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Histology for PathologyMale Genital Tract
Theresa Kristopaitis, MDAssociate Professor
Director of Mechanisms of Human Disease
Kelli A. Hutchens, MD, FCAPAssistant Professor
Assistant Director of Mechanisms of Human Disease
Loyola Stritch School of Medicine
• Describe the pathway for sperm conduction through the genital ducts.• Testis
– On a cross section of testis identify seminiferous tubules and interstitial connective tissue.
– Name the two types of cells in the seminiferous tubules - spermatogenic (germ) and supporting (Sertoli cells).
– Explain the function of Sertoli cells.– On an H&E stained section, identify interstitial cells of Leydig and explain
their function.
• Prostate Gland– On a section of the prostate, identify prostate glands and stroma.– Identify corpora amylacea (prostatic secretions) and explain their
significance.– On a high power view of the prostate describe the epithelium that lines the
glands.• Penis
– On a cross section of the penis identify the corpora cavernosa, corpora spongiosum, urethra and epidermis.
Male Reproductive System Histology Objectives
I. Spermatozoa leave the seminiferous tubules via the tubuli recti
II. From the tubuli recti to the rete testis and efferent ductules which lead to the extratesticular ducts
III. Ductus epididymisIV. Ductus / Vas deferensV. Ejaculatory ducts of the
prostateVI. Urethra
Seminiferous Tubules
• Consist of germinal epithelium and basement membrane– Epithelium contains various stages of spermatogenic
cells and supporting cells = Sertoli Cells• Sertoli cells provide blood-testis barrier, secrete fructose,
androgen binding protein, anti-Mullerian hormone, inhibin, and activin
• Connective tissue in between tubules contains tubuli recti, vessels, and Leydig cells– Leydig / interstitial cells secrete testosterone
Seminiferous tubule
Germinal Epithelium
Sertoli Cell
Leydig cell
Prostate
Composed of branched tubuloalveolar glands
Lumens often contain prostatic secretions = corpora amylacea
High power view of gland with its simple columnar epithelium that is highly folded creating an irregular lumen.
Corpora amylacea
Full cross section image: University of Michigan Medical School Histology website
Penis
urethra
Corpora spongiosumCorpora Cavernosa
Corpora Cavernosa of the Penis