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IRS-1 IRS-2 Pdk-1 Akt2 GLUT-4 p85 p11 0 PIP 3 PIP 2 p 1 1 0 Facilitat ed Glucose Transport Insul in Insulin Receptor GSK3α Glycogen Synthesi s Pfkfb2 Acly Glycolys is Fatty Acid Synthesi s Schenk Lab / Jerry Cheng / 3.3.15 PI3- Kinase P TBC1D4 Ser2 1 PH PH GSK3β Ser9 Thr30 8 PH PH Ser45 5 Ser46 6 SH2 GA Thr64 2 Ser47 3 P

Insulin Signaling Pathway

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Page 1: Insulin Signaling Pathway

IRS-1 IRS-2

Pdk-1 Akt2

GLUT-4

p85

p110

PIP3

PIP2

p110

Facilitated Glucose TransportInsuli

n

Insulin Receptor

GSK3α

Glycogen Synthesis

Pfkfb2

Acly

Glycolysis

Fatty Acid Synthesis

Schenk Lab / Jerry Cheng / 3.3.15

PI3-Kinase

P

TBC1D4

Ser21

PH

PH

GSK3βSer9

Thr308

PH

PH

Ser455

Ser466

SH2

GA

Thr642

Ser473

P

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