Healthy Aging: Role of Soy Protein - Nutra India · PDF fileAmitabh Bachchan Born 1942 Madhuri Dixit ... Data summarized from studies using soy protein isolate to dairy protein Adapted

Healthy Aging: Role of Soy Protein Suresh Itapu, Ph.D.

Consulting Scientist – DuPont Nutrition & Health Copyright © 2012 Solae, LLC. All rights reserved.

Solae™ and the Solae logo are trademarks of Solae, LLC.

© Datamonitor and Solae, 2010

Developing a lifestyle of good behaviors

… nutrition, exercise, preventative healthcare, etc.

that will enable consumers age 40+ to

enjoy full health and vitality

while extending life expectancy and quality of life

What Is the Healthy Living Segment?

New opportunities are developing as a consequence of our aging society.

Awareness of the aging process begins to impact consumer mindset

around 40, and adapts based on health state going forward.

Healthy Aging: A Hot Topic In Today’s Media

April 25, 2011 February 10, 2010

Healthy Living

A Large and Rapidly Growing Market Segment: Nearly 769 Million Consumers Over the Age of 65 by 2020

North America 61,558,900, +36.2%

Latin America 57,165,000, +42.8%

Mid East & Africa 61,543,600, +42.0%

Western Europe 93,655,800, +18.6%

Eastern Europe 52,950,300, +14.6%

Asia Pacific 437,558,800 , +52.1%

Australasia 4,991,100, +39.4%

2020 Projected Population >65 Years of Age

% Change 2010-20

Source: Euromonitor, 2012

Copyright © 2012 Solae, LLC. All rights reserved.


Who Represents the “Aging” Segments?

40-50’s

Milind Soman

Born 1965

50-60’s

Shashi Tharoor

Born 1956

60-70’s

Sunil Gavaskar

Born 1949

70-80’s

Amitabh Bachchan

Born 1942

Madhuri Dixit

Born 1967 Hema Malini

Born 1948

100+

Fauja Singh

Born 1911

Healthy Living

How is the Aging Opportunity Impacting

the Food Industry?



Healthy Living

Market Analysts See Opportunities For Food

Marketers Across The Aging Spectrum

“FORTY IS THE

NEW TWENTY” “SENIORS DRAW

ATTENTION”

• Consumers’ desire to hold

onto youth, maintain an

active, vibrant lifestyle, &

defy the aging process is

creating demand for

products that speak to their

mental, not physical, age.

• Growing number of seniors

is creating demand for

targeted nutritional products,

products with adapted taste,

texture, packaging.

2 of the Top 10 Trends Shaping the Future

of the Food and Beverage Industry

Source: Innova Market Insights, 2012



Healthy Living

How Food Marketers Are Positioning Today to

Capitalize on The Aging Opportunity

“FORTY IS THE

NEW TWENTY” “SENIORS DRAW

ATTENTION”

Example positioning for health maintenance –

bone, eye; energy, anti-aging, mental sharpness

Example positioning for more serious & multiple health

issues, joint health, calorie/nutrient density, easy-open

packaging

Source: Innova Market Insights, 2012



http://www.innovadatabase.com/search/displayimage.rails?productId=1130912&type=large&guid=E61B8247-3BFC-4F58-B4DD-AC2E3C3522BC

Healthy Living

Consumer Perception of Protein Needs as They Age

Q: We would like to know more about your attitudes toward

proteins. How much do you agree with each of the following

statements . . .

47%

87%

73%

57%

40%

55%

66%

69%

42%

75%

• India, China, Brazil,

South Korea –

indicate higher levels

of agreement >70%

(top-2 box).

• North America and

Western European

countries indicate

lower agreement,

overall.

• Across all markets,

consumer education

on this issue will be

key to product

success.

Source: Solae’s Global Healthy

Aging Consumer Survey, 2011



Healthy Living

The Market Opportunity

• Population trends indicate that the aging market is growing in

numbers and influence and will be a key force in shaping

future opportunities in the health and wellness market.

• Targeting & positioning will be challenge, as the market

represents very diverse needs, niches and interests.

• The market for protein enhanced foods and beverages

targeting aging populations is one analysts predict is well

positioned for future growth.



Healthy Living HEALTHY LIVING

• Soy Protein Opportunities for

the Aging Population Copyright © 2012 Solae, LLC. All rights reserved.


