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Friuli Innovazione and FVG biotech enterprise network
Lodi, 6th September 2016
CASE
STUDY
Prof. Stefano Marchetti
CEO Transactiva srl
© Friuli Innovazione 2 2
Science and Technology Park Luigi Danieli
Udine
• www.friulinnovazione.it
© Friuli Innovazione 3
3 main buildings
6.400 m2 offices and laboratories
80.000 m2 total area
> 30 enterprises and laboratories hosted
Friuli Innovazione at a glance Infrastructures
© Friuli Innovazione 4
Friuli Innovazione at a glance Activities
• Laboratory of Metallurgy, Surface Technologies and Advanced Materials
• Applied Genomics Institute
Laboratories
• Biotechnologies
• Metallurgy, Surface Technologies and Advanced Materials
• Extended ICT
• Energy and Environment
Main Sectors
Enterprise
Development
Technology
Transfer
Enterprise
Funding
Friuli Innovazione
Spazio Impresa
Hosting
© Friuli Innovazione 5
Research
Entrapreneurs
Public
Banking
Friuli Innovazione at a glance Approach
© Friuli Innovazione 6
Technology
Transfer
Enterprise
Funding
Friuli Innovazione
Spazio Impresa
Friuli Innovazione integrated offering for enterprises and business ideas
Enterprise
Development Hosting
6
© Friuli Innovazione 7
Enterprise Development
• To support and assist the creation of high-technology
enterprises, the Techno Seed incubator undertakes:
• guidance and training
• business plan development
• technological feasibility studies
• assistance with enterprise creation formalities
• assistance with fund raising and access to innovative forms of
finance
• networking, searching for partners and alliances
• mentoring
Promotes ICT and Hi-Tech start-ups
based on innovative ideas
Certified incubator in Italy
Enterprise Development
Techno Seed incubator
© Friuli Innovazione
• 2005 business incubator Techno Seed
begun
• 2011 Techno Seed went international
• 2013 Techno Seed was the second
incubator certified at national level and
the first at regional level
2005 - 2015
© Friuli Innovazione
• 560 business ideas
• 180 business plans
• 1900 young entrepreneurs educated
• 2500 consultancy hours delivered
• 47 new enterprises started
• 12 groups (business ideas) running
• 1,5 millions Euro of own
resources delivered to groups and
enterprises (financing with European
national and regional projects)
2005 – 2015 (some figures)
© Friuli Innovazione
• > 190 new jobs
• > 5 millions Euro revenues
• 30 young entrepreneurs moved in
Europe through Erasmus for Young
Entrepreneurs
• 11 regional entrepreneurs who
hosted foreign young entrepreneurs
• 16 patents
2005 – 2015 (some figures)
© Friuli Innovazione 12
LR 26/2005 art. 21, comma 1, lettera a
Unione Europea
Programma Erasmus per
Giovani Imprenditori Programmi di scambio a livello europeo
Fondo speciale per start
up innovative Finanziamenti senza garanzie e
basso tasso di interesse
Formazione, consulenza
Enterprise
Academy
Incubator Pipeline
© Friuli Innovazione
Trilateral Start up ecosystem
13
© Friuli Innovazione
Trilateral Start up ecosystem
• “The Landing Point for Start-ups entering the European
Market”
• Joint trilateral acceleration program for best trilateral start-ups
• Joint trilateral events
• Joint communication platform including event calendar
• Building trilateral start-up community and branding
• Joint coordinated infrastructure (like co-working spaces)
• ….
14
© Friuli Innovazione 15
References
Fabio Feruglio
Managing Director
Mobile +39 335 6988766
Email [email protected]
Direct +39 0432 629933
www.friulinnovazione.it
Friuli Innovazione
Parco Scientifico e Tecnologico Luigi Danieli
Via J. Linussio, 51
33100 Udine
Italia
Elisa Micelli
Techno Seed Responsible
Mobile +39 345 9646875
Email [email protected]
Direct +39 0432 629941
Friuli
Innovazione
and
Biotech 16
© Friuli Innovazione
Friuli Innovazione and Biotech
• Associazione Istituto di Genomica Applicata
www.appliedgenomics.org
• IGA Technology Services www.igatechnology.com
• Transactiva www.transactiva.it
• Laboratori Turval Italia www.turval.com
• Gadamed www.gadagroup.it
• Biofarma www.biofarma.it
17
Biotech SME
Academic spin-off of the University of Udine Year of establishment Capital stock Registered office Employees Active members Facilities Molecular biology laboratory Biochemistry laboratory In vitro laboratory Growth chambers Greenhouses
2001 105 € PST Udine
7 3 150 sq. mt. 100 sq. mt 60 sq. mt. 50 sq. mt. 2750 sq. mt.
Parco Scientifico e Tecnologico "Luigi Danieli“ Via J. Linussio 51 33100 Udine T + 39 0432 629.745/753 F + 39 0432 603.887 [email protected] www.transactiva.it
The use of plant-based innovative expression systems for the production of non-food, non-feed, non-fibre commodities like therapeutic molecules, fuels, biodegradable plastics, industrial and commercial proteins.
