Gnipst Bulletin 34.2

8/12/2019 Gnipst Bulletin 34.2

1/18

1

1118-1177-4796-9849-

7562-5062mail

GGGNNNIIIPPPSSSTTTBBBUUULLLLLLEEETTTIIINNN222000111444

06th

June , 2014 Volume No.: 34 Issue No.: 02

Contents Message from GNI

Letter to the Edito News Update

Health awareness

Disease Outbreak N

Forth Coming Event

Drugs Update Campus News

Students Section

Editors Note

Archive

Vision

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD O

PHARMACEUTICAL AND BIOLOGICAL SCIENCE

EDITOR: Jeenatara BegumGURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE

AND TECHNOLOGY

GNIPST Photo Gallery

For your comments/contributionORFor ack-Issues,

mailto:[email protected]
https://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7mailto:[email protected]:[email protected]:[email protected]://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7


2/18

06-06-2014

Click here to go at the top

MESSAGE FROM GNIPSTGNIPST BULLETIN is the official publication of Guru Nanak

Institute of Pharmaceutical Science & Technology. All the

GNIPST members are proud to publish the 34th Volume ofGNIPST BULLETIN. Over the last three years this bulletin

updating readers with different scientific, cultural or sports

activities of this prestigious institute and promoting knowledge

of recent development in Pharmaceutical and Biological

Sciences. Students section is informing readers about some

curious facts of drug discovery, science, sports and other

relevant fields. All the viewers are requested to connect withtheir views, ideas and comments.

NEWS UPDATE

World Environment day: 5thJune

The United Nation General Assembly declared 2014 as theInternational Year of Small Island Developing States (SIDS).

The official slogan for the year 2014 is 'Raise Your Voice Not

The Sea Level.

1

1


3/18

06-06-2014


High blood pressure in middle age may affect

memory in old age (04thJune, 2014)

Researchers report that High blood pressure in middle ageplays a critical role in whether blood pressure in old age may

affect memory and thinking. The study found that the

association of blood pressure in old age to brain measures

depended on a history of blood pressure in middle age. Higher

systolic and diastolic blood pressure were associated with

increased risk of brain lesions and tiny brain bleeds. This was

most noticeable in people without a history of high bloodpressure in middle age.

Poor health, lifestyle factors linked to

memory complaints(04thJune, 2014)

Alzheimers disease, is the most common form ofdementia.

UCLA researchers and the Gallup organization polled more

than 18,000 people about their memory and a variety of lifestyle

and health factors previously shown to increase the risk of

Alzheimer's disease and dementia. They found that many of

these risk factors increased the likelihood of self-perceived

memory complaints across all adult age groups. The known risk

factors the researchers focused on included depression, lower

education levels, physical inactivity, high blood pressure,

diabetes, obesity and smoking. he researchers noted that, ingeneral, memory issues in younger people may be different from

those that plague older individuals. For younger adults, stress

may play more of a role, and the ubiquity of technology --

including the Internet and wireless devices, which can often

2

2
http://en.wikipedia.org/wiki/Dementiahttp://en.wikipedia.org/wiki/Dementiahttp://en.wikipedia.org/wiki/Dementiahttp://en.wikipedia.org/wiki/Dementia


4/18

06-06-2014


result in constant multi-tasking -- may impact their attention

span, making it harder to focus and remember.

Hemorrhagic fevers can be caused by bodys

antiviral interferon response (04thJune, 2014)

Hemorrhagic fevers caused by Lassa, dengue and other viruses

affect more than one million people annually and are often fatal,

yet scientists, until now, have never understood why only some

virus-infected people come down with the disease and others

do not. Virologists and immunologists have found a major clue

to the mystery of hemorrhagic fever syndromes. The team

showed that Interferon Type I immune proteins are key drivers

of a viral syndrome in mice that closely mimics human

hemorrhagic fevers. "Blocking IFN-I signaling in certain genetic

mouse strains completely prevented disease signs such as

vascular leakage leading to death," While IFN-I proteins

traditionally have been considered essential for an effective

antiviral response and are still used to treat some chronic viralinfections, the new study suggests that these proteins

sometimes do much more harm than good -- and that blocking

them, or specific biological pathways they activate, might be a

good therapeutic strategy against hemorrhagic fevers.

