288%JWH-022 233%AM-2201 N-(4-hydroxypentyl) metabolite 166%1’-Naphthoyl Indole 153%JWH-018 N-(5-hydroxypentyl) ß-D-glucuronide

136%MAM 2201 132%JWH-018 6-hydroxyindole 126%AM 694 109%JWH-019 94%JWH-015 83%JWH-018 4-hydroxyindole metabolite 60%JWH-122 51%JWH-018 5-hydroxyindole metabolite 50%AM-2201 6-hydroxyindole metabolite 50%JWH-007 34%JWH-398 13%WIN 55,212-3 mesylate 11%JWH-081 6%JWH-210 5%JWH-250 N-(5-carboxypentyl) metabolite 2%JWH-250 N-(5-hydroxypentyl) metabolite 1%JWH-250 N-(4-hydroxypentyl) metabolite 1%RCS-4 N-(5-hydroxypentyl) metabolite 0.7%JWH-203 0.50%JWH-250 0.50%

RCS-4 0.4%RCS-8 0.3%PB-22 N-(5-hydroxypentyl) metabolite 0.2%PB-22 N-pentanoic acid 0.12%5-fluoro PB-22 0.11%PB-22 N-(4-hydroxypentyl) metabolite 0.11%PB-22 0.06%BB-22 0.03%

Synthetic Cannabinoids (JWH-250) #133719JWH-250 100%JWH-250 N-(5-carboxypentyl) metabolite 160%JWH-250 N-(5-hydroxypentyl) metabolite 158%JWH-250 N-(4-hydroxypentyl) metabolite 123%JWH-073 N-(4-hydroxybutyl) metabolite 107%JWH-018 N-(5-hydroxypentyl) metabolite 104%JWH-073 94%(+)-JWH-018 N-(4-hydroxypentyl) metabolite 90%AM 2232 90%AM 1220 86%JWH-200 84%JWH-203 76%JWH-018 N-pentanoic acid 64%JWH-018 N-(5-hydroxypentyl) ß-D-glucuronide 59%JWH-015 59%JWH-250 5-hydroxyindole metabolite 55%AM 2201 54%JWH-073 N-butanoic acid metabolite 53%JWH-022 47%JWH-018 33%AM 2201 6-hydroxyindole metabolite 33%RCS-8 33%MAM 2201 30%PB-22 N-(5-hydroxypentyl) metabolite 23%JWH-018 6-hydroxyindole metabolite 21%5-fluoro PB-22 19%PB-22 N-(4-hydroxypentyl) metabolite 19%1’ Napthoyl Indole 18%JWH-018 5-hydroxyindole metabolite 16%PB-22 N-pentanoic acid 14%JWH-019 14%JWH-007 11%PB-22 11%JWH-018 4-hydroxyindole metabolite 10%JWH-122 10%(+) WIN 55212-2 (mesylate) 8%JWH-081 7%BB-22 6%AM 2201 N-(4-hydroxypentyl) metabolite 6%JWH-398 4%JWH-210 1%AM 694 1%RCS-4 N-(5-hydroxypentyl) metabolite 0.8%RCS-4 0.7%XLR11 N-(4-hydroxybutyl) metabolite 0.01%

Synthetic Cannabinoids (UR-144/XLR-11) #133919UR-144 N-pentanoic acid 100%A-796260 89%UR-144 N-(5-hydroxypentyl) metabolite 89%(±)-UR-144 N-(4-hydroxypentyl) metabolite 62%XLR-11 45%A-834735 36%XLR11 N-(4-pentenyl) analog 20%UR-144 18%UR-144 N-(2-hydroxypentyl) metabolite 11%XLR-11 N-(4-hydroxypentyl) metabolite 7%XLR11 Degradant 6%UR-144 Degradant 2%STS-135 (RM) 0.44%AKB48 N-(5-fluoropentyl) metabolite 0.33%AKB48 0.18%JWH-250 N-(5-hydroxypentyl) metabolite 0.1%JWH-203 0.08%JWH-250 N-(5-carboxypentyl) metabolite 0.07%JWH-250 N-(4-hydroxypentyl) metabolite 0.07%JWH-250 0.04%AM 694 0.03%RCS-8 0.02%AM 1220 0.02%JWH-200 0.01%JWH-073 0.01%AM 2232 0.01%JWH-073 N-(4-hydroxybutyl) metabolite 0.01%JWH-018 N-(5-hydroxypentyl) metabolite 0.01%


