1
needs of prisoners and at avoiding giving spurious labels to large numbers of "normal" criminals. Criminality and substance misuse were recorded independently and the diagnosis of personality disorder reserved for those with other evidence of disordered functioning. We did not find the subcategories in the ICD (ninth revision) useful in describing inmates with personality disorder as most of the inmates (over 80%) showed pronounced features of two or more subcategories. Axis II of DSM-III-R suffers from a similar problem, assigning several labels to one patient. This phenomenon has been called comorbidity but can best be regarded as reflecting the unsatisfactory state of existing classifications of personality disorder. Despair over the diagnosis of personality dis- order has led some professionals to reject the diagnosis' and others to reject patients who have been given the diagnosis. We adopted Lewis's view that the diagnosis is problematic but indis- pensable in referring to a group of patients who show profound psychiatric disturbance but do not fit readily into other categories of mental illness.4 The inmates we identified stood out from their peers by virtue of their mental state or behaviour. Usually the interviewee, other inmates, prison officers, and doctors shared our view that their personality problems were of a nature and severity that warranted psychiatric attention. More time or information may have yielded more cases, but we would claim a degree of face validity. A comprehensive psychiatric service for prisoners would have to take these inmates into account. Deciding which diagnosis is primary depends on the purpose for which the question is asked. Our criterion in compiling table II was the provision of services: which problem would dictate the immediate management of the patient? It repre- sents an oversimplification of the reality of psychiatric practice. A MADEN Department of Forensic Psychiatry, Institute of Psychiatry, Loindon SE5 8AF I Guze SB. Criminalliv and psychiatric disorders. New York: Oxford University Press, 1976. 2 1)ell S, Robertson G. Sentenced io hospital: offenders in Broadmoor. Oxford: Oxtord University Press, 1988. (Maudslev monograph No 32.) 3 Lewis G, Appleby L. Personality disorder: the patients psy- chiatrists dislike. Brj Psych 1988;153:44-9. 4 Lewis A. Psychopathic personality: a most elusive category. PsycholMfed 1974;4:133-40. HIV and discrimination SIR,-Although there is much emphasis on the discrimination carried out by the United States with the travel restrictions on foreigners with HIV infection,' very little is officially known on the discrimination carried out by health workers against people with HIV infection either in or outside of the United States. In Italy we conducted a prospective study to evaluate this phenomenon. A coded questionnaire was distributed to all outpatients and inpatients of the AIDS unit of our institution. Informed consent had been obtained and questionnaires were anonymous. Between 30 May and 7 August 1991, 86 subjects filled in the questionnaire. Sixty three used intravenous drugs (48 men and 15 women), 11 were heterosexuals (five men and six women), nine were homosexual men, and three were men without known risk factors for HIV infection. Among these persons, 84 were HIV positive; the two others were HIV negative but at high risk of HIV infection. Of the 34 reporting episodes of discrimination by health workers in public or private Italian institutions, eight reported more than one episode. Twenty three of the 42 episodes involved dentists; seven involved surgeons; six involved internists; four involved other specialists; and one involved a general practitioner. It must be emphasised, however, that some persons reported the opposite -for example, that general practitioners took care of them in a more heedful way than previously. Different kinds of episodes of discrimination were reported, but particularly common was the refusal to give the requested health service (37 episodes). If these findings are confirmed in other prospective studies the health authorities should consider intervening with practitioners who are not follow- ing the ethical rules of their profession. UMBERTO TIRELLI VINCENZO ACCURSO MICHELE SPINA EMANUELA VACCHER AIDS Unit, Centro di Riferimento Oncologico, 33081 Aviano, Italy Delamothe T. America worries about contagion. BMJ 1991302: 1418. (15 June.) General practitioners' access to x ray services SIR,-Dr N E Early states, "It might be pertinent to ask radiologists how many referrals they reject (as a proportion of the total) from junior hospital staff, consultant hospital staff, non-fundholding general practitioners, and fundholding general practitioners."' I do not have any figures for the number of referrals rejected but can assure him that general practitioners are not the only group of doctors being asked to reduce the number of requests for examinations. We have achieved a considerable reduction in the numbers of preoperative chest radiographic examinations and of contrast ex- aminations of the urinary tract that we perform. Hospital doctors as well as general practitioners are being asked to reduce their requests