Catecholamines:

Basic and

Clinical Frontiers

Volume Two

Proceedings of the Fourth International Catecholamine SymposiumPacific Grove, California, September 17-22, 1978

Edited by

Earl Usdin*Psychopharmacology Research Branch

National Institute of Mental Health

Rockville, Maryland

Irwin J. Kopin*Laboratory of Clinical Science

National Institute of Mental Health

Bethesda, Maryland

Jack Barchas

Nancy Pritzker Laboratory

Department of PsychiatryStanford University School ofMedicine

Stanford, California

This book was edited by Drs. Usdin and Kopinjn their private

capacities. No official support or endorsement by the NIMH is

intended or should be inferred.

Pergamon Press

UNIVERSITATSBIBLIOTHEKHANNOVER

TECHNISCHE

INFORMATJONSB1BLIOTHEK

NEW YORK • OXFORD • TORONTO • SYDNEY • FRANKFURT • PARIS

TABLE OF CONTENTS

Volume II: Neuroregulator Interactions, Lesions and Histochemistry,

Clinical Aspects

Section J: Neuroregulator Interactions

Immunocytochemical Studies on Catecholamine Cell Systems with

Aspects on Relations to Putative Peptide Transmitters (TomcU Hoki,eZ£,KjoIZ Fttxe, Me.ne.fe Goldstein, Olli Johamion, Ake. lju.ngda.kt, .Jan

LundbeAg and MaJuannt Schnltzbtnq)'

1007

Interactions of Enkephalinergic and Catecolaminergic Neurons

in CNS and Periphery (E. Coita, A. VI G-UdJU.0, W. FwJUtss., J. Hong

and H.-Y.T. Yang) 1020

A Review of Some of the Technical Problems Associated with

the Analysis of Neurotransmitter Localization and Interactions

in the Central Nervous System (N. WelneA., ?.K. Nakant and J.K.

Stzphzni) 1026

Studies on GABA-Monoamlne and GABA-Endorphin Interactions

(M. PeAez de la. Moao., K. r~uxt, K. AndeMion, T. Hdk&ult, A.

Ljangdaht, L. VoManl and R. Tapia) 1032

Opiate Receptor Stimulation Blocks the Activation of Striatal

Tyrosine Hydroxylase (TH) Induced by Haloperidol (A. Guldottl,F. \koKonl, K. Gait and K. Kumakita) 1035

Catecholamine Mechanisms: Interaction with g-EndorphinInduced Seizures [Sttven J. Htn>vLki>e.n and Floyd E. Bloom) 1038

Effects of Opiates on Nigrostriatal Dopaminergic Activity:

Electrophysiological and Behavioral Analyses [Agu. Vojdi, LoiuAe. A.

Veltiald and Vofwtky W. GallageA) 1041

Ultrastructural Evidence for a Synaptic Relation Between

Catecholaminergic and Peptidergic Neurons (l/.M. Vickol, T.H. Joh,

D.J. ReXi, S.E. Leeiwi and R.J. HilloA) 1044

g-Endorphin and Met-Enkephalln Induced Changes in Amine Turn¬

over in Discrete DA Nerve Terminal Systems of the Neostriatum and

the Limbic Forebrain {RobeAt Sc.hfian.tz, Kjell Ftixe, KuAt AndtLM&on

and LoudMz FeAland) 1047

A Search for Neurochemical Mechanisms Mediating Analgesia

Produced by Stimulation of the Nucleus Locus Coeruleus [He.nah.2m

Szgal) 1050

Interaction Among Enkephalinergic and Dopaminergic Systems

in Striatum and Limbic Forebrain (M. T/tabuccki, A. Poll, G.C.

Tonon and P.F. Spano] 1053

Enkephalin and Endorphin: Catecholamine Interactions [Stanliy

J. Watson, C.W. TUchand, R.0. ClaAaneMo and Jack V. BaAcdai) . . . 1056

Acetylcholinesterase is Synthesized and Transported by Dopamine

Neurons in Pars Compacta of the Substantia Nigra: Functional

Significance and Histochemical Correlations on the Same Brain

Section [lahhy L. ButakeA and Raymond MaJichand) 1059

V

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

Regulation of Hippocatnpal Cholinergic Neurons by DopaminergicSynapses in Septum [V.L. Ckznzy, S.E. Robtmon, V. Halthz-Sin.zm>izn,P.L. Wood and E. Co&ta) 1062

Adenylate Cyclase-Coupled Dopamine Receptors in Parkinson'sDisease [Maiato ShA.bu.ya and Olzh HoAnyktzwtaz) 1065

GABA-Mediated Regulation of Dopaminergic Neurons [K.G. Lloydand P. iilonmi) 1068

Effect of Electrical Stimulation of the Substantia Nigra and

A1 Area on the Turnover Rate of GABA (TRGABA) and HVA Content in

N. Caudatus and N. Accumbens (E. PeAalta ancTE. Coita) 1071

Interactions Between Biogenic Amines and Acetylcholine in the

Cerebral Cortex [T.A. ReadeA, J. do. Champlain and H.H. Jaipzn). . . 1074

The Regulation of Hlppocampal Cholinergic Neurons by

Noradrenergic Mechanisms [S.E. RobtrUOn, V.L. Chznty and E. COAta.) .1077

Interaction of GABA-ergic and Dopaminergic Systems in the

Caudate Nucleus of the Rat [Johannzi C. Stoo^ and Aniz H. MuXdeA). . 1080

Opiate Receptors Localized Presynaptically on Dopaminergicand Noradrenergic Neurons in Brain: Relevance to Tolerance and

Dependence to Opioids [Jzan-CkaAlzi SzhwaAtz, SopkLz de la Baumz,Cath.eAA.ne. Llon.zn&, GUlu Ratty and Hitznz VoULaAd] 1083

Peptide Effects on Mammalian and Invertebrate Dopamine (DA)

Neurons (W. LizhtznitzlgzA, F. Manned and V. Fztlx) 1086

The Interaction of Neuropeptides with Brain Catecholamines

[VlAk H.G. Vzutzzg) 1089

Enkephaline Interaction with Dopaminergic System in Rat CNS

[SeAg-io AlgznJL, AdAJxma Con&olaziom, Gabilzlla CatdeAtnl and

vin0 LOmiL&CJ-O) ^'^•^•,^\\..^ 1092

Microinjections of Opiate Agonists and Antagonists in the Area

of the Locus Coeruleus in Cats. Effects on Behavior (P.A.M. van

Vongzn and A.R. CooJU) 1095

Effects of a Nigral Application of Substance P and of an Anti-

Substance P Serum on Dopamine Release From Dendrites and Nerve

Terminals of the Nigrostriatal Dopaminergic Neurons in the Cat [AndAZCheAamy% RobeAt ULchzlot, Andul Hlzoullon, Vtncznt Lzv-LeZ and BeAnaAd

KzAdelhuz) 1098

Infusion of Substance P into Rat Substantia Nigra Increases

Dopamine Metabolism in the Striatum [PztZA C. WaldrnzieA, RogeA Kam

and KuAt Stocklin) 1101

Dopamine-Serotonin Interactions in the Nigro-Striatal Feed¬

back Loop [PzteA C. Waldmttzu, RogeA Kam and LauAznt MattAz) .... 1104

Effect of 5-Hydroxytryptophan on Brain Levels of Monoamines

and Dopamine Metabolite DOPAC [Guy M. EveAztt) 1107

A Morphological and Biochemical Dissociation Between Dopamineand Serotonin in Cat Brain (AndA.ee C. RobeAgz) 1110

