ICON plc Global Organization

Calcutta

Bangalore

Mumbai

Delhi

Hyderabad

Chandigarh

Pune

Chennai

Vellore

Cochin

Mangalore

Bikaner

Jaipur

Karnal

Aligarh

Patiala

Ahmedabad

Nagpur

Indore

Bhopal

Trivandrum

Thrissur

Nashik

Lucknow

Manipal.

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Clinical Research in China Longer term opportunityTop investigators-5-10 years global experiencePatient pool/ Recruitment reliability (216 hospitals,53 different specialties for GCP certified clinical trials centers)Rapidly expanding pharmaceutical market ---5th largest by 2010, 2nd/3rd largest by 2020Huge CRO market potentialCost-competitive : 40% reduction Vs EU & USAGlobal trials accelerated China marketing registrationMore clinical trials for domestic NDAsLong timeline for CTA approval

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ICON plc Global Organization

ChairmanDr. John ClimaxICON Corporate DevPresidentBill TaaffeCEOPeter GrayCFOCiaran MurrayICON Development SolutionsPresidentDr Thomas Frey

Beacon BioscienceCEOTed Gastineau

ICON Central LaboratoriesPresidentBob Scott-EdwardsICON Contracting SolutionsTony SouthersSnr VPVP Corporate QAJo CoyleVP Global ITMike McGrathVP Process DevelopmentAlan MorganExec. VP Organisational Development Sean LeechVP Strategic HREimear KennyGroup Director Market DevelopmentSimon HolmesICON Clinical EUPresidentDr Peter SowoodICON Clinical USPresidentDr John HubbardICON Clinical ROW PresidentDr Dan Weng

ICON Clinical Research

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ICON Development SolutionsMedeval: Full Service Clinical Pharmacology Unit, Manchester, UKGloboMax: Strategic Product Development Consulting, Baltimore, USICON Consulting (YRCR): Regulatory Affairs Consulting, Early Phase Clinical Operations, Marlow, UK

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ICON Development Solutions

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Regulatory and Development StrategyProtocol DesignRegulatory Submissions and Agency MeetingsStudy/Program ExecutionEvaluation and Reporting

From compound selection through development to approval and beyond

Service Proposition

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Scientific Capability

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Strategy For Growth

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Beacon BioscienceCEODr Ted Gastineau



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Central Laboratory 2006 OverviewRevenue grew by +65%Europe: +93%USA:+62%Won 289 New studiesStrike rate:47%Repeat business:88%(31 New Clients)Backlog:~$100m(+26%)Customer Satisfaction:94% would use us again94% would recommend us to colleagues54% thought we were the best Central Laboratory33% thought we were as good as the othersHeadcount grew to 356

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Central Laboratory 2007 OutlookTarget Revenue growth:>20%Target margin:8-10% at year endExpanding Sales TeamOrganization growth tailored to demandExpanded use of Six Sigma and MetricsContinue to expand test menu/platformsFocus on Flow Cytometry and key biomarkers

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Central Laboratory 2007 OutlookKit output:~45,000 kits/month compared to ~25,000 in 2005Upgrading systems & processes to yield further efficienciesKit automation initiative underwayUpgrade to IT systems underwayLaunched new RDA systemDublin has expanded Laboratory & Support TeamsWill continue as new HQ comes on lineSingapore is on lineSample receipt/ReportingActively seeking partners in India & China

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Kits & Accessions - 2006

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ChallengesExtending our Global presenceSingapore, India, ChinaUpgrading our Affiliate activityAdding high caliber staffRetaining our distinctive style -A service business built around a Lab Producing high quality dataNoted for Responsiveness and FlexibilityFocused on Customer Delight!Keeping focused:Efficiency & Effectiveness with High Quality!

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Beacon BioscienceCEO Ted Gastineau



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What we doBeacon provides a Complete Solution for medical imaging based product development.

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A Complete SolutionDesignClinical Trial Design focused on imaging. Regulatory _________________________________________________________________ Implementthe imaging at hospitals _________________________________________________________________ Manageall digital images centrally from radiology department _________________________________________________________________ AnalyzeProvide centralized analysis of images quantitative, qualitative _________________________________________________________________ DeliverDevelops comprehensive digital databases for Sponsor and Agency

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We think differentlyImaging sees/measures structure and functionEach pixel represents a physiologic/metabolic characteristic. Images are spatially distributed data.

Foglio1

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23.750220160228.979244688334.208269216539.388748424144.774967323650.161186223156.166935880164.546782880372.926629880678.705834708486.130957071193.556079433898.4406633542100.528112138102.6155609218

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29.987138010335.616083512641.245029014845.861457831251.992038312558.122618793865.120079999372.651539730880.182999462383.669015814590.234192498896.7993691831101.2747854018101.938238116102.6016908302

32.495312905638.852438216145.209563526650.3969777856.529869943362.662762106569.694898540976.20228317782.70966781386.209554256792.582861340898.9561684249103.0686505803102.9738716211102.8790926619

Foglio2

Foglio3

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Information is a VerbInformation: verb active information derived from passive data using a new level of information analysis.

