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The New ESC Guidelines:
HFrEF:
Devices & Interventions.
John GF ClelandImperial College
London
8:30am: 9.15-9.30
www.escardio.org/guidelines
ESC Guidelines on Heart Failure
• Professional (Expert) Guidelines– No patient involvement (yet)
• Evolved from 2012 Guideline– Discouraged from re-interpreting old evidence– Encouraged to respond to new evidence (trials or meta-/re-analyses)
• Interpret & Apply Results (Not a Textbook!)– Rather than long summaries
• Coordinated with Other ESC Guidelines
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www.escardio.org/guidelines
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New (Published) Landmark Trials Since 2012
BIOPACE not yet published
Echo-CRT
BLOCK-HFMortality
Inappropriate Activation
2013
www.escardio.org/guidelines
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New Published Meta-Analyses Since 2012
Only QRS duration predicts CRT prognostic benefit
Independent predictors of Benefit of CRT• Younger patients• Women• QRS Duration
• Not LVEF• Not Aetiology• Not QRS Morphology
www.escardio.org/guidelines
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20122016
The ‘Rise’ of Rhythm in Heart Failure
www.escardio.org/guidelines
Recommendations for implantable cardioverter-defibrillator in patients with heart failure
8
2012
www.escardio.org/guidelines
9
‘New’ Issues: >30% of ICD Implants are for Generator Exchange EHRA: units pa ~4,000 (32%) Italy, ~2,000 (27%) UK; ~20,000 (39%) Germany (includes CRT-D)
Of patients who required exchange 68% had received no ATP/shock of whom 11% received ATP/shock (FU ~30m) 24% of whom died anyway
ATP/Shock
Shock
www.escardio.org/guidelines
Recommendations for cardiac resynchronization therapy implantation in patients with heart failure
www.escardio.org/guidelines
QRS Duration / Morphology Debate
• Longer QRS Duration• Consistently associated with
benefit• Threshold 130-140ms• Planned trial inclusion criterion• Prospective subgroup analyses
• LBBB QRS Morphology• Most of the data is LBBB
But• Not used for inclusion• Mainly retrospective subgroup analyses• Most reports conflate RBBB/IVCD
• IVCD have shorter QRS
• RBBB more IHD; often sicker• LBBB is a surrogate for longer QRS,
DCM and less sick patients
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Is LBBB is just a surrogate for QRS duration?
www.escardio.org/guidelines
Conclusions: CRT13
QRS >150ms (+/- LBBB)(+/- AF)
NYHA III
LVEF <35%
QRS 120(130 if NYHA II)-150ms• Only LBBB• Only AF if NYHA III
NYHA II
LVEF <30%
2016• QRS >130ms• LVEF <35%• If SR - NYHA II-IV• If AF - NYHA III-IV
• Longer QRS Greater Benefit• Does QRS Morphology Matter?
2012
www.escardio.org/guidelines
Coronary Revascularization
• Two RCTs:- HEART-UK & STICH – both neutral
• If revascularization does not improve outcome – why do a coronary angiogram?
• Revascularization improved neither cardiac function nor HF symptoms• Neither the presence of viability, ischaemia nor angina identify those
who had a greater benefit from CABG on mortality.• CABG does improve angina
www.escardio.org/guidelines
Other Interventions
• Other Implantable Devices• Vagal Stimulation• Baroreceptor Stimulation• Cardiac Contractility Modulation• Circulatory Support
• Other Interventions• Valves• Ablation (AV / PV / Renal)• Transplantation• Ultrafiltration• Algisyl LVR• Other