Retrograde Transport of Serotonin in Central MonoaminerglcNeurons (P. BoblllizA, L. LtgeA, S. Atanzda, C. Font and J.F. Pujol] 1113

Serotonergic Involvement in the Regulation of Striatal Dopamine

Synthesis [Ronald KuczzmkA.) 1116

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM Vii

Interactions Between Noradrenergic and Cholinergic Systems in

the Brain (f/.C. FiblgeA and S.T. Ma&on) 1119

Physostigmine Induced Alterations of Dopamine Metabolites in

CSF of Normal Subjects [Kenneth L. Vavii, Kym F. FauU., Lzo E. HolliiteA,Jack V. BaAchaj, and Philip A. BeAgeA] 1122

Role of Striatonigral Pathway and GABA Systems in Methamphetamine-Induced Depression of Striatal Tyrosine Hydroxylase Activity[Jamu ill. Glbb and Adalu J. Hotzhki&i) 1125

Striatal Dopamine Release Induced by the Intranigral Perfusion

of GABAergic Agonists in the Conscious Rat [GAzgoKy E. UaAtin, NanL. Papp, A. BoAbaAa P&luzgeA and Vzan R. Haabnich) 1128

Effects of Gammahydroxybutyric Acid on Dopamine Mechanisms and

Sleep [G. Stock, A. StzigeA, P. Kummzn. and K..H. SckloA) 1131

Altered Brain Dopamine Metabolism: An J[B. Vivo Comparison of

the Effects of Amphetamine and Prostaglandins (S.B. SpaAbz/i, J.A.Nizl&zn and L.H. FoMom)

, 1134

Microtubules Regulate Catecholamine and Prostaglandin E.

Function (Rab-i. Simantov and Lzo Sachi) 1137

Role of Catecholamine and Vasopressin Release in the TRH-

Induced Vasopressor Response (A. Honita, M.A. CaAlno and R.E.

islzitzman) 1140

A New Effect of Thyroliberin (TRH): Induction of Hyper¬

glycemia by Epinephrine Release (H. Kauaz and J. UozlleA) 1143

Adenosine - A Transsynaptic Modulator of NorepinephrineRelease? (BeAtt£ B. Fuzdholm and Pen. Hzdqvi&t) 1146

Purinergic Feedback Regulation of Catecholamine Release

[Chz Su) 1149

Angiohypotensin: A Selective Endogenous Inhibitor of Neuro¬

muscular Transmission in Vascular Smooth Muscle [Jozizi Knolt) . . . 1152

Thyroid Hormones and Adrenergic Neurotransmitters [Many B.

VAatman and Floy L. Cn.utc.mzld) 1155

The Role of Cyclic AMP on the Synthesis of Phenylalanine

Transaminase [Jzan Ckzn Skik and Yuen-Ling Chan) 1158

Phosphorylation of Contractile Proteins by Cyclic Nucleotide

Dependent and Independent Protein Kinases (Jome/5 T. Stull, Vavid

R. Manning, Chanlzi III. High, Pnimal dzLaneAollz and Vonald K.

Blumznthal) 1161

Histamine in the Heart and Spinal Cord of Hypertensive Rats

[J.P. CkalmeAA, P.R.C. Horn, J.C. Ptovii and M.J. ttiut) 1164

Serotonin Causes Accumulation of Cyclic AMP in Aplysia Heart

(P.R. Kzbabian, J.iil. Kzbabian and V.O. CaApzntZA) 1167

Allosteric Regulation of Brain Tryptophan Hydroxylase by

Submicromolar Calcium [Sazannz Knapp and Annold J. Mandzll) 1170

Plasma Melatonin in Manic-Depressive Illness [Al{n.zd J. Lwy,Thomai A. DIzhA, Philip ill. Gold and FtizdeAick K. Goodwin) 1173

A Vasopressin Hypothesis of Affective Illness: Preliminary

Findings (P.W. Gold, J. BallzngeA, A.P. lib, G. RobzAUon, R.M.

Po&t and F.K. Goodwin) 1176

The Pharmacology and Metabolism of Tyramine (A.A. Soulton and

A.V. Juohio) 1179

vili FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

Dopamine Neuron Activity: Effect of SL 76 002, A New GABA

Mimetic Candidate (G. BaAtholini, B. Scatton, B. Zivkovic, P.

Ulonmi and K.G. Lloyd) 1182

Section K: Neuroendocrinological Processes

Central Catecholamine Systems and Neuroendocrine Regulation.Controllers of Anterior Pituitary Secretion [Kjzll FuX.Z, KuAt

AndeAi-ion, Luigi F. Agnati, Loui&z FeAland, Tomaj, Hoklzlt, Pztzn.

EneAoth, Jan-Afee Gabta&uon and Paul Skztt) 1187

Neuroendocrine Regulation - An Overview [Roland V. CiaAanzllo

and Richand Kvttnaniky) 1204

Estrogen Dependent Efflux of Endogenous Catecholamines from

the Hypothalamus In Vitro [Stzvzn M. Paul, Juliai AxzVwd and Phil

Skolnick) 1206

Effects of Peptides on Brain Monoamine Metabolism and on

Gross Behaviour in Rats (Toa MagnuMon, JeAui A. GaAcAa-Szvilla

and Anvid CanJU&on). 1209

Participation of Calmodulin in the Regulation of Dopamine

Receptors [Ingzbong Hanbauzn.). 1212

Catecholaminergic Control of Growth Hormone Secretion in Rats

[Kjzll Modigh, Paola BoHe. and Sta^an Edzn) 1215

Anterior Pituitary Dopamine Receptors and Prolactin Secretion

[RichaAd I. iileinzA, Michael J. CAonin, Czcilia V. Chzung, Nacia.

Fouaz, Bnicm R. Clank and Paul C. Goldsmith) 1218

Effects of Progesterone on the Noradrenergic System of Rabbit

Oviducts (J. BzimaA, H. LaAa, J. Sainz and H. ViveAOi) 1221

Intrahypophyseal Dopamine and Endocrine Events [MaAgoAzthzHolzbauzn. and V.F. Shanman) 1224

Regulation of Adrenoceptors by Thyroid Hormone [Shailzik P.

BcuaeAjee, HiAzndAa K. Skanma and Svaan E. Pointon) 1227

Regulation of Tuberoinfundibular Dopamine Neurons [Kznnzth E.

Mooaz, Kohei, Umzzu and Kzith T. VemoAz&t) 1230

Prolactin-Catecholamine Interactions and Puberty [ill. iiluttkz,K.G. Hohn, P. illittz and K.J. Honma) 1233

A New Strategy for the Selection of Dopamine Agonists and

Antagonists (J.R. Boi&AieA, F. LabAiz, M. Bzaulizu., T. Vi Paolo, C.

