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G G G N N N I I I P P P S S S T T T B B B U U U L L L L L L E E E T T T I I I N N N 2 2 2 0 0 0 1 1 1 4 4 4 31 st October, 2014 Volume No.: 38 Issue No.: 04 Vision TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASED LEARNING AND PRACTICE Contents Message from PRINCIPAL Editorial board Historical article News Update Knowledge based Article Disease Related Breaking News Upcoming Events Drugs Update Campus News Student’s Section Editor’s Note Archive GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:[email protected] GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY Website: http://gnipst.ac.in

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GGGNNNIIIPPPSSSTTT BBBUUULLLLLLEEETTTIIINNN 22200011144431st October, 2014 Volume No.: 38 Issue No.: 04

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELDOF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASED

LEARNING AND PRACTICE

Contents • Message from PRINCIPAL• Editorial board• Historical article• News Update• Knowledge based Article• Disease Related Breaking

News• Upcoming Events• Drugs Update• Campus News• Student’s Section• Editor’s Note• Archive

GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:[email protected]

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

W e bs i t e : ht t p: / / gni ps t. a c. i n

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen. But it can't happen if you quit." Lauren Dane.

‘We are what we repeatedly do. Excellence then is not an act, but a habit.’ Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the last year’s editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academic excellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are supported in maximizing their potential and talents. Education needs to focus on personalized learning and instruction, while promoting an education system that is impartial, universally accessible, and meeting the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to achieve their aims. We are all very proud of you, our students, and your accomplishments and look forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in this direction and fruits of these efforts will be received by our students in the near future. Our Teachers are committed and dedicated for the development of the institution by imparting their knowledge and play the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTA EDITOR MS. JEENATARA BEGUM ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE Sardar Vallabhbhai Patel: Sardar Patel the iron-man of India was one of Mohandas Gandhi’s closest associates, and he organized and led several satyagrahas during India’s struggle for freedom from British rule. When India achieved independence in 1947, Patel became Home Minister and Deputy Prime Minister, and he presided over the most difficult task facing the nascent nation-state, namely the integration of over 500 princely states into the Indian Union. Vallabhbhai Patel was born in Nadiad in present-day Gujarat in 1875. He completed his schooling in the local area and subsequently, in his 30s, he went to Britain; like many of his generation of political leaders, he qualified as a barrister. Patel returned to India around the same time as Gandhi returned to India from South Africa, on the eve of World War I, and the two met shortly thereafter. Patel joined Gandhi in representing the weavers in the dispute with millowners in Ahmedabad in 1918, and he played a pivotal role in helping to redress the grievances of peasants in Kheda district. "I will say", wrote Gandhi in his autobiography, "that without the help of Vallabhbhai Patel, we should not have won the campaign. He had a splendid [law] practice, he had his municipal work to do, but he renounced it all and threw himself in the campaign." In 1930 Sardar Vallabhbhai Patel was imprisoned for participating in the famous Salt Satyagraha called by Mahatma Gandhi. His inspiring speeches during the "Salt Movement" transformed the lives of numerous people, who later played a major role in making

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the movement successful. Sardar Patel was freed in 1931 following an agreement signed between Mahatma Gandhi and Lord Irwin, the then Viceroy of India. The treaty was popularly known as the Gandhi-Irwin pact. The same year, Patel was elected as the president of Indian National Congress Party for its Karachi session. In the Karachi session, the Indian National Congress Party committed itself to the defence of fundamental rights and human rights and a dream of a secular nation. An agreement regarding this was also sanctioned. In 1934, Sardar Vallabhbhai Patel led the all-India election campaign for the Indian National Congress. Though he did not contest a seat for himself, Sardar Patel helped his fellow party mates during the election. Sardar Patel was annoyed at Jawaharlal Nehru for the latter's declarations of the adoption of socialism in 1936. Patel also considered Netaji Subhash Chandra Bose a "keen of more power within the party. Sardar Vallabhbhai Patel's health declined in 1950. He, himself realized that he was not going to live much longer. On 2 November his health deteriorated further and was confined to bed. After suffering a massive heart attack, on 15 December 1950, the great soul left the world.

