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5 S T'lSl^T I4(,ut S •t^^„
)± E • Ji
1 is^pgaoisctt. Fpii:i-e)Fp^9 0 4-e<D9 0B§o
2 Mi§-yj^li}k<Dtiii)X'i)i>o
(1) i o-c^^o
Fpis®sf?K®tt'5j>e.:^x«r io«!>% )k(Dmzt£h-oxi^mmmzmxt^
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4 SSawfilSlC'^v^-CtiSPgL^v^i to
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1 2 :ty^^ 3
4 =^y h 5
Pp^2 TU:=^^y (Arrhenius) T^n y h COllI'jfriil/^; '̂̂ InJt = 26.2—10250' (l/f) 'X:$:)^:^M^J^
(kJmol-i) iC:ft>b3£V^fi{i^tL;6\ 1 Oii-<o tifcL.
= 8.3 J K"! mol"! tir^,
1 1.2X103 2 1.0X104 3 8.5X104 4 - 8.5X104 5 85.1
Pp^3 ilk(DmM^mm(D^h. IojI
1 lie 2 32p 3 90S 4 1251 5 1311
Pp^4 y>m~7km--i-hv^j>>-vi^m-Ti^mr.i-hyph
1 Oii^o
1 pH 2~4 2 pH 4~5 3 pH 6~8
4 pH9~10 5 pH8~ll
— 1 —
1 X I&II0J
2 PET (positron emission tomography)
4 MRI (magnetic resonance imaging)
5
Po^6 ioii-<c
1 NO 2 NO2 3 N2O4 4 N2O 5 N2O5
Pp^ 7 07r
NH2
H2N''
1 Oil
NH2 NH2 o o\V/
N NH2
1 ^ ^
4 yyv
2 1,4-i^t Kd fc"!) v^>
5
— 2 —
3
HBr
HO OH
H3C ) ( CH3H3C CH3
H2SO4
Br
O, CH3y-(-CH3
H3C CH3
NO2 NO2Cl NaOH .OH
H2SO4 SO3H
Pp^ 9 y.r(Dm^m(Dmii: a t b omo 0 h. 1 OjI
B
COOH
H-
H-
H-
HO-
-OH
-OH
COOH
COOH
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-H
COOH
COOH
H-
H-
•OH
-OH
COOH
HO-
HO-
COOH
-H
-H
COOH
H pH
H OH
H pHX^C02HHO2C
H OH
— 3 —
COOH
OH
H'^^OHCOOH
COOH
OH
HO-^-^HCOOH
COOH
Hy^^OHH'̂ ^OH
COOH
COOHHO^HCOOH
BgiO KToAi 1 oa'<.
1 2 3 4 5
A oO
UHsC^CHa
H. .H,C=C,
H H
0
uHaC^OCHa
0 0
X XHaC^C^CHa
H2
B o0 0
X XHaC^C^CHa
H2
H-CEC-H
0
uHaC"^CHa
0 0
X XHaCC^C^OCHa
H2
P=111 y y/-<lirSS|L^troi41 o»^.
1 %mv 2
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5 cr'^^^-yi-
1 Gq^' yy<
4 Na'^y^-r^/V
5 ffFI
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1 ^'y/^yRroyy^ittt.-feyy< hy:t:^yxi4rp^/-«7^ya*T-fir5.
2 N^-g-a»«Ci<4APtt. -®^:l^^/^^'Sy^SS^^:er5<,
3 0 -mi^f-o-yy^smcmz6.
4 y yo#< liTkKlkSti-cv'^i,
5 t h yro y -yyaattTkiift^Sit-c dna t
— 4 —
Fp^i4 ioii-<o
3 MWt. Mm^^Xh^o
5 ^?^CV^AX;@tfeT^ti5itT^ §o
1 TKl/-:J-y:/ 2 =i/U^y—/V 3 lj;Wyh=^y
4 5 "T^nyy^y
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4 5
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Fb^2o i-3ii'<,
1 5feAtth^yy9X-7jm 2 yxxyr 3 H0I®
4 5 T-yyT
6 —
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1 K«*ti®ris 2 m&Wiomm s t
4 iSAig* 5
1 2 7iy-/wtt;!K^Sro;y/i'^ct=^ K
5 y®3i/Jfdr-> K
Bg23 1-Dm^.
