ICTR Biostatistics Research Resource

Mary LindstromProfessor, Dept. of Biostatistics and Medical Informatics

Director, ICTR Biostatistics Research Resource

Resource Faculty and Staff20 UW Faculty Biostatisticians

8 UW Staff Biostatisticians

4 Marshfield Clinic Biostatisticians

ICTR Biostatistics Resource Faculty and Staff

Clinical Research• UW Faculty: AC Andrei, T Becker, K Buhr, R Chappell, T Cook, M Detry, NM Dowling, M Fisher, P Hutson, R Gangnon, M Lindstrom, M Palta, M Rosenberg, S Wang• UW Staff: J Barnet, M Evans, S Hetzel, Z Li, V Rajamanickam, S Seo• Marshfield Clinic: R Berg, P Chyou, H Liang

Statistical Genetics • UW Faculty: K Broman, S Keles, C Kendziorski, R Mau, M Newton, S Wang, B Yandell• UW Staff: A Andrei, A Broman• Marshfield Clinic: Z Ye

Areas of Expertise

Traditional Areas• Clinical Trials• Prospective Cohort Studies• Case Control Studies• Retrospective Studies• Pre-clinical StudiesSpecial Areas (growing, unique) • Statistical Genetics• Qualitative Outcomes• Cost and Policy Issues• Pharmacokinetics & Pharmacodynamics

Biostatistics Resource Activities

ConsultingCollaborative ResearchMethodology Research

TrainingProtocol & Pilot Project Review

26%

21%39%

14%

ICTR

Departments &centersCollaborative grants

Methodology grants

UW - Madison Resource Funding Model

13.8 FTEs devoted to ICTR Biostatistics

Leveraging UW ICTR Resources

Funding Source

ActivityICTR

(3.7 FTE)

Departments & Centers

(2.9 FTE)

Collab. Grants(5.4 FTE)

Method. Grants(1.9 FTE)

Consulting X X

Collaboration X X X X

Methodology X X

Review X

Marshfield Clinic Funding Model

Funding Source FTEs

Collaborative Projects 2.10

Institutional Support 0.10

ICTR 0.25

2.45 FTEs devoted to ICTR Biostatistics

Prioritizing Requests

UW - MadisonWhen we have a waiting list:• New investigators over established• Projects leading to proposals for

funding• One active project per investigator• Deadlines given priority• First come, first serve Long term management:• Departments, centers, and

investigators with substantial use are asked to provide direct funding.

All requests must:• come from ICTR Members• be related to clinical

and/or translational research

Marshfield Clinic• External, large grant

proposals• Internal proposals• Deadlines given priority

Units Using Resource

Madison • Pediatrics• Population Health

Sciences• Psychiatry• Radiology• Surgery

Other Schools• Agricultural and Life

Sciences• Education• Engineering• Human Ecology• Library and

Information Studies• Letters and Science• Nursing• Pharmacy• Veterinary Medicine

Other• Waisman Center• Center for Health

Enhancement Systems Studies

• Office of Continuing Professional Development in Medicine and Public Health

• Department of Veterans Affairs

MarshfieldMedical School• Anatomy• Anesthesiology• Dermatology• Family Medicine• Medical Physics• Medicine• Neurological Surgery• Neurology• Obstetrics and

Gynecology• Ophthalmology & Visual

Sciences• Orthopedics and

Rehabilitation• Pathology and

Laboratory Medicine• Pharmacology

• Cardiology• Dermatology• Division of

Education• Internal

Medicine• Neurology• Oncology• Pediatrics• Rheumatology• Sleep Lab• Surgery

Red indicates funding forindividual statisticians

ICTR Biostatistics 2009 Activity

UW - Madison Marshfield Clinic

407 Projects 79

275 Investigators 36

90 Collaborative Publications 10

28 Collaborative Grants 56

50 ProtocolsReviewed

59

88 Pilot ProjectsReviewed

The Future

• Upgrade the Activity Tracking System to follow:– the life cycle of grants, protocols, manuscripts,– the effect of training and collaboration on

investigator success.• Increase capacity for qualitative endpoints

collaboration.• Encourage junior Biostatistics faculty to compete for

ICTR pilot grants.• Improve interaction between UW and Marshfield

Clinic Biostatistics Research Resources.

Examples of Collaboration

Clinical Trials Wisconsin Network for Health Research (WiNHR) presented by Mary Lindstrom

Stat-Gen Statistical Genetics and Genomics Program presented by Christina Kendziorski

Wisconsin Network for HealthResearch (WiNHR)

•A statewide network of clinical sites to collaborate on trials of•Diagnostic, preventative and therapeutic interventions•Comparative effectiveness

•Expands capabilities of Wisconsin researchers•More studies done faster•Population of > 3 million

•Centralizes some aspects of the research•Data management• IRB approval process•Statistical analysis

•Each site has a PI and local research staff

WiNHR Sites

Marshfield Clinic

Gundersen Lutheran

UW-Madison

Aurora Health Care

WiNHR Studies

•Protocols • come from all participating sites• are funded independently

•Studies• 9 ongoing, 1 completed• 712 patients accrued• 8 different lead investigators• 9/10 studies use 3 or 4 sites.