Synthetic Cathinones (Methcathinone)R(+) Methcathinone 100%Mephedrone 167%Methedrone 150%Methylone 120%Buphedrone 103%4-Fluoromethcathinone (Flephedrone) 94%3-Fluoromethcathinone 75%(±) Methcathinone 73%Ethylone (bk-MDEA) 43%Ethcathinone 40%4-Methylethcathinone 35%Pentylone 2%Pentedrone 1%R(+) Cathinone 0.43%S(+) Methamphetamine 0.088%(±) MBDB (Butylone) 0.055%(-)-(S)-Cathinone 0.050%1R,2S(-) Ephedrine 0.043%1S,2R(+) Ephedrine 0.012%Diethylpropion 0.006%(±) N-Ethylcathinone ephedrine 0.006%R,R(-) Pseudoephedrine 0.005%MDPV < 0.003%PVP < 0.003%(±) MDA < 0.003%R(-) Amphetamine < 0.003%(+) Norpseudoephedrine < 0.003%(+)-N,N-Diethylnorephedrine < 0.003%(±) Phenylpropanolamine < 0.003%Naphyrone < 0.003%S,S(+)-Pseudoephedrine < 0.003%

THC #131019∆9-THC-COOH 100%∆8-THC-COOH 88%11-OH-∆9-THC 13%∆8-THC 5%∆9-THC 4%Cannabinol 2%Cannabidiol 0.01%

Tramadol #131819Tramadol 100%O-Desmethyl Tramadol 22%N-Desmethyl Tramadol 7%N,N-Bisdesmethyl Tramadol 5%

Trazodone #132819Trazodone 100%Nefazodone 20%m-CPP 0.7%N-(3-(Trifluoromethyl)phenyl)piperazine 0.3%1-(3-(Trifluoromethyl)benzyl)piperazine 0.2%Doxepin 0.1%1-(4-(Trifluoromethyl)benzyl)piperazine 0.07%Acepromazine 0.01%Imipramine 0.01%

Tricyclics Group #132019Imipramine 100%Amitriptyline 464%Doxepin 364%Cyclobenzaprine 315%Dothiepin 232%Nortriptyline 155%Clomipramine 143%Protriptyline 44%Trimipramine 44%Promazine 21%Chlorpromazine 20%Desipramine 12%Perphenazine 9%Prochlorperazine 8%Cyproheptadine 4%Maprotiline 4%Triflupromazine 3%Fluphenazine 3%Trifluoperazine 3%Thioridazine 2%

Orphenadrine 2%Acetophenazine 0.7%Acepromazine 0.6%Amoxapine 0.5%Clozapine 0.4%Thiethylperazine 0.2%Propionylpromazine 0.1%Olanzapine 0.05%Mesoridazine 0.04%Thiothixene 0.04%Glycopyrrolate 0.02%Nefopam 0.02%Hydroxyzine 0.02%Trazodone 0.01%Pyrilamine 0.01%Pyrimethamine 0.01%

Zolpidem #132619Zolpidem 100% Carboxy-Zolpidem 0.02%

Zopiclone/Eszopiclone #181719Zopiclone 100% Zopiclone-N-Oxide 100%N-Desmethyl-Eszopiclone 350%Eszopiclone 194%6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy

-5H-pyrrolo[3,4b]pyrazin-5-one 0.4%Zaleplon <0.04%Zolpidem <0.04%

Oral Fluid KitsCocaine Oral Fluid #120119Benzoylecgonine 100%m-Hydroxybenzoylecgonine 140%Cocaethylene 59%Cocaine 58%Tropacocaine 4%Ecgonine 1%Norbenzoylecgonine 0.5%Ecgonine methyl ester 0.5%Methylene Blue 0.3%Anhydroecgonine methyl ester 0.2%Norcocaine 0.2%

Methamphetamine Oral Fluid #120219S (+) Methamphetamine 100%PMMA (p-Methoxymethamphetamine) 367%(+/-) MDMA (3,4,-Methylene-dioxymethamphet-

amine) 97%p-Hydroxymethamphetamine 52%(+/-) MBDB (1,3-Benzodioxolyl-N-methylbutana-

mine) 43%(+/-) MDEA (Methylenedioxyethylamphetamine) 9%Mephentermine 5%(+/-) HMMA (4-hydroxy-3-methoxymandelic

acid) 4%PMA (p-Methoxyamphetamine) 3%Hydroxyephedrine 2%1R, 2S (-)Ephedrine 2%R (-) Methamphetamine 2%(+/-) MDA (3,4-Methylenedioxyamphetamine) 0.9%(+) Amphetamine 0.6%Fenfluramine 0.5%Hordenine 0.5%Methoxyphenamine 0.5%(+) Pseudoephedrine 0.5%Phentermine 0.1%Nicotine 0.1%R (+) Methcathinone 0.1%