1 K-ras 2 HB 3 APC 4 src 5 As
BS 24 j lb, tt^iM.ffi'(t;4^-7->'->-^/i'A5g:t>iBiV''®i4ifti'^s 1 o3
1 -K-ftra?g 2 a
4 5 yny
Bg25 ;ii#ffl7k«lcff5±ffiSiE®«^(cB|-r5««Sii®5'^, Si^KSflSiL^toitifivA'
1 oa^o
1 pH 2 DO 3 *:»®ll
4 5 ss (mm^w)
7 —
mm}
Pb^ 26 G ^5^ t ^^mmt t'tif)\ i -om^,
1 rvui-vy^i^mi^ 2 rvy'rvy^2^mi^
3 hy<^yi>2^^i^ 4 12^^#:
5
1
4 yyV1^^(D^^
5 7 5/
WMmk
T-fe:^/v=i y >-
y yyy-Y^)y
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yzii::^yy y y
M^B
r hp t^y
Tyy p-zw
yyfy % y
-fy^yy
Pb^28 1 oii-<.
1 'bY^WcWt'P 2 3
4 mm 5 mm
Pb^29 TY^ui-vy^ a ^^-ron t'M\ i -om^c
1 yuz^y y u^/U 2 ^zl/-7:^P—zW 3 Tp^/p^zI^
4 f-zl'T'i^^^—zv 5 hT'pp—zl/
— 8 —
PpIso 1051
1 =i:fy^y 2 -fuijyCy 3 V
4 5 'rhy:^4y
Pb^ 31 (COMT) J: «9 ]'y<(Di'^m^m^ir^(Ditt^ti
1 Oil^o
1 2 •^V^))y 3
4 5
Pb^32 TF^i-vyaio^-<,
1 y<yay^,y 2 3 'f'Ty'V F
4 yt:ii-ify<M 5
1 yt2±^F 2 f^^yyy 3 }jy/y"}J/i-
4 5 :^/U^V^F
— 9 —
1 OjI^o
1 yD;^'<vT^K 2 i^yt:"'75:K 3
4 5 fcVViy;&-f^K
Pp135 -fen h^y 5-HT3§:^#:^iiflc:J:!9. 1 oil
1 TT'l^t'yyh 2 3 iyyytKy-:^—h
4 Ky^y Ky 5 y^irhoy
Pp^36 loji
1 2 3 i^hny—/v
4 yx/ny 5 yn i^yy
Pp137 1 oil
1 2 Tny^yy—3 yn^;^i/K
4 y'nn—A 5 yyyy;^—if
PpI 38 iltR^vy n ;^-=3r Vffy---^XC0X)-2 1 Oii-<o
1 ±u=2:^i/zf 2 3 -yynyj^y-y
4 ndryyny^cy 5
— 10 —
Pp^39 1051
1 y/i^i/h-y^ 2 3
4 ^ hyn-^y"—/!✓ 5 ry^>
Pol 40 ^(Dm^m(D 9 ib.
1 03i^„
1 i^tKn^xVy 2 yy:^\i°y 3
4 y^y hr:i ^ h/i^yy y 5 -yy^/uyry
— 11 —
Bg41 glbteftlcM-rSffia® 5 t.,
2 pH;asSV'iii*Ji®®L-^-rv\
5
fSAZ P-^t^'V/^^'a(co^^T^ 1 ol
5
Pb143 3ELV>ro(4i:'JX/!i>o 1 oa
2 ^J-^-l:(4 4000aS4?fc5o
5
F=^44 CYP3A4S:^<K*-f5ft#til4i:*tL7S^ 1
1 2 rf'a-fyjn—iv 3
4 'yzl^i/-y 5
— 12 —
BB45 y CLr SrS-rSt 1 Oj8'<o fcfc*L> GFR »*«»-?>
issff, cLse y T 7 . r ttw®iix¥^ t-rs.
1 CU- = ft) (GFR+CLse) (1-R)
2 CLr = ft) (GFR+CLse) -R
3 CLr = ft) (GFR-ft)+CLse) (1-R)
4 CLr = (GFR-ft) + CLse) (1-R)
5 CLr = GFR-ft)+CLse-R
Fo^ 46 h ^ h+'x/V/iSgjcfi-rsS-g-,
1 -o'M^c
1 a-¥*iifii1'««^FBW«TB«AUCi4it^J1-5o
3 yr7>'^tt-$T-fc5.