ObeAlandeA and C. EuvAaAd) 1236

Effect of Catecholamines in the Regulation of Melatonin Syn¬thesis in Mammalian and Avian Pineal Glands (Ttf.fe.eo Vzguchi) 1239

Endorphin Stimulation of Prolactin (PRL) Release: Its Re¬

lationship to Median Eminence DA Neurons (L. GAdndiion and A,

Guidotti) 1242

Role of Dopamine and Serotonin in the Morphine-Induced Release

of Prolactin [L. FeAland and F. LabAiz) .1245

Effects of Some New Dopamine Agonists on Prolactin Secretion

and Turning in 6-Hydroxydopamine Lesioned Rats (Jam&i A. Clzmzni

and E. BanAy Smal&tig) 1248

Relative Potencies of Dopamine Agonists on Prolactin Secretion

in Rats [H.V. MzltzeA, M. Simonovic, V.ill. NicholA, R.J. MillZA, J.

McVznmzd and V.S. Fang) 1251

FOURTH INTERNATIONALCATECHOLAMINE SYMPOSIUM ix

Serum Prolactin as an Indicator of Alterations in Brain DopamineSystems [IHaitzA A. Bn.own, Hatbam, Lai 'and GlzgoAy Bnown) 1254

Self Regulation of Prolactin Via Hypothalamic Catecholamines(Jome^ L. iloogt, LauAzncz Com. and Jay Lzvin] 1257

Hormonal Regulation of Dopamine Synthesis and Release in theMedial Basal Hypothalamus [Thomai C. illzitiall, Nancy A. PeAkini,i/ickiz TittznmaAy and Caxol Paul) 1260

Antagonism Between Estrogens and Dopamine at the AnteriorPituitary Level on Prolactin Secretion [Mickelz BzauLLzu., Thinz&Z VIPaolo, LouJj>z FeAland, Vincznt Raymond and FeAnand Labniz) 1263

Catecholamine Mechanisms in the Hormonal Regulation of

Sexual Behavior [Enic W.F.iH. Alton, Chanloitz H. iilnight and

Baxny J. EveAiXt), 1266

Antidopaminergic Effect of Estrogens at the Striatal Level

(C. EuvAand, F. Labniz and J.R. Boii&ieA) 1269

Involvement of Central Catecholamines in ReproductiveNeuroendocrine Processes [William R. CAOwlzy, Thomai L. O'Vonohuz

and Vavid M. Jacobowitz) 1272

Monoamine Regulation in Rat Endometrium and Brain Regions

During Early Pregnancy and Oestrous Cycle [V. CaiimiAi, C. QZmzdo,H. Poavzz, S. Poavzz and A. Piyckoyoi) 1275

Synthesizing Enzymes and Norepinephrine Turnover During Uterine

Adrenergic Nerve Degeneration and Regeneration Associated With

Normal Pregnancy (P. Aim, Ch. Owman, N.-O. Sj'obeJig and G. Thonbznt) 1278

Stimulation-Induced Release of Norepinephrine From Guinea-Pig

Ovary and Ovarian Ligament [Guiynnzth M. HandbeAg, Joctlyn W.

PznnziatheA and John A, Foaaoa) 1281

The Role of Central Noradrenergic and Dopaminergic Neurons

in the Control of TRH-TSH Secretion [Lucia Annanziato, Aldo

QpjattAonz, Gian^Aanco Vi Rznzo, Gznnano Schtttini and Paolo Pnzzioii)1284

Oral Contraceptive Thermogenesis and Urinary Amine (E, NE)Alterations [FAzdeAick P. luMpan) 1287

Hypothalamic-Pituitary Dopaminergic Function - Clinical

Studies (5. Lai and N.P.I/. NaiA) 1290

Defects in Brain Catecholamine Neurons in Patients with Growth

Hormone or Prolactin-Secreting Pituitary Tumours [Gltn R. Van Loon). I2?3

Hormonal Regulation of Monoamine Synthesis and Metabolism

[H. Poavzz, A.R. Bukhani, F. Bnion, V. CaiimiAi and S. Poavzz). . .1296

Section L: Lesions and Histochemistry

Distribution of Catecholamine-Containing Cell Bodies in the

Rabbit Hindbrain: A Study Using Formaldehyde-Glutaraldehyde Induced

Fluorescence [HI.U1. Blziiing, P.R.C. Howz and J.P. CkalmzAi). . . .1301

Similar Effects of Indoleamine and Phenylethylamine Hallu¬

cinogens on Dorsal and Median Raphe Neurons (MtfAfe A. GzyeA and

AAnold J. MandeU) 1304

Axonal Catecholamines Following Subdural Brain Trauma:

Examination Using an Improved SPG Hlstofluorescence Method (J.C.

dz la ToKAt) I307

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

The Relationship Between the Noradrenergic and Dopaminergic

Innervation of Medial Cortex in the Rat [John H. MoAniion, ReinhaAd

Gn.za.nna and Monk E. Moltivzn) 131°

The Topography of the Mesencephalic Dopamine Neuron Systems

[Jamzi H. Fallon and Robznt V. Mooaz) 1313

The Role of the Striatonigral Pathway in the Control of the

Substantia Nigra (M. GaAcia-Munoz and G.iD. AAbuthnott) 1316

Microfluorimetric and Neurochemical Studies on Dopamine

Neurons in the Central Nervous System - Effects of Haloperidol and

Sulpirid [Hakan HaWnan and Goita. Joniion) 1319

Afferents and Efferents of the Ventral Mesencephalic Teg-

mentum-AlO Region Studied by Using Tracing Techniques (H. Simon,M. Lz-Moal, L. StinuA and A. Calai) 1322

Integrated Morphology of Catecholamine and NeurophysinNeurons [John R. Sladzk, Jn..,Eanl A. ZimmeAman, J. Lobo Antunzi

and Thomai H. McNeill) 1325

Retrograde Axonal Transport of Nerve Growth Factor by Central

Monoaminergic Neurones of the Rat [Ian HzndAy and Suz Ebbott) . . . 1328

Histochemical and Biochemical Characterization of the Bullfrog

Lumbar Sympathetic Ganglia and Sciatic Nerves (I. Nagatiu, H. Kojima,V. Kondo, S. Inagaki and T. Nagat&u) 1330

Small, Intensely Fluorescent (SIF) Cells of the Human Sympathetic

Ganglia [Antti HeAvonzn, Paul! Hzlzn, Hannu Alho and Lai&z KanzAva) 1333

Regenerative Growth of Sympathetic Fibers into Rat Hippocampus

[Rzbzkah Lay and RobeAt V. Mooaz) 1336

Dopaminergic and Noradrenergic Neurons in Spinal Cord: Func¬

tional implications [John ill. CommiAiiong and Nonton H. NzlD. . . .1339

Sympathetic Innervation of the Spinal Cord [LauAa F. McNicholai,iilillLam R. Mantin, Jewell ill. Sloan and Mo&ako Nozaki) 1342

Catecholaminergic Autonomic Fibers in Human Male Pelvic/

Perineal Viscera (J.A. McConnell, Joz Wood and G.S. Bznion) .... 1345

Microspectrofluorimetric Mapping of the Formaldehyde Induced

Fluorescence (FIF) in the Rat Superior Cervical Ganglion [Hannu

Alho, PojjJLL Hzlzn and Antti HzAvonzn) 1348

Autoradiographic Localization of Monoamine Oxidase in Cardio¬

vascular Tissues [Michael C. Lowe) 1351

Non-Neuronal Localization of Catechol-O-Methyltransferase in

Brain [GaAy P. Kaplan, Boyd K. HaAtman and CynuA R. Cn.zveJU.ng). . .1354

Immunocytochemical Localization of Tyrosine Hydroxylase byPeroxidase Labeled Antibody Method [J.K. Stzphzni, P.R. VulLizt, P.K.

