Friends and Colleagues,

Welcome to the Fourth Annual Roseman University of Health Sciences Research Symposium. We are pleased and grateful to continue the momentum that has been building since our first Symposium three years ago. This year, we received 118 abstracts to date across both campuses in South Jordan and Henderson as well as from a growing contingent from our colleagues outside of Roseman. We look forward to featuring the discoveries and scholarly work of our faculty members, staff, post-doctoral researchers, residents, and students from all of Roseman’s health disciplines. Many of the presenting authors both inside and outside of Roseman carry affiliations with other great universities and entities worldwide like Virginia Commonwealth University, University of Michigan, University of Southern California, NYU, UNC Chapel Hill, Touro University Nevada, University of Chicago, University of Dresden, Germany, Mekelle University in Ethiopia and pharmaceutical manufacturer Merck & Co. Our presenters are immensely talented and in demand, working across borders to create solutions, collaborating with other great minds, and bridging our communities.

This year’s abstracts cover a wide range of topics in various areas including bench-top science, clinical research, and educational research. These works independently and collectively represent prodigious planning, methodical execution, and deeply insightful findings. These works, with a wide breadth and depth of scientific subject matter, are steps towards solutions, solutions that advance not only our work and our national and international reputation, but advance the human race. Some interesting presentations to note include research on healthcare policy and which social determinants of health are most likely to acted upon in US policymaking, a retrospective cross-sectional study on an antiretroviral therapy among HIV patients in Northern Ethiopia, and research on how Roseman faculty use and understand the Six-Point Mastery Learning Model, Roseman’s innovative learning model which has challenged the way healthcare education is taught. As you can see, the work being conducted is truly transformational and holds great possibility in evolving our understanding of critically important issues.

We believe that this thinking, input and collaboration not only showcases current thinking, but sparks new ideas, new modes of thinking, and imagination. We are proud of the minds and hearts of those in this room today.

Thank you to all those responsible for making this important event happen, as well as to all those attending the symposium and supporting the work of colleagues, students and friends. We believe this symposium will continue to grow and serve as a platform for the best thinking and research and a home for sparking imagination, solutions, discovery and learning.

Sincerely,

Renee Coffman, President

Agenda 2:00 PM – 3:30 PM Registration & Presenter Check-in 2:30 PM – 3:30 PM Poster Presentation & Judging 3:30 PM – 3:40 PM Welcome Remarks & Introductions P1 Classroom

3:40 PM – 4:45 PM Keynote Speaker, Dr. Ching-Chang Ko, Chair & Program Director, Department of Orthodontics, School of Dental Medicine, University of North Carolina-Chapel Hill

P1 Classroom

4:45 PM – 5:00 PM Break & Dinner

5:00 PM – 6:00 PM Podium Presentations P1 & N2 Classrooms

6:00 PM – 6:20 PM Awards Ceremony & Wrap-up P1 Classroom

Keynote Speaker: Dr. Ching-Chang Ko P1 Classroom 3:40 PM Topic: Developing a polydopamine laced hydroxyapatite-gelatin nanocomposite for bone tissue engineering

Dr. Ching-Chang Ko Chair & Program Director Department of Orthodontics School of Dental Medicine University of North Carolina-Chapel Hill

Dr. Ching-Chang Ko is Professor of Orthodontics in the School of Dentistry at the University of North Carolina- Chapel Hill (UNC). He received his dental training at the Kaohsiung Medical University in Taiwan, a MS in bioengineering from the Yang-Ming Medical University in Taiwan, and a PhD in bioengineering and biomaterials from the University of Michigan in US. He was the faculty in the Department of Oral Biology at the University of Minnesota from 1994 to 2006 and joined the faculty of UNC Orthodontics in 2006.

In the past three years, he has served as Program Director and Vice Chair of the Department of Orthodontics at UNC, and in 2014 was name Hale Professor, a distinguished professorship in the University. Since 2017 he has become the Chair of the department. He is an established biomaterial/biomechanical scientist and American Board of Orthodontics Certified. Dr. Ko has contributed more than 130 publications to the scientific literature, which include original research articles and chapters in books. Dr. Ko received B.F. Dewell Memorial Research Award from AAOF (American Association of Orthodontists Foundation) in 2007, and has lectured nationally and internationally. His research is funded by NIH, 3M, and Whitaker Foundation to develop new biomaterials for bone tissue engineering and to study orthodontic biomechanics. He has nurtured numerous PhD and Master students. He is a member of many associations and societies, including AADR, AAO, ORS, ASME, ASCer, and Biomaterials. He has served as the reviewer for various orthodontic and biomedical research journals.