NEWS UPDATE High prevalence of vitamin D deficiency across

the board in neuromuscular disease: (31st October, 2014) More credence has been added to a growing awareness of the high prevalence of vitamin D deficiency in neuromuscular disease by newly presented research. Vitamin D supplementation has been suggested to improve function in frail elderly patients at risk for falls, as well as

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individuals with myasthenia gravis and Parkinson's. The impact of vitamin D deficiency and supplementation on function in other neurologic conditions has yet to be explored.

Digital Therapist: Computer program analyzes speech, mental health: (31st October, 2014) A program that analyzes your speech and uses it to gain information about your mental health could soon be feasible, thanks in part to new research showing that certain vocal features change as patients’ feelings of depression worsen.

Researchers probe link between newborn health, vitamin A: (30th October, 2014) The impact vitamin A has on newborns is virtually unknown, but nutrition researchers have published two papers that may provide a framework for future investigations of the vitamin and neonatal health.

Unlocking the secrets of pulmonary hypertension: (30th October, 2014) A protein that plays a critical role in metabolism, the process by which the cell generates energy from foods, is important for the development of pulmonary hypertension, a deadly disease. Pulmonary hypertension is caused by the narrowing of the blood vessels in the lung, due to excessive growth of cells in the blood vessel wall. The cells grow in number until they obstruct the vessels, causing the heart to struggle pushing blood through the lungs to the point where the heart fails and the patient dies.

Doubt cast over air pollution link between childhood leukemia, power lines: (30th October, 2014) Researchers from the UK have called into question a theory suggesting that a previously reported risk of leukemia among

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children born close to overhead power lines could be caused by an alteration to surrounding air pollution.

Scientists trigger self-destruct switch in lung cancer cells: (30th October, 2014) Scientists have found a drug combination that can trigger the self-destruct process in lung cancer cells - paving the way for new treatments, according to research. "There's an urgent need to save more lives from lung cancer and we hope these findings will one day lead to effective new treatments to help lung cancer patients and potentially those with other cancer types too," authors noted.

Heart's own immune cells can help it heal: (30th October, 2014) The heart holds its own pool of immune cells capable of helping it heal after injury, according to new research. In a mouse model of heart failure, the researchers showed that blocking the bone marrow's macrophages from entering the heart protects the organ's beneficial pool of macrophages, allowing them to remain in the heart, where they promote regeneration and recovery. The findings may have implications for treating heart failure in humans.

Genetic factors behind surviving or dying from Ebola shown in mouse study: (30th October, 2014) A newly developed mouse model suggests that genetic factors are behind the mild-to-deadly range of responses to the Ebola virus. The frequency of different manifestations of the disease across the lines of these mice are similar in variety and proportion to the spectrum of clinical disease observed in the 2014 West African outbreak. The new mouse model might be useful in testing candidate therapeutics and vaccines for Ebola, and in finding genetic markers for susceptibility and resistance to the disease.

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High-intensity sound waves may aid regenerative medicine: (30th October, 2014) Researchers have developed a way to use sound to create cellular scaffolding for tissue engineering, a unique approach that could help overcome one of regenerative medicine’s significant obstacles.

Making lab-grown tissues stronger: (30th October, 2014) Lab-grown tissues could one day provide new treatments for injuries and damage to the joints, including articular cartilage, tendons and ligaments. Cartilage, for example, is a hard material that caps the ends of bones and allows joints to work smoothly. Biomedical engineers are exploring ways to toughen up engineered cartilage and keep natural tissues strong outside the body. For detail mail to editor

KNOWLEDGE BASED ARTICLE Encephalitis

Encephalitis is inflammation of the brain tissue. Most cases are caused by viral infections. In rare cases it can also be caused by bacteria. There are two main types of encephalitis—primary and secondary. Primary encephalitis is when a virus directly infects the brain and spinal cord. Secondary encephalitis is when an infection that starts elsewhere travels to brain. This disease is rare. According to the Centers for Disease Control, encephalitis occurs in one of every 2,000,000 people. Most people who contract it are young children, individuals over 65, or those with weak immune system. Though rare, the disease is very serious—severe cases can cause death.

