GATE Life Sciences 1996

8/13/2019 GATE Life Sciences 1996

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IGKfE- 1996 I olI LIFE S IEN ESc ============M: CHEJIISTIIlY COMPULSORY)

ONE MARKa QUESTIONS 114)F 1 each question given below, fou1 ans wese JII'Ovided, out of which only one is r e c tWtile the rOJTect answer on the answe.r-bookby wri1i.ng n. b. r or II.

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(14 X I = 14)For a two component system ofA and BatI atm. hich fo rms a compow1d AR.. thenumber ofphases at the eutecuc poin t rutdcongruent point are respecuvella. land 3b. 3 ru1d Ic. 3and1d 2 ru1dJThe precipitate of Cnll1 (K,l' ; 1.7 ,is obtained hen equal \ OIum es of thefollowing solut ions are mixeda Ill - ' M Cn l + 10 4 M rb - ~ Men-)+ 10- M rc. 10 'M Cn 1 t JO ' M Fcl I l l- ' M Ca ' t tu- M rThe ;:orrecl order or second IOnizationpotcmials Cf Sl. P, S and CI ISI Si> I >S > Cll P >S > CJ > Si3 S > CI > P> Sit S > I' > )iWllich of he following does no t have the

c o r r ~ o r d ~ r of crysull odd split.tlngparameters?a. [cor;, t > [car;.J -b, Nln NlT >[MnF.t

[Ct:>CIr->[C6Ci,j'c.a Co .] >[Cr(cu) ]A ltru>sbon clement M forms he oxidesMO . MoO, . MO , and Wh1ch of the

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fo JIOwHig Statemen tS about these OX Ides ISlrue1a. MO is the nwst ac1dic.b ts the most likel) I bestrong oxidising agent.c. MO , is the most baste.d. Mo01 is the one that cmmo l be areducing agentAlumUJIUUl trichloride r o m t ~ 0 dimerbecausea. it cru1oot be a trimerb h1gher coordmation number sachieved bv alununwmc. aluminium belongs to third groupd alwmmum has 11 h1gher 1omzauonpotentialWh1ch of fo llowing species wi ll bearomatic?n.

Qb.c.

0dWhen super cooled water suddenly

f r l l ) ) : e ~ the free enerm of the e mn mcreasesb decreasesc. remarns the same


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d. bt:com"" zcroFor s cllernioal reaction U1e proposedDleeham sm is AD u B IS.pres ent in only negligibly '' II nn111unt AIoil times. U1 e concenlr.l tion of B in lennsof major reagents A und C i>

1,[11. k,f.tJ+k,b. k, [.tl

A.,+ k, [ cJ]c. [AJ- k,[c]J. k, [ ]- k, - k (A)rhc ffiOJOT prlltlUC fonncd in theclimin:nion reaotion of

eCH OH

H C CHisi\.

c.

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l o l l111e reoc tion or c .H,C ; C/J 1\ith wn terin the presence of' HgSO , ondJI,SO , Icd too. C H,CN =CR,b ~ H , C H O H Hc. c.Jl ,CH,CH,OHd. c ncocn,\Vhich uf Ihe fnllo\\ ing COin J QI.Ind Wi ll

) p t i : ~ l oo. 2-methyl lbutanolh 2-chloro-2-m ethylpenU>nec.

CHH t r

f BrCH

d. CJJ1C 1CJ (OH )CJI ,CJJ1l'he correct bond order of niuvgonoxygen bond in NO. Jo O; . NO;. NO ' iso. vo > ,vo >No; > No;h. IIV1 >NO, >NO> NO c. NO >li O> NO > NOd. vo; >.VO>NO >NO,Out uf BF 1. NF ,. S F ond SiCt. tl1e tnntrosi,a.nl tn hydroly io. B f'1b. NF ;c. SiE,d. SiCL.Por ench given beiiJw. fnur

m w e r s nr


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1 1 ~ 6 k J t : . o J < , M t r o C I J ~ c.n,mm,

I 7 MDlch each enlry n clumn X chooln with potaSSJllln J'Mlnleglle ' qufl lllllllfvc ) 1cld ofnnrogen gus and polussonm il'(lidcWru.: 11 hlllnnced . : q u ~ l'or I n ~rc:lctiun.

