HEPATITIS C PATHWAY

Aviva Product

Not a Aviva Product

Indirect effect

Another molecule, mostly chemical compound

InhibitionDissociationPhosphorylation+pDephosphorylation-p

Nucleus

Pathway diagram below is compiled from data from the Kyote Encylopedia of Genes and GenomesKanehisa, M., Goto, S., Furumichi, M., Tanabe, M., and Hirakawa, M.; KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 38, D355-D360 (2010). Kanehisa, M., Goto, S., Hattori, M., Aoki-Kinoshita, K.F., Itoh, M., Kawashima, S., Katayama, T., Araki, M., and Hirakawa, M.; From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res. 34, D354-357 (2006). Kanehisa, M. and Goto, S.; KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27-30 (2000). © 2011 Aviva Systems Biology

Outside

Hepatocyte

NS3/4A

Endosome

E2

NS5A

NS5A

NS3Core

PIP3

Ca2+

ROS

miR-122

Hepatitis C virusE2

GAGs

Core

DNA

HCV genome RNA

+p+p

+p+p+p

+p

LDLRSR-B1

OCLN

Apoptosis

IFNβIL8

RNaseL

RIP1

DNADNADNA

NS3

2’-5’ oligo(A)

NS5A

Control of replication

Endocytosis

CD81CLDN

Translated HCV proteinsStructural proteins

Nonstructural proteins

CoreE1E2p7

NS2NS3

NS5A

F protein

NS5BNS4ANS4B

Control of translation

Cellproliferation

Controlof apoptosis

Core

Interferonstimulated genes

Steatosis

MA

PK signaling pathway

PPARsignalingpathway

Jak-STAT signaling pathw

ay

Toll-like receptorsignaling pathw

ay

RIG-I-like receptorsignaling pathway

IFNα/β

IFNAR1IFNAR2EGFR

Jak1/Tyk2

GRB2

P13KTRADD TRAF2

PDK1

Akt

NFkBIkB

SOS

Ras

Raf

Bad GSK3βp21

STAT1/2

LXRa

PA28y

RXRa PPARa RXRa

PP2A

PIAS1

SOCS3

p53

P38JNK

ERK1/2IKKyIKKaIKKβ

IRF9 STAT3ISG56

eIF3 eIF2a

IRF1 IkB

NFkB

RIG-I

PKR

IPS-1TRIF

TRAF3

2-5OAS

IRF3/7

TRAF6

TBK1IKKe

TLR3

TNFR

TNFaEGF