Discovery of compound may open new road to

diabetes treatment (04thJune, 2014)

Researchers say the discovery of an inhibitor of the Insulin

Degrading Enzyme (IDE), a protein responsible for the

susceptibility of diabetes because it destroys insulin in the

3

3


5/18

06-06-2014


body, may lead to new treatment approaches for diabetes,.

More than 20 million people live with type II diabetes in the

United States, a disease in which the body cannot make

sufficient amounts of the hormone insulin.

Human stem cells successfully transplanted,

grown in pigs (04thJune, 2014)

In this study, the team of researchers implanted humanpluripotent stem cells in a special line of pigs. The pigs were

created with immune systems that allow the pigs to accept alltransplants or grafts without rejection. Once the scientistsimplanted the cells, the pigs did not reject the stem cells andthe cells thrived.

Heart disease without coronary plaque buildup

linked to heart attack risk (04thJune, 2014)"Unlike obstructive CAD, which blocks blood flow, non-

obstructive CAD may initially appear less threatening onangiography tests since it doesn't result in decreased bloodflow, but it appears to have significant risk for heart attack anddeath".Non-obstructive coronary artery disease was associated with a

28 to 44 percent increased risk of a major adverse cardiac event

such as a heart attack or death. The possible cause is that the

non-obstructive plaques can still rupture and cause heart

attacks. Providers and patients should take note of non-obstructive CAD and consider lifestyle changes and

medications that could help prevent it from causing future

adverse cardiac events such as heart attacks.

4

4


6/18

06-06-2014


Small-molecule drugs moved through blood-

brain barrier (04thJune, 2014)The blood-brain barrier is meant to protect the brain from

numerous undesirable chemicals circulating in the body, but it

also obstructs access for treatment of brain tumors and other

conditions. Too often the only recourse is invasive, which often

limits a drug's effectiveness or causes irreversible damage to an

already damaged brain. Nearly all of the drugs that could

potentially help are too large to normally pass through the

barrier. Additionally, other methods may damage the vascular

system. In this case, the synthetic peptide K16ApoE, onceinjected into a vein, binds to proteins in the blood to create

entities that can pass for near-normal ligands to some receptors

present on the blood-brain barrier. The 'pseudo-ligand' receptor

interaction creates what the researchers believe to be transient

pores through which various molecules can be transported to

the brain. The molecules they've transported in this manner

include cisplatin, methotrexate, cetuximab, three different dyes,and synthetic peptides Y8 and I-125.

Cell death clues may lead to disease treatment

(04thJune, 2014)The mechanism of necroptosis has been unraveled byreseachers. This is a type of cell death that plays a crucial role innumerous diseases, from viral infections and loss of auditorynerve cells to multiple sclerosis, acute heart failure and organtransplantation.

For detail mail to editor

5

5


7/18

06-06-2014


HEALTH AWARENESS

Brain CancerBrain cancer is a disease of the brain in which cancer cells

(malignant) arise in the brain tissue. Cancer cells grow to forma mass of cancer tissue (tumor) that interferes with brain

functions such as muscle control, sensation, memory, and other

normal body functions. Tumors composed of cancer cells are

called malignant tumors, and those composed of mainly

noncancerous cells are called benign tumors. Cancer cells that

develop from brain tissue are called primary brain tumors while

tumors that spread from other body sites to the brain aretermed metastatic or secondary brain tumors.

Causes:

Primary brain tumors include anytumor that starts in thebrain. Primary brain tumors can start from brain cells, themembranes around the brain (meninges), nerves, or glands.

Tumors can directly destroy brain cells. They can also damage

cells by producing inflammation, placing pressure on otherparts of the brain, and increasingpressure within the skull.

The cause of primary brain tumors is unknown. There are manyrisk factors that could play a role:

Radiation therapy used to treat brain cancers increases the riskof brain tumors up to 20 or 30 years later.

Some inherited conditions increase the risk of brain tumors,

including neurofibromatosis, Von Hippel-Lindau syndrome, Li-Fraumeni syndrome, and Turcot syndrome.

Lymphomas that begin in the brain in people with a weakenedimmune system are sometimes linked to infection by theEpstein-Barr virus.

