HISTOLOGY Using your basic HISTOLOGY .for UNDERSTANDING DISEASE 2 things to remember (teacher only) Thankfulness Success OBJECTIVE Review basic NORMAL histology as examples of how this acts as a FRAMEWORK for understanding the primary morphologic classifications of human diseases DEGENERATIVE INFLAMMATORY NEOPLASTIC E = mc 2 All diseases are alterations of normal histology How are diseases classified? Test Question #1 What are the 3 primary morphologic classifications of diseases? Genetic Collagen Degenerative Autoimmune Inflammatory Granulomatous Neoplastic Toxic Microbial Test Question #1 What are the 3 primary morphologic classifications of diseases? Genetic Collagen DegenerativeDegenerative Autoimmune InflammatoryInflammatory Granulomatous NeoplasticNeoplastic Toxic Microbial INFLAMMATION ACUTE CHRONIC Test Question #2 What are the 2 primary morphologic classifications of inflammation? Subacute Granulomatous Degenerative Necrotizing Acute Pyogenic Viral Dysplastic Chronic Test Question #2 What are the 2 primary morphologic classifications of inflammation? Subacute Granulomatous Degenerative Necrotizing AcuteAcute Pyogenic Viral Dysplastic ChronicChronic NEOPLASM BENIGNBENIGN (no infiltration) MALIGNANTMALIGNANT (infiltration) Test Question #3 What are the 2 primary morphologic classifications of neoplasms? Metastatic Dysplastic Lymphoma Primary Benign (non-inflitrative) Pyogenic Carcinoma Malignant (infiltrative) Sarcoma Test Question #3 What are the 2 primary morphologic classifications of neoplasms? Metastatic Dysplastic Lymphoma Primary Benign (non-inflitrative)Benign (non-inflitrative) Pyogenic Carcinoma Malignant (infiltrative)Malignant (infiltrative) Sarcoma DEGENERATION Degenerative diseases are generally characterized by loss of normal histologic structures, WITHOUT significant infiltration of inflammatory cells or proliferation of indigenous cells, such as degenerative osteoarthritis (aka, osteoarthritis, or atherosclerosis, and are processes which, historically, are often associated with aging, or hormonal involution or atrophy or hypoplasia, or slow buildup of substances whi eventually interfere with tissue function. Test Question #4 What are some primary processes associated with degeneration? Aging Atrophy Hypoplasia Infiltration Hyperplasia Hypertrophy Dysplasia Neoplasm Hormonal involution Test Question #4 What are some primary processes associated with degeneration? AgingAging AtrophyAtrophy HypoplasiaHypoplasia Infiltration Hyperplasia Hypertrophy Dysplasia Neoplasm Hormonal involutionHormonal involution How to answer Dr. Schneiders question What does all this mean? NORMAL histology Infiltration Infiltration of polys or monos Proliferation Proliferation of inherent cells Loss Loss of normal cells Review of Histo Lab Schedule URINARY LYMPH BLOOD/MARROW RESPIRATORY CARTILAGE/BONE ANGIOLOGY CNS SKIN A visual FEEL for the tissue is MUCH more important than remembering the names of all the cells CORTEX/MEDULLA GLOMERULI/TUBULES/VESSELS ARTERY GLOM TUB NORMAL ARCHITECTURE: EFFACED or NOT? SUBCAPSULAR sinus CELLULARITY, MEGAS, HETEROGENEITY Heterogeneity, Mat-RBC, Mat-WBC, LYM, PLAS, BLASTS, Fe, METS? BRONCH, ALVEOLI, VESSELS BONE, CARTILAGE, MARROW V.A.N. V.A. MYOCARDIUM CNS= NEURONS + GLIA + VESSELS SKIN