Molecular Farming
R&D activities in Transactiva are primarily aimed at devising novel industrial platforms for the production of pharmaceuticals in plants.
Comparison of the available hosts for the production of therapeutical recombinant proteins
Transgenic plants as an industrial system for pharma production
Depending on the requested amounts and considering other specific needs, target molecules are synthesised in tobacco leaves or rice seeds
Both system are suitable for the production of active proteins with a high level of bioequivalence as compared to their native counterparts.
whose manufacturing cannot be achieved by chemical synthesis available in limited amounts or completely excluded from clinical practice due to the inadequacy of their production systems
Attention is given to therapeutic molecules:
Pharmaceuticals in the pipeline
Transactiva is currently working on two main research areas: Production of recombinant human enzymes to be used in the enzyme replacement therapy (ERT) of rare metabolic diseases Acid Beta Glucosidase (rhGCase) Acid Alpha Glucosidase (rhGAA)
Expression of immunoglobulin-like molecules, with particular focus on personalized NHL vaccines and monoclonal antibodies
Anti-idiotype NHL vaccines Monoclonal antibodies
TOBACCO
RICE
RICE
Pharmaceuticals in the pipeline
Institute of Applied Genomics
• No-profit Research Institute funded on April 13th, 2006 • Legally recognised by FVG Regional Adiministration on August 4th,
2008
To explore and exploit the genetic variation underlying the
phenotypic diversity occurring in nature, and to make
achievements available to the scientific community and to
society.
Mission
IGA sequencing projects
IGA ‘genomes’ papers: Citrus (2014)
• Start-up company founded by Institute of Applied Genomics (IGA) in
September 2009
• 100% ownership of IGA
• Provides ‘classical’ and next generation sequencing services as well as
bioinformatics analyses
• Works exclusively on Illumina NGS platform
• Illumina Certified Service Provider for sequencing
since 2009
www.igatechnology.com
Computer infrastructures
• 1104 GB of RAM for data analysis • 140 TB for storage for big data
conservation • Currently expanding
Transcriptome Epigenome
• Gene expression profiling
• ncRNA analysis
• Whole transcriptome analysis
• RNA immunoprecipitation sequencing (RIP-seq)
• Chromatin immunoprecipitation sequencing (ChIP-seq)
• Methylation analysis (BS-seq)
NGS applications
• Targeted resequencing
• Metagenomic & microbial diversity
• Whole genome resequencing
• De novo sequencing
Genome
Developing the scientific knowledge on probiotics and the Probiotic Lactic Yeast®
Kluyveromyces marxianus fragilis B0399 (TURVAL® B0399®)
• to produce the active ingredient
• to supply users and distributors
• to provide scientific information and updates
• Food, Yogurt, Snacks and Probiotics
• Nutraceutical and clinic field for human use
• Zootechnical field such as cattle, swine and piglets
Specific formulations for: Horses, Pets, Poultry, Ostriches, Pigeons, Camels and camelids
MARKET
Laboratori TURVAL Italia srl MISSION
PROBIOTIC BRANDS BASED ON TURVAL® B0399®
Zootechnical Products:
Human Products:
Probiotic Lactic Yeast® TURVAL® B0399® brought multiple AWARDS to yogurts producers for the
most innovative product:
EUFYR: recognizing innovation in Private Label
(Amsterdam, 2014)
JOGOFIR: innovative probiotic fermented milk
beverage (NoviSad, 2015)
GADA® Group
Company Profile
37 GADA® Group
Operative Companies & Business Units
Divisions
Strategic Areas
Integrated Services
Logistic & Maintenance
Labo & Transfusion Cardiac
Surgery
Int. Radio
Int. Cardio Dialysis
Blood Management Business Unit
Cardiovascular
Business Unit
SALES & DISTRIBUTION SERVICES
GENERAL Hospital
40
FVG: regional
research system
• 2 Universities
• 2 Academic hospitals
• 4 Science and Technology Parks
(Open Innovation System)
• BioHighTech NET
• 2 Startups incubators
• SISSA
• 2 ITS
• Elettra Sincrotrone
• 2 CNR institutes
• ICGEB
• Italian Liver Foundation
• LNCIB
• 2 research and therapy institutes
(CRO, Burlo Garofolo)
• ITIS Trieste
• …
41
FVG: Biotech
Enterprise Network
• Formalized in 2016
• 32 enterprises (…and
counting!)
• Promoter of the SMART
HEALTH S3
42
FVG: Biotech
Enterprise Network
Smart Health cluster
Biomedical, in vitro and in vivo
Diagnostics
Medical informatics and Bioinformatics
Innovative Therapy
Ambient Assisted Living
• More than 150
regional
enterprises
• 4 technological
development
trajectories
FVG: Biotech
Enterprise Network