6

6
http://www.medicinenet.com/tumor_grade/article.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001310.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000793.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000793.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001310.htmhttp://www.medicinenet.com/tumor_grade/article.htm


8/18

06-06-2014


Exposure to radiation at work or to power lines, as well as headinjuries, smoking, and hormone therapy have not been provento be risk factors.

Studies have found that cell phones, cordless phones, and

wireless devices are safe and do not increase the risk.

SPECIFIC TUMOR TYPES

Brain tumors are classified depending on:

Location of the tumor Type of tissue involved Whether they are noncancerous (benign) or cancerous

(malignant) Other factors

Sometimes, tumors that start out less aggressive can changetheir biologic behavior and become more aggressive.

Tumors can occur at any age, but many types are most commonin a certain age group. In adults, gliomas and meningiomas arethe most common.

Gliomas come from glial cells such as astrocytes,oligodendrocytes, and ependymal cells. Gliomas are dividedinto three types:

Astrocytic tumors include astrocytomas (can be noncancerous),anaplastic astrocytomas, and glioblastomas.

Oligodendroglial tumors. Some primary brain tumors are madeup of both astrocytic and oligodendrocytic tumors. These are

called mixed gliomas. Glioblastomas are the most aggressive type of primary brain

tumor.

Meningiomas and schwannomas are two other types of braintumors. These tumors:

7

7


9/18

06-06-2014


Occur most often between ages 40 and 70. Are usually noncancerous, but can still cause serious

complications and death from their size or location. Some arecancerous and aggressive.

Other primary brain tumors in adults are rare. These include:

Ependymomas Craniopharyngiomas Pituitary tumors Primary (central nervous system - CNS) lymphoma Pineal gland tumors Primary germ cell tumors of the brain

Symptoms

Some tumors do not cause symptoms until they are very large.Other tumors have symptoms that develop slowly.

Symptoms depend on the tumor's size, location, how far it hasspread, and whether there is brain swelling. The most commonsymptoms are:

Changes in the person's mental function Headaches Seizures (especially in older adults) Weakness in one part of the body

Headaches caused by brain tumors may:

Be worse when the person wakes up in the morning, and clear

up in a few hours Occur during sleep Occur with vomiting, confusion, double vision, weakness, or

numbness Get worse with coughing or exercise, or with a change in body

position

8

8


10/18

06-06-2014


Other symptoms can include:

Change in alertness (including sleepiness, unconsciousness, andcoma)

Changes in hearing, taste, or smell Changes that affect touch and the ability to feel pain, pressure,

different temperatures, or other stimuli Confusion or memory loss Difficulty swallowing Difficulty writing or reading Dizziness or abnormal sensation of movement (vertigo) Eye problems such as eyelid drooping, pupils of different sizes,

uncontrollable eye movement, vision difficulties (includingdecreased vision, double vision, or total loss of vision)

Hand tremor Lack of control over the bladder or bowels Loss of balance or coordination, clumsiness, trouble walking Muscle weakness in the face, arm, or leg (usually on just one

side) Numbness or tingling on one side of the body Personality, mood, behavior, or emotional changes Trouble speaking or understanding others who are speaking

Other symptoms that may occur with apituitary tumor:

Abnormal nipple discharge Absent menstruation (periods) Breast development in men Enlarged hands, feet Excessive body hair Facial changes Low blood pressure Obesity Sensitivity to heat or cold

9

9
http://www.nlm.nih.gov/medlineplus/ency/article/003192.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000704.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/007278.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/007278.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000704.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003192.htm


11/18

06-06-2014


Exams and Tests

The following tests may confirm the presence of a brain tumorand find its location:

CT scan of the head EEG Examination of tissue removed from the tumor during surgery

or CT-guidedbiopsy (may confirm the type of tumor) Examination of the cerebral spinal fluid (CSF) (may show

cancerous cells) MRI of the head

TreatmentTreatment can involve surgery, radiation therapy, andchemotherapy. Brain tumors are best treated by a team thatincludes:

Neuro-oncologist Neurosurgeon Medical oncologist

Radiation oncologist Other health care providers, such as neurologists and social

workers

Early treatment often improves the chance of a good outcome.Treatment depends on the size and type of tumor and yourgeneral health. Goals of treatment may be to cure the tumor,relieve symptoms, and improve brain function or comfort.

