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7/18/2019 Hipersensitivitas Dan Autoimunitas
http://slidepdf.com/reader/full/hipersensitivitas-dan-autoimunitas 1/22
immunesystem
Foreign molecules/antigen
Immuneresponse
HYPERSENSITIVITY
7/18/2019 Hipersensitivitas Dan Autoimunitas
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HYPERSENSITIVITY
Type I
Type IIType III
Type IV
humoral
--- cellular
7/18/2019 Hipersensitivitas Dan Autoimunitas
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TYPE I HYPERSENSITIVITAS
Phases:
• sensitization
• activation• effector
= anaphylactic reaction
= immediate hypersensitivity= IgEmediated hypersensitivity
7/18/2019 Hipersensitivitas Dan Autoimunitas
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TYPE I HYPERSENSITIVITY
Plasmacell
Y
Y
Y
Y
Y Y
Y
Y
Y
Y
Y
Y
degranulation
Mast cell
Re-
exposureFirstexposure
!istamine
leu"otrien
E#F$
%#F
etc
o
o
oo
oo
o
o
o
o
o
o
oo
oo oo
o
o
o
Specific IgE
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Anaphylactoid reaction
#omplement activation #&a
#'a(orphine) codein
*adioactve contrast
(ast cell degranulation
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TYPE II HYPERSENSITIVITY
= anti+odydependentcytoto,ic hypersensitivity
#omplement activation
Phagocytosis
"iller cell activity
Examples:
•Transfusion rx.•Rh Incompatibilit•!utoimun reaction
Y Y
Y
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TYPE III HYPERSENSITIVITY
= immunecomple,mediated hypersensitivity
Arthrus Reaction
$g -
$+
"omplement acti#ation$"%a& "'a
Inflamation
Tissue damage
.ocaldeposit
7/18/2019 Hipersensitivitas Dan Autoimunitas
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Serum Sickness
#irculatingimmune comple,
*E
phagocytosis
Tissue:(idne
)oints(in
damage
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TYPE IV HYPERSENSITIVITY
= cell mediated hypersensitivity
=delayed type hypersensitivity
T cell
cto(ines macrophage
Tissue
damage
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AUTOIMUNITY
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self tissue/antigen
SISTEM IMUN
X immune
response
self tissue/antigen
tolerance autoimmune
istem imun normal
mem+eda"an self dari nonself
Induksi toleransi :
ter0adi pada paparan se+elumnya
dengan $g yang sama
7/18/2019 Hipersensitivitas Dan Autoimunitas
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autoantibody
auto-reactive
T cell
AUTO
IMMUNITY
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self tissue/antigen
immune system
X immuneimmuneresponseresponse
self tissue/antigen
tolerance Autoimmunereaction
tissue damage
autoimmunedisease
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self tissue/antigen
immune system
X immuneresponse
self tissue/antigen
tolerance autoimmune
tissue damage
autoimmunedisease
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Supresi oleh sel T regulator
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PENYAKIT AUTOIMUN
Penya"it 1rave
Tiroiditis !ashimoto
I22(
Penya"it $ddison
Pemphigus vulgaris Pemphigoid +ulosa
(yasthenia gravis
$nemia pernisiosa
$I!$ ITP
dll3
$rtritis reumatoid
.upus eritematosussistemi" 4.E5
ORGAN SPESIFIK NON-ORGAN SPESIFIK
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AUTOANTIBODI ORGAN SPESIFIK
PENA!"T A#T$ANT"%EN
Penya"it 1rave
reseptor T! Tiroiditis !ashimoto tiroglo+ulin)
pero"sidase I22( sel pan"reas
Penya"it $ddison
sel "orte"s adrenal (yasthenia gravis reseptor asetil"holin $nemia pernisiosa sel parietal)
fa"tor intrinsi"
$I!$
eritrosit ITP
trom+osit dll3
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AUTOANTIBODI NON-ORGAN SPESIFIK
PENA!"T A#T$ANT"%EN $rtritis reumatoid imunoglo+ulin
.E 2%$) *%P) m
7/18/2019 Hipersensitivitas Dan Autoimunitas
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SLE
Penya"it autoimun nonorgan specific
6elainan pada +er+agai organ
Autoantibodi:antinuklearanti-ds&NA
lain-lain
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BERSIFAT SISTEMIK
'alar Rash&iscoid RashPhotosensitivity$ral #lcer
ArthritisSerositisRenal &isorderNeurologic &isorder
(ematologic &isorder"munologic &isorderANA