Healthy Living

World Health Organization Report (2002) Active Aging: A Policy Framework. WHO/NMH/NPH/02.8

Realities of Aging

Functional capacity increases in childhood, peaks in early adulthood and then declines

Rate of decline is determined by lifestyle (diet, physical activity, smoking), external and environmental factors

The acceleration in decline can be influenced, even reversed, at any age

In the realities of aging, one must consider that older people are not

a homogeneous group, individual diversity tends to increase with

age and one’s health choices are important at all stages of life.



Healthy Living

Theories of Aging

Native Protein &

DNA

Damaged Protein &

DNA

↑ROS

Antioxidant

X Oxidative

Stress

Oxidative Status of Older Cells 3 molecular mechanisms

An increase in oxidative stress

A decreased resistance to DNA

damage and/or ability to repair

damaged DNA

A decreased resistance to

prevent protein damage

↑ X

Ryan-Borchers et al. (2006) compared

consumption of (2 X353 ml/day) soy milk

or cow’s milk in post-menopausal women

over 16 weeks

↓ 8-deoxy-

guanosine

Soymilk

Ames et al. (2010) J Nucleic Acids 2010: 1-10 Ryan-Borchers et al. (2006) AJCN 83(5): 1118-25



Metabolic syndrome is rapidly

becoming a major global health

problem.

Soy protein could play a role in effective lifestyle intervention.

Metabolic Syndrome



Healthy Living

Metabolic Syndrome – A Vicious Cycle Adapted from Gong Z et al. (2012) Int J Endocrinol. 2012:1-13 discovermagazine.com/2007/feb/visceral-fat

Aging Chronic

Inflammation

Visceral

Fat

There’s a link between aging, accumulation of visceral fat,

inflammation and development of metabolic syndrome.

Metabolic Syndrome

Obesity

Hypertension

Cardiovascular Disease

Insulin Resistance

Type II Diabetes

Visceral fat increases with age

Increased visceral fat induces inflammation

Chronic inflammation accelerates aging process

Visceral or “intra-abdominal” fat, is thought to be the primary fat depot

related to obesity co-morbidities



Healthy Living

Metabolic Syndrome & Soy Protein (SP)

Consumption

Obese, postmenopausal, women

Casein (n=16) vs soy (n=17)

20g protein/day in shakes

No weight loss or gain was noted (no change in BMI)

SP induced a significant reduction in total and abdominal fat after 3 months

Sites CK et al. (2007) Fertil Steril 88: 1609-1617

Assessed by CT Scan

Soy protein decreases abdominal fat.



Healthy Living

Metabolic Syndrome & Soy Protein (SP)

Consumption

Criteria Thresholds Soy Protein (SP) Impact vs Control Diets

Abdominal Obesity Men > 40 in (102 cm); Women > 35 in (88 cm)

SP can be useful in weight management programs1

Plasma Triglycerides (TG)

≥ 150 mg/dL (1.7 mM) SP consumption is associated with lower TGs2

HDL-Cholesterol (HDL-C)

Men < 40 mg/dL (1.03 mM); Women < 50 mg/dL (1.29 mM)

SP consumption maintains HDL-C levels2

Blood Pressure (BP) ≥ 130 / ≥ 85 mm Hg SP consumption is associated with lower BP3

Fasting Blood Glucose (FBG)

≥ 110 mg/dL SP consumption is associated with lower incidence of diabetes in

some populations4,5,6

1Cope MB et al. (2008) Obes Rev 9:219-235; 2Harland JI et al. in Soy: Nutrition, Consumption & Health, Nova Publishers, in press; 3Dong JY et al. (2011) Br J Nutr 106: 317-326; 4Villegas R et al. (2008) Am J Clin Nutr 87: 162-167; 5Nanri A et al. (2010) J Nutr 140: 580-586; 6Mueller NT et al. (2012) Eur J Nutr, doi 10.1007/s00394-011-0276-2



Heart Health

Heart Disease is the number one cause of death

globally.

In 2004, 7.2 million and 5.7 million people died

due to coronary heart disease and stroke,

respectively.

By 2030, it is projected that 23.6 million people

will die due to heart disease and stroke.

http://www.who.int/mediacentre/factsheets/fs317/en/index.html (2009)



http://www.who.int/mediacentre/factsheets/fs317/en/index.html

http://www.who.int/mediacentre/factsheets/fs317/en/index.html

Healthy Living

A Number of Meta-Analyses Confirm Cholesterol

Lowering Property of Soy Protein Anderson JW (1995) NEJM 333:276; Zhan S & Ho SC (2005) AJCN 81:397; Balk E et al. (2005) AHRQ Pub No 05-E024-2;

Reynolds K (2006) Am J Card 98:633; Harland JL & Haffner TA (2008) Atherosclerosis 200: 13; Anderson JW et al. (2011) J

Am Coll Nutr 30: 79-91; Harland JI et al. (2012) in Soy: Nutrition, Consumption & Health, Nova Publishers

13/29 (45%) 16/20 (80%) 33/50 (66%) 24/27 (89%) 18/30 (60%) 26/43 (61%) 16/27 (59%)

Studies using

Solae® soy

protein

Soy protein consumption is associated with lower cholesterol.