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Causes: The most common virus that causes encephalitis is herpes simplex. Usually the herpes virus travels via a nerve to the skin. There it causes a cold sore. In rare cases, the virus travels to the brain. This form of encephalitis will often affect the temporal lobe—the part of the brain that controls memory and speech. It can also affect the frontal lobe—which affects emotions and behavior. Herpes encephalitis can cause severe damage. Other common viruses that can cause encephalitis include:

• mumps• Epstein-Barr virus• HIV• cytomegalovirus (CMV)

Childhood VirusesThe childhood viruses that used to commonly cause encephalitisare now preventable by vaccines. Therefore, these types ofencephalitis are rare.Some childhood viruses that can cause encephalitis include:

• Chicken pox (very rare)• Measles. According to BBC health, measles causes encephalitis in

approximately one out of every 1,000 cases. In most cases, thecondition is mild. However 20 percent of those affected will havelong-term nerve damage. Up to 10 percent of cases are fatal.

• Rubella. Approximately one in 5,000 rubella patients developencephalitis. It is fatal up to 20 percent of the time.ArbovirusesArboviruses are viruses carried by insects. The disease they causedepends on the type of insect and what viruses they carry.

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• California encephalitis is transmitted by mosquito bites. It is alsoknown as Lacrosse encephalitis. It mainly affects children. It hasfew to no symptoms.

• St. Louis encephalitis occurs in the rural Midwest and southernstates. It is generally mild. However, in people over 60, there is a 30percent mortality rate.

• West Nile is most often found in Africa and the Middle East.However, it can occur in the US. West Nile is usually relativelymild. It can be fatal among older individuals and those withweakened immune systems.

• Colorado encephalitis is also called Colorado tick fever. It istransmitted by the female wood tick.

• Eastern equine encephalitis is spread by mosquitoes. It affects bothhumans and horses. It is often mild but it does have a two percentmortality rate.

• Kyasanur forest disease is transmitted by tick bites. It can also betransmitted by drinking raw milk from goats, sheep, or cows. Ithas a one to two percent mortality rate. People most at risk arehunters, campers, forest workers, and farmers.Risk Factors:The groups most at risk of encephalitis are:

• older individuals• children under 1 year of age• people with weakened immune systems.

Living in an area with high mosquito or tick populations also putsyou at risk. So does participating in outdoor activities wheninsects are present.Symptoms:The symptoms of encephalitis can range from mild to severe. Eachtype can have its own particular set of symptoms.

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Mild symptoms include: • fever• headache• neck stiffness• lethargy• general feeling of being unwell• headache will continue to get more severe• vomiting

Severe symptoms include:• very high fever• confusion• drowsiness• hallucinations• slower movements• coma• seizures• irritability• light sensitivity• unconsciousness• severe dementia

The symptoms in very young children are different.• vomiting• bulging fontanel (soft spot in the scalp)• non-stop crying• body stiffness• lack of appetite

Diagnosis:If encephalitis is suspected, the following tests may be used:

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Spinal Tap Or Lumbar Puncture: In this test, doctor will collect a sample of spinal fluid. The sample is then tested for signs of infection Brain Imaging With CT Scan Or MRI: These tests detects changes in brain structure. They can rule out other possible explanations for symptoms, such as a tumor or stroke. Electroencephalograph (EEG): An EEG uses electrodes attached to the scalp to record brain activity. Blood Tests: Blood testing can reveal signs of a viral infection. Brain Biopsy: In a biopsy, doctor will remove small samples of brain to test for infection. This test is rarely performed. There is a high risk of side effects. It is usually only used if doctors cannot tell what is causing the brain swelling and treatments are not working. Treatment: Anti-viral medications are effective for treating herpes encephalitis. However, they have not yet been shown to work for other forms. Instead, treatment often focuses on relieving symptoms, using:

• pain killers• corticosteroids (to reduce brain inflammation)• mechanical ventilation, or breathing treatments• lukewarm sponge baths• anticonvulsants• sedatives (for seizures, restlessness, aggressiveness, and

irritability)• rest

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• fluids (IV fluids are sometimes necessary)Sometimes hospitalization is needed to deal with brain swellingand seizures.