Surgery is often needed for most primary brain tumors. Sometumors may be completely removed. Those that are deep insidethe brain or that enter brain tissue may be debulked instead ofremoved. Debulking is a procedure to reduce the tumor's size.

Tumors can be hard to remove completely by surgery alone.This is because the tumor invades surrounding brain tissue

10

10
http://www.nlm.nih.gov/medlineplus/ency/article/003786.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003931.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003416.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003791.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003791.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003416.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003931.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003786.htm


12/18

06-06-2014


much like roots from a plant spread through soil. When thetumor cannot be removed, surgery may still help reducepressure and relieve symptoms.

Radiation therapy is used for certain tumors.Chemotherapy may be used with surgery or radiation

treatment.

Other medicines used to treat primary brain tumors in childrenmay include:

Medicines to reduce brain swelling and pressure Anticonvulsants to reduce seizures Pain medicines

Possible Complications

Brain herniation (often fatal) Loss of ability to interact or function Permanent, worsening, and severe loss of brain function Return of tumor growth

Side effects of medications, including chemotherapy Side effects of radiation treatments

DISEASE OUTBREAK NEWS

Ebola virus disease (04thJune, 2014)

WHO and partners continue to support the implementation

of preventive and control measures in Ebola virus affectedcountries. WHO continues to provide guidance onpreparedness activities in accordance with the EVDpreparedness plans developed by each country. WHO doesnot recommend any travel or trade restrictions be applied to

11

11
http://www.nlm.nih.gov/medlineplus/ency/article/001918.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001421.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001421.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001918.htm


13/18

06-06-2014


Guinea, Liberia, or Sierra Leone based on the currentinformation available for this event.Read more

FORTHCOMING EVENTS5th International Conference on Stem Cells and Cancer 2014,

JNU Convention Centre, New Delhi,India from 8-10

November.2014

DRUGS UPDATES

FDA approves first generic version of

Celecoxib(30thMay, 2014)

The U.S. Food and Drug Administration approved the firstgeneric versions of Celebrex (celecoxib) capsules, a treatmentfor rheumatoid arthritis, osteoarthritis, short-term (acute) pain,and other conditions. Teva Pharmaceutical Industries receivedapproval to market celecoxib capsules in 50 mg, 100 mg, 200mg, and 400 mg strengths, and has 180-day exclusivity on the

100 mg, 200 mg, and 400 mg strength products. MylanPharmaceuticals, Inc. received approval to market 50 mgcelecoxib capsules.Read more

CAMPUS NEWS

Reminiscence, 2014(GNIPST Reunion) was held in Collegecampus on 2ndFebruary,2014.

1stAnnual Sports of GNIPST was held on 3rdFebruary,2014 inCollege campus ground.

12

12
http://who.int/csr/don/2014_05_16_mers/en/http://who.int/csr/don/2014_05_16_mers/en/http://who.int/csr/don/2014_05_16_mers/en/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398065.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398065.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398065.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398065.htmhttp://who.int/csr/don/2014_05_16_mers/en/


14/18

06-06-2014


An industrial tour and biodiversity tour was conducted inSikkim for B.Pharm and B.Sc. students under the supervision of

Mr. Asis Bala, Ms. Jeentara Begum and Ms. Moumita

Chowdhury.

B.Pharm 3rdyear won the GNIPST Football Champions trophy,2013. B.Pharm 3rdyear won the final match 1-0 against B.Pharm

2ndyear. Deep Chakrabortywas the only scorer of the final.

Students of GNIPST organized pre puja celebrationprogramme, Saaranya on 7th October, 2013 in college

Auditorium.

GNIPST organized a garment distribution programme on28th September, 2013 at Dakshineswar Kali Temple and

Adyapith, Kolkata. On this remarkable event about hundred

people have received garments. More than hundred students

and most of the faculties participated on that day with lot of

enthusiasm.

GNIPST celebrated World Heart Day (29thSeptember) andPharmacists Day (25th September) on 25th and 26th

September, 2013 in GNIPST Auditorium. A seminar on

Violence against woman and female foeticide was held on

GNIPST Auditorium on 25th September organized by JABALA

Action Research Organization. On 26

th

September an intra-college Oral and Poster presentation competition related to

World Pharmacists day and Heart day was held in GNIPST.