Healthy Living

Soy Protein Consumption and Blood Pressure

Consumption of soy

protein is associated

with a reduction in

Systolic and Diastolic

Blood Pressure (SBP &

DBP) when it replaces

carbohydrate or a non-

dairy protein in the diet

Studies show that soy

lowers BP similarly to

dairy protein so that

there is a more modest

or no net effect of soy

protein when compared

to dairy protein Data summarized from studies using soy protein isolate

Adapted from: Dong J-Y et al. (2011) Br J Nutr 106: 317-326

Soy protein consumption is associated with lower blood pressure.



Healthy Living

Soy Protein Consumption Reduces Progression of

Carotid Atherosclerosis in Postmenopausal

Women

Parallel design (3 years)

Postmenopausal women

25 g/protein: 2 x 12.5 g

protein as bar or

beverage:

Total milk protein

(Placebo) (N=163)

Soy protein (ISP)

(N=162)

Carotid intima-media

thickness (CIMT) every 6

months

Hodis HN et al. (2011) Stroke 42: 3168-3175

These data are the first

to show a direct effect of

soy protein consumption

on a physical measure of

blood vessel health and

provide support for the

heart health benefit of soy

protein. Copyright © 2012 Solae, LLC. All rights reserved.


Healthy Living

Soy Protein Diet Increases Skilled Forelimb

Reaching Function After Stroke in Rats

*

* * *

*p<0.04

Cheatwood JL et al. (2011) Behav Brain Res 216: 681-684

Improvement in stroke outcome, if translated to humans, could have a

significant impact on the quality of life post-stroke.

Male Long Evans hooded

rats

2 diet groups (21% PROT;

12% FAT):

Caseinate

Soy protein

While on diet rats trained to

reach for sugar pellet until

consistent success

achieved

Surgical stroke induced by

occluding middle cerebral

artery

Forelimb reaching

measured daily for 8 weeks



Muscle Loss and Sarcopenia

Nutritional intervention and exercise can

help alleviate muscle loss.

Soy protein can supply adequate amino

acids needed to maintain muscle.



Healthy Living

Muscle Loss and Sarcopenia

A complex, multi-factorial process facilitated by a more sedentary lifestyle and less than optimal diet

Involuntary muscle loss

After age 30, there is a 3-8% reduction in lean muscle mass per decade

Affects about 30% of individuals over 60 years of age and more than 50% of those over 80 years

Dietary derived amino acids are the primary source of muscle protein synthesis

Amount of dietary protein needed appears to be greater in the aging populations

Paddon-Jones D et al. (2009), Curr Opin Clin Nutr Metab Care, 12(1) 86-90 . Narici MV et al. (2010) Br Med Bull. 95:139-59



Healthy Living

Body weight decreases in 60% of the population after age 60-65.

Much of the weight loss is loss of muscle mass.

Changes in Body Weight over Lifespan

Adapted from Wittert GA: Obesity in older adults. In Geriatric Nutrition. CRC Press; 2007: 46-58 Adapted from Morley JE et al: Sarcopenia and cachexia. In Geriatric Nutrition. CRC Press; 2007: 59-68

Birth Adolescence Adulthood ‘Aging’

Ch

an

ges in

Weig

ht

Age-related

weight gain

Growth

spurt

Age-related

weight loss



Healthy Living

Sarcopenia – Muscle Loss, Fat Accretion

Muscle

(light

gray)

Fat

(dark

gray)

Roubenoff R et al. (2003) J of Gerontology, 58(11) 1012-1017, 2003

MRI images of a 25-yr old vs a 75-yr old (both healthy)



Healthy Living

Mechanism for Development of Sarcopenia

Healthy Skeletal Muscle

Anabolism (muscle

synthesis)

Catabolism (muscle

breakdown)

Physical Activity Insulin Resistance

Skeletal Muscle Atrophy

Inflammation Oxidative Stress (ROS)

Aging Process

Increased protein intake, along with exercise, is essential to

maintain or increase muscle mass in the sarcopenic elderly.