19 ( i) E s u r n a t ~ lhe nutgnuudc or the.CFSE nf CoCI In em' If t h ~Olugllllutlc of C'FS E l lf I an;lo8oo rm1

(1)In ) T h ~ magncuc moments ofICo(Nl l, 1, ICI. and KJIFeF.I ore )and 5.92 13M re5J)etmely Predte tIhe hvbrid1znuon of Co nnd Fe 111tbc nbovc compounds

(2)1ll ( 1) An ophcully ;tcllvc ~ h J e A ondehydrobmmmaiH>n g;.ve a mnJorprod uct of m,JI l'onnulu c, II 11hlch

c s o ~ t s on 1he form of cwogeomemcnl tsomers .tl and .C.\IInte the c r u c c u m ofa, Jinnd ::(2)lnl An orgtmic cornpow1d Q reoctswnb IICN to g.ove g wh och on ac1dhydrolys1s rcsuhs m an ophcallyncuvc nerd E or mol formulac,n.ol Wrote 1hc struccures of,

[ amiE (3)21 l ll Sucrose when h)'dmll'sed m t111acid medium is u firS orde rr at 27"C Wh:u lntcJilm orSuc10s" ocuoains wthyJwlvsetlafter I l hr.."'


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Ooe liter of a buJTcr solutionconlajns 0,2 moles of acetic acidand 0.2.5 mole$ of odium acetate,Calculate change in pH of thesolution if 0.5 ml of I.U M NO isadded tv i t n>c tlissocintionconlllnt Cl[ ncc tic ttcid is 1.8 1()'>.

(3)AJJ .ot.hle t OIIII$U1Detl ISO g ol'glucose in a 100 meter raco: at2rcCalcu Ia o Uo c anti'Upy chllllgcof the 11thlcte, only rluc to theconsumption of glucooe. nthnlpyof combustion Clf glucose is -673kea l mor1 .t.rutdartl fr..:< c:neryicoof fomuotion of ff lco, ,anti lf nro :;us - >4.5 and -561 kcal rotJ1'1 I"C.'ill"Ctivdy.

(:\)(h) Calcu late lite molar bnl pH 6.0 ouldn. mov., townr


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7.c. our fragmen tsd. llueefnsgrm:nL11 latch lhc entries in Colwnu A agnrnstthose in C'o lumn B :tnd write the mlchmlpa1rs ln yo ur book.

(4 I = -I)( 'ul umrt AA. The amino :acid with ma.:;;imumtturnber of coouus (6)B The d>t Tnctc:nsti" umino acid in papain

ucli\ c :sitaC. 'Tlt


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c. sn:dto.xutd. i p h ~ r i o toxin

In each nf thr sub luJi(toIn parb leugt J of J em gu1 e ruubsomunto nr 0.7. Whnt i> theubs.,.. rhnnce wh ..n tvrusinlcuuoentmlioo is 1 5 10-> ~ o l L 1uncllhe patlt lengtloos cot1/


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(2)(ii) Cnlculnte h A tc>r Jl C>Im lr:mHpo11

from cy1:t;>plnsru 1nlo a lysosom


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cL PhotoyruhesisTitc: conccmlrillion or oxygHibernation in rcp til , nes t-h nllding 111birds 011d wrrning in ins< els 11011 ;:o f)iumal r h ~ h m h Annual rhythmso.. Cit=di:tn rhythmsti>2. Cydiu-depond""L kimse3 Sooond.Jt 1 induction4. Orgnizcr

II. 1\htll:h Ute producL (rum the q u a t ill livinlresources mentioned in Column withtheirso urces ment iQned U Column U

ro Jumn rA. GuaninB. Ag.1r agnrC CltitosnD. TcinglCo lumn l ll I sh wim blllduco2. Crus tnccan cxoskdctcm3. Fish4. s grnss

2)

12. Mo lch the scientists mentioned m Columnr witb lltc nnm


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I n Match the items in Calumn Iwith tltose inColnmo.ll.(2)c;,1hunn 1

A, Genetic improvement ofhnman IllCeB. btbrcedingC. Carp inducedbreedinp,D . Out breedingc ,, lumu III. Hybnd vigour2. Hypophysation3. ConsanC()WteoiU14. Eugenics

14. Matdt tlte W Jtlllfic a r ~ i m a l s it t Colwrut 1with their osm oreg .llutory system$ iJtColonmllColumulA. AmoebaB. Freslt water CrayC. Marine teleostD. ElasmobranchColonmllL Retiintain equilibrium.