Ms. Purbali Chakraborty of B.Pharm 4th year won the first

prize in Oral Presentation. The winner of Poster presentation

was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr.

13

13


15/18

06-06-2014


Niladri Banerjee (B.Pharm 4th year). A good number of

students have participated in both the competition with their

valuable views.

STUDENTS SECTION

WHO CAN ANSWER FIRST????

Which new word is derved from 2 Portugese

word for football and ecology ?

Name of which animal is derived from Spanish

word little armored one ?

Answer of Previous Issues QuestionsA) Ponds Cold cream B)Lifebuoy

Identify the person

Answer of Previous Issues ImageLever Brothers

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for StudentsSection answers of this Section [email protected]

14

14


16/18

06-06-2014


EDITORS NOTE

I am proud to publish the 2nd

issue of 34th

Volume of GNIPST

BULLETIN. GNIPST BULLETIN now connected globallythroughfacebook account GNIPST bulletin

I want to convey my thanks to all the GNIPST members and

the readers for their valuable comments, encouragement and

supports.

I am thankful to Dr. Abhijit Sengupta, Director of GNIPST

for his valuable advice and encouragement. Special thanks to

Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr.Soumya Bhattacharya, Dipanjan Mandal for their kind co-

operation and technical supports. An important part of the

improvement of the bulletin is the contribution of the readers.

You are invited to send in your write ups, notes, critiques or any

kind of contribution for the forthcoming special and regular

issue.

ARCHIVE

Teachers daywas celebrated on 5thSeptember, 2013 by

the students of GNIPST in GNIPST Auditorium.

A zalea exotic flower ) , the fresher welcome programmefor newcomers of GNIPST in the session 2013-14 was held on8th August in GNIPST Auditorium.

One day seminar cum teachers development programme forschool teachers on the theme of Recent Trends of Life

Sciences in Higher Educationorganized by GNIPST held on

15

15


17/18

06-06-2014


29th June, 2013 at GNIPST auditorium. The programme was

inaugurated by Prof . Asit Guha, Director of JIS Group, Mr.

U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit

Sengupta, Director cum Principal of GNIPST with lamp

lighting. The programme started with an opening song

performed by the B.Pharm students of this institute. The

seminar consists of a series of lectures, video presentations and

poster session. On the pre lunch session 4 lectures were given

by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms.

Swati Nandy and Ms. Tamalika Chakraborty respectively. On

their presentation the speakers enlighten the recent

development of Pharmacy, Genetics and Microbiology and theircorrelation with Life Sciences. On the post lunch session, Ms.

Saini Setua and Ms. Sanchari Bhattacharjee explained the

recent development and career opportunities in Biotechnology

and Hospital Management. The programme was concluded

with valedictory session and certificate distribution.

About 50 Higher secondary school teachers from different

schools of Kolkata and North& South 24 Parganas district ofWest Bengal participated in this programme. A good interactive

session between participants and speakers was observed in the

seminar. The seminar was a great success with the effort of

faculties, staffs and students of our Institute. It was a unique

discussion platform for school teachers and professional of the

emerging and newer branches of Life Science.

The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15th June, 2012. The program started

with a nice presentation by Dr. Pulok Kr. Mukherjee, School of

Natural Products, JU on the skill to write a good manuscript for

16

16


18/18

06-06-2014


publication in impact journals. It was followed by nearly two

hour long discussion among more than thirty participants on

different aspects of pharmacy education. Five nonmember

participants applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for

conducting the two years post graduate course (M.Pharm) in

P H A R M A C O L O G Y .The approved number of seat is 18.The number of seats in B.Pharm. has been increased from 60 to

120.

AICTE has sanctioned a release of grant under Research

Promotion Scheme (RPS) during the financial year 2012-13to

GNIPST as per the details below:

a. Beneficiary Institution: Guru Nanak Institution of

Pharmaceutical Science & Technology.

b.Principal Investigator:Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 yearse. Title of the project: Screening and identification of

potential medicinal plant of Purulia & Bankura districts of

West Bengal with respect to diseases such as diabetes,

rheumatism, Jaundice, hypertension and developing

biotechnological tools for enhancing bioactive molecules in

these plants.

17

Documents

Gnipst Bulletin 34.2