4 a-^*(Cj:e,-f^>:|))^«f4-®-eS)5o
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H47 $47^y;^-^:/xi'a(cii6-oT('^at;6se#5S-a'> 1 Km
i454)7;y7.^V7Vmax(4fl:*{t»f)iSi-fS,
1 S«ii«(cJt6ajLT(+l«)tS^s±;455.
2 SKSISASKm S:*(tat)i«i''45o
3 y T9Vmax/Km
4 Km J: y a®®SdS(gV)tff;lit)SS(4-^iC)fe5.
5 Km:6S*#V)(5i*e^i:*Ki:®«?Ptt:)Si«SV\
— 13 —
F>848 i t>»Pa-^Sro¥i®®eB#FflMRT:i^?>^ftSK)MRT
1 o»'<,
1 2 1 / PliKita^S: 3
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1 BET ^ 2 Washburn ^ 3 KozenyCarman ^
4 Young S 5 Langmuir
BgSO 2fe©#BStt»lro4'T?, 1 oS
1 bso 2 W-y^V 3 Span20
4 5^t^ 5 -<yy-Vv=i = !yAlg{t;#i
Rgsi ».<r>mnmijm<o<px\
1 y7/yy o—:^:^7yyy^>A 2 3 fyoyn—y
4 5 y'9^;y-fe/H3—
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1 bn-y^jSfiJ 2 ST® 3 4 5 ifM-M
— 14 —
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1 2 3 rzn^ K^/i^
4 i/ai y h^/i" 5 if—
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i -om^o
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4 iryiry^i—h 5
— 15 —
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4 HBc—HBe^HBs ©lif
5 HBsiiift:©IH4(i< BaffFI)Se"fJ;OTftfiLft:©®#^E?te-f5,
B958 UttBliTH (CKD) (:i|a-t-5iea©5*>^ 1 ©a-<<,
1 (GFR) vm^ti6Wmm(DlS:Ti^3:^M&.±i^^i-6il^mr-t>6,
3 lflil£©'ff9@Stt 140/90 mmHg 5|?)St"f"5o
5 (NSAIDs) ttWmm^&r'D!) 7.^
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1 X D ^2 Tyt'T"?;/—yW 3 y K-^ t°n vy
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— 16 —
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3
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5 yh3y-y-/Kl, »fil::J;5«fettjeSilE(-*a-Cfc5,
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Fb163 mmru/uif-(Dm!¥x'9im-r6^miit'ti7i\
1 T h f—i4ftjSi<s 2 3
4 a e^&iKtt»jfn.tt®ifiL 5 ^.i.
— 17 —
Rg64 HllSrSISE*<01SHt1
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BRSS AIDS i-MI-SiaiiCi 5 ]Et^^©(4^4^^!l^ 1 0)g'<„
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B3 66 i:^r©af£:ciiB-g-a:<0 5%. iELV^®(4if4i,As 1 oi
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4 vy^'y-ry CD2om^O'Bm\t4¥^yy^'yV y^m
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Fb^67 L-croH2feS»l4f4xd^o 1
1 Excerpta Medica
2 Index Medicus
3 Annals of Internal Medicine
4 Goodman & Gilman's The Pharmacological Basis of Therapeutics
5 Journal ofAmerican Medical Association
— 18 —
—61—
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4 ESgp'i. EBSa!^p°p, {t;ffliPpS.U'Bit«Srop°p®faro**(:iM1-'5€^ (GQP)
5 is«p°p> Bna^p^p, (gvp)
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— 20 —
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4 y y -Xi^y
2 -y- y K
5 y D D
3
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1
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5 \s.m&<r)mm^w>i^m
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— 22 —
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7' 180 t-rso
1 28 2 36 3 180 4 280 5 360
— 23 —
Pp186 1 o5l
1 -20 "CUT 2 2-6 °C 3 10 "Ci^T
4 20-24 5 30 'Ci^T
Pp187 1 Oj|
3 -^4 4 5
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5
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— 24 —