Opiates Oral Fluid #120319Morphine 100%Ethylmorphine 162%Codeine 136%6-Acetylcodeine 103%6-Acetylmorphine 86%Heroin/Diacetylmorphine 86%Dihydrocodeine 39%

Morphine-6-β-D-Glucuronide 35%Dihydromorphine 28%Morphine-3-β-D-Glucuronide 25%Thebaine 23%Hydrocodone 17%Hydromorphone 12%Levorphanol 5%Nalorphine 4%Oxymorphone 0.2%Oxycodone 0.2%Norcodeine 0.2%Meperidine 0.1%Diprenorphine 0.1%Normorphine 0.1%Norbuprenorphine <0.4%Buprenorphine <0.4%Noroxymorphone <0.4%

PCP Oral Fluid #120419PCP 100%Metaphit 200%4-Methoxy PCP (hydrochloride) 100%PCPr (hydrochloride) 4%PCP morpholine 3%4-Hydroxy PCP 0.2%PCMPA (hydrochloride) 0.2%Furosemide 0.03%Promazine 0.02%Acepromazine 0.02%

THC Oral Fluid #120519(-) ∆9-THC 100%11-nor-9-carboxy- ∆8-THC 252%(+/-) 11-hydroxy-∆9-THC 146%(-) 11-nor-9-carboxy- ∆9-THC 138%(+/-) 11-nor-9-carboxy- ∆9-THC 87% (-) ∆8-THC 62%Cannabinol 22%

Hair KitsCocaine Hair #140119Cocaine 100%Benzoylecgonine isopropyl ester 167%Cocaethylene 133%Benzoylecgonine 83%Meta-Hydroxybenzoylecgonine 71%Ecgonine 0.6%Norbenzoylecgonine 0.3%Norcocaine 0.2%Norcocaethylene 0.2%Ecgonine methyl ester <0.1%Anhydroecgonine methyl ester <0.1%Anhydroecgonine <0.1%Atropine <0.1%

Methamphetamine Hair #140219(+/-) MDMA 100%PMMA 250%S (+) Methamphetamine 53%(+/-) MBDB 33%p-Hydroxymethamphetamine 33%(+/-) MDEA 17%Mephentermine 7%(+/-) 4-Hydroxyephedrine 5%1R,2S (-) Ephedrine 3%(-) Methamphetamine 3%(+/-) HMMA 2%PMA 2%(+/-) MDA 0.8%Fenfluramine 0.6%(+) Pseudoephedrine 0.6%Methoxyphenamine 0.3%(-) Amphetamine 0.2%1S,2R (+) Ephedrine <1.3%4-Fluoroamphetamine HCl <1.01%

(+) Amphetamine <0.1%Diphenhydramine <0.1%Phenylpropanolamine <0.1%R,R (-) Pseudoephedrine <0.1%Phendimetrazine <0.1%R (+) Methcathinone <0.1%Phentermine <0.1%R ( +) Cathinone <0.1%Labetalol <0.1%(-) Phenylephrine <0.1%(+/-) 2,5-Dimethoxy-4-bromoamphetamine <0.1%

Opiates Hair #140319 Morphine 100%Dihydrocodeine 243%Heroin 142%Codeine 121%6-Monoacetylmorphine 85%Morphine-6-Glucuronide 8%Morphine-3-Glucuronide 8%Hydrocodone 5%Hydromorphone 3%Oxycodone 0.06%Oxymorphone 0.04%