Meet the Researchers, Poster Presentations 2:30 PM

Category

Poster Number

Title Presenter

Basic Sciences

Abstracts

1 In Vitro Evaluation of Antimicrobial Activity of Chlorhexidine Hexametaphosphate Nanoparticle Coatings on Orthodontic Elastomeric Chains

Han Na Seo, DMD

2 CYP3A5 Promotes AR Downstream Signaling and Contributes to Therapeutic Resistance

Priyatham Gorjala, PhD

3 Identification of a Tripartite Protein Complex Essential for Nuclear Delivery of Proteins and Nucleic Acids of Extracellular Vesicles

Aurelio Lorico, MD PhD

4 Inhibition of CYP3A5 Downregulates Cancer Drug Resistance Genes and Induces Synthetic Lethality in Prostate Cancer Cells

Ranjana Mitra, PhD

5 Role of the Tetraspanin CD9 in Exosomal Uptake

Mark Santos, PhD

6 Targeting DNA Damage Response to Overcome Taxane Resistance

Olivia Chao, PhD

7 Analogs of the Rapid-Acting Antidepressant RO-25-6981 Exhibit Antidepressant-Like Effects Independent of Glutamatergic Antagonist Activity

Lisa Nguyen, BS

8 Evaluation of RPE-1 Cell Line as a Cell Culture Model for Degenerative Retinal Diseases

Sadia Haleem, PharmD Candidate 2019

9 Exploring the Effects of Essential Oils on the Variability of Caenorhabditis Elegans under Oxidative Stress

Briana Le, PharmD Candidate 2018

10

Improved Antinociception and Decreased Withdrawal of Prescription Opioids via In Vivo Dysregulation of G Protein Signaling

Mariya Y. Zhudeva, BS

11 In Search of Better Antidepressants: The Synthesis and Structure-Activity Relationship of RO-25-6981 Analogs

Angela Torosian, PharmD Candidate 2019

12 Increased Sensitivity of GRK5-Null Cervical Cancer Hela Cells to Actinomycin D- Mediated Cell Death

Alec Jacinto, PharmD Candidate 2019

Basic Sciences

Abstracts

13 Increased Sensitivity of GRK5-Null Cervical Cancer Hela Cells to Paclitaxel- Mediated Cell Death

Christina Lee, PharmD Candidate 2018

14 Investigation into the Components of Black Pepper Essential Oil Responsible for the Anti-Oxidant Properties in Caenorhabditis Elegans

B. Adam Baillio, PharmD Candidate 2020

15 Predicting G Protein Coupled Receptor Kinase Interactions with Proteins within the Notch Signaling Pathway

Robert Kinan, PharmD Candidate 2018

16 Predicting G Protein Coupled Receptor Kinase Interactions with Proteins within Various Cancer Pathways

Russel Arceo, PharmD Candidate 2019

17 The Protein Expression of G Protein Coupled Receptor Kinases Vary during Different Cell Stresses

Megha Patel, PharmD Candidate 2017

18 Using C. Elegans as an Experimental Model to Test the Importance of G Protein Coupled Receptor Kinases in Controlling the Responses of the Heart to Stress

Angela Caracci, PharmD Candidate 2018

19 Using Caenorhabditis Elegans as an Experimental Model to Test the Importance of G Protein Coupled Receptor Kinases in Controlling the Heart’s Responses to Oxidative Stress

Stacy Henry, PharmD Candidate 2019

20 Zerumbone Inhibits Growth and Migration of Ovarian Cancer Cells Including Paclitaxel Resistant Ovarian Cancer Cells by Targeting Jak2/Stat3 and NF-kB Signaling Pathway In Vitro