for x ray examinations. T S BROWN Bradford Royal Infirmary, Bradford, West Yorkshire BD9 6RJ I Early NE. General practitioners' access to x ray services. BM_ 1991;303:122. (13 July.) Complications of pregnancy and delivery and psychosis in adult life SIR,-Do obstetric complications constitute a risk factor for later schizophrenia? From the results of their national follow up study Dr D John Done and colleagues conclude that they do not.' Their study is impressive, with large numbers and elegant statistical analyses. But is their conclusion justified? Two aspects of the study give cause for concern: the statistical power and the clinical factors used to define risk. With an overall sample size of some 16000 the issue of statistical power might seem irrelevent. Yet, as the authors themselves hint, the final number of under 50 cases of schizophrenia may well be too small to test adequately the hypothesis in question. Obstetric complications in general probably confer in the order of a twofold increased risk of later schizophrenia.2 This is not a large effect in comparison with that of familial risk factors, for example. The analyses of the subgroup of patients with high risk showed that all the groups with psychosis, including schizophrenia, but not those with neurosis had an odds ratio of stillbirth or neonatal death of between 1-4 and 2 4. The wide confidence intervals on these figures testify to the small sample sizes and may well explain the inability to show a significant effect. The second problem is the choice of clinical variables used to define obstetric risk. A model that includes only one variable, the prescription of drugs, as indicating the condition of the baby must be interpreted with the greatest caution. Under- standing of neonatal physiology at that time was poor, and drug treatments were empirical-for instance, the main indication for treatment with nikethamide (Coramine) was impending death from any cause, and most babies dying in hospital would have received this as a last resort. It thus makes little sense to include this as an independent predictor of neonatal death. Increased rates of obstetric complications in the histories of patients with affective psychosis, as well as schizophrenia, compared with neurotic patients have been shown before.' One way in which the authors might examine further the issue of obstetric risk and later schizophrenia is to look for an inverse correlation between calculated risk and age at onset of the illness. Several previous studies have reported that obstetric complications predict an earlier onset, and if this can be shown not to be the case in the reported sample it will strengthen the authors' conclusions that no link between obstetric risk and later schizophrenia has been shown, SHON LEWIS Department of Psychiatry, Charing Cross and Westminster Medical School, London W6 8RP ANN STEWART Department in Paediatrics, University College and Mliddlesex School of Medicine, London V'C1 E 6JJ 1 Donc DJ, Johnstone EC, Frithi CI), Giolding J, Shepherd PM, Crow TJr. Complications of pregnancy and delivery its relation to psychosis in adult life: data from the British perinatal mortality survey sample. B.MJ 1991;302:1576-80. ( 29 June.: 2 Lewis SW. Congenital risk factors for schizophrenia. I'syvchol Mtd 1989;19:5-13. 3 Lewis SW, M\urray RMi. Obstetric complication, neurodevelop- mental deviance, and risk of schizophrenia. .7 Psvchiatr Res 1987;21:413-2 1. Child sexual abuse SIR,-Dr Brendan McCormack's editorial on sexual abuse and learning disabilities drew atten- tion to an important problem affecting the lives of children and adults who are unable to speak for themselves because of severe communication or cognitive impairments, or both.' The inadequate protection provided by current law is particularly worrying. There is one aspect of the author's discussion of diagnosis, however, that needs clarification. Dr McCormack emphasised the difficulty of recognising that sexual abuse is occurring and mentioned the presence of "sexualised behaviour, temper tantrums, and challenging behaviour" as pointers. Unfortunately, the latter two features are very common in conditions in the spectrum of autistic disorders; they arise from the characteristic severe impairments of understanding of social interaction and the rules governing social be- haviour. "Sexualised behaviour" in the form of masturbation in public is also frequently seen. If the author's recommendation that "such behaviour should always give rise to suspicion of abuse in an adult with learning disabilities" is adopted uncritically then this would involve a large pro- portion of people with autistic conditions. If it is assumed that the parents or other carers are at fault, this would add immeasurably to the stress of looking after those with communication problems and socially inappropriate behaviour. I have recent experience of three such cases in which parents were unjustly accused solely because of the behaviour of their autistic children-classic examples of the difficulty of proving a negative. Autistic children and adults are, of course, potentially vulnerable to all kinds of abuse. The 582 BMJ VOLUME 303 7 SEPTEMBER 1991