-Michael Dertouzous, M.I.T. 1998

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Therapeutic Growth (%Revenues)20052006

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Global RFP Value ($ Million) Medical Imaging 2005 and 2006

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New Awards and Backlog

Chart4

483941716503067

1394610921183260

1868537827696315

Net Business Awards

Backlog

Sheet1

Category2004200520062007

Net Business Awards$4,839,417$13,946,109$18,685,378$31,000,000

Backlog$16,503,067$21,183,260$27,696,315

Revenue$5,245,626$8,457,396$11,604,234$15,315,000

Growth %61%37%32%

EBITDA$417,577$1,184,759$1,698,126$2,589,001

Growth %184%43%52%

Staff Numbers89

Active Projects63

Active Sponsors33

* Four Months figures from Sept 04 (before which Beacon did not track)

FY 2006 -Therapeutic RevenuesTotal%

Cardiovascular$1,253,20711%

CNS$288,3842%

Diagnostic$848,4037%

Gastroenterology$64,6931%

Musculoskeletal$74,4941%

Oncology$8,994,01478%

Other$81,0391%

Grand Total$11,604,234100%

Sheet1

0

0

0

0

Net Business Awards

Sheet2

0

0

0

Backlog

Sheet3

0

0

0

0

Revenue

00

00

00

00

Revenue

EBITDA

0

0

0

0

0

0

0

Therapeutic Distribution 2006

0

0

0

0

0

0

0


00

00

00

Net Business Awards

Backlog

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Revenue and Margin

Chart1

5245626417577

84573961184759

116042341698126

Revenue

EBITDA

Sheet1

Category2004200520062007

Net Business Awards$4,839,417$13,946,109$18,685,378$31,000,000

Backlog$16,503,067$21,183,260$27,696,315

Revenue$5,245,626$8,457,396$11,604,234$15,315,000

Growth %61%37%32%

EBITDA$417,577$1,184,759$1,698,126$2,589,001

Growth %184%43%52%

Staff Numbers89

Active Projects63

Active Sponsors33

* Four Months figures from Sept 04 (before which Beacon did not track)

FY 2006 -Therapeutic RevenuesTotal%

Cardiovascular$1,253,20711%

CNS$288,3842%

Diagnostic$848,4037%

Gastroenterology$64,6931%

Musculoskeletal$74,4941%

Oncology$8,994,01478%

Other$81,0391%

Grand Total$11,604,234100%

Sheet1

0

0

0

0

Net Business Awards

Sheet2

0

0

0

Backlog

Sheet3

0

0

0

0

Revenue

00

00

00

00

Revenue

EBITDA

0

0

0

0

0

0

0


0

0

0

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0

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0


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Re-branding Beacon Bioscience to ICON Medical ImagingBeacon Bioscience will be re-branded to become ICON Medical ImagingThis reflects our further integration and our status as a core division of ICONWe are launching a year long campaign including mailers, meetings, and trade showsExcellent opportunity to re-tell our growth story, emphasize our size and differentiate the value proposal

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Beacon BioscienceCEO Ted Gastineau



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BPA / MCS Acquisition October 2002Two business segments BPA and MCS

BPAClinical Division with good Transplant, Oncology and Vaccine experienceBPA integrated into the US clinical division

MCS Focused on contract staffingNew service for ICONStand alone status

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BPA Post AcquisitionBPA was integrated into ICON and many of the personnel are still with ICON 4 years on

Added to the overall value of ICONCritical mass when required andTherapeutic expertise and experience

Success !!!!!!

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June 2005Tony Southers (Ex VP of BD-Europe) appointed Head of MCSIntroduced a Sales Team and a Client Service focusImproved / Updated processes & technologyUpgraded candidate package Developed growth strategyRe-aligned the group into ICON and improved operational leverageChange of name

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ICS Revenue HistoryMCS Re-launchPlan

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ICS Future Growth OpportunitiesGrowth within the US will continue35% growth next year (current NY location)Expand permanent placement capabilitiesWest Coast market exploration (build or buy)

Other opportunities within new marketsEurope (build or buy)Advantage of offering global coverageSame clients within US and EU

Further opportunities beyond EU would include the new emerging marketsSouth America & Asia

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ICON PLCQ&A Session

Increasing Regulation due to:The Number of Studies required to be performedStricter monitoring of complianceIncreasing safety studies

Amgen is 9.9% ClientQ3, 06 is to September 06

Q3, PY is to August 05

Change of Financial Year as at December 2005.YTD PY excludes one time charge of US$11.5m due to:Lease termination in USWrite-off of Lab Goodwill.Increasing Regulation due to:The Number of Studies required to be performedStricter monitoring of complianceIncreasing safety studies

Enabling Future GrowthFinancial Systems StrategyCurrent Systems built around a robust platform implemented in 1998Augmented by bespoke systems developed 2000-2004Issues of scalability will be experienced if target growth levels achievedOracle eBusiness Suite selected to provide Enterprise Financial and Project Accounting solution for ICONImplementation started July 2006, phased rollout starting Q3 2007

Process Improvements (Abridged)Single view of Project Based Financials (Revenue / Billing / Profitability) will enable better decision support within the businessSingle global chart of accounts will streamline accounting processesBetter solution for project billing will improve DSO managementImproved inter-company visibility will support our global tax modelAutomation of existing manual approvals processes (e.g. Travel Expenses / Supplier Invoices) will cut down administration time for project managersReduced overall cost/risk by phasing out bespoke systems

Whats in other??Book to BillReasons for increased salesReasons for backlog growing faster than awardsRevenue growth and margin improvement. Know percentagesRevenue and margin targetsGross revenue

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ICON plc Global Organization