Nakanz and N. WzinzA) 1357

Observations on the Structure and Function of Catecholaminergic

Presynaptic Dendrites [Philip M. Gaovza, CkaAlzi J. illilion and StzphanJ. Young) 1360

Experimental Studies on the Origin of the Limbic Catecholamin¬

ergic Nerve Terminals [Mikloi Palkoviti) 1363

Continuities Between Mitochondria and Catecholamine-Storage

Vesicles [S.W. CoAmichazl, V.J. Smith) 1366

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM XI

Ultrastructural Characterization of Monoamine Storage Com¬

partments After Permanganate Fixation [La&iz KaneAva and Antti

HeAvonzn) 1369

Ultrastructural Localization of Amine Stimulated Adenylate

Cyclase Activity (L. Rzchatdt, H. Hznvonzn and P. Panula) 1372

Transynaptic Regulation of Dopamine Synthesis After Raphe and

Striatal Lesions [Czcilio. T. Giombalvo and S. Robznt SnodgAaii) . .1375

Chemical and Biological Studies of 6-Hydroxydopamine Analogs

[Nzal Caitagnoli, CnanleA A. Ckavdanian and Vaiji KaAaihima) . . . 1378

Studies on the Mode of Action of 6-Hydroxydopamine and Re¬

lated Neurotoxins [Richand E. Heikkila) . , 1381

Role of Central Catecholaminergic Pathways in CirculatoryReflexes (P.I. Kon.nzA, J.A. Rzynoldion, J.R. OZivzn. and G.A.

Head) 1384

Analysis of the "Ventral Mesencephalic Tegmentum Syndrome"Possible Involvement of A10 Dopaminergic Neurons (L. StLnai, H.

Simon, 0. GaUoni and M. Lz Moat) 1387

Quantification of Catecholamine Terminals After 6-0H-DA. A

Correlated EM/FM Study [TeAzncz H. iilittiami, G.-H. Hwang and

Jzan Jew) 1390

Dopamine Sensitive Adenylate Cyclase in Substantia Nigra: Pos¬

sible Site of Action of Psychotropic Drugs (A. GAOppztti, G.

Racagni, M. PaAznti, A. Bugatti, A.M. Vi Giulio, A. Maggi and

F. Cattabzni) 1393

Plasticity of Mesolimbic Dopamine Neurons [G.M. Gilad and

J. Rtii) 1396

Adaptive Neurochemical Changes Following Destruction of Central

Dopamine-Containing Terminals [Mickazl J. ligmond and EdWOKd M.

StAickzn.) 1399

Selective Enhancement of the Effects of Haloperidol on a

Conditioned Avoidance Response by Lesions in the Parafascicular

Nucleus of the Rat [Svzn Ahlzniai) 1402

Extraneuronal Uptake of Isoprenaline into Guinea-Pig Trachealis

Smooth Muscle Cells as Studied by Fluorescence Histochemistry and

Quantitative Microphotometry [Stella R. O'Vonnzll and Lz&lzy J.

Buyan) 1405

Section M: Cardiovascular Mechanisms

Central Control of Blood Pressure [M. Palkovitz) 1411

Central Adrenergic Neurons in Spontaneous (Genetic) and Ex¬

perimental Hypertension [Juan M. SaavzdAa) 1416

Correlation Between CNS Angiotensinogen and Central Catecholamine

Pathways [Monton P. Pnintz, ClzatuM J. Waltu, John A. Lemicki and

JameA H. Fallon) 1419

Plasma Catecholamines and Direct Stimulation of Rat

Hypothalamus [C.L. Sun and I.J. Kopin) 1422

Role of the Medullary Adrenalin-Contajning Cells in Cardio¬

vascular Regulation [Mikloi Palkoviti, and Eva Mezei/l 1425

Adrenoreceptors of the Hypothalamus: Their Importance for the

Regulation of the Arterial Blood Pressure (A. Philippu., H. Viztl, U.

StAohl and V.T. Tiaic) 1428

xii FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

The Role of Peripheral and Central Catecholamines in the

Regulation of Renin Secretion [William F. Ganong, Handin JoneA, Ja.

and Jonathan Chalztt) 1431

Role of Central Adrenergic Mechanisms in the Cardiovascular

Actions of Gamma-Hydroxybutyric Acid [Czdlia. Gornzi, MattA Hznning

and GuAtai Tiolin) 1434

Role of A2 Neurons in Control of Arterial Pressure in Rat

[Vavid ill. SnydeA, William T. Talman and Vonald J. RzU) 1437

On the Role of Noradrenaline and Adrenaline Neuron Systemsin Control of Central Cardiovascular Functions [PeA Bolmz, KjtllFuxz, Goita Joniion, Vztlzv Gantzn, Luigi Agnati, KuAt AndeAAAon,Hakan Hallman, Mznzk Gold&tzin and TomaA Hokizlt) 1440

Serum-Dopamine-Beta-Hydroxylase and Hypertension (F. LampAZcht) 1443

Mechanism of Antihypertensive Effect of Propranolol [Budh Vzv

Bhagat)'

1446

Catecholamine Synthesizing Enzymes in a New Strain of Spon¬

taneously Hypertensive Rats (B. Renatid, L. VznoAoy, M. Vincznt, S.

FouAniznz, J.F. Pujol and J. SaAiOAd) 1449

Deficient SIF Cell Dopamine Metabolism in Celiac Ganglion of

Young Spontaneously Hypertensive Rats (SHR) Before the Onset of

Hypertension [N.H. Nz&&, B.E. Lutold and F. KoAoum) 1452

Turnover of Hypothalamic Catecholamines in Spontaneously

Hypertensive Rats (C.C. Chiuzh and N.B. Thoa) 1455

Decreased Cardiac Beta-Adrenergic Receptors in Hypertensive

Rats [Elizabeth Woodcock, J.W. Fundzn. and C.I. Johmton) 1458

The Area Postrema and the Long-Term Regulation of Blood Pressure

(J.E. Szilagyi, K.B. Bhoinihan, K.L. Bomiza and C.F. FeAAaAto). . . 1461

Origin of Cardiovascular Effects of g Stimulating and Blocking

Drugs After Intracerebroventricular Injection [V. Poh.qu.zt, A.

Lindznbaum, Y. Cohzn and J. iUzpieAAz) . 1464

Relationship Between Ventromedullary Clonidine Sensitive

Area and Hypothalamus (RogeA Bloch, Joiianz Feldman, Paical BouAquztand Jean SchwaAtz] 1467

Hypotensive Effect Obtained by Application of Drugs to the

Ventral Surface of the Medulla: A Membrane Stabilising Mechanism?

[PoacoI BouAquzt, Jo&ianz Fzldman, RogeA Bloch and Jzan SchwaAtz) . 1470

Adrenergic Activation by Intracerebroventricular Administration

of Acetylcholine and 5-Hydroxytryptamine in Rats [Milovan K. KnAtic) 1473

Plasma and Tumor Catecholamines and Blood Pressure in 38 Patients

With Pheochromocytoma [William MuiA Manqzh.) 1476

Dopamine Excretion in Benign Pheochromocytoma [PzdAo A. S2AAO.no,BzatAiz Chavez-LaAa and GuAtavo Sa.nckzz-To.HAeA) 1479

y-Glutamyl Dopa and y-Glutamyl Dopamine as Kidney Specific

Pro-Drugs [ShzAwin Wilk, Hanuko Mizoguchi, Skexman Kup&tn. and

Manian Onlowiki) 1482

Central Catecholamines and Renovascular Hypertension in the

Rat (Jonn L. Rzid and MaAganzt A. Petty) 1485

High Pressure Liquid Chromatographic Analysis of EndogenousNorepinephrine (NE) Released From Canine Saphenous Veins [SheilaM. Muldoon, GeAtAudz M. Tycz, TkomaA P. MoyeA and Vuanz K. Roniz) .