(5)DiSc'USS Ue physical pheuomemt by whicltan organism may lose or gain henl tromtlte env:irolllllentitlivesin

(5)Describe ~ d L scheJuatic diagtrulJ theJlrocesseg by whidt H honnooe sucli asaclt:euul.iite and n SIJ:oid homtone sndt allproge.sterone affect their respective lnrg;etcells (5)Show witlL schematic diagram tilt' possibT0Lpes of d1111hle :rosSVf l'l' (two, Otree(tw o types) and four-strand) between UteIW Q Oanlcing markers (1oci o and b,centmrnere located outside of the matkers)and the results of each (m tonus of

r e c o m l > i n : ~ t i o n betweeu flankiriJ markers)to prove that recombinatiorL fracti\lncannot exc.,.,_50%, no matter how manycroosovers occur between the two foct ,


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\fenti(m lht: h:.sic: i> \C:nl.\ UJ 1 et1C: hming.ex-periment in PJOehedchi ooj witht :Uilable Jiagram.

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ln .sub-quf. \tiuns I to 20 nut a.nswcr :unoogstHw nltllrn.utivcs ghtlft CorrNt.. Cboost-1 thecnrr1 ~ w c r ttnd wric in your :.tn ri"\n :>r book

~ m t ~ (a. b. c or d). along with h ~corn>3pondug >U IHjue.tiou number.(20 I = 20)

I. Wl1kh or the following kingdom; bcllornctcrizcd by mtthrospnr"c. blaslospoto


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b. V> has far lcs o t 1 l l l i n J u t n t i ~ 1 o n.. V .llSSOciates rar less readily Wltblteovy cltoin compared to V

d. \ ,.suppresses V.: divcrsilyTit e primary function of interlcukin-2 (ILl) i.1, pruGferntion of Acells1:>. pro lifcro ion ofT cellsc. difl'CronLialion of cellscL uclivntinn If c m g c sWhich uf the follo"iug dotentCnh aboutE.schcrichla coi l lex A protein is notco rrect/a, It i> deoved by reb. Jj hinds i l l c a l l to DNA wbunit ;. bound to orobinO Itc. lt hind. lo opernwr o) and hut< oni1s o n n , l l e s i sd, In tho: presence of cAJ\ofP. the \ ra Crohin011e complex hind tn l it nnd to ' "gion uf DNA (aro I) adjacent lo hepromoter JoJtile5lructural genesA mulD.nl is isolatod iiom 11 wild typoculture which loses ability to grow onlaclose l \ r a b i n o . ~ J e , g l ctose and severnutlter sugars. l be cM IP .wei m Lbjsmutnt U foun d to be normal Wl ;tt k.indt1fmutation mjj ht give these ~u deft:ct in cntr hol ilc: nc livnwr proteinb. ddocl in lac opcrolor"" dotb:t ill Sl.rUaturoJ geno.:s Of IU a OI>CfOJld. deJ\:d in slprumoterThe wattrrsolublc pigrutuls pbycoory lhrinand phycocyanin.. a.rc found ina. grc:en algaeh. brown lgoe..:.. t.liatoms

IS.

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l luf I.\d. red algocThe Ameli rest ;,. , p l o to lind 11ut il chemical isa. thcrnpeuticb I\.11'C:inogeni Ct untigenicd. ero togenic'The asodaHon hotwcon llage l11l.edprolo?.on living in the gut or "'miles is anQ:arnplc ofa. C nmmtn-:alhmtb. Parasitismc. u L ~ i nd. Opportunistic a;;soJC iation"'rgoti m Is caus ed hy ergot alk:o loiospmduced b) fU11 ,11.'ia. As pergillus tl.n'llsh o\n1tnit:1 vt:mJc. Rhizoetomo sppd. Clavicep< purpureat- l tch the c in olumn A WithUeir contributio11 list.cd 1n \o lumn B.

(5 5)( pJumn(1) J;dclmon(ii) Kobut(ii1) M e d a w ~ r(iv) t hahaharty(VI MonadColu mn. ll(i \)(BJ(C)\D)(E)

(hl

(n)

tlcne synthDliisAnt ibody t.ructurcPtonting of fjJilt hactcrinlliJe limnJmmunorolcrnnCAJl lypc,n nablc rugioo orimmunoglobul inDi.sco,ery ofy-glohulinConcept of operon\\11u t nrc: tbe dislingu sltiugfenhlre. nf retrnvinl \ :md( H n - : a m y ~ u V l n ~

Describe brietly the t r n t e g i e s they p to replicate tboir genom ...

(2)\\'hat are the major diffcrcnc.csllctwccu genomic DNA lihrary 1111deDNA lih1'llry?


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3)

b)

(al

(2)Define the IBmiS plasmid, ccsmidand transposon.