Adapted from Roubenoff R et al. (2000) J. Gerontol A Biol Med Sci. (12):M716-24. Jackman RW et al. (2004) Am J Physiol Cell Physiol 287:C834-C843

Protein Intake



Healthy Living

Effect of Protein Source on Exercise-Induced

Changes in Muscle Strength in Older Men

Baseline

12-week

New

ton

•se

c-1

New

ton

met

er•

sec-1

Men (age 51-69)

Replaced 50% of protein intake with soy (n=11) protein meat analog or beef (n=10) protein

Included resistance training over the 12-week study duration

Diet Diet

Assessment of Upper and Lower Body Muscle Strength

0

500

1000

1500

2000

2500

VEG BEEF 0

500

1000

1500

2000

2500

VEG BEEF

Knee Extension Arm Pull

Both diet groups showed increased muscle strength and cross-sectional area

Serum LDL, TC and HDL increased with beef-containing diet but not with soy

D ( POST – Baseline ) P value

CHOL ( mmol /L) VEG – 0.06 + 0. 7 0.160 BEEF – 0.30 + 0. 3

HDL - C ( mmol /L) VEG – 0 .10 + 0. 1 0.0 04 BEEF – 0 .08 + 0 . 1

LDL - C ( mmol /L) VEG – 0 .08 + 0. 6 0. 102 BEEF – 0 .3 0 + 0. 4

( POST – Baseline ) P value

CHOL ( mmol /L) VEG – 0.06 + 0. 7 0.160 BEEF – 0.30 + 0. 3

HDL - C ( mmol /L) VEG – 0 .10 + 0. 1 0.0 04 BEEF – 0 .08 + 0 . 1

LDL - C ( mmol /L) VEG – 0 .08 + 0. 6 0. 102 BEEF – 0 .3 0 + 0. 4

Adapted from Haub M, et al. (2005) Metab Clin Exp. 54:769-74



Clinical Nutrition Soy is a high quality protein.

Clinical data for soy protein in enteral

(tube feeding) nutrition is limited.

Soy/dairy blends are used in many

enteral products.



Healthy Living

Protein Energy Malnutrition (PEM) in the

Elderly Population

Nu

rsin

g H

om

e

Ho

spit

al

Co

mm

un

ity

Reh

abili

tati

on

50.5%

38.7%

13.8%

5.8%

Sample of elderly people from 12 countries by nourishment status. The prevalence of malnutrition was 22.8% overall with variability noted

between the settings above.

Kaiser MJ et al. (2010). J Am Geriatr Soc 2010, 58:1734-1738

Confirms that there is a persistent and significant incidence of

PEM in the elderly population. Copyright © 2012 Solae, LLC. All rights reserved.


Healthy Living

Mean Intake of Energy and Macronutrients, by

Age, Sex, and Race/Ethnicity: Protein

0

20

40

60

80

100

120

140

20-29 30-39 40-49 50-59 60-69 70-79 80+

Age, y

Gra

ms

of

Pro

tein

In

tak

e/D

ay

White Men

White Women

Black Men

Black Wome

Wakimoto P et al. (2001) J Gerontol A biol Sci Med Sci,56 Spec No 2; p 65-68

This may be an indication that protein adequacy is compromised

for a majority of older adults.



Healthy Living

Aging and Age-Associated Diseases and

Conditions

Protein Energy Malnutrition (also Vit D, Vit B12, Ca++)

Chronic Inflammation Immune Dysfunction (Immunosenescence)

Pro-inflammatory cytokines

• Cardiovascular Disease • Renal Disease • Osteoporosis • Arthritis • Metabolic syndrome/Type 2 Diabetes • Alzheimer’s disease/cognitive decline

• Frailty (sarcopenia, sarcodynia) • Body composition changes ( adipose, muscle)

• Susceptibility to infections • Response to vaccines • Cellular aging • Susceptibility to cancer • Chronic pain

Schiffrin EJ et al. (2010) MutRes 690: 50-56; Morley JE (2002) Curr Opin Gastroenterol 18: 240-245; Marik PE et al. (2010) JPEN 34: 378-386



Healthy Living

Reduced Gastrointestinal (GI) Symptoms in

Soy-Based vs Casein-Based Enteral Nutrition Espin NV G-T et al. (2010) Nutr Hosp 25: 606-612

Parallel design; tube

feeding (enteral)

Mean age = 79 yrs

14-28 days on enteral

nutrition

Casein-based tube

feed (N=24)

Soy-based tube

feed (N=26)

Formulations differed

only in protein source

Soy protein based enteral formula equally effective at restoring

nutritional status as casein-based formula.

