interaksiSSS2011

8/2/2019 interaksiSSS2011

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1. Intranasal Mometasone

Adult Dosing & Uses

Dosing Forms & Strengths

nasal spray suspension

50mcg/spray

Allergic Rhinitis

Indicated for treatment of nasal symptoms of allergic rhinitis

2 sprays (100 mcg) in each nostril qDay

Seasonal Allergic Rhinitis

Indicated for treatment of nasal congestion associated with seasonal allergic rhinitis;

also indicated for prophylaxis of seasonal allergic rhinitis

Treatment: 2 sprays (100 mcg) in each nostril qDay

Prophylaxis: 2 sprays (100 mcg) in each nostril qDay; initiate 2-4 weeks prior to allergy

season

Nasal Polyps

2 sprays (100 mcg) in each nostril BID; qDay dosing may be effective in some patients

Pharmacology

Minimal systemic absorption occurs, mostly by small amount swallowed during nasal

administration

Bioavailability:


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2. Chlorpheniramine

Adult Dosing & Uses


tablet

4mg

8mg

12mg

Allergic Rhinitis

Tablets or syrup: 4 mg q4-6hr; not to exceed 24 mg/24 hours

Extended-release tablets: 8 mg q8-12hr or 12 mg q12hr; not to exceed 24 mg/24 hours

Extended-release capsules: 12 mg PO qDay; not to exceed 24 mg/24 hours

Sustained-release capsules: 8-12 mg q12hr, up to 16-24 mg/day

Additional Information

See also combo with hydrocodone (Tussionex)

Other Indications & Uses

Perennial & seasonal allergic & vasomotor rhinitis, relief of symptoms from colds,

urticaria, angioedema, anaphylactic reactions, pruritus, allergic conjunctivitis

Pharmacology

Half-Life: 12-43 hr

Duration: 24 hr

Onset: 6 hr

Peak Plasma Time: 2-6 hr

Protein Bound: 69-72%

Vd: 2.5-3.2 L/kg

Metabolism: GI mucosa, liver


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Metabolites: monodesmethylchlorpheniramine, didesmethylchlorpheniramine

Excretion: urine

Sedative effect: low

Antihistamine activity: moderate

Anticholinergic acitivity: moderate

Mechanism of Action

Histamine H1-receptor antagonist

3. Pseudoephedrine (Sudafed) = Decongestant

Adult Dosing & Uses


tablet

15mg

30mg

60mg

120mg

syrup, Peds

3mg/mL

Nasal Congestion

60 mg PO q6hr PRN

Time release: 120 mg PO BID

Priapism (Off-label)

60-120 mg PO

See Also Combos

with fexofenadine

with desloratadine

with loratadine


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Other Indications & Uses

Eustachian tube congestion

Off-label: low-flow priapism

Pharmacology

Absorption: minimal systemic

Half-Life: 5-8 hr

Onset: 30 min

Duration

60 mg: 4-6 hr

120 mg: 12 hr

Peak Plasma

Time: 1.97 hr

Concentration: 422 ng/mL

Other Information

Metabolism: liver, by N-demethylation

Metabolites: inactive

Clearance: 7.3-7.6 mL/min/kg

Excretion: urine

Mechanism of Action

Alpha adrenergic agonist

4. Paracetamol (Acetaminophen)

Adult Dosing & Uses


(tablet)


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325mg

500mg

(capsule)

500 mg

(caplet, extended-release)

650 mg

(tablet, chewable)

80mg

160mg

(tablet, oral-disintegrating)

80mg

160mg

(oral solution/suspension)

160mg/5mL

(suppository rectal)

120 mg

325 mg

650 mg

Analgesia & Fever

Immediate-release: 325-650 mg PO/PR q4hr PRN, or 500 mg PO q8hr PRN

Extended-release: 2 capsules (1300 mg) PO q8hr PRN

Maximum dose

Acetaminophen containing products: Not to exceed a cumulative dose of

4 g/day of acetaminophen

Tylenol Extra-Strength (ie, 500 mg/tab or cap): Not to exceed 3 g/day (6

tabs or caps)

See Also Combo

Acetaminophen Combos

Acetaminophen & NSAIDs


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Renal Impairment

CrCl 10-50 mL/min: give q6hr

CrCl


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Documents

interaksiSSS2011