Synthetic Opiates Hair #140419Oxycodone 100%Hydrocodone 120%Oxymorphone 20%Dihydrocodeine 12%6-Acetylcodeine 8%Codeine 7%Ethylmorphine 6%Hydromorphone 5%Heroin 2%Dihydromorphine 2%Levorphanol 2%6-Monoacetylmorphine 2%Morphine 1%Noroxycodone 1%Thebaine 0.8%Morphine-3-glucuronide 0.2%Naloxone 0.1%Morphine-6-glucuronide <1.5%Norbuprenorphine <1.5%Buprenorphine <1.5%Noroxymorphone <1.5%Nalorphine <0.2%Normorphine <0.2%Diprenorphine <0.2%Dextromethorphan <0.2%Naltrexone <0.2%Naltriben <0.2%Nalmefene <0.2%Apomorphine <0.2%3-Methoxy-naltrexone <0.2%

PCP Hair #140519 Phencyclidine 100%Metaphit 60%Phencyclidine Morpholine 20%4-Hydroxy-Phencyclidine 5%

THC Hair #140619∆9-THC 100%(-)-11-nor-∆9-THC-9-COOH 417%(-)-11-nor-∆9-THC-9-COOH-glucuronide 313%(-)-11-nor-∆8-THC-9-COOH 167%(+/-)-11-nor-∆9-THC-9-COOH 125%(+/-)-11-Hydroxy-∆9-THC 100%Cannabinol 71%∆8-THC 71%Cannabidiol 0.17%


ReferencesV. Spiehler, D. Isenschmid, P. Mathews, P. Kemp, T. Kupiec. Performance of a Microtiter Plate ELISA for Screening of Postmortem Blood for Cocaine and Metabolites. J. Analytical Toxicol. 27:587–591 (2003).

V. Spiehler, L. DeCicco, R. McCutcheon, T. Kupiec, P. Kemp. Screening Postmortem Whole Blood for Oxycodone by ELISA Response Ratios. J. Forensic Sci. 49, No. 3:621–626 (2004).

T. Kupiec, L. DeCicco, V. Spiehler, G. Sneed, P. Kemp. Choice of an ELISA Assay for Screening Postmortem Blood for Amphetamine and/or Methamphetamine. J. Analytical Toxicol. 26:513–518 (2002).

P. Kemp, G. Sneed, T. Kupiec, V. Spiehler. Validation of a Microtiter Plate ELISA for Screening of Postmortem Blood for Opiates and Benzodiazepines. J. Analytical Toxicol. 26:504–512 (2002).

H.R. Wallage and J-P.F.P. Palmentier. Hydromorphone-Related Fatalities in Ontario. J. Analytical Toxicol. 30:202–209 (2006).

N. Harun, R.A. Anderson, E.I. Miller. Validation of an Enzyme-Linked Immunosorbent Assay Screening Method and a Liquid Chromatography-Tandem Mass Spectrometry Confirmation Method for the Identification and Quantification of Ketamine and Norketamine in Urine Samples from Malaysia. J. Analytical Toxicol. 33:310–321 (2009).

A. Negrusz, P. Adamowicz, B.K. Saini, D.E. Webster, M.P. Juhascik, C.M. Moore, R.F. Schlemmer. Detection of Ketamine and Norketamine in Urine of Nonhuman Primates after a Single Dose of Ketamine using Microplate Enzyme-Linked Immunosorbent Assay (ELISA) and NCI-GC-MS. J. Analytical Toxicol. 29:163-168 (2005).

Brzenski AB, Phan J, Yaksh TL, Rossi SS, Benumof JL (2013) Intravenously Administered Fentanyl is Not Detectable in Exhaled Breath. Analg Resusc: Curr Res 2:1. doi:10.4172/2324-903X.1000104

L. Reidy, B. Nolan, A.R. Ramos, H.C. Walls, B.W. Steele. Zolpidem Urine Excretion Profiles and Cross-Reactivity with ELISA Kits in Subjects Using Zolpidem or Ambien® CR as a Prescription Sleep Aid. J. Analytical Toxicol. 35:294-301 (2011).

P. Adamowicz, B. Tokarczyk, R. Stanaszek, M. Slopianka. Fatal Mephedrone Intoxication – A Case Report. J. Analytical Toxicol. 37:37-42 (2013). doi:10.1093/jat/bks085

N.B. Tiscione, X. Shan, I. Alford, D.T. Yeatman. Quantitation of Opioids in Whole Blood by Electron Impact-Gas Chromatography–Mass Spectrometry. J. Analytical Toxicol. 35:99-107 (2011).

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Forensic Drug Detection - Neogen Toxicologytoxicology.neogen.com/pdf/catalogs/forensic_catalog_15.pdf · • Synthetic Cathinones (Methcathinone) • Designer Benzodiazepines