Jeenatara Begum

Assistant Professor

GNIPST

DISEASE RELATED BREAKING NEWS Human infection with avian influenza A(H7N9)

virus – China: (29th October, 2014) On 19 October 2014, the National Health and Family Planning Commission of China notified WHO of 2 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus, including 1 death. Read more

UPCOMING EVENTS 5th International Conference on Stem Cells and Cancer 2014, JNU

Convention Centre, New Delhi, India from 8-10 November, 2014

DRUGS UPDATES FDA Approves Xigduo XR (dapagliflozin and metformin hydrochloride) for Type 2 Diabetes: (30th October, 2014) AstraZeneca announced that the U.S. Food and Drug Administration has approved once-daily Xigduo XR (dapagliflozin and metformin hydrochloride extended-release) for the treatment of adults with type 2 diabetes. Read more

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CAMPUS NEWS Today the students of GNIPST have participated in the ‘Run for

Unity’ as a mark of tribute to the efforts of the country's first Home Minister Sardar Vallabhbhai Patel.

Congratulation to the winner of Cricket Tournament-B.Pharm 3rd year, 2014 Runner up team-B.Sc and BHM, 2014

Congratulation to the highest run scorer of Cricket Tournament-Tanmoy Das Biswas, B.Pharm 3rd year, 2014

Congratulation to the highest wicket taker of Cricket Tournament-Subhodip Das, B.Pharm 3rd year, 2014

Congratulation to the winner of Carom Tournament (Boys)- Sk. Abdul Salam, B.Pharm 2nd year, 2014 1st Runner up-Subhayan Dutta, M.Sc (Biotechnology Department) 2nd year, 2014 2nd Runner up-Nirupan Gupta, B.Pharm 1st year, 2014

Congratulation to the winner of Carom Tournament (Girls)- Aishwarya Datta, B.Pharm 2nd year, 2014 1st Runner up-Krishnakali Basu, B.Pharm 3rd year, 2014 2nd Runner up-Rituparna Das, B.Pharm 3rd year, 2014

Congratulation to the winner of Chess Tournament (Boys)- Basab Brata Dey, M.Sc (Biotechnology Department) 2nd year, 2014 1st Runner up-Ankit Chowdhury, B.Pharm 1st year, 2014 2nd Runner up-Smaranjeet Banik, B.Pharm 3rd year, 2014

Congratulation to the winner of Chess Tournament (Girls)- Rituparna Das, B.Pharm 3rd year, 2014 1st Runner up-Varsa Srivastav, B.Sc(Bioptechnology Department) 1st year, 2014 2nd Runner up- Krishnakali Basu, B.Pharm 3rd year, 2014

The GNIPST Cricket Tournament, Carom Tournament and Chess Tournament was held on 21st and 22nd October, 2014.

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The Cultural Programme on Bijoya Dashami and Kali Puja was held on 20th October, 2014

An exhibition on Photography and Painting was held on 20th October, 2014

Congratulation to the winner of Football Tournament-B.Pharm 3rd year, 2014 Runner up team-B.Pharm final year, 2014

Congratulation to the winner of Table Tennis Tournament-Krishnakali Basu, B.Pharm 3rd year, 2014 1st Runner up-Aindrila Bhowmick, B.Pharm 2nd year, 2014 2nd Runner up-Sayani Banerjee, B.Pharm 2nd year, 2014

The GNIPST Football Tournament (for male students) and Table Tennis tournament (for female students) was held on 25th and 26th September, 2014.

On 5th September, 2014 the students of GNIPST have arranged a wonderful Teacher’s Day Programme. On behalf of all the teachers of GNIPST I would like to thank our beloved students.