HIV and Discrimination

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  • needs of prisoners and at avoiding giving spuriouslabels to large numbers of "normal" criminals.Criminality and substance misuse were recordedindependently and the diagnosis of personalitydisorder reserved for those with other evidence ofdisordered functioning.We did not find the subcategories in the ICD

    (ninth revision) useful in describing inmates withpersonality disorder as most of the inmates (over80%) showed pronounced features of two or moresubcategories. Axis II of DSM-III-R suffers froma similar problem, assigning several labels toone patient. This phenomenon has been calledcomorbidity but can best be regarded as reflectingthe unsatisfactory state of existing classifications ofpersonality disorder.

    Despair over the diagnosis of personality dis-order has led some professionals to reject thediagnosis' and others to reject patients who havebeen given the diagnosis. We adopted Lewis'sview that the diagnosis is problematic but indis-pensable in referring to a group of patients whoshow profound psychiatric disturbance but do notfit readily into other categories of mental illness.4The inmates we identified stood out from theirpeers by virtue of their mental state or behaviour.Usually the interviewee, other inmates, prisonofficers, and doctors shared our view that theirpersonality problems were of a nature and severitythat warranted psychiatric attention. More time orinformation may have yielded more cases, butwe would claim a degree of face validity. Acomprehensive psychiatric service for prisonerswould have to take these inmates into account.

    Deciding which diagnosis is primary depends onthe purpose for which the question is asked. Ourcriterion in compiling table II was the provisionof services: which problem would dictate theimmediate management of the patient? It repre-sents an oversimplification of the reality ofpsychiatric practice.

    A MADENDepartment of Forensic Psychiatry,Institute of Psychiatry,Loindon SE5 8AF

    I Guze SB. Criminalliv and psychiatric disorders. New York: OxfordUniversity Press, 1976.

    2 1)ell S, Robertson G. Sentenced io hospital: offenders in Broadmoor.Oxford: Oxtord University Press, 1988. (Maudslev monographNo 32.)

    3 Lewis G, Appleby L. Personality disorder: the patients psy-chiatrists dislike. Brj Psych 1988;153:44-9.

    4 Lewis A. Psychopathic personality: a most elusive category.PsycholMfed 1974;4:133-40.

    HIV and discriminationSIR,-Although there is much emphasis on thediscrimination carried out by the United Stateswith the travel restrictions on foreigners with HIVinfection,' very little is officially known on thediscrimination carried out by health workersagainst people with HIV infection either in oroutside of the United States. In Italy we conducteda prospective study to evaluate this phenomenon.A coded questionnaire was distributed to all

    outpatients and inpatients of the AIDS unit of ourinstitution. Informed consent had been obtainedand questionnaires were anonymous. Between30 May and 7 August 1991, 86 subjects filled in thequestionnaire. Sixty three used intravenous drugs(48 men and 15 women), 11 were heterosexuals(five men and six women), nine were homosexualmen, and three were men without known riskfactors for HIV infection. Among these persons,84 were HIV positive; the two others were HIVnegative but at high risk of HIV infection. Of the34 reporting episodes of discrimination by healthworkers in public or private Italian institutions,eight reported more than one episode. Twentythree of the 42 episodes involved dentists; seveninvolved surgeons; six involved internists; four

    involved other specialists; and one involved ageneral practitioner. It must be emphasised,however, that some persons reported the opposite-for example, that general practitioners took careof them in a more heedful way than previously.Different kinds of episodes of discrimination werereported, but particularly common was the refusalto give the requested health service (37 episodes).If these findings are confirmed in other prospectivestudies the health authorities should considerintervening with practitioners who are not follow-ing the ethical rules of their profession.

    UMBERTO TIRELLIVINCENZO ACCURSO

    MICHELE SPINAEMANUELA VACCHER

    AIDS Unit,Centro di Riferimento Oncologico,33081 Aviano,Italy

    Delamothe T. America worries about contagion. BMJ 1991302:1418. (15 June.)

    General practitioners' access tox ray servicesSIR,-Dr N E Early states, "It might be pertinentto ask radiologists how many referrals they reject(as a proportion of the total) from junior hospitalstaff, consultant hospital staff, non-fundholdinggeneral practitioners, and fundholding generalpractitioners."'

    I do not have any figures for the number ofreferrals rejected but can assure him that generalpractitioners are not the only group of doctorsbeing asked to reduce the number of requestsfor examinations. We have achieved a considerablereduction in the numbers of preoperative chestradiographic examinations and of contrast ex-aminations of the urinary tract that we perform.Hospital doctors as well as general practitioners arebeing asked to reduce their requests for x rayexaminations.

    T S BROWNBradford Royal Infirmary,Bradford,West Yorkshire BD9 6RJ

    I Early NE. General practitioners' access to x ray services. BM_1991;303:122. (13 July.)