Ivy Leung, PharmD Candidate 2019

21 Zerumbone, a Dual Inhibitor of Jak2/Stat3 and NF-kB Signaling Pathways, Inhibits Growth and Migration of Paclitaxel Resistant Ovarian Cancer Cells and Improves Chemosensitivty of 2-Deoxyglucose in Hypoxic as well as Normoxic Conditions

Eddy Chan, PharmD Candidate 2019

22 Are C. Elegans “People” Enough to Study Human Neurological Conditions?

Erika Sembrano

23 Difference in Nuclear Envelope Invaginations between Normal and Cancer Cell Lines

Matthew Stein, DO Candidate 2020

Clinical Sciences

Abstracts

24 Cranial Base Angle and Maxillary Sagittal Position: A Comparison of CV Value (Combined Variation) and A-Point to N-Perpendicular in Adults

Jared Error, DMD

25 Biomarkers and Orthodontics Veronica Lee, DDS

26 Force Decay of Invisalign Aligners after Repeated Load Cycling

Andrew Dinh, DMD

27 In Vitro Evaluation of Force Decay of Chlorhexidine Hexametaphosphate Nanoparticle Coated Orthodontic Elastomeric Chains

Joseph A Dougherty, DMD

28 Prevalence of Posterior Alveolar Bony Defect in Adults with Posterior Crossbite: A CBCT Study

JinYoung Choi DMD

29 Relationship Between Insulin-Like Growth Factor 1, Height, Weight, and Cervical Maturational Stage in Orthodontic Patients over a One Year Period

Casey Luu, DDS

Clinical Sciences

Abstracts

30

The Effect of Bracket Pad Shape on Shear Bond Strength, an In Vitro Study in Human Enamel

Nirav Patel, DMD

31 The Effect of Dental Chair Light Duration on Shear Bond Strength of Orthodontic Brackets

Kevin Andrews, DMD

32 Salivary Biomarkers in Assessment of Skeletal Maturation in Orthodontic Patients

Manas Mandal, PhD

33 Association of Vitamin D with Skeletal Maturation and Growth in Orthodontic Patients

Manushri Desai

34 Real World Evaluation of Ceftolozane/Tazobactam (C/T) Use and Clinical Outcomes at an Academic Medical Center in Las Vegas

Truong Nguyen, PharmD Candidate 2018

35 Retrospective Study of Aztreonam in Gram-Negative Pneumonia

Vy Dang, PharmD Candidate 2019

36 Use of Ceftaroline for Off-Label Indications in a Community Hospital

James Mitchell, PharmD

37 Evaluating Risk Factors for Subtherapeutic Vancomycin Serum Concentrations in Hospitalized Adults

Desiree Chang, PharmD

38 Potential Serotonin Syndrome with Linezolid and SSRIs in a Community Hospital

Amy Hale, PharmD, RN

39 Positive Correlation between Abnormal Rib Development and Anatomic Variations of the Subcostal and Lumbar Nerves

ViTuong Nguyen and HoangAnh Nguyen

40 Development of a Penicillin Skin Testing Protocol in a 400-Bed, Acute Care Teaching Hospital

Peter Bautista, PharmD, MBA

Educational Research Abstracts

41 Perceptions of Faculty about the Roseman Six-Point Mastery Learning Model

Stephanie Wragg, PhD

42 Competence Requirements of Newly Licensed Nurses as Reported by Hiring Nurse Managers

Delos Jones, RN, MSN

43 Developing Cultural Competency Tools to Improve Cultural Awareness in an Accelerated Health Care Program

Arup Chakraborty, PhD

44 Evaluating the Economic Impact of a Medicare Elective Course for Medicare Beneficiaries

Natalie Peng, PharmD Candidate 2019

45 The Economic Rationale of Repaying Student Loans at the Minimum Required Level for New Orthodontists

Doyon Chung, DMD

46 Using Critical Thinking Skills Tests as a Predictive Admissions Tool for Success in Pharmacy School

Helen C. Park, PharmD

47 Comparison Of Student Stress In Colleges Of Pharmacy With A Three-Year Doctor Of Pharmacy Program

Jennifer Te, PharmD Candidate 2018

48 Evaluating How Types of Opportunities can Influence Membership Enrollment in an American Society of Consultant Pharmacists (ASCP) Student Chapter

