IRS-1 IRS-2
Pdk-1 Akt2
GLUT-4
p85
p110
PIP3
PIP2
p110
Facilitated Glucose TransportInsuli
n
Insulin Receptor
GSK3α
Glycogen Synthesis
Pfkfb2
Acly
Glycolysis
Fatty Acid Synthesis
Schenk Lab / Jerry Cheng / 3.3.15
PI3-Kinase
P
TBC1D4
Ser21
PH
PH
GSK3βSer9
Thr308
PH
PH
Ser455
Ser466
SH2
GA
Thr642
Ser473
P