HEMOSTAZHEMOSTAZ

Yard. Doç. Dr. Murat ÖRMENYard. Doç. Dr. Murat ÖRMEN

SUNUM PLANISUNUM PLANI

Hemostaza genel bakışHemostaza genel bakış Hemostatik sistemlerin bileşenleriHemostatik sistemlerin bileşenleri Primer hemostazPrimer hemostaz Sekonder hemostazSekonder hemostaz

Hemotaz, kanama,tromboz Hemotaz, kanama,tromboz animasyonanimasyon

Coagulation FactorsCoagulation Factors

Fibrinogen GroupFibrinogen GroupFactors I, V, VIII and XIIIFactors I, V, VIII and XIII

Prothrombin GroupProthrombin GroupFactors II, VII, IX and XFactors II, VII, IX and X

Contact GroupContact GroupFactors XI, XIIFactors XI, XIIPrekallikrein (Fletcher Prekallikrein (Fletcher Factor) Factor) High Molecular Weight High Molecular Weight KininogenKininogen (Fitzgerald Factor) (Fitzgerald Factor)

Thrombolytic Therapy

• t-PA• Streptokinase• Urokinase

• Anaphylaxis• GI Bleeding• Intracranial Hemorrhage

Anatomy of a PlateletAnatomy of a Platelet

Dense BodyADP SerotoninATP Calcium

Microtubular System

Glycogen

Exterior Coat(Glycocalyx)

Mitochondria

SurfaceConnecting System

CytosolFactor XIII

Alpha GranulesPF4 FibrinogenFactor V FibronectinFactor VIII R:ag Thromboglobulin

(vWF)

Plasma MembranePF3

Dense Tubular System

Platelet FunctionPlatelet Function

Aggregation

Coagulation

Shape Change Release

FibrinFormation

A

B

C

3 seconds

10 seconds

5 minutes

ADPRelease

Adhesion

PRİMER HEMOSTAZ