*p<0.05



Healthy Living

Soy is a High Quality Protein - PDCAAS (Protein

Digestibility-Corrected Amino Acid Score)

Soy protein is a high

quality protein

Solae’s SUPRO ISP

(Isolated Soy Protein) has

a PDCAAS score of 1.00

SUPRO ISP is

comparable to high

quality animal proteins

(casein, egg white, beef)

ISP is the only widely

available high quality

plant-based protein

ISP is low in fat and

saturated fat and is both

lactose- and cholesterol-

free

PDCAAS is the globally recognized method for

determining protein quality based on amino

acid profile and digestibility

Hughes GJ et al. (2011) J Agric Food Chem. 59(23):12707-12

(ISP)



How to Translate the Opportunity and Science Into Foods and Beverages Consumers will Love

Applications for Soy Protein Targeting Aging Consumers



Healthy Living

Soy Protein Product Forms

• Example Applications:

– Powders:

• Beverages

• Liquid/Semi-Liquid Systems

• Nutrition Bars

• Bakery

• Extruded Systems

• Meat/Poultry

– Textured Flake

• Meat/Poultry

• Breakfast Cereal

– Extruded Crisp

• Nutrition Bars

• Breakfast Cereal

• Snack Mixes

• Toppings

Powders

Textured

Flake

Extruded Crisp



Healthy Living

Solae’s Broad Application Expertise

Solae maintains a library of concepts

targeting adults, demonstrating the

versatility and application depth of our

soy proteins.

Beverages:

Ready-to-Drink, Dry-Blended,

Spray-Dried, Acidic (i.e.,

Smoothies) & Neutral (Milk-

Type)

Nutrition Bars:

Baked, Extruded, Slab (Sheet & Cut) Snacks & More:

Extruded Snacks,

Snack Mixes &

Toppings, Crackers,

Cookies, Puddings,

Soups & More

Protein Supplements: Powders,

Chews & Novel Formats

Breakfast Cereal:

Hot/Cold, Extruded,

Flake, Granola Type



Healthy Living

Where Are the Strongest Opportunities for

Protein?

Market Predictions:

• New Formats for Protein Fortification Will Emerge:

Food and Beverage Forms Familiar to Target

• Protein Supplements Will Also Play a Key Role; New

Delivery Formats Will Emerge (i.e., Chews,

Gummies, Shots)

• Foods, Beverages, Supplements to Address Specific

Health Concerns & Conditions of Aging

• Taste, Texture, Nutrient Density Execution in

Formulation Will Play A Key Role In Market Success

• Products Targeting Specific Day-Parts, Particularly

Breakfast and Snacks

• Active lifestyle support – products addressing energy,

endurance and performance needs

• Positioning To Benefit & Mindset, Not Age Will

Enhance The Appeal of Brands

Supple-ments

Novel Formats

Condi-tion

Specific

Meal Occasions

Taste, Texture

Execution

Nutrient Density

Benefit Position-

ing Snacks

Breakfast Active

Lifestyle



Why Soy

Protein?

Protein Quality

Health Benefits

Economic Value

Perform-ance

Applica-tion

Versatility

Sustain-ability

To Execute on the Opportunity,

You’ll Need Proteins that Deliver . . .

• High-Quality, Plant-Based

• Unique Health Benefits

• Economic Value (Price, Supply Stability) vs. Dairy

• Excellent Flavor & Functional Performance

• Versatile Across Multiple Applications

• Sustainability – Requires less land, energy & natural resources to produce than animal-based proteins



Healthy Living

Summary

Soy protein has many health and nutrition

benefits for the aging population

Including soy protein in the diet as a high-

quality protein source helps aging adults:

• Improve Heart Health

• Intervene in the development of Metabolic

Syndrome

• Maintain muscle mass especially with resistance

training

• Benefit enteral nutrition



Healthy Living

Summary

• The future is bright for protein-enhanced foods and beverages targeting aging consumers:

• Spurred by market growth, emerging science, consumer awareness, ingredient technology

• Science suggests that protein needs increase with aging, and soy protein has unique benefits for aging consumers

• The diverse needs, interests and lifestyles of aging consumers will create opportunities to deliver the benefits of protein in many different food, beverage and supplement formats

• Solae can help further explore the opportunity:

• Consumer Insights, Concept Ideas, Marketing, Nutrition and Product Development Support



Healthy Living

Thank You

Documents

Healthy Aging: Role of Soy Protein - Nutra India · PDF fileAmitabh Bachchan Born 1942 Madhuri Dixit ... Data summarized from studies using soy protein isolate to dairy protein Adapted