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Genesis of fatigue: Objective: After completing this experiment we will be able to : 1. Define Fatigue 2. Demonstrate the site of fatigue in nerve-muscle preparation 3. List the precautions taken during the recording of the genesis of fatigue 4. Name the site of fatigue in isolated and intact preparations 5. Explain the cause of fatigue in isolated preparations 6. Explain how the recovery can be expedited Results: Interpretations: Conclusions Questions: 1. Why is the staircase obtained only with fresh uninjured muscle preparation? Give the mechanism of its production 2. What substance is responsible for the onset of fatigue? How di you establish that its is this substance? How is it formed in the body? What normally happens to it that did not happen to your specimen 3. What factors aid in the onset of fatigue 4. What factors may influence the height of contraction

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Genesis of fatigue:

Objective:After completing this experiment we will be able to :1. Define Fatigue2. Demonstrate the site of fatigue in nerve-muscle preparation3. List the precautions taken during the recording of the genesis of fatigue4. Name the site of fatigue in isolated and intact preparations5. Explain the cause of fatigue in isolated preparations6. Explain how the recovery can be expeditedResults:Interpretations:Conclusions

Questions:1. Why is the staircase obtained only with fresh uninjured muscle preparation? Give the mechanism of its production2. What substance is responsible for the onset of fatigue? How di you establish that its is this substance? How is it formed in the body? What normally happens to it that did not happen to your specimen3. What factors aid in the onset of fatigue4. What factors may influence the height of contraction