Victoria Te, PharmD Candidate 2019

49 Quantifying Community Based IPPE: A 2-Year Analysis and Estimated Cost Savings

Catherine Leiana Oswald, PharmD

50 Depressive Symptoms and Novel Correlates Early in the Residency Year

Marissa Ross, PharmD Candidate 2019

51 Evaluating the Effect on Student Pharmacist Education after Participation in Advanced Practice Experience (APPE) with a Dual Licensed Pharmacist-Physician Assistant

Gary Manley, PharmD, PA-C

52 Survey on the Efficacy of a Longitudinal Case Study in an Accelerated Three –Year Pharmacy Program

Yana Avnilova, PharmD Candidate 2019

Public Health Research Abstracts

53 Using a Statistical Model to Determine Relative Supply and Demand Of Orthodontic Services in Southern California

Steven Speaker, DDS

54 A Qualitative Assessment on Marketing Effectiveness in Orthodontic Offices

Michelle Hsiao, DDS

55 Financing Options and The Relationship to Patient Account Delinquencies in a University Orthodontic Clinic

Melanie Seto, DDS

56 Patient Access to HIV Non-Occupational Post-Exposure Treatment and Transition to Pre-Exposure Prophylaxis Treatment

Sebastien Arziari, PharmD Candidate 2018

57 Perceptions and Prevalence surrounding Adolescent Substance Abuse: A Cross-Sectional Study of the Nonmedical Use of Prescription Medications by High School Students in Nevada

Krystal Riccio, PharmD

58 Web-Based Survey of Non-Medical Use of Prescription Medications, Illicit Drugs, and Other Substances by Adolescents in Nevada: Completion Rates using Mobile Technology

Krystal Riccio, PharmD

Research Podium Presentations P1 & N2 Classrooms 5:00 PM

Time Educational and Clinical Research Podiums

(P1 Classroom)

Benchtop Science Research Podiums (N2 Classroom)

5:00-5:20 PM Perceptions of Faculty about the

Roseman Six-Point Mastery Learning Model Presented by Stephanie Wragg, PhD

CYP3A5 Promotes AR Downstream Signaling and Contributes to Therapeutic Resistance Presented by Priyatham Gorjala, PhD

5:20-5:40 PM Evaluating the Economic Impact of a Medicare Elective Course for Medicare Beneficiaries Presented by Natalie Peng, PharmD Candidate 2019

Using C. Elegans as an Experimental Model to Test the Importance of G Protein Coupled Receptor Kinases in Controlling the Responses of the Heart to Stress

Presented by Angela Caracci, PharmD Candidate 2018

5:40-6:00 PM Retrospective Study of Aztreonam in Gram-Negative Pneumonia Presented by Vy Dang, PharmD Candidate 2019

Zerumbone, a Dual Inhibitor of Jak2/Stat3 and NF-kB Signaling Pathways, Inhibits Growth and Migration of Paclitaxel Resistant Ovarian Cancer Cells and Improves Chemosensitivty of 2-Deoxyglucose in Hypoxic as well as Normoxic Conditions

Eddy Chan, PharmD Candidate 2019

2018 Research Symposium Sponsors Thank you to our sponsors!

Presenting Sponsor Huntridge Family Clinic

Awards Sponsor American Nutritional Products Inc.

Roseman University of Health Sciences Henderson Campus Research Symposium Organizing Committee

Evan Williams, PharmD, MBA, BCPS, BCACP – Chair College of Pharmacy Christopher So, PhD College of Pharmacy Kristi Singer College of Pharmacy Robert Fox, MSN/Ed, BS, RN, PCOE College of Nursing Jené Hurlbut, RN, MSN, MS, PhD, CNE College of Nursing Karthikeyan Subramani, PhD College of Dental Medicine Joslyn Hatfield Marketing Communications Specialist

Our committee would like to extend a special thanks to Dr. Jeff Talbot, Dr. Arup Chakraborty, Dr. Susan Nguyen, Anna Ferri, Kitti Canepi, and the student volunteers of the American Association of Pharmaceutical Scientists (AAPS).

We are glad you were able to attend our 4th Annual Research Symposium. Thank you to our presenters, faculty, students, staff, administrators, judges, and volunteers who made this event possible.