Upload
angelina-mcmahon
View
213
Download
0
Tags:
Embed Size (px)
Citation preview
Institut Pluridisciplinaire Hubert-CurienUMR 7178, UDS, CNRS-IN2P3
David Brasse
Biomedical Applications @ IN2P3
Nautilus Pompilius
Fundamental Research
Radiobiology: particle interaction / cellIn vitro ImagingCellular ImagingIn vivo Imaging
Bioinformatics
Therapy
Radio-ImmunotherapyHadrontherapy
Surgery
DiagnosisClinical Exam
Medical & Molecular ImagingContrast Agent
GDR MI2BInstruments and Methodsagainst Cancer
Modeling & Simulation (Geant4, Gate)Reconstruction Algorithms
Molecular Imaging should beAccurate, at an early stage,predictive.
Diagnosis Improve Spatial Resolution & Detection Efficiencyof Positron Emission Tomography (PET)
- Time Of Fly (TOF)- Dedicated Readout Electronics- Crystal/photodetectors coupling- Innovative Instrumentation (Sc-44 PET 3γ)- Reconstruction Algorithms
FORE + 2D OSEM 3D OSEM + TOF
LAPPD Project (Fermilab, UC)
020406080
100120140
0 10 20 30 40
Number of photoelectrons
Tim
ing
reso
lutio
n (p
s)
LPC Clermont, IMNC, CPPM, IPHC
Molecular Imaging should beAccurate, at an early stage,predictive.
Diagnosis
Development of new radiolabeled molecules for PET - Two Research and Production Sites (ARRONAX, IPHC) - Innovative Radionuclide for Nuclear Medicine
- Rb-82, Ge-68/Ga-68, Cu-64/67, Sc-44/47, Zr-89- Research in Radiochemistry
Tc-99m / Rb-82Tumor angiogenesis (FDG/Cu-DOTA)
Subatech, IPHC
Small Animal Imaging Platform: Sequential Approach
µCT µSPECT
Screening 2D (fused images)IPHC
Small Animal Imaging Platform: Combined Approach
+
XPAD (CPPM)ClearPET (EPFL)
=
RX TubeXPAD3camera
PET modules
CT PET+CT
Conventional CT / Spectral CT
CPPM
Small Animal Imaging: Awake…PixSic Project
Objectives:
Avoid the bias introduced by the anesthesia
Real time behavioral study
Multimodal Imaging approach
First Prototype
Implant test
IMNC, CPPM
Simulation Tools: GATE
To design:- Prototypes
To optimize:- Acquisition protocols- Reconstruction algorithms
To improve:- Quantification- Corrections
Courtesy of C Morel, CPPM
CEA/SHFJ Collaboration openGATE
Simulation is also used for Radiobiology:Geant4-DNA
« A major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis »L. Mullenders et al. (2009), Nature Reviews Cancer
Objective : to adapt the general purpose Geant4 Monte Carlo toolkit for the simulation of interactions of radiation with biological systems at the cellular and DNA level (« microdosimetry »)
Example: single cell irradiation by 3 MeV alpha particles in a high resolution cellularPhantom.
Collaboration Geant4-DNA
Validation by Experimental Facilities
CENBG, LPC Clermont
Hadrontherapy
Objective: Optimize the Treatment Planning System (TPS) for Carbon
Detector
Dose Measurement
Dose Control
Beam Control
Imaging System
Dose Calculation
Simulations
TPS
Physical Data& Model
Biological Data& Model
Photon Carbon
ETOILE, ARCHADE, ENVISION (FP7)LPC Caen, LPC Clermont, IPNL, IMNC, IPHC, CPPM
Isotope for Therapy
Principle of Radio-Immunotherapy: - (1) Specific recognition of cancer cells (eg monoclonal Ab’s, Ab-fragments, peptides) + (2) Chelate/Linker (derivatives of DTPA, DOTA) + (3) Effective killing
β-: Cu-67, Sc-47
α: At-211
Applications for Alpha-Immunotherapy: - Monocellular cancers (eg Leukemia) - Micrometastatic disease - Minimal residual disease after chemotherapy - Residual tumor tissue after tumor resection
(1) (2) (3)
Cluster of cells
Individual cell
ARRONAX, Subatech
Per-Operative Systems
Sentinel Lymph Node Biopsy
Optical and β Detection+
Excision Tool
1- To check the radioactivity distributionbefore the surgery (γ camera)2- To localize the SLNs during the surgery(γ probe + γ camera)3- To check the removal of all SLN after the surgery(γ camera)
Mainly dedicated to glioma radioguided surgery.Objective: Localization and excision of brain tumors during surgery
Brain Tumors
IPHC, IMNC
Conclusions
Thank you for your attention
LPC ClermontLPC CaenLAL OrsayIPNL LyonIMNC OrsayCENBG BordeauxIPHC StrasbourgCPPM MarseilleSubatech NantesLPSC GrenobleCSNSM Orsay
- An increasing number of IN2P3 laboratories are involved in Biomedical Applications
- Mainly devoted against cancer- From fundamental researches to
therapeutic approaches- Involved in European and International
collaborations- PI Geant4-DNA- PI openGate- …