The Fresher’s welcome programme was held on 14th August, 2014. Welcome 1st year students.

We congratulate the following M.Pharm. final year students who have made their positions in different pharmaceutical companies. Anirban Banerjee (Emami Ltd.) Mahender Roy (Stadmed private Ltd.)

We congratulate the following B.Pharm. final year students for their success. Samadrita Mukherjee (Abbott India Ltd.) Suman Sarkar (Tata Medical Centre-Apollo Pharmacy) Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition) Avishek Naskar (Glaxo SmithKline-Marketing) Bappaditya Manik (USV Limited)

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Sarbani Das (Nutri Synapzz-Marketing) Ankita Roy (Nutri Synapzz-Marketing) Rahul Mitra (B M Pharmaceuticals-Production)

The following B.Pharm. final year students have qualified, GPAT-2014. We congratulate them all. Utsha Sinha Satarupa Bhattacharya Sandipan Sarkar Purbali Chakraborty

Reminiscence, 2014(GNIPST Reunion) was held in College campus on 2nd February,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 in College campus ground.

An industrial tour and biodiversity tour was conducted in Sikkim for B.Pharm and B.Sc. students under the supervision of Mr. Asis Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy, 2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd year. Deep Chakraborty was the only scorer of the final.

STUDENTS’ SECTION WHO CAN ANSWER FIRST????

Dr. S. K. Burman established whichpharmaceutical company?

Kavli prize is awarded in whichdiscipline?

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Answer of Previous Issue’s Questions: A) Santosh Trophy

B) Football

Identify the person

Answer of Previous Issue’s Image: Magnus Carlsen

Send your thoughts/Quiz/Puzzles/games/write-ups or any other contributions for Students’ Section& answers of this Section at [email protected]

EDITOR’S NOTE

It is a great pleasure for me to publish the 4th issue of 38th Volume of GNIPST BULLETIN. All the followers of GNIPST BULLETIN are able to avail the bulletin through facebook account ‘GNIPST bulletin’ I am very much thankful to all the GNIPST members and readers who are giving their valuable comments, encouragements and supports. I am also thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr. Soumya Bhattacharya for their kind co-operation and technical supports. Thank you Mr. Soumya Bhattacharya for the

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questionnaires of the student section. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE GNIPST organized a garment distribution programme on 28th

September, 2013 at Dakshineswar Kali Temple and Adyapith, Kolkata. On this remarkable event about hundred people have received garments. More than hundred students and most of the faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th September) and Pharmacist’s Day (25th September) on 25th and 26th September, 2013 in GNIPST Auditorium. A seminar on ‘Violence against woman’ and ‘female foeticide’ was held on GNIPST Auditorium on 25th September organized by JABALA Action Research Organization. On 26th September an intra-college Oral and Poster presentation competition related to World Pharmacist’s day and Heart day was held in GNIPST. Ms. Purbali Chakraborty of B.Pharm 4th year won the first prize in Oral Presentation. The winner of Poster presentation was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year). A good number of students have participated in both the competition with their valuable views.

Teacher’s day was celebrated on 5th September, 2013 by the students of GNIPST in GNIPST Auditorium.

Azalea (exotic flower ) , the fresher welcome programme for newcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium.

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One day seminar cum teachers’ development programme for school teachers on the theme of “Recent Trends of Life Sciences in Higher Education” organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit Sengupta, Director cum Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty respectively. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and professional of the emerging and newer branches of Life Science.

The general body meeting of APTI, Bengal Branch has beenconducted at GNIPST on 15th June, 2012. The program started witha nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural

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Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT forconducting the two years’ post graduate course (M.Pharm)in PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to120.

AICTE has sanctioned a release of grant under ResearchPromotion Scheme (RPS) during the financial year 2012-13toGNIPST as per the details below:a. Beneficiary Institution: Guru Nanak Institution of PharmaceuticalScience & Technology.

b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 yearse. Title of the project: Screening and identification of potential

medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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