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Inflammation and RepairInflammation and Repair

(Keeping your genes in the gene pool.)(Keeping your genes in the gene pool.)

The Shallow End of the Gene PoolThe Shallow End of the Gene Pool Grand Old TermsGrand Old Terms

TumorTumor RuborRubor CalorCalor DolorDolor Functio laesaFunctio laesa

Exudate and TransudateExudate and Transudate

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Vascularized TissueVascularized Tissue

The Invisible UniverseThe Invisible Universe

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The portal to the other side.The portal to the other side.

Allow Fluid to ExitAllow Fluid to Exit

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Sometimes the vessels are injured too.Sometimes the vessels are injured too. Warriors causing troubleWarriors causing trouble

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NeutrophilsNeutrophils

PMNs in tissuePMNs in tissue

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Red QueenRed Queen

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Mast Cells in OmentumMast Cells in Omentum(red blobs are fat cells)(red blobs are fat cells)

Though they are dead, yet they beckonThough they are dead, yet they beckon

ArachidonicArachidonic Acid Acid DerivativesDerivatives

ShortShort--livedlived Locally actingLocally acting CyclooxygenaseCyclooxygenase Moby DickMoby Dick

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Necrosis vs. ApoptosisNecrosis vs. Apoptosis

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Chronic Chronic inflamationinflamation Three aspectsThree aspects

Cell typeCell type DurationDuration FibrosisFibrosis

Abscess = acuteAbscess = acute Abscess = acuteAbscess = acute GranulomaGranuloma = chronic= chronic

Insoluble antigenInsoluble antigen Can’t destroyCan’t destroy Wall it offWall it off

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Clone your warriors on the battlefieldClone your warriors on the battlefield

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SignalingSignaling

Extracellular GoopExtracellular Goop

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Liver regeneration, human and rat.Liver regeneration, human and rat.

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Serous ExudateSerous Exudate

ExudateExudate Chemically may Chemically may

fool you and look fool you and look like a transudate.like a transudate. Paucity of cellsPaucity of cells Lower than Lower than

expected SPexpected SP At the site of At the site of

injury, because injury, because of injury.of injury.

Fibrinous ExudateFibrinous Exudate

Lots of proteinLots of protein Not just fibrinNot just fibrin No bugs, so no Ab No bugs, so no Ab g ,g ,

and C’and C’ Very few cellsVery few cells Still, it’s and exudateStill, it’s and exudate Site of injury, because Site of injury, because

of injuryof injury

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Suppurative or Purulent ExudateSuppurative or Purulent Exudate

PusPus BugsBugs HerterolysisHerterolysis Zit juiceZit juice Zit juiceZit juice AbscessAbscess

Rubor, Dolor, Tumor…Rubor, Dolor, Tumor…

Local ChangesLocal Changes

Vascular changesVascular changes HistamineHistamine

Nearly Local ChangesNearly Local Changes

Lymphatic Lymphatic drainagedrainage

LymphangitisLymphangitis LymphadenitisLymphadenitisy py p What does the What does the

‘itis’ tell us?‘itis’ tell us?

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Sedimentation RateSedimentation Rate

Rouleaux formationRouleaux formation Serum ProteinsSerum Proteins

C’ Reactive ProteinC’ Reactive Protein

Liver proteinLiver protein BloodBlood Aids complement Aids complement

binding tobinding tobinding to binding to damaged or damaged or foreign cells.foreign cells.

Rises quicklyRises quickly Follows ESRFollows ESR

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Wound DehiscenceWound Dehiscence

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