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* Mouse only
TRAF6TRAF6
TRAF6
EndocytosedTLR4
TLR7/8
TLR13
TLR9
ssRNA
Unmethylated CpG DNA
Unmethylated CpG DNA
dsRNA
TLR3
TRIFTRIF
TRAM RIP1
RIP1
23srRNA
TIRAP
Pro�lin
TLR12Homodimer
TLR11/12Heterodimer TRAF3
TRAF3
TRAF3
IKKεTBK-1
ProteasomalDegradation
Ubiquitin
Ubiquitin
RICK/RIP2
RICK/RIP2
Procaspase-1
Procaspase-1
Caspase-1
Pro IL-1βPro IL-18
IL-1β IL-18 In�ammationPyroptosis
NLRP3
TXNIP
TXNIP
Active State
TRX
TRX TXNIPTRX
ROS
Cathepsins
Crystalline Structures
Pannexin-1
P2X7
PAMPs NOX Enzymes
NOD1
NOD2
Ubiquitin
IKKβ
IKKβ
NF-κB
NF-κB
NF-κB
NF-κBActivation
MAPKActivation
NF-κB
NF-κB
NF-κB
IKKα
IKKβ
IKKγ/NEMO
IKKα
IKKα
AP-1 Activation
TBK1
TBK1
pol IIIViral DNA
Viral RNA
STING
IntracellularBacteria
Proin�ammatoryFactors
Cyclic Dinucleotides
NEMO
IRAK1 IRAK2
IRAK4
LPS
TIRAPMyD88
MyD88
MyD88
?
Lipopeptides
Flagella
TLR5
TLR10TLR2
TLR2
TLR1/6
CD14
CD14
TLR4/MD2
TRAF6
IRAK1 IRAK2
IRAK4IRAK1 IRAK2
IRAK4
TAB2/3
TAB2/3MuramylDipeptide
Endocytosed BacteriaDAMPsPore-forming toxinsCalcium In�ux?
γ-D-glutamyl-mesodiaminopimelic acid
TAK1
TAK1
TAB1
TAB1
TAB2/3
IRF7
ASC
AIM2
ASC
Foreign dsDNA
JAK1
JAK1
Tyk2
Tyk2
STAT1
STAT2
TRF9
ISGF3
IFNStimulatedGenes
Type 1 IFNs
IFNAR1IFNAR2
MAVS Aggregation
Dimerization
TRIM25
Riplet RNF135
K63 Polyubiquitination
Heterotetramer Formation
RIG-I
IRF7
Type 1IFNs
IRF3
IRF3
IRF3
IL-15RANTESCXCL10
IL-1βIL-6IL-10IL-16iNOSTNF-αGM-CSFMIP-1αMIP-1βMCP-1RANTES
TAK1
TAB1
c-JunJNK
p50p60
RelA
c-Fas AP-1
AP-1
AP-1
CREB
RAS
Dectin-1
DC-SIGN
Dectin-2
Mincle
β-glycan
SYK
FcγR
FcγR
α-Mannose,Cord Factor
High Mannose,α-Mannans
High Mannose,Fucose
SYK
SYK
RAF-1
NLRP3 Activation
CARD9
ROS
MALT1Bcl-10
ptd Ins (3, 4, 5) P3
ptd Ins (4, 5) P2
PKC
BTK
RAC
DAGRHO
p38
PKC
InsP3
PLCγ
PLCγ
PI3K
SYKLyn
Antigen
ITAM
IgG Antibodies
FcγRs
α subunit
γ2subunit
SOS
RAS
CGAS
Mda5
IPS-1
ERKJNK
ADCCPhagocytosisCytokine ReleaseOxidative Burst
Ca2+
Ca2+Export
CalcineurinNFAT
NFAT
CREB
p38/MAPK
ParasitesParasites
BacteriaBacteria
BacteriaBacteria
FungiFungi
BacteriaBacteria
VirusesViruses
VirusesViruses
NucleusNucleus
In�ammasomeFormationIn�ammasomeFormation
LysosomeLysosome
MitochondriaMitochondria
EndoplasmicReticulumEndoplasmicReticulumEndoplasmicReticulumReticulumEndoplasmicReticulumEndoplasmicReticulumEndoplasmicReticulumEndoplasmicReticulumEndoplasmicReticulumEndoplasmicReticulumEndoplasmicReticulum
©BioLegend, Inc. 2016
Innate Immune Signaling
biolegend.com
EndosomesEndosomes
Toll - Like Receptor LigandsToll - Like Receptor Ligands
TLR1 - Triacetylated lipopeptidesTLR2 - Glycolipids, lipopeptides, lipoproteinsTLR3 - Double-stranded RNATLR4 - Lipopolysaccharide, heat shock proteins, �brinogenTLR5 - FlagellinTLR6 - Diacyl lipopeptidesTLR7 - Single-stranded RNATLR8 - Single-stranded RNA (Human) Imidazoquinoline, poly T oligonucleotides (Mouse)
TLR9 - Unmethylated CpG DNA, haemozoinTLR10 - ? TLR11* - Flagellin, pro�linTLR12* - Pro�linTLR13* - 23s rRNA
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04-0069-00
US Headquarters:San Diego, CA 92121
Interactive Poster: biolegend.com/innate_signaling_posterWe would like to thank Dr. Glen N. Barber of the University of Miami Miller School of Medicine
for his contributions to this poster.
![treatment of autoinflammatory JAK1/2 inhibition with … · with SAVI (stimulator of IFN genes–associated [STING-associated] vasculopathy with onset in infancy), and 4 patients](https://img.pdfslide.net/doc/110x75/5b890aa47f8b9aa81a8b8339/treatment-of-autoinflammatory-jak12-inhibition-with-with-savi-stimulator-of.jpg)
