Interdisciplinary Biomedical

Engineering Researchat the

University of Florida

College of Engineering at a Glance

• 275 faculty, 4600 undergraduate students, 1900 graduate students

• 900 BS, 600 MS, 140 PhD per year

• $90M research expenditures

• 11 academic departments

• Engineering in biology and medicine

• New Department of Biomedical Engineering – July 2002

Evolution into

EpilepsyResearchers from the College of Engineering, the College of Medicine and the Department of the Navy are working together to find a method of predicting and controlling epilepsy-triggered seizures. The NIH recently awarded the team a $1.4, 4-year grant.

[PI: Dr. William L. DittoNIH 1R01EB004752-01]

Evolution into Epilepsy:A dream team of researchers from the University of Florida and Shands at UF.

Dr. William L. Ditto, PI — Biomedical Engineering

Dr. Paul R. Carney — Pediatric Neurology

Dr. Thomas B. DeMarse — Biomedical Engineering

Dr. Thomas Mareci — Biochemistry & Molecular Biology

Dr. J. Chris Sackellares — Biomedical Engineering

Dr. Justin C. Sanchez — Pediatric Neurology

Dr. Mark C. Spano — Department of the Navy

Michael D. Furman — Biomedical Engineering

Jennifer Simonotto — Biomedical Engineering

Evolution into Epilepsy

analysis

raw data

image data

mea data

brain

/ ani

mal

Slice

EEG / histology

Brain Dynamics Bioengineering

Research Partnership

The mission of the Brain Dynamics Bioengineering Research Partnership is to develop an online, real-time automated seizure warning and prevention system for use by epileptic patients and their caregivers. 

[PI: Dr. J. Chris SackellaresNIH NIBIB R01EB002089]

Brain Dynamics Bioengineering Research Partnership

Dr. J. Chris Sackellares, PIBiomedical Engineering

Dr. Paul R. CarneyPediatric Neurology

Dr. Panos M. PardalosIndustrial & Systems Engineering

Dr. José C. PrincipeElectrical & Computer Engineering

Dr. Deng-Shan ShiauNeuroscience

Dr. Mark C. YangStatistics

Dr. Leonidas D. IasemidisArizona State University

Optical Imaging of

Breast CancerHuabei Jiang, a widely known innovator in the field of optical imaging, is supported by a 5-year, $1.4 million grant awarded to him in 2002 by the National Institutes of Health.

He's developing a relatively painless, non-invasive technique to detect breast cancer. Instead of allowing their breasts to be compressed between two plastic plates and held firmly in place, as in a mammogram, patients in Jiang's study lie face down on a special exam table. An array of fiber optics gently surround the breasts and project near-infrared light at different angles

Dr. Huabei Jiang, PI Biomedical EngineeringStephen Grobmyer Department of Surgery

[NIH R01CA090533]

Monitoring Intraperitoneal

Bleeding

Bleeding in the abdominal cavity is a frequent consequence of the blunt trauma suffered in motor vehicle accidents. Often it is undetected by conventional clinical screening techniques. Rosalind Sadleir’s group has developed a monitoring method that can quantify the rate of bleeding and thus the urgency of surgery. Now, they’re readying a new commercial device for clinical trial.

Dr. Rosalind Sadleir, PIBiomedical Engineering

Dr. Edward RossMedicine (Nephrology)

Advanced Magnetic

Resonance Imaging and Spectroscopy

FacilityAMRIS is a state-of-the-art NMR facility for high-resolution solution NMR, solid-state NMR, microimaging, animal imaging and human imaging.

AMRIS currently has seven spectrometer systems, including a 750 MHz wide bore, an 11 T/40 cm bore horizontal animal imaging magnet, and two 3T human systems. AMRIS was developed in part through a grant from the Department of Defense. An external users program in AMRIS is supported by the National High Magnetic Field Laboratory through funds from the National Science Foundation.

Dr. Arthur Edison, Director

Advanced Magnetic

Resonance Imaging and Spectroscop

y FacilityFaculty at

the University of Florida

Dr. Steve Blackband — Neuroscience

Dr. C. Russell Bowers — Chemistry

Dr. Ioannis Constantinidis — Medicine

Dr. Bruce A. Crosson — Clinical & Health Psychology

Dr. Arthur Edison — Biochemistry & Molecular Biology

Dr. Jeffrey R. Fitzsimmons — Radiology

John Forder — Radiology

Huabei Jiang — Biomedical Engineering

Dr. Peter Lang — Clinical & Health Psychology

Dr. Yijun Liu — Psychiatry

Dr. Joanna Long — Biochemistry & Molecular Biology

Dr. Thomas Mareci — Biochemistry & Molecular Biology

Ilona Schmalfuss — Radiology

Krista Vandenborne — Physical Therapy

Glenn Walter — Physiology

Norbert Wilke — Radiology (Jacksonville)

Biomaterials Research

Bio-erodable Micro-porous Polysaccharide Foams Scaffolds

Spinal Cord Regeneration in rats using a Combination of Polymer Scaffolding and Microglia Cells

Research supported by the Christopher Reeves Foundation

Goldberg (Materials Science) and Streit (MBI)

Nano-particles for

Medical Applications

A specially designed particle, quantum dot based contrast agent, that is paramagnetic, fluorescent, and radio-opaque

Potentially useful as a biomarker for imaging and surgery

Santra (PERC), Moudgil (MSE, PERC), Holloway (MSE), Mercle (Neurosurgery), Walter (Neurosurgery)

-1000 -750 -500 -250 0 250 500 750 1000-1.5x10

-5

-1.0x10-5

-5.0x10-6

0.0

5.0x10-6

1.0x10-5

1.5x10-5

300K

Mag

netiz

atio

n(em

u)

H(Gauss)

Fluorescent Radio-opaque

Paramagnetic

(a) (b)

(c)

Gross view

(a) and (b) represent dorsal views and (c) represents

coronal section

Brain Machine

Interfaces

UF Collaboration with Duke and MIT

The CNEL Lab (Principe, Harris) designs models which “decode” neuronal activity into motor commands for prostheticsModels are implemented in low power, hybrid (analog VLSI-DSP) chips

IT for Medical

Applications

Assistive Environments for Successful Aging (GatorTech Smart House)

Radiation Treatment and Planning - Dose computation, Leaf sequencing

Medical Imaging

Bioinformatics

Preserving a `Hands-on’ Knowledge Base of Essential but Rare Surgical Procedures

Interdisciplinary Bioimaging &

BioengineeringBuilding

The proposed facility will house and integrate the biomedical-focused groups within one 275,000 square foot building to create completely new research and funding opportunities.

The physical and cultural integration of researchers within this building will provide synergistic and collaborative environments that will establish UF as a leader in interdisciplinary biomedical science, engineering, technology, translational research and technology transfer. A state-of-the-art animal care facility in the same building will add to the synergy and allow UF researchers access to the finest biomedical research infrastructure in the world.

Interdisciplinary Bioimaging & Bioengineering

Building

Biological Imaging Center [70,000 sq. ft.]- Clinical translational

research- Technology Liaison Office- Structural Biology and

Molecular Biophysics

Brain Research Labs[50,000 sq. ft.]- New programs for

brain/neuroscience

Department of Biomedical Engineering

[75,000 sq. ft.]- Administrative offices- Research labs

Animal Care Facility[62,000 sq. ft.]

Support Programs & Public Space

[18,000 sq. ft.]