1488

FOURTH INTERNATIONALCATECHOLAMINE SYMPOSIUM xiii

On the Pathophysiology of Cerebral Vasospasm: Transmitter

Changes in Perivascular Sympathetic Nerves, and Increased Pial

Artery Sensitivity to Norepinephrine and Serotonin [Ch. Oman,N.-Aa. SvzndqaaAd, L. Edvin&ion, T. Olin and Ck. Saklin) 1491

Dopaminergic Action on Brain Vessels [L. Edvin&ion, J.E.

Handzbo, J. McCulloch and Ch. Oman) 1494

Effects of^Diuretics and Diazoxide on Rat Brain Catecholamine

[HzctoA M. laldlvaA, BzatnXz Ckavzz and Ptdho SeAAano) 1497

Studies on 2-Methyl-3-(2,4,5-Trihydroxyphenyl)alanine, the

"6-Hydroxy Analog" of a-Methyldopa [Nzal CoAtagnoli, Vonald MiUAon,

Vaiji Kaha&hima and Kznnzth Melmon) 1500

Formation of a-Methylnorepinephrine in Rat Brain Stem and

Nucleus Tractus Solitarius After Acute Injection of a-Methyldopa(E.L Conway, B. JaAnott and W.J. Louii) 1503

Possible Direct Antagonism of Norepinephrine by Alpha Methyldopa

[illaltzn. M. BookzA, RichoAd ElliA, Aldzn FlztcheA, Lynnz G. Elliott

and William L, Wz&t) 1506

Dopamine-Beta-Hydroxylase of Plasma and Cerebrospinal Fluid

in Animal Stress and Human Hypertension [Luigi Cubeddu Ximznzz). .±509

Effect of Diuretic and Beta-Receptor Blocker Treatment on

Catecholamines [Bzatniz Ckavzz-Lana, GuAtavo Sanchez and Pzdno

SeAAano) 1512

Catecholamine Excretion by Spontaneous Hypertensive Rats on

Abrupt Withdrawal of Imidazoline Antihypertensives [V.B. ElliA,

W.J. Novick, Ja. and J.C. Wilkzn.) 1515

Vascular and Circulating Catecholamines in Diabetes and Hyper¬

tension [R.J. Hzad and B.A. Bznkowitz) 1518

The Dynamics of Catecholamine (CA) Metabolism in the Intact Human

Subject With Essential Hypertension (EH) [Stanlzy E. Gitlow, LauAa M.

Vzizdzic, Stanley W. Vzizdzic and liaac Roubex.nl 1521

Pulmonary Clearance of Circulating Catecholamines in Normal

Man and in Patients with Pulmonary Hypertension [Michael J. Solz,

Milutin Vnxibac, LzonaAd Schwantz, M. Naiin. HuAiain and Edwand F.

i/aughan-Nzil) 1524

Beta Receptor Desensitization in Congestive Heart Failure

(Jamei Thomai and BeAnan.d H. Manki) 1527

Interaction of Sodium (Na+) and Catecholamines (CA) on the

Control of Blood Pressure (K.B. Bnoinihan, J.E. Szilagyi, I. Maiaki

and CM. FzaaoaLo) 1530

Effect of Cardiac Presynaptic a-Adrenoceptor Stimulation

by Clonidine and its Antagonism by Phentolamlne and Prazosin on

Coronary Sinus Plasma Norepinephrine Overflow in Dogs (I. CaveAO,

A.G. Roach and B. Scatton) 1-533

Adrenergic and Cardiovascular Effects of Disulfiram in Man

[Nzal L. Bznowitz, Wattzn. K. Rogzu, MonxiA Se.fiambei.an and HangaAzt

WilAon)1536

Role of Dopamine and Norepinephrine in Carotid Body [Stzn

HzllAtAom and IngzboKg HanbauzA) 1539

Neurochemical Characterization of Pyroxamidin, A New

Antihypertensive Drug [ChniAtoph Szyinizd, HeAbzht Nowak and Hani-

PzteA WoU)1542

Xiv FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

Section N: Neurological Disorders; Animal Models in Neurology

Current Approaches to Parkinsonism [Donald B. Calnz, AdAian

Wiltiami, ToomaA Eiklzn. and Hzikki Tznavainzn) 1547

Central Catecholamines and Neurologic Disease [Thomai N. ChaAz) 1554

Animal Models of Parkinson's Disease (M. GoldAtzin, J.Y. Lzw,S. NakamuAa, A.F. BattiAta and A. Lizbznman) 1559

Homovanillic Acid in Cerebrospinal Fluid and Carbon-11 Labelled

Dopa for the Detection of Cerebral Dopamine Processes _In Vivo

(J. Koh-l, M.L. Aizznitzin, S. RziHeAA, W. VaalbuAg and M.G.

Woldning) 1564

Oxygen-18 Use for Clinical Studies of Central Monoamine

Metabolism [T.N. ChaAz, A. NzophytidzA, V. Samuel, G. Szdvall and

C-G. Swahn) 1569

Monoamine Oxidase Activity in Fibroblasts From Control In¬

dividuals and Patients with Inherited Neurologic Diseases [SUAanB. EdzlAtzin, Mania R.C. Co&ta, Canmela M. CaAtiglionz and Xandna0. BAzakziield) 1572

Selective MAO Inhibition: A New Strategy in the Treatment of

Parkinson's Disease [J.V. ElAWoKth, 1/. GloveA and M. Sandlzn.) . . . . 1575

Neurotransmitters in Neurological Disorders of Childhood (I.J.

ButleA, W.E. Szi&znt, S.H. Koilow, R.M. CapAioli and H.S. SingzA). . 1578

Central Dopamine Metabolism in Human Paradoxical Sleep Dis¬

orders [JacqueA MouAet, BeAnaAd Rznaud and Robznt BloiA) 1581

Bromocriptine and Lergotrile in Parkinson Disease [AbnahamLizbznman, Elihu, Eitzy, Govindan Gopinathan, MaAfe. KupznAmitk and

Mznzk GoldAtzin) 1584

Catecholamine-Related Enzymes in the Brain of Parkinsonian

Patients (T. NagatAu, T. Koto, 1. Nagatiu, Y. Kondo, S. Inagaki, R.

Izafea and H. NaAabayoAki) 1587

Clinical Trials of Dopamine Receptor Sensitivity Modification

[MuAAay AlpeAt and Arnold J. Fnizdho^) 1590

Approaches to Study CA Turnovpr in Man Using In Vivo Deuterium

Labelling [BiAgitta SjoquiAt, E/tik AnggaAd, Enik WideAlbv and

Tommy LzwandeA) 1593

Apomorphine Prodrug Derivatives as Long-Acting Dopamine Re¬

ceptor Active Agents With Potential Clinical Utility [RoM J.