(3jgrowlh r:lle, growth yl,ldand ~ y n c o u s grow1h as 1heyapply lo a gmwmg microbial

cuhure. (3)Calcu.lale dte generauon li me tnhours of a bac1erial cuilure whirhmcreases fm m milia rorulalion ofI07 cells to I01 celis in 20 houts.

(21Differennn te belween c t e r t e i dand bactenostallc.agenrs.

(2)(b) Define pheno l coeffictenl and lindilS value for tbe disinfectant fromfollowing observ(Uious madeunder standard co nduions oftesting (- Indica tes groWih. -indica1es no grr>wth )

Di1mibl1l:li IOU21150111Juoo1;1>01100

o :st-Nrdli.J pit/ ....PJbadCW. rubf an..,

w

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Obligale anae robes sucb il Clostridiuutpasteurint m fem1ent gltocose to bu lyrarewtder reduced etw tronments. Titey llseEMP pa thwny lor c Onversionof g) ucose 10py ruva1e. 1-fowever. they d() nol ltsepyruvate dehydrogenase en.zyme systemfor oonverstou of pyru vale 10 acety l CoA.instead they employ IY rtJvale ferredo . noxido-reductase enzyme sys tem wtud1resulls in formauon of te.duced ferre doxinReduced ferredol(in on rum ITansfers oseleclrous to IJ on the presence ofhydrogenase 10 evo lve H, gas. Two mo lesof acelyl C oA subsequen lly produce o emo le of bulyrate wnh the r put of2 molesof NADH and do outpul of I mole ofi\TPWh a1 advan 1age do you d1ink lhesebnc1ena de rive by employing pyruva te

o 11fc rredoxm mo do-reduc1aso cn.zymc systemover dehyllrogenase enzymesyslem?[Gtven:E{ (NAD+- NADiJ) - Cl.32 wl1s{ (fd/fdJip - - 0..41 wliJe: l H -I Hl) - 0 42 voila

5)

fd and fd .I-lJ rcpwseniS lhe ox1dized andred uced fonns ofterredoxto respective.Ty.Jll PHARMACY

ONE MAIU S QUESTIONS 113)F or each qu es lloo g1ven below four (lllswer.; ureprovided , out of wh1cb only one os correc1s WrneIhe correct answer on the by wrning A. H, C oragru nst the correspoodmg sub-queshon number onthe answer book

(13 I lJ)C LON IDtl\'E HYORO C HLORJ DE . tp ISn. monoamone oxidase onhibilor whichconlnins ru oun idliZOiine ri ng systemb anentll and Veno11s Vasodl lalor whichcontains imida.zoline ring systemc. monoamine oxidase inhibilor which

contains Py nmidone nng l\ystemd monoamme oXJdase inhtb ttor whichcontatns l'hthala:ane ri ng ~ m2 Born trager's 1s1 is fortdennfication of

a. 01 omxiub Reserponec. Digoxmd Oianthroneof tltein

3, The electmda sys1em emp loyed inPotentiometric titmnons of ncods by nonaqueous method in basic solvents tsa. Glass-Cal0mel electrodesb. Al1111ll()ny-Giass ~ l e c t r o d e sc. Glass-i\nh mony e lec1rodesd Antunony-Calomel electrodes

4. Tile drug NALAXONEn. produces morphine Joke ac livnyb produces r e s p ~ r m o r y depressionC. 11\tlUC


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,L preetpi Mco widtdr: W3 l m p t o m mmolllhme addiCISfJt1aovl nl;anme:. ornithine :md melhir.u1fnenn: ;.;volvcd IJtthec bioge110sis ofo. I, \'ShRGIC ActOII. Rl'.i>ERPINJ 'c:. /-IWOSL'Y.-\>'v11N'Ed. PAPAVERINE

are:. under th.: ~ . : r u m .:(mc.,.,trotiontimcugic h,,ft' lilc nt he ~h urno unl or d n ~ g thai Is clearetl by the

k . i t l J I ~c. amuunLof drug absorb


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C To prevent cross contaminationD For regula1ing the ilowE For avo iilingweig,htvaoationI F1'r l'ini:1erird rt. SiS IJtrrce

.3. For the drugs listed [ to 4 mecluummof ac1ion is indicated front A to FMatc-h titem .I VINCRISTINE2 STR8PTOMYCRN3 CHLORAMl'HEN ICOT.r4 RIFAMPICINA Macrocyclic anlibtotic \Vlti.cltinhlbits DNA dependent RNAPolymeraseB An wt libio tic con taining nitrQ ?fllupwlticlt binds co SOS noosomolsobunitC A dimeric ind

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GATE Life Sciences 1996