Genetics of Behavior

• Overview• Animal Models• Single genes• Multigenes

Animal Models

• Use model animal• Different strains with

behaviors• Genetic crosses• Transgenic animals

Transgenic models

Leptin: activates a control in hypothalamus

Single Genes: Huntington DiseaseNormal mouse brain tissue

Huntington

Bipolar Mood disorders

Schizophrenia

Schizophrenia and relationship

Blue low gene activity, red high gene activity

AlzheimersAmyloid beta protein on chromosome 21,

Amygdala Hippocampus

Limbic system: Controls emotions and memory

Emotional stability

Convert stimuli to longTerm memory