BaldzAiOAlni) 1596

The Antiparkinsonian Efficacy and Dopaminerphillic Propertiesof Ergot Alkaloids and of Tetrahydroisoquinolines [J.W. Lew, Y. Baba,S. NakamuAa, J. Engel and M. GoldAtzin) 1599

Assays of Monoamine Metabolites in CSF Samples From Control and

Narcoleptic Canines [Kym Fault, Antkun. S. Foatz, R. Baucz Holman,Patnicia J. AndeAAon and William C. Vzmznt) 1602

Characterization of [3H] Spiroperidol Binding in the Rat

Substantia Nigra [JzAemy I. Fizldi, TzhAy V. RziAinz, Nonman W. Pzdigoand HznAy I. ^amamuAa) 1605

An Animal Model for Huntington's Disease: Striatal Kainic

Acid Lesion [Joizph T. Coylz, Katklzzn BizieAz, Pztzn. CampochiaAo,Edythz London, Robznt Sckwancz and RobeAt Zaczefe) 1608

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM XV

Duration of Drug-Induced Dyskinesias: A PharmacologicDistinction (BAu.ce I. Viamond and RichoAd L. BoniAon) 1611

An Animal Model of Pharmacological Therapy for Tardive

Dyskinesia Using Cholinergic Drugs (B.J. Sakakian, J.H. Gnowdon, W.R.

Millington, J.K. Boaa and R.J. Wuntman) 1614

Hypothalamic Hyperphagia Prevented by Destruction of Brain

Dopamine-Containing Neurons [John F. MaAAkall, Neil Rowland, SzymOUAM. Antelman and Vavid J. Edwandi) 1617

Neuropeptides and Other Dopamine Modulators in the Extra¬

pyramidal System [Bnucz I. Viamond, Rodznick Waltex, Gany S. Sudako^,Hznni S. Havdala, Gany A. OltmanA and Richand L. BoniAon) 1620

On the Mechanisms of Extrapyramidal Reactions Induced by

Neuroleptic Drugs (P. JznnzA, B.S. Mzldnum and C.V. Maudzn). . . .1623

CNS and Adrenal Gland Tyrosine Hydroxylase and the Influence

of Drug-Treatment on cAMP - Activity in Parkinson's Disease -

Human Post Mortem Studies (Pei:eA RizdzAeA, WaltkeA BiAkmzyeA, Wol&-VieteA RauAch, KuAt JzllingzA and Waltzx Vanizlczyk) 1625

A Comparison of the Effects of Chronic (Six Month) Administration

of Trifluoperazine and Thioridazine on Striatal Dopamine Function

in Rats [PztzA JznneA, Angela Clow, Andnzai Tkzodonou and C. Vavid

MaAidzn) 1628

Dopamine-Beta-Hydroxylase (DBH) and Pupillary Sympathetic

Activity in Idiopathic Torsion Dystonia (ITD) (A.P. KoACZljn, E.

Kahana, M. AltzA, R. Rabinowitz and M. Stnei&leA) 1631

Differential Clozapine Action on CNS Stimulants [EvzAztt H.

Eltinwood, Ja. and M. Manlynz Kilbzy) 1634

The Role of Scheduling in Amphetamine Hypersensitivity and

Tolerance (J.J. Fzigznbaum, W.J. isleinzn and H.L. Klawani) 1637

The Involvement of Monoaminergic Mechanisms in a Chemically-

Induced Hyperkinetic Syndrome in the Rat [Sabit Gabay) 1640

The Anticonvulsant Effect of Neuroleptics: Dependence on

Intact Noradrenergic Transmission (P. Wohmi and K.G. Lloyd) ....1643

Turnover and Excretion of VMA by Normal Volunteers and Patients

With Neural Crest Tumors (Etaood H. LaBhOAAZ) 1646

Brain Monoamines in Human Metabolic Encephalopathies [PetZA

Ri.zdzn.2A, KuAt JzllingeA and Wol^-VieteA RauAch) 1649

Immune Lesions of Central Noradrenergic Neurons Produced by

Dopamine 3-Hydroxylase (DBH) Antibodies (L.B. Gz^Zn, M. Coita, R.A.

RuAkand V. BnidgzA) 1652

Chronic Lead Exposure, Hyperactivity, and Alteration of Basal

and Catecholamine-Sensitive Adenylate Cyclase [Jamzi A. Nathanion) .1655

The Daily Fluctuation of Striatal Dopamine Content and d-

Amphetamine and Apomorphine Induced Stereotypic Behavior (P.M.

CaAvzy, W.J. WeinzA, P.A. NauAizda and Han.old L. Klawani) 1658

Section 0: Catecholamines and Behavior

Behavioral Neurochemistry—Expanding Perspectives (John Maddzn, 11/,

Glzn R. Elliott and Jack V. BoacMa) 1663

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

f

Age-Dependent Effects of 6-Hydroxydopamine on Locomotor

Activity in Rats (L. Szidzn, L. Eninoil, R. MacPhail, A. HzllzA

and F. E. MUIza) ,1669

Nonstriatal Dopamine Mechanisms in the Response to Repeated

D-Amphetamine Administration 1(0,5. Szgal, P.H. Kelly, G. Koob and

V.C.S. RobeAtA) 1672

Midbrain-Hypothalamic Catecholamine Projection Systems Mediating

Feeding Stimulation and Inhibition in the Rat [SaAak Fn.yeA Leibowitz)1675

Role of Forebrain Noradrenaline in Reward and Nonreward

[S. Owzn, M.R. BoaxdzA, J. Fzldoh, J.A. Gnay and M. Fillznz). . . .1678

Dopamine in Prefrontal Cortex of Rhesus Monkeys: Evidence for

A Role in Cognitive Function [Tkomai J. BAOzOiki, RogeA M. BAoWn,

JzhlAy Ptak and PatAicta S. Goldman) .... - .1681

Strain-Specific Mechanisms Regulating Adrenal Catecholamine

Synthesizing Enzymes During Repeated Immobilization Stress (Jon

M. Stolk, Vavid 0. Coopzn, Jz{iAzy H. HuAAt, MoJty Lzz LzdbztteA

and PztzA Q. HoaaAa ) 1684

Central Adrenergic Neurons as Mediators of Motivation and

Behavior-Evidence From the Specific Inhibition of PNMT (R.J. Katz,BaAbana B. TuAnzA, K.A. Roth and Bzxnand J. CaAAolt) 1687

The Role of Drugs Affecting Catecholamines on Shock-Elicited

Fighting in Rats [Mickazl H. ShzaAd) 1690

Evidence for the Involvement of a Brain Norepinephrine System

In Anxiety [V.E. Rzdmond, Ja., Y.H. Huang, J. Bauhi. and M.S. Gold). 1693

Social Setting: Effect on Physiological and Catecholamine

Parameters Elicited by Stress in the Rat (BuAA Eichzlman) 1696

Emergent Social Behavior and Hormonal Activity [Pathicia R.

BaAchai, William A. HahAiA, Pamela Angwin and Jack V. BaAchai). . .1699

The Effects of Amphetamine on Agonistic Behaviors in Non-

human Primates Suzannz HabzA, Philip A. BzAgzn. and PatAicia R.

BaAchai) 1702

Interaction of Alterations in Biogenic Amine Metabolism With

the Despair Response to Peer Separation in Rhesus Monkeys [GaAy W.