    Complications ofpregnancy anddelivery and psychosis in adultlifeSIR,-Do obstetric complications constitute a riskfactor for later schizophrenia? From the results oftheir national follow up study Dr D John Done andcolleagues conclude that they do not.' Their studyis impressive, with large numbers and elegantstatistical analyses. But is their conclusion justified?Two aspects of the study give cause for concern:

    the statistical power and the clinical factors used todefine risk. With an overall sample size of some16000 the issue of statistical power might seemirrelevent. Yet, as the authors themselves hint, thefinal number of under 50 cases of schizophreniamay well be too small to test adequately thehypothesis in question. Obstetric complications ingeneral probably confer in the order of a twofoldincreased risk of later schizophrenia.2 This is not alarge effect in comparison with that of familial riskfactors, for example. The analyses of the subgroupof patients with high risk showed that all thegroups with psychosis, including schizophrenia,but not those with neurosis had an odds ratio ofstillbirth or neonatal death of between 1-4 and 2 4.The wide confidence intervals on these figurestestify to the small sample sizes and may well

    explain the inability to show a significant effect.The second problem is the choice of clinical

    variables used to define obstetric risk. A model thatincludes only one variable, the prescription ofdrugs, as indicating the condition of the baby mustbe interpreted with the greatest caution. Under-standing of neonatal physiology at that time waspoor, and drug treatments were empirical-forinstance, the main indication for treatment withnikethamide (Coramine) was impending deathfrom any cause, and most babies dying in hospitalwould have received this as a last resort. It thusmakes little sense to include this as an independentpredictor of neonatal death.

    Increased rates of obstetric complications in thehistories of patients with affective psychosis, aswell as schizophrenia, compared with neuroticpatients have been shown before.' One way inwhich the authors might examine further the issueof obstetric risk and later schizophrenia is to lookfor an inverse correlation between calculated riskand age at onset of the illness. Several previousstudies have reported that obstetric complicationspredict an earlier onset, and if this can be shownnot to be the case in the reported sample it willstrengthen the authors' conclusions that no linkbetween obstetric risk and later schizophrenia hasbeen shown,

    SHON LEWISDepartment of Psychiatry,Charing Cross and Westminster Medical School,London W6 8RP

    ANN STEWARTDepartment in Paediatrics,University College and Mliddlesex School of Medicine,London V'C1E 6JJ

    1 Donc DJ, Johnstone EC, Frithi CI), Giolding J, Shepherd PM,Crow TJr. Complications of pregnancy and delivery its relationto psychosis in adult life: data from the British perinatalmortality survey sample. B.MJ 1991;302:1576-80. ( 29 June.:

    2 Lewis SW. Congenital risk factors for schizophrenia. I'syvcholMtd 1989;19:5-13.

    3 Lewis SW, M\urray RMi. Obstetric complication, neurodevelop-mental deviance, and risk of schizophrenia. .7 Psvchiatr Res1987;21:413-2 1.

    Child sexual abuseSIR,-Dr Brendan McCormack's editorial onsexual abuse and learning disabilities drew atten-tion to an important problem affecting the lives ofchildren and adults who are unable to speak forthemselves because of severe communication orcognitive impairments, or both.' The inadequateprotection provided by current law is particularlyworrying.

    There is one aspect of the author's discussion ofdiagnosis, however, that needs clarification.Dr McCormack emphasised the difficulty ofrecognising that sexual abuse is occurring andmentioned the presence of "sexualised behaviour,temper tantrums, and challenging behaviour" aspointers. Unfortunately, the latter two features arevery common in conditions in the spectrum ofautistic disorders; they arise from the characteristicsevere impairments of understanding of socialinteraction and the rules governing social be-haviour. "Sexualised behaviour" in the form ofmasturbation in public is also frequently seen. Ifthe author's recommendation that "such behaviourshould always give rise to suspicion of abuse inan adult with learning disabilities" is adopteduncritically then this would involve a large pro-portion of people with autistic conditions. If it isassumed that the parents or other carers are atfault, this would add immeasurably to the stress oflooking after those with communication problemsand socially inappropriate behaviour. I haverecent experience of three such cases in whichparents were unjustly accused solely because ofthe behaviour of their autistic children-classicexamples of the difficulty of proving a negative.

    Autistic children and adults are, of course,potentially vulnerable to all kinds of abuse. The

    582 BMJ VOLUME 303 7 SEPTEMBER 1991