Kn.azmeA and William T. McKinnzy) 1705

The Role of Catecholamine in Hyperactivity Induced by Social

Isolation (R. Aihkznazi, I. SpziAeA and M. Wzinitock) 1708

Effect of Haloperidol (HAL) and Pimozide (PIM) on Pavlovian

Conditioning of the Rabbit Nictitating Membrane Response [MichaelP. Gimpl, liidoAz Gonmzzano and John A. HaAvzy) 1711

Hormonally-Mediated Noradrenergic Modulation of MemoryProcesses [Paul E. Gold 1714

Drug Induced Amnesias: Behavioral, Pharmacological and Neuro¬

chemical Studies [LzwiA S. FAzzdman and Vavid QuaAteAmain) 1717

The Interaction Between Brain Noradrenaline and the Pituitary-

Adrenal Axis in Avoidance Learning (5.0. OgAzn, K. Fuxz, C. KohlzA

and R. ScnwaAcz) 1720

Absence of Operant Behavioral Effect Following Specific Nor¬

adrenaline Lesions in the Rat Hippocampus [Vale, W. PzteAion andRichand Lavznty) 1723

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM Xvi i

Blockade of the Different Enzymatic Steps in the Synthesis ofBrain Amines and Learning (CAR) in Hypobaric Hypoxic L.Dopa TreatedRats [FhanciA BoiimaAz, Moniquz Lz Poncin-Laiittz and Jzan Rapin) . . 1726

Activity of Central Catecholamine Systems and Feeding Be¬havior (Jan van dzn. Qugten and Jzi L. Slangzn) 1729

Monoamlnergic Function During Perinatal Life Under PerturbedFeeding Patterns and Undernutrition [S. Poavzz, G. limahan, A.

VzguzuAcz and H. Poavzz) 1732

Parallel Increase of Feeding and Hypothalamic Self-StimulationAfter Midbrain 6-Hydroxydopamine, But No Correlation of HyperphagiaWith Norepinephrine Depletion (Lu-c6 HzAnandzz and Bantlzy G. Hozbel). 1735

Roles of Catecholamines in Self-Stimulation and Other Behaviorsand Their Modifications by Drugs (5.W. Pnadkan and 5. Pnadhan). . . . 1738

Brain Stimulation Reward Sites Mapped in Relation to the

Ascending Catecholamine Systems [Vale CoAbztt and Roy A. llliAz). . . .1741

Dopamine Mediates the Rate-Increasing Effect of D-Amphetamineon Intracranial Self-Stimulation (A.G. Phiilipi and H.C. Fibigex) . .

1744

Models of Manic Behavior in Rats [3ohgz PeAzz-Cnazt, TkomaiVoutkitt and Walid Shzkim) 1747

Catecholamines and Sleep [EAnzit L. HaAtmann) 1750

The Role of the Mesolimbic Dopamine System in Locomotor

Activity, Eating and Drinking in the Rat [Gzongz F. Koob and TKzvohW. RobbiM) 1753

Behavioral Problems in Farm Animals [V.F. Shanman] 1756

Persistent Effects of Stress on Dopamine-Related Behaviors:

Clinical implications [SzymouA M. Antzlman and Alan J. EichleA). . . 1759

Decreased Activity and Increased Arborizations of the Rat

Mesocortical DA Neurons After Destruction of Ascending NE Bundles

(J.P. Taiiin, L. Lavizltz, G. Blanc, A.M. TklzhAy and B. BeAgeA). . .1762

Brain Dopamine and Sexual Behavior: Psychopharmacological and

Electrophysiological Evidence for an Antagonism Between Active and

Passive Components (A.R. Cagg-uiXa, 5.M. Antzlman, L.A. Chiodo andC.G. LintbeAAy) . 1765

The Type of MAO in the Nigrostriatal Dopaminergic Neurons of

the Rat [Bzntha Knoll, Julia Timan. and J. Knoll) 1768

Effect of Catecholamine Depletion on Alcohol Tolerance and De¬

pendence [Jzanzttz M. Wood and R. LaveAty) 1771

Recovery of Cocaine Self-Administration After 6-OHDA Lesion of

The N. Accumbens Correlates with Residual Dopamine Levels [V.C.S.

Robznti, M.E. CoAconan and H.C. Fibigzn.) 1774

Structure-Activity Relations in the Behavioral Effects of

Cocaine Derivatives [R.V. Spzalman and R.T. Kzlizkzn.) 1777

Lesions of the Meso-Cortico-Limbic Neurons in Rats: Dramatic

Increase of the Sensitivity to D-Amphetamine in a Self-Administration

Acquisition Paradigm [Mickzl Lz Moot, LouiA Stinui, Odilz Gai{oniand Hzavz Simon) 178°

Central Reward Systems and Substance Abuse (Conon Konnztikyand Ralph (J. Eipoiito) 1783

xviii FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

Electroconvulsive Shock and Reserpine: Effects on Mono-

aminergic Receptor Binding in Rat Brain [Vzbha A. BeAgitAOm,SuAan TAziizn and Kznnzth J. Kzltan.) 1786

Plasma Catecholamines and Behavior of Rats During Stress

[Richand McCaxty and Inwin J. Kopin) 1789

Hypothesis for the Local Control of Norepinephrine Release

[Vavid M. Jacobowitz) 1792

Plasma Catecholamines Under Basal and Stressful Conditions

in Rat Strains Selectively Bred for Differences in Response to

stress [Vavid A. BlizaAd and Baucz Liang) 1795

In Vivo Release of Neurotransmitters Monitored by Continuous

Cerebral Ventricular Perfusion in the Rat: Effects of Alcohol

(R. Bhu.cz Holman, GAzg EgeA, Patnicia J. AndeAion and Kym Fault) . . 1798

Daily Fluctuation in Dopamine, Norepinephrine, Gamma-

Aminobutyric Acid and Melatonin Metabolism in the Non-Human Primate

(MoAfe J. Pzhlaw) 1801

Section P: Catecholamines and Psychiatric Disorders

A Possible Role for Dopamine in Schizophrenia and Manic-

Depressive Illness (A Review of Evidence) [William E. Bunnzy, Ja.,

Vanizl P. van Kammzn, Robznt M. Pobt and Blynn L. Ganland) 1807

Catecholamine Related Substances and Schizophrenia: A Review

[RichaAd Jed Wyatt, Llewellyn B. Big2low and J. Ckhiitian Gitlin). . 1820

Depression [John M. Vavii) 1826

Monoamine Metabolites in CSF in Psychiatric Disorders [PhilipA. BeAgeA, Kym Faull, Kenneth L. Vavii and Jack V. BaAchai) 1827

Pharmacologically Induced Bidirectional Change in Sensitivity

of Central Nervous System Dopamine Receptors (A.J. Fhizdho^, K.

Bonnet and H. Roizngantzn) 1830

Phenylethylamine (PEA) and Chronic Schizophrenia [RichaAd Jzd

Wyatt, Stzvzn G. Potkin, H. Elzanon. Cannon, Montz S. Buchibaum,VznniA L. MuAphy, VaAouk KaAoum, J. ChAiAtlan Gillin and Vavid M.

StoU) 1833

Dopamine Agonist Treatment of Schizophrenia (C.A. Tamminga,

M.H. SchaiieA, r'.C. Smith and John M. Vavii) 1836

Inhibition of Dopamine Synthesis in Chronic Schizophrenia:A Follow-Up Study (J. ChAiitian Gillin, Joel E. Kleinman, HznAy A.

NaAKallak, Llewellyn B. Bigzlow, Allan Rogo£, Vanizl Luchini, John

Canman, Vanizl WzinbeAgzA and RichaAd Jzd Wyatt) 1839

The Dopamine Hypothesis of Schizophrenia: A Reappraisal

(M. Sandlzn.) 1842

Catecholamines and Metabolites in the Brains of Psychotics and

Normals: Post-Mortem studies [Joel E. Klzinman, Pztzn. Bnidgz, FaAouk

KaAoum, Sam Spzcialz, Rickand Staub, Stzvzn lalcman, J. CkniAtian

Gillin and Richand Jzd Wyatt). . 1845

Skeletal Muscle Monoamine Oxidase Activity in Psychiatric Pa¬

tients and Normal Controls [Ramzih C. AAOAa and HeAbzAt Y. Mzltzzh.) ,1848

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM Xlx

Propranolol Treatment of Chronic Schizophrenia: Clinical

Response, Catecholamine Metabolism and Lymphocyte g-Receptors

[Llzwellyn B. Bigzlow, Stzvzn lalcman, Joel E. Klzinman, Vanizl

WzinbzAgzA, Vanizl Luckini, John Tollman, FaAouk KaAoum and

Richand Jzd Wyatt) 1851

Phenylethylamine, A Putative Dopaminergic Agonist: Its;

Possible Role in the Pathogenesis of Schizophrenia [G.P. Rzynoldi,C.R.J. Ruthvzn, B.L. Goodwin and M. Sandlzh) 1854

Genetics and Biochemistry of Schizophrenia in a Defined

Population [Lznnant WztX.zh.bzAg, Jan A. Book, Ylva Flodzhui and

Svantz B. Ron) 1857

Biochemical Discrimination of Subtypes of Depressive Dis¬

orders (Joseph J. Schild.kna.ut, Paul J. OhAulak, Alan F. Schatzbzng,Jon E. Gudzman, Jonathan 0. Colz, RichaAd A. LaBniz and William

Rohdz) 1860

Norepinephrine Metabolite Studies in Affective Illness

[FAzdznick K. Goodwin and William 1. Pottzn.) 1863

Studies of Norepinephrine Metabolism in Manic and Depressive

States [Anqzloi E. HalohiA and Edutand M. VeUet) 1866

Platelet MAO and Urinary MHPG in Affective Disorders [Vavid

J. Edwandi, Vuanz G. SpikeA, Vavid J. Kupizn. and John F. Neil). . . 1869

Trace Amines in Depression: Tyramine and Octopamine Deficit

(M. Sandlzh., C.R.J. Ruthvzn, B.L. Goodwin, G.P. Rzynoldi, A. Coppzn) 1872

Metabolism and Turnover of MHPG in the Monkey (P. Blombzhy,I.J. Kopin, E.K.Gohdon and M.H. Ebznt) 1875

Neurotransmitter Metabolite Production by Human Brain [Jamei ill.

Maai, Nicholai M. GKzznz, Suian E. Hattox and V. Hanold Landii) . .1878

Research Strategies in Depression: A Clinical Pharmaco-

therapeutic Approach (Baton Shopiin) 1881

Dopamine Metabolites in Brain Regions of Schizophrenics

[Nicholai G. Bacopouloi, Edwahd V. Bind and Robznt H. Roth) .... 1884

Plasma and CSF Dopamine Metabolites in Psychiatric Patients:

Effects of Probenecid and Haloperidol (G. HzningeA, N. Bacopouloi,

R. Roth, M. Bowzaa, Ja. and V. Swzznzy) 1887

Heterogeneity of Prolactin Response to Haloperidol (RobeAt T.

Rubin and Sally E. Hayi) 1890

Cerebrospinal -?luid (CSF) Homovanillic Acid (HVA), CyclicAdenosine Mono-Phosphate (cAMP), Prolactin and Serum Prolactin in

Acute Psychotic Patients at Two Points During Early Chlorpromazine

(cpz) Treatment (M.S. BoweA6, Jn., G.R. HzningeA and H.Y. Mzltzzn.) 1893

Heterogeneity in Response to Amphetamine in Schizophrenia:Effects of Placebo, Chronic Pimozide and Pimozide Withdrawal [Vanizl

P. van Kammzn and William E. Bunnzy, Jn..) 1896

Dopaminergic Agents in Affective Illness: Studies with

Piribedil, Amphetamine and Pimozide [RobzAt M. Poit, Vavid C. Jimzuon,

ilicton. 1. Rzua, FfLzdzhick K. Goodwin, Edwand Sitbzhman and W.E.

Bunnzy, Ja. ). .

1899

Methylphenidate Induced Changes in Behavior, Growth Hormone

and Prolactin [V.S. JawWiky, L.L. Judd, L. Huzy, V. Pahkzh. and

P. Lzicknzn.) 1902

FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM

Dopamine and Schizophrenia: Relationships to Blinking and

REM (J.R. Stzvzni, A. Livzhmofiz, Ja.,

K. Wztzel and S. Roiznblum). . 1905

Catecholamine Metabolizing Enzymes and Primary Affective

Disorders [Vavid L. VunneA and Ronald R. Fizvz) . 1908

The Effect of Lithium Pretreatment on Cardiovascular and Be¬

havioral Responses to Amphetamine (B. AnghiAt and 5. GzAihon) .... 1911

Urinary Amine Metabolites as Predictors of Response to

Antidepressant Medication (A. Paulinz RidgeA) , 1914

Urinary 3-Methoxy-4-Hydroxyphenethylene Glycol and State

Variables in Affective Disorder [Vonald R. Swzznzy, Jamzi W. Maai

and Vavid Pickax) 1917

EEG Sleep and Affective Disorders: What Can it Predict?

[Vavid J. Kuplex, Vuanz G. Spikzn, Patxicia Coblz, John F. Neil,linazl Hanin, Vavid J. Edwoxdi, Richaxd J. McPantland, Vavid H.

Shaw, Bahxy Holzzn. and Tkomai Ghau) .1920

Clinical Studies With Drugs Affecting Biogenic Amine Mechanisms

[Louii LembzAgzA, H. Rowz, R. Caxmichael and R. Chjabtxtt) 1923

Brain and Platelet Monoamine Oxidase (MAO) Activities in

Relation to Ethanol Abuse (L. QKzland, C.-G. Gott{hizi, A. WibeXg and

B. Winblad) 1925

Platelet Monoamine Oxidase and Cortical Evoked Potentials as

Predictors of Psychiatric Vulnerability [RichaAd J. HaieX, Montz S.

Buchibaum and Vznnii L. Muxphy) 1928

Noradrenaline and Fear [Stzphzn T. Maion and Hani C. Fibigzh.) . 1931

Reduced Erythrocyte COMT and Plasma DBH Activities Not Associated

With Affective Disorders in Patients and Relatives [Elliot S. GZAihon,C. Raymond Lakz and Jamzi F. Lzckman) 1934

Catecholamine Response to Short-Time Stress in Schizophrenicand Depressive Patients (M. Ackznhzil, M. AlbuA, F. M'ullZA, Th.

M'ultex, V. Wzltex, K. landzn. and R. Engel) 1937

Serum Dopamine-B-Hydroxylase in Schizophrenic Patients

[K. Fujita, T. Ito, K. Mahuta, R. Texadaixa, H. Bzppu, V. Nakagami,V. Koto, T